139 research outputs found
Detecting a single molecule using a micropore-nanopore hybrid chip
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The effects of selective head cooling versus whole-body cooling on some neural and inflammatory biomarkers: a randomized controlled pilot study
- Author
- A Peliowski-Davidovich
- A Roka
- A Róka
- AD Edwards
- AJ Gunn
- American College of Obstetricians and Gynecologists (ACOG)
- AN Massaro
- AR Horn
- Aytuğ Atıcı
- B Kracer
- CC Huang
- CF Hagmann
- D Azzopardi
- D Gazzolo
- DM Ferriero
- DV Azzopardi
- E Kasdorf
- Gülçin Eskandari
- IN Mir
- J Gardiner
- K Daetwyler
- KA Allen
- Khatuna Makharoblıdze
- L Hellstrom-Westas
- LF Chalak
- M Douglas-Escobar
- M Thoresen
- Mehmet Ali Sungur
- MF Guo
- MI Levene
- N Bayley
- N Ghotbi
- N Nagdyman
- PD Gluckman
- S Shankaran
- SE Jacobs
- Selvi Gülaşı
- Serin Akbayır
- SL Olsen
- T Austin
- T Takenouchi
- V Ramaswamy
- Yalçın Çelik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Conservation strategies for Arapaima gigas (Schinz, 1822) and the Amazonian várzea ecosystem
- Author
- BAYLEY PB
- BEERLI P.
- BEERLI P.
- CANTANHEDE AM
- COCKERHAM CC
- CRANDALL KA
- CROSSA M.
- CROSSA M.
- CROSSA M.
- DINIZ-FILHO JAF
- EPPERSON BK
- EXCOFFIER L.
- FARIAS IP
- FARIAS IP
- FRANKHAM R.
- GAGGIOTTI OE
- GOUDET J
- GOULDING M.
- GOULDING M.
- HALL T
- HRBEK T
- IP. Farias
- LAVOUÉ S
- LUNDBERG JG
- LÜLING V
- M. Crossa
- MANLY BFJ
- MANTEL N.
- MENEZES RS
- NELSON G
- NELSON JS
- PEARSE DE
- QUEIROZ HL.
- RAYMOND M.
- RICHARD M.
- ROOSEVELT AC.
- SAINT-PAUL U.
- SAMBROOK J.
- SANTOS MDCF.
- SLATKIN M.
- SMOUSE PE.
- SOKAL RR.
- SOKAL RR.
- SOKAL RR.
- T. Hrbek
- VASCONCELOS WR.
- VERÍSSIMO J.
- WRIGHT S.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The Potential and Challenges of Nanopore Sequencing
- Author
- A Aksimentiev
- A Aksimentiev
- A Meller
- A Meller
- A Meller
- A Meller
- AF Sauer-Budge
- AJ Storm
- AJ Storm
- Amit Meller
- Andre Marziali
- Andrew Hibbs
- B Hornblower
- C Cheikh
- C Tropini
- Carlos H Mastrangelo
- CC Harrell
- CM Joyce
- CM Payne
- D Fologea
- D Fologea
- D Fologea
- Daniel Branton
- David W Deamer
- DK Lubensky
- DW Deamer
- ER Mardis
- G Sigalov
- Gautam V Soni
- GV Soni
- H Liu
- H-C Wu
- Hagan Bayley
- HC Loebl
- I Huopaniemi
- J Golovchenko
- J He
- J Lagerqvist
- J Lagerqvist
- J Li
- J Li
- J Mathe
- J Mathe
- J Michael Ramsey
- J Nakane
- J Shendure
- JA Schloss
- JB Heng
- JB Heng
- Jeffery A Schloss
- JH Jett
- JJ Kasianowicz
- JJ Nakane
- JM Rothberg
- John S Oliver
- JW Lee
- K Healy
- M Akeson
- M Gershow
- M Muthukumar
- M Wanunu
- M Wanunu
- M Wanunu
- M Xu
- M Zwolak
- M Zwolak
- MA Holden
- MA Holden
- Massimiliano Di Ventra
- Matthew Wiggin
- ME Gracheva
- ME Gracheva
- ME Hughes
- Meni Wanunu
- MJ Kim
- N Ashkenasy
- N Tobkes
- O Braha
- P Chen
- P Chen
- P Chen
- Predrag S Krstic
- R Drmanac
- R Zikic
- RJ White
- RMM Smeets
- Robert Riehn
- S Benner
- S Matysiak
- S Meng
- SL Cockroft
- Slaven Garaj
- SS Chern
- Stevan B Jovanovich
- Steven A Benner
- Stuart Lindsay
- T Ohshiro
- Thomas Butler
- V Meunier
- V Tabard-Cossa
- Vincent Tabard-Cossa
- X Zhao
- X-G Zhang
- XF Kang
- XF Kang
- Xiaohua Huang
