Time for revision of seafarers vision testing?

No evidence-based vision test for selecting bridge crew considers the realistic, demanding vision requirements at sea. This may be the cause of serious accidents. A proposal is outlined for development of a test that recreate the visually demanding conditions at sea with video that provides 3D images of objects to be observed

Accidental exposure to electromagnetic fields from the radar of a naval ship: a descriptive study

Part of a crew on a Norwegian naval ship was exposed to the radar waves for approximately 7 min from an American destroyer during an incident at sea in August 2012. Information about the exposure was not given by the navy. This is a description of what happened with the crew on board after this event. 14 persons had been on the ship bridge or outside on the deck during the exposure and the rest of the crew had been inside the ship. 27 persons were examined at a hospital 6–8 months after the event, as they had developeda large number of symptoms from different organ systems. They were very worried about all types of possible adverse health effects due to the incident. All were examined by an occupational physician and anophthalmologist, by an interview, clinical examinations and blood tests at the hospital. The interview of the personnel revealed that they had not experienced any major heating during the episode. Their symptoms developed days or weeks after the radar exposure. They had no objective signs of adverse health effects at the examination related to the incident. Long-term health effect from the exposure is highly unlikely. The development of different symptoms after the incident was probably due to the fear of possible health consequences. Better routines for such incidents at sea should be developed to avoid this type of anxiety

Accidental exposure to electromagnetic fields from the radar of a naval ship; a descriptive study

Part of a crew on a Norwegian naval ship was exposed to the radar waves for approximately 7 min from an American destroyer during an incident at sea in August 2012. Information about the exposure was not given by the navy. This is a description of what happened with the crew on board after this event. 14 persons had been on the ship bridge or outside on the deck during the exposure and the rest of the crew had been inside the ship. 27 persons were examined at a hospital 6–8 months after the event, as they had developeda large number of symptoms from different organ systems. They were very worried about all types of possible adverse health effects due to the incident. All were examined by an occupational physician and anophthalmologist, by an interview, clinical examinations and blood tests at the hospital. The interview of the personnel revealed that they had not experienced any major heating during the episode. Their symptoms developed days or weeks after the radar exposure. They had no objective signs of adverse health effects at the examination related to the incident. Long-term health effect from the exposure is highly unlikely. The development of different symptoms after the incident was probably due to the fear of possible health consequences. Better routines for such incidents at sea should be developed to avoid this type of anxiety.publishedVersio

Nitrogen in Current European Policies

Europe, and especially the European Union (EU), has many governmental policy ¿ measures aimed at decreasing unwanted reactivenitrogen (N r ) emissions from combustion, agriculture and urban wastes. Many of these policy measures have an ¿eff ects-basedapproach¿, and focus on single N r compounds, single sectors and either on air or waters.¿ Th is chapter addresses the origin, objectives and targets of EU policy measures related to Nr emissions, considers which instrumentsare being used to implement the policies and briefl y discusses the eff ects of the policy measures.Approaches¿ Th e chapter starts with a brief description of the basic elements of governmental policy measures.¿ A review of the main international conventions and EU policies related to emissions of Nr to air and water is then provided.¿ Finally the chapter provides a semi-quantitative assessment of the eff ectiveness and effi ciency of European policy measures.Key fi ndings/state of knowledge¿ International conventions and other treaties have played a key role in raising awareness and establishing policy measures for Nr emissionsabatement in EU through so-called Directives and Regulations.¿ Th ere are many diff erent EU Directives, oft en addressing individual Nr compounds from individual sectors (e.g. NOx emissions fromcombustion; NH 3 emissions from agriculture, pollution of groundwater and surface water by nitrates from agriculture, discharge oftotal nitrogen from urban sewage to surface waters).¿ Many EU Directives have been revised following review and evaluation. Th ere are increasing eff orts to cluster single EU Directives intolarger Framework Directives.¿ Compliance with, and eff ectiveness of, the Directives diff ers between sectors; it decreases in the order (i) reducing NO x emissions fromcombustion sources, (ii) reducing nitrogen (and especially Phosphorus) discharges to waters from industries and households, and (iii)reducing NH 3 emissions and NO 3 leaching from agriculture.¿ Th ere is not much literature on the diff erences in the eff ectiveness and effi ciencies of Directives; a number of factors seem to be involvedin eff ectiveness and effi ciency, but these have not yet been analysed in a coherent manner.Major uncertainties/challenges¿ Th ere is a huge diversity in N r emission sources and pathways, while the number of policy instruments is limited. Th ere is need to fi ndthe optimal mix of policy instruments targeted to the emission sources as well as the stakeholders involved.¿ It has been indicated that some EU Directives addressing emissions of nitrogen compounds from specifi c sources have antagonisticeff ects. Th e magnitude of these eff ects is not yet well known.¿ Th ere is a delay in the environmental and ecological responses following the introduction of Directives; these are due to legislativedelays, lack of enforcement and control, constraints in practice and because of biogeochemical hysteresis eff ects; these eff ects are notyet well understood quantitatively.¿ In general, only modest reductions in Nr emissions from agriculture have been achieved to date; this refl ects the need for more eff ectiveand effi cient policy measures and/or greater enforcement of current policies.Recommendations¿ To examine further the diff erences between sectors of the factors that contribute to the eff ectiveness and effi ciency of policy measuresfor the abatement of N r emissions.¿ T o explore further the eff ectiveness and effi ciency of more integrated N management and integrated policy measures for the abatementof adverse impacts of N r emissions.JRC.DDG.H.2-Climate change and air qualit

