An Infrared High Proper Motion Survey Using 2MASS and SDSS: Discovery of M, L and T Dwarfs

A search of the Two Micron All Sky Survey and Sloan Digital Sky Survey reveals 36 previously unknown high proper motion objects with J<17. Their red-optical colors indicate that 27 are M dwarfs, 8 are early-type L dwarfs, and 1 is a late-type T dwarf. The L dwarfs have J-Ks colors near the extrema of known L dwarfs indicating that previous surveys for L dwarfs using color as a selection criterion may be biased. Followup near-infrared spectroscopy of 6 dwarfs confirm they are all late-type with spectral types ranging from M8 to T4. Spectroscopy also shows that some of the L dwarf spectra exhibit peculiar features similar to other peculiar "blue" L dwarfs which may indicate that these dwarfs have a relatively condensate free atmosphere or may be metal poor. Photometric distance estimates indicate that 22 of the new M, L and T dwarfs lie within 100 pc of the Sun with the newly discovered T dwarf, 2MASS J10595185+3042059, located at about 25 pc. Based on the colors and proper motions of the newly identified objects, several appear to be good subdwarf candidates. The proper motions of known ultracool dwarfs detected in our survey were also measured, including, for the first time, SDSS J085834.42+325627.6 (T1), SDSS J125011.65+392553.9 (T4) and 2MASS J15261405+2043414 (L7).Comment: 14 pages, 7 tables, 9 figures: Accepted for the January 2009 AJ issu

A spectroscopic and proper motion search of Sloan Digital Sky Survey : red subdwarfs in binary systems

Red subdwarfs in binary systems are crucial for both model calibration and spectral classification. We search for red subdwarfs in binary systems from a sample of high proper motion objects with Sloan Digital Sky Survey spectroscopy. We present here discoveries from this search, as well as highlight several additional objects of interest. We find 30 red subdwarfs in wide binary systems including: two with spectral type of esdM5.5, 6 companions to white dwarfs and 3 carbon-enhanced red subdwarfs with normal red subdwarf companions. 15 red subdwarfs in our sample are partially resolved close binary systems. With this binary sample, we estimate the low limit of the red subdwarf binary fraction of similar to 10 per cent. We find that the binary fraction goes down with decreasing masses and metallicities of red subdwarfs. A spectroscopic esdK7 subdwarf + white dwarf binary candidate is also reported. 30 new M subdwarfs have spectral type of >= M6 in our sample. We also derive relationships between spectral types and absolute magnitudes in the optical and near-infrared for M and L subdwarfs, and we present an M subdwarf sample with measured U, V, W space velocities.Peer reviewe

Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with type 2 diabetes with and without fatty liver

To investigate the potential of therapies which reduce glucocorticoid action in patients with Type 2 diabetes we performed a randomized, double-blinded, placebo-controlled crossover study of acute glucocorticoid blockade, using the glucocorticoid receptor antagonist RU38486 (mifepristone) and cortisol biosynthesis inhibitor (metyrapone), in 14 men with Type 2 diabetes. Stable isotope dilution methodologies were used to measure the rates of appearance of glucose, glycerol, and free fatty acids (FFAs), including during a low-dose (10 mU·m −2·min−1) hyperinsulinemic clamp, and subgroup analysis was conducted in patients with high or low liver fat content measured by magnetic resonance spectroscopy (n = 7/group). Glucocorticoid blockade lowered fasting glucose and insulin levels and improved insulin sensitivity of FFA and glycerol turnover and hepatic glucose production. Among this population with Type 2 diabetes high liver fat was associated with hyperinsulinemia, higher fasting glucose levels, peripheral and hepatic insulin resistance, and impaired suppression of FFA oxidation and FFA and glycerol turnover during hyperinsulinemia. Glucocorticoid blockade had similar effects in those with and without high liver fat. Longer term treatments targeting glucocorticoid action may be useful in Type 2 diabetes with and without fatty liver

The Hyperactive L Dwarf 2MASS J13153094-2649513: Continued Emission and a Brown Dwarf Companion

We report new observations of the unusually active, high proper motion L5e dwarf 2MASS J13153094-2649513. Optical spectroscopy with Magellan/MagE reveals persistent nonthermal emission, with narrow H I Balmer, Na I and K I lines all observed in emission. Low-resolution near-infrared spectroscopy with IRTF/SpeX indicates the presence of a low-temperature companion, which is resolved through multi-epoch laser guide star adaptive optics imaging at Keck. The comoving companion is separated by 338 \pm 4 mas, and its relative brightness (\Delta K_s = 5.09 \pm 0.10) makes this system the second most extreme flux ratio very low-mass binary identified to date. Resolved near-infrared spectroscopy with Keck/OSIRIS identifies this companion as a T7 dwarf. The absence of Li I absorption in combined-light optical spectroscopy constrains the system age to >~0.8-1.0 Gyr, while the system's kinematics and unusually low mass ratio (M_2/M_1 = 0.3-0.6) suggests that it is even older. A coevality test of the components also indicates an older age, but reveals discrepancies between evolutionary and atmosphere model fits of the secondary which are likely attributable to poor reproduction of its near-infrared spectrum. With a projected separation of 6.6 \pm 0.9 AU, the 2MASS J13153094-2649513 system is too widely separated for mass exchange or magnetospheric interactions to be powering its persistent nonthermal emission. Rather, the emission is probably chromospheric in nature, signaling an inversion in the age-activity relation in which strong magnetic fields are maintained by relatively old and massive ultracool dwarfs.Comment: 15 pages, accepted for publication in Astrophysical Journa