- Xinsheng Sean Ling
- Y Astier
- Yuriy V Pershin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2008
- Field of study
A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore. The nanopore provides a highly confined space within which single nucleic acid polymers can be analyzed at high throughput by one of a variety of means, and the perfect processivity that can be enforced
in a narrow pore ensures that the native order of the nucleobases in a polynucleotide is reflected in the sequence of signals that is detected. Kilobase length polymers (single-stranded genomic DNA or RNA) or small molecules (e.g., nucleosides) can be identified and characterized without amplification or labeling, a unique analytical capability that makes inexpensive, rapid DNA sequencing
a possibility. Further research and development to overcome current challenges to nanopore identification of each successive nucleotide in a DNA strand offers the prospect of ‘third generation’ instruments that will sequence a diploid mammalian genome for ~$1,000 in ~24 h.Molecular and Cellular BiologyPhysic
Primate TNF Promoters Reveal Markers of Phylogeny and Evolution of Innate Immunity
- Author
- A Baena
- A Fischer
- A Hamann
- A Richardson
- A Varki
- AE Goldfeld
- AE Goldfeld
- AG Wilson
- AG Wilson
- AH Hajeer
- Alan R. Mootnick
- Alla V. Tsytsykova
- AM Uglialoro
- Andres Baena
- Anne E. Goldfeld
- AR Mootnick
- AR Mootnick
- AV Tsytsykova
- AV Tsytsykova
- BM Brinkman
- C Roos
- C. Groves
- CA Alper
- CC Muir
- CG Schrago
- CG Schrago
- Christopher Arendt
- Claudia Brieva
- D Boffelli
- D Boffelli
- D Brandon-Jones
- D Hata
- DA Hinds
- DA Tagle
- DE Wildman
- DL Swofford
- E Bailes
- EC Hernández
- EH McConkey
- EJ Yunis
- EY Tsai
- EY Tsai
- EY Tsai
- F Gao
- F Heissig
- F Mérien
- F Villinger
- F Waldron-Lynch
- Filipa Ligeiro
- GM Cooper
- GV Glazko
- HC Ackerman
- HH Stedman
- I Ebersberger
- I Hellmann
- I Ovcharenko
- J Felsenstein
- J Klein
- J Wienberg
- James V. Falvo
- JC Aguillon
- JC Delgado
- JC Opazo
- JD Thompson
- JG Hacia
- JG Hacia
- JM Heraud
- JP Bayley
- JP Noonan
- JV Falvo
- JY Leung
- L Li
- L Zhi
- M Caceres
- M Goodman
- M Ruvolo
- ME Woolhouse
- MT Webster
- MV Hollegaard
- MV Olson
- MV Rockman
- MV Rockman
- MW Hahn
- MW Karaman
- N Patterson
- Oliver A. Ryder
- Ousmane M. Diop
- P Gagneux
- P Khaitovich
- PA Zimmerman
- Pascal Gagneux
- PE Posch
- R Barthel
- R Wimmer
- RA Mittermeier
- RD Allen
- RE Green
- RL Raaum
- RL Stauffer
- S D'Alfonso
- S Kumar
- S Kumar
- S Mummidi
- S Müller
- SB Carroll
- SB Carroll
- SB Haudek
- SB Haudek
- SL Page
- Stephen J. O'Brien
- T Higuchi
- W Enard
- W Enard
- W Enard
- WB Harland
- X Gao
- X Xu
- Y Gilad
- Y Gilad
- Y Zhang
- Z Takacs
- Publication venue
- NSUWorks
- Publication date
- 01/01/2007
- Field of study
Background. Tumor necrosis factor (TNF) is a critical cytokine in the immune response whose transcriptional activation is controlled by a proximal promoter region that is highly conserved in mammals and, in particular, primates. Specific single nucleotide polymorphisms (SNPs) upstream of the proximal human TNF promoter have been identified, which are markers of human ancestry.
Methodology/Principal findings. Using a comparative genomics approach we show that certain fixed genetic differences in the TNF promoter serve as markers of primate speciation. We also demonstrate that distinct alleles of most human TNF promoter SNPs are identical to fixed nucleotides in primate TNF promoters. Furthermore, we identify fixed genetic differences within the proximal TNF promoters of Asian apes that do not occur in African ape or human TNF promoters. Strikingly, protein-DNA binding assays and gene reporter assays comparing these Asian ape TNF promoters to African ape and human TNF promoters demonstrate that, unlike the fixed differences that we define that are associated with primate phylogeny, these Asian ape-specific fixed differences impair transcription factor binding at an Sp1 site and decrease TNF transcription induced by bacterial stimulation of macrophages.
Conclusions/significance. Here, we have presented the broadest interspecies comparison of a regulatory region of an innate immune response gene to date. We have characterized nucleotide positions in Asian ape TNF promoters that underlie functional changes in cell type- and stimulus-specific activation of the TNF gene. We have also identified ancestral TNF promoter nucleotide states in the primate lineage that correspond to human SNP alleles. These findings may reflect evolution of Asian and African apes under a distinct set of infectious disease pressures involving the innate immune response and TNF
HIV and cancer in Africa: mutual collaboration between HIV and cancer programs may provide timely research and public health data
- Author
- A Del Mistro
- A Mocroft
- A Rowhani-Rahbar
- AC Bayley
- AC Templeton
- AE Friedman-Kien
- AE Grulich
- AE Grulich
- AJ Sasco
- AK Chaturvedi
- AK Chaturvedi
- Annie J Sasco
- B Ensoli
- BN Maggwa
- BS Sylla
- C Ateenyi-Agaba
- C Ateenyi-Agaba
- CC McGowan
- Clement Adebamowo
- CS Rabkin
- D Morgan
- D Morgan
- D Serwadda
- D Serwadda
- DC Stefan
- DM Parkin
- DM Parkin
- DM Parkin
- DM Parkin
- E Chokunonga
- E Lanoy
- EA Engels
- F Bonnet
- F Sitas
- F Sitas
- F Sitas
- G La Ruche
- G La Ruche
- GM Clifford
- GM Clifford
- H Amir
- HR Wabinga
- HR Wabinga
- HW Jaffe
- J Mermin
- JF Taylor
- JJ Goedert
- JJ Goedert
- JK Kreiss
- JL Ziegler
- JL Ziegler
- JL Ziegler
- JL Ziegler
- JL Ziegler
- JM Pawlotsky
- JP Ioannidis
- JR Moodley
- JT Boerma
- KB Hymes
- KH Maclean
- Kishor Bhatia
- KM Waddell
- KO Buabeng
- L Stein
- LT Banda
- M Bower
- M Egger
- MA Eltom
- MH Mwanahamuntu
- ML Tornesello
- MM Nsubuga
- MN de Koning
- MW Otieno
- N Mutalima
- N Mutalima
- P Das
- P Ebbesen
- P Mayaud
- P Ocama
- R Bunnell
- R Newton
- R Newton
- R Newton
- R Newton
- R Newton
- R Newton
- RG Downing
- RJ Biggar
- RJ Biggar
- RJ Lingwood
- S Rosen
- S Sutcliffe
- Sam M Mbulaiteye
- SB Lucas
- SE Hawes
- SH Kapiga
- SM Mbulaiteye
- SM Mbulaiteye
- SM Mbulaiteye
- TR Cote
- V Leroy
- W Cavert
- WM Tierney
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
- Chen T-W
- Chen TX
- Chen X
- Chen Y
- Chen Y
- Chen YB
- Chen YP
- Chenevez J
- Cheng H-P
- Cherry ML
- Cheung CC
- Cheung E
- Chevalier J
- Chia H
- Chiang J
- Chiarusi T
- Chincarini A
- Chinellato JA
- Chirkin D
- Chiummo A
- Chmiel T
- Cho HS
- Cho M
- Choi C
- Choi J-S
- Chornock R
- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
- Chung S
- Ciani G
- Cikota A
- Ciolfi R
- Ciprini S
- Circella M
- Cirelli CE
- Cirone A
- Clara F
- Clark JA
- Clark K
- Clark P
- Clarke TE
- Classen L
- Clay RW
- Clearwater P
- Cleva F
- Cleveland WH
- Cline T
- Cobb BE
- Cocchieri C
- Coccia E
- Coelho JAB
- Coelho P
- Coenders S
- Cohadon P-F
- Cohen D
- Cohen-Tanugi J
- Colafrancesco S
- Colafrancesco S
- Colalillo R
- Colazo C
- Coleiro A
- Coleman A
- Colla A
- Collaboration ALMA
- Collaboration ANTARES
- Collaboration BOOTES
- Collaboration CALET
- Collaboration DLT40
- Collaboration HAWC
- Collaboration HESS
- Collaboration IceCube
- Collaboration IKI-GW Follow-up
- Collaboration Insight-Hxmt
- Collaboration IPN
- Collaboration KU
- Collaboration LOFAR
- Collaboration MASTER