Pressure Load: The Main Factor for Altered Gene Expression in Right Ventricular Hypertrophy in Chronic Hypoxic Rats

BACKGROUND: The present study investigated whether changes in gene expression in the right ventricle following pulmonary hypertension can be attributed to hypoxia or pressure loading. METHODOLOGY/PRINCIPAL FINDINGS: To distinguish hypoxia from pressure-induced alterations, a group of rats underwent banding of the pulmonary trunk (PTB), sham operation, or the rats were exposed to normoxia or chronic, hypobaric hypoxia. Pressure measurements were performed and the right ventricle was analyzed by Affymetrix GeneChip, and selected genes were confirmed by quantitative PCR and immunoblotting. Right ventricular systolic blood pressure and right ventricle to body weight ratio were elevated in the PTB and the hypoxic rats. Expression of the same 172 genes was altered in the chronic hypoxic and PTB rats. Thus, gene expression of enzymes participating in fatty acid oxidation and the glycerol channel were downregulated. mRNA expression of aquaporin 7 was downregulated, but this was not the case for the protein expression. In contrast, monoamine oxidase A and tissue transglutaminase were upregulated both at gene and protein levels. 11 genes (e.g. insulin-like growth factor binding protein) were upregulated in the PTB experiment and downregulated in the hypoxic experiment, and 3 genes (e.g. c-kit tyrosine kinase) were downregulated in the PTB and upregulated in the hypoxic experiment. CONCLUSION/SIGNIFICANCE: Pressure load of the right ventricle induces a marked shift in the gene expression, which in case of the metabolic genes appears compensated at the protein level, while both expression of genes and proteins of importance for myocardial function and remodelling are altered by the increased pressure load of the right ventricle. These findings imply that treatment of pulmonary hypertension should also aim at reducing right ventricular pressure

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Nye datakilder i evaluering av store statlige investeringer - et potensiale for Big data?

Denne rapporten kartlegger og drøfter hvordan Big Data kan brukes til evaluering av store statlige investeringer. I vårt tilfelle med fokus på evaluering er vi egentlig interessert i «nye data», ikke bare de ekstremt store. Vi finner få publikasjoner som eksplisitt omtaler Big Data relatert til evaluering, men det finnes flere eksempler på analyser som hadde kunnet vært brukt i evalueringssammenheng. Big Data kan deles inn i internettaktivitet, bevegelsesrelaterte data, data om fysiske omgivelser og kommersiell aktivitet. I tillegg finnes ulike former for interne data i flere etater som har potensiale til å brukes i evalueringer. Rapporten diskuterer spesielt følgende aspekter som det må tas hensyn til ved bruk av Big Data i evaluering; personvern, tilgjengelighet, anvendbarhet og relevans, eiendomsrett, kostnader og kompetanse. Vi ser at nye og større datamengder bør være interessante til bruk i både tidligfase av store statlige investeringer som beslutningsgrunnlag (ex ante), og i evaluering av ferdigstilte tiltak (ex post).publishedVersio

Big Data as Innovative Approach for Usability Evaluations of Buildings

Purpose: The purpose of this paper is to investigate how Big Data can add a new dimension to usability evaluations of buildings. Background: There is a tremendous growth in the volume of available data, creating the “Big Data” trend. Industries such as IT, retail and transportation can present a number of examples of successful applications of Big Data. Usability has traditionally been analysed by qualitative research methods, and Big Data gives an opportunity to add quantitative data in such evaluations. Approach: The study is based on literature research and interviews with 15 professionals in IT facilities management and government agencies. We discuss potential data that can be used for usability evaluations of buildings. Results: Big Data is creating new opportunities to analyse a phenomenon based on different types of data. Interesting data categories include: internet traffic, movement-related data, physical environment data, typically from different types of sensors and commercial activity. Possible problematic issues related to use of Big Data are availability, applicability, relevance, privacy policy, ownership, cost and competence. The study indicates that none of the challenges need to hinder use of Big Data when evaluating the usability of in buildings evaluation, provided that the issues are properly managed. We present a sample of Big Data that may be used for evaluation of building usability. Practical Implications: Our conclusion is that there are major advantages in using Big data, increasing the opportunities for the evaluator to find indicators that are relevant to the building being evaluated. Use of Big Data can serve as a step towards a stronger technology focus in usability evaluations of buildings, and thus support innovation in building design and facilities management. Research limitations: The research is mainly done in a Norwegian context. Originality: We have found few previous studies that explicitly link Big Data and evaluation