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial (Nature Medicine, (2021), 27, 11, (2012-2024), 10.1038/s41591-021-01488-2)

In the version of this Article initially published, there was an omission in the member list for the CONCOR-1 Study Group. Valérie Arsenault (Héma-Québec, Montreal, Quebec, Canada) has now been included in the CONCOR-1 Study Group in the online version of the article

Discovery and Characterization of a Faint Stellar Companion to the A3V Star Zeta Virginis

Through the combination of high-order Adaptive Optics and coronagraphy, we report the discovery of a faint stellar companion to the A3V star zeta Virginis. This companion is ~7 magnitudes fainter than its host star in the H-band, and infrared imaging spanning 4.75 years over five epochs indicates this companion has common proper motion with its host star. Using evolutionary models, we estimate its mass to be 0.168+/-.016 solar masses, giving a mass ratio for this system q = 0.082. Assuming the two objects are coeval, this mass suggests a M4V-M7V spectral type for the companion, which is confirmed through integral field spectroscopic measurements. We see clear evidence for orbital motion from this companion and are able to constrain the semi-major axis to be greater than 24.9 AU, the period > 124$ yrs, and eccentricity > 0.16. Multiplicity studies of higher mass stars are relatively rare, and binary companions such as this one at the extreme low end of the mass ratio distribution are useful additions to surveys incomplete at such a low mass ratio. Moreover, the frequency of binary companions can help to discriminate between binary formation scenarios that predict an abundance of low-mass companions forming from the early fragmentation of a massive circumstellar disk. A system such as this may provide insight into the anomalous X-ray emission from A stars, hypothesized to be from unseen late-type stellar companions. Indeed, we calculate that the presence of this M-dwarf companion easily accounts for the X-ray emission from this star detected by ROSAT.Comment: 9 pages, 6 figures, Accepted to Ap

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

Low intensity, non-noxious, stimulation of cutaneous somatosensory nerves has been shown to trigger oxytocin release and is associated with increased social motivation, plus reduced physiological and behavioural reactivity to stressors. However, to date, little attention has been paid to the specific nature of the mechanosensory nerves which mediate these effects. In recent years, the neuroscientific study of human skin nerves (microneurography studies on single peripheral nerve fibres) has led to the identification and characterisation of a class of touch sensitive nerve fibres named C-tactile afferents. Neither itch nor pain receptive, these unmyelinated, low threshold mechanoreceptors, found only in hairy skin, respond optimally to low force/velocity stroking touch. Notably, the speed of stroking which c-tactile afferents fire most strongly to is also that which people perceive to be most pleasant. The social touch hypothesis posits that this system of nerves has evolved in mammals to signal the rewarding value of physical contact in nurturing and social interactions. In support of this hypothesis, in this paper we review the evidence that cutaneous stimulation directly targeted to optimally activate c-tactile afferents reduces physiological arousal, carries a positive affective value and, under healthy conditions, inhibits responses to painful stimuli. These effects mirror those, we also review, which have been reported following endogenous release and exogenous administration of oxytocin. Taken together this suggests C-tactile afferent stimulation may mediate oxytocin release during affiliative tactile interactions

Movements of marine fish and decapod crustaceans: Process, theory and application

Many marine species have a multi-phase ontogeny, with each phase usually associated with a spatially and temporally discrete set of movements. For many fish and decapod crustaceans that live inshore, a tri-phasic life cycle is widespread, involving: (1) the movement of planktonic eggs and larvae to nursery areas; (2) a range of routine shelter and foraging movements that maintain a home range; and (3) spawning migrations away from the home range to close the life cycle. Additional complexity is found in migrations that are not for the purpose of spawning and movements that result in a relocation of the home range of an individual that cannot be defined as an ontogenetic shift. Tracking and tagging studies confirm that life cycle movements occur across a wide range of spatial and temporal scales. This dynamic multi-scale complexity presents a significant problem in selecting appropriate scales for studying highly mobile marine animals. We address this problem by first comprehensively reviewing the movement patterns of fish and decapod crustaceans that use inshore areas and present a synthesis of life cycle strategies, together with five categories of movement. We then examine the scale-related limitations of traditional approaches to studies of animal-environment relationships. We demonstrate that studies of marine animals have rarely been undertaken at scales appropriate to the way animals use their environment and argue that future studies must incorporate animal movement into the design of sampling strategies. A major limitation of many studies is that they have focused on: (1) a single scale for animals that respond to their environment at multiple scales or (2) a single habitat type for animals that use multiple habitat types. We develop a hierarchical conceptual framework that deals with the problem of scale and environmental heterogeneity and we offer a new definition of 'habitat' from an organism-based perspective. To demonstrate that the conceptual framework can be applied, we explore the range of tools that are currently available for both measuring animal movement patterns and for mapping and quantifying marine environments at multiple scales. The application of a hierarchical approach, together with the coordinated integration of spatial technologies offers an unprecedented opportunity for researchers to tackle a range of animal-environment questions for highly mobile marine animals. Without scale-explicit information on animal movements many marine conservation and resource management strategies are less likely to achieve their primary objectives