Cretaceous-Cenozoic growth of the Patagonian broken foreland basin, Argentina: Chronostratigraphic framework and provenance variations during transitions in Andean subduction dynamics

The Cretaceous-Cenozoic evolution of the Patagonian broken foreland basin system at 42–43°S in the northern Chubut province of Argentina is associated with variable retroarc phases of fold-thrust belt shortening, extension, and basement uplift during changes in the dynamics of oceanic slab subduction. Basement inheritance and progressive shallowing of an east-dipping subducting slab are important mechanisms of foreland partitioning, as dictated by the preexisting (pre-Andean) structural architecture and forelandward (eastward) advance of Late Cretaceous arc magmatism. Previously recognized growth strata help define the timing of fold-thrust belt shortening and retroarc basement-involved uplift, but the precise consequences for sediment routing remain poorly understood, with uncertainties in patterns of basin evolution before, during, and after shallowing and resteepening of the subducting slab. In this study, distinctive sediment source regions and magmatic histories enable evaluation of the stratigraphic and tectonic evolution of the retroarc foreland basin using new provenance results, maximum depositional ages, and isotopic signatures from detrital zircon U-Pb geochronology and Lu-Hf geochemical analyses. A compilation of published bedrock crystallization ages and distributions of metamorphic and igneous basement rocks identify: a western source region defined by the Andean magmatic arc and associated pre-Andean basement; and an eastern source region consisting of intraplate magmatic units and the North Patagonian Massif. We demonstrate that Aptian-Cenomanian retroarc basin fill was derived principally from the basement massif and intraplate volcanic units to the east, followed by a Late Cretaceous (Campanian-Maastrichtian) reversal in sedimentary polarity and subsequent exclusive derivation from the Andean arc and orogenic belt to the west. Late Cretaceous-Paleocene slab shallowing and arc cessation was succeeded by late Eocene–earliest Miocene extension during slab rollback and renewal of arc magmatism. Thereafter, Miocene sedimentation was closely linked to shortening in the Andean fold-thrust belt. Within the retroarc succession, new U-Pb ages provide estimates of depositional ages for Lower Cretaceous through Miocene stratigraphic units. Finally, in addition to U-Pb provenance and chronostratigraphic constraints, zircon Hf isotopic signatures from the detrital record provide confirmation of a Cretaceous-Cenozoic history involving: (1) initial establishment of a continental magmatic arc; (2) transition from a neutral to compressive tectonic regime; (3) shallowing of the subducting slab and arc cessation during retroarc basement partitioning; (4) arc retreat and foreland basin abandonment during slab rollback (with modest extension and crustal thinning); and (5) final renewed shortening during arc rejuvenation.Fil: Butler, Kristina L.. University of Texas at Austin; Estados UnidosFil: Horton, Brian K.. University of Texas at Austin; Estados UnidosFil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Fuentes, Facundo. YPF - Tecnología; Argentin

Northward propagation of Andean genesis: Insights from Early Cretaceous synorogenic deposits in the Aysén-Río Mayo basin

Decoding the earliest orogenic stages in the Andes, the largest subduction orogen on Earth is fundamental to understanding changes in climate, drainage organization, and biodiversity in South America. Furthermore, it is crucial to unraveling the driving mechanism behind the initiation of orogeny. To track the earliest stages of Andean growth, we studied the Aysén/Río Mayo basin (ARB) in the North Patagonian Andes. The small degree of Cenozoic tectonic overprinting in this part of the Andes has allowed outstanding preservation of the deformational and sedimentary record of the earliest Andean deformation. In this study, we employ a multidisciplinary approach involving structural geology, sedimentology, geochronology, and provenance studies from the Early Cretaceous Apeleg Formation (~130?122 Ma) in the ARB and geochemical analysis of intrusive Cretaceous igneous rocks. Particularly, the recognition of syncontractional growth strata at several localities indicate a syntectonic origin for this unit and provide additional structural evidence of Early Cretaceous contraction in the North Patagonian Andes. Thus, the Apeleg Formation is interpreted as deposited during a contractional basin stage. Geochemical data from Aptian-Albian intrusive igneous rocks indicate that initial contraction emplaced over thinned crust likely inherited from the Jurassic extension in the ARB. This stage is then compared with a new synthesis of the earliest Cretaceous contraction along the Andes. This analysis reveals that the ARB likely holds the oldest post-Gondwanic synorogenic unit along the orogen and more significantly, that Andean birth was a diachronous process which propagated northward since the late Early Cretaceous. The latter findings have major implications for the evolution of the Andes and shed light into the driving mechanism behind initial orogeny.Fil: Gianni, Guido Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Navarrete Granzotto, César Rodrigo. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Díaz, Marianela Ximena Yasmin. Universidad Nacional de San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Butler, Kristina L.. University of Texas at Austin; Estados UnidosFil: Horton, Brian K.. University of Texas at Austin; Estados UnidosFil: Encinas, Alfonso. Universidad de Concepción; ChileFil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentin

Development and Evaluation of a Psychosocial Intervention for Children and Teenagers Experiencing Diabetes (DEPICTED): a protocol for a cluster randomised controlled trial of the effectiveness of a communication skills training programme for healthcare professionals working with young people with type 1 diabetes