- Collaboration Pi Sky
- Collaboration Pierre Auger
- Collaboration Swift
- Collaboration VINROUGE
- Collette CG
- Collica L
- Collin GH
- Colmenero E Romero
- Coluccia MR
- Cominsky LR
- Cominsky LR
- Conceicao R
- Concu R
- Condon B
- Coniglione R
- Connaughton V
- Conrad J
- Conrad JM
- Consolati G
- Consortium TZAC
- Constancio M
- Conti L
- Contreras F
- Cook DO
- Cook ER
- Cooke J
- Cooper MJ
- Cooper SJ
- Copperwheat C
- Corban P
- Corbitt TR
- Cordero-Carrion I
- Corley KR
- Cornish N
- Corongiu A
- Corral-Santana JM
- Corsi A
- Cortese S
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- London LT
- Longinotti AL
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- Pandya H
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- Pant BC
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- Parmiggiani N
- Parra A
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- Passuello D
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- Pea-Rodriguez J
- Pearlstone BL
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- Pekeur NW
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- Piccinni OJ
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- Piergiovanni F
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- Pinto IM
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- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
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- Pirronello V
- Pisanu T
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- Podsiadlowski P
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- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Prado RR
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- Principe G
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- Prodi GA
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- Prokhorov LG
- Prokoph H
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- Przybylski GT
- Pulone L
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- Rojas-Bravo C
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- Romie JH
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- Salvadori I
- Salvaterra R
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- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez LE
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- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
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- Schulz A
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- Schwalbe SG
- Schwanke U
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- Sciutto SJ
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- Segreto A
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- Seitenzahl IR
- Sekiguchi Y
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- Sevilla-Noarbe I
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- Shah AA
- Shahriar MS
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- Shannon RM
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- Shimizu Y
- Shimomukai R
- Shingles LJ
- Shiningayamwe K
- Shoemaker DH
- Shoemaker DM
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- Siebert MR
- Siegel MH
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- Siemens X
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- Slagmolen BJJ
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- Starling RLC
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- Strunk A
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- Summerscales TZ
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A
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- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0×10−8. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of (+1.74±0.05)s between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between −3×10−15 and +7×10−16 times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
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- Ab Rahman AS
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- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
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