Background Diabetes is the third most common chronic condition in childhood and poor glycaemic control leads to serious short-term and life-limiting long-term complications. In addition to optimal medical management, it is widely recognised that psychosocial and educational factors play a key role in improving outcomes for young people with diabetes. Recent systematic reviews of psycho-educational interventions recognise the need for new methods to be developed in consultation with key stakeholders including patients, their families and the multidisciplinary diabetes healthcare team. Methods/design Following a development phase involving key stakeholders, a psychosocial intervention for use by paediatric diabetes staff and not requiring input from trained psychologists has been developed, incorporating a communication skills training programme for health professionals and a shared agenda-setting tool. The effectiveness of the intervention will be evaluated in a cluster-randomised controlled trial (RCT). The primary outcome, to be measured in children aged 4-15 years diagnosed with type 1 diabetes for at least one year, is the effect on glycaemic control (HbA1c) during the year after training of the healthcare team is completed. Secondary outcomes include quality of life for patients and carers and cost-effectiveness. Patient and carer preferences for service delivery will also be assessed. Twenty-six paediatric diabetes teams are participating in the trial, recruiting a total of 700 patients for evaluation of outcome measures. Half the participating teams will be randomised to receive the intervention at the beginning of the trial and remaining centres offered the training package at the end of the one year trial period. Discussion The primary aim of the trial is to determine whether a communication skills training intervention for specialist paediatric diabetes teams will improve clinical and psychological outcomes for young people with type 1 diabetes. Previous research indicates the effectiveness of specialist psychological interventions in achieving sustained improvements in glycaemic control. This trial will evaluate an intervention which does not require the involvement of trained psychologists, maximising the potential feasibility of delivery in a wider NHS context. Trial registration Current Controlled Trials ISRCTN61568050

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was reproduced in four additional cohorts, but was not seen in a fifth cohort. To further assess the general reproducibility of this association, we genotyped rs7566605 in nine large cohorts from eight populations across multiple ethnicities (total n = 16,969). We tested this variant for association with BMI in each sample under a recessive model using family-based, population-based, and case-control designs. We observed a significant (p < 0.05) association in five cohorts but saw no association in three other cohorts. There was variability in the strength of association evidence across examination cycles in longitudinal data from unrelated individuals in the Framingham Heart Study Offspring cohort. A combined analysis revealed significant independent validation of this association in both unrelated (p = 0.046) and family-based (p = 0.004) samples. The estimated risk conferred by this allele is small, and could easily be masked by small sample size, population stratification, or other confounders. These validation studies suggest that the original association is less likely to be spurious, but the failure to observe an association in every data set suggests that the effect of SNP rs7566605 on BMI may be heterogeneous across population samples

Rapid Dissemination of SIV Follows Multisite Entry after Rectal Inoculation

Receptive ano-rectal intercourse is a major cause of HIV infection in men having sex with men and in heterosexuals. Current knowledge of the mechanisms of entry and dissemination during HIV rectal transmission is scarce and does not allow the development of preventive strategies. We investigated the early steps of rectal infection in rhesus macaques inoculated with the pathogenic isolate SIVmac251 and necropsied four hours to nine days later. All macaques were positive for SIV. Control macaques inoculated with heat-inactivated virus were consistently negative for SIV. SIV DNA was detected in the rectum as early as four hours post infection by nested PCR for gag in many laser-microdissected samples of lymphoid aggregates and lamina propria but never in follicle-associated epithelium. Scarce SIV antigen positive cells were observed by immunohistofluorescence in the rectum, among intraepithelial and lamina propria cells as well as in clusters in lymphoid aggregates, four hours post infection and onwards. These cells were T cells and non-T cells that were not epithelial cells, CD68+ macrophages, DC-SIGN+ cells or fascin+ dendritic cells. DC-SIGN+ cells carried infectious virus. Detection of Env singly spliced mRNA in the mucosa by nested RT-PCR indicated ongoing viral replication. Strikingly, four hours post infection colic lymph nodes were also infected in all macaques as either SIV DNA or infectious virus was recovered. Rapid SIV entry and dissemination is consistent with trans-epithelial transport. Virions appear to cross the follicle-associated epithelium, and also the digestive epithelium. Viral replication could however be more efficient in lymphoid aggregates. The initial sequence of events differs from both vaginal and oral infections, which implies that prevention strategies for rectal transmission will have to be specific. Microbicides will need to protect both digestive and follicle-associated epithelia. Vaccines will need to induce immunity in lymph nodes as well as in the rectum

2017 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1004/thumbnail.jp

Transnational Motherhood and the Production of Subjectivity: Experiences of migrant Brazilian women living in London

This study explores how transnational motherhood is experienced by a group of Brazilian women participating in the global care chain. Our analysis indicates that transnational motherhood is an experience ripe with contradictions and emotional constraints. On one hand, transnational motherhood can subjugate women for not conforming to conventional motherhood norms. On the other hand, the migratory experience allows women to (re)negotiate their maternal roles, producing new meanings for care and mothering practices

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead