142 research outputs found
Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- Author
- Publication venue
- HORIZON PUBLISHER INDIA [HPI]
- Publication date
- 15/05/2024
- Field of study
This study explores the potential of essential oils, Eugenol (EUG), and Beta-Caryophyllene (BCP) in enhancing the efficacy of the chemotherapeutic drug 5-fluorouracil (5-FU) in treating metastatic colorectal cancer (CRC). Pharmacokinetic assessment through ADMET analysis indicates that EUG and BCP adhere to the rule of five with good bioavailability, ensuring their drug-likeness properties. The study employs a multitarget strategy to reduce drug dosage and enhance effectiveness, testing the compounds on the HCT116 human colorectal cancer cell line. MTT assay revealed in-vitro cytotoxic effects of EUG, BCP, and 5-FU, with a noteworthy reduction in IC50 values observed when combining the compounds, indicating synergistic effects (CI < 1) as depicted in the Fa-CI plot. Network pharmacology-based analysis of the compound-disease-target (C-D-T) network identifies 58, 24, and 49 target proteins for EUG, BCP, and 5-FU, respectively, in metastatic CRC. Venn diagram intersection reveals 11 common target proteins, and the merged C-D-T network highlights 84 target proteins, with 16 selected based on edge count, including HSP90AA1, IGF-1R, ESR1, and CASP3. Molecular docking studies indicate that EUG, BCP, and 5-FU effectively inhibit the core target protein HSP90AA1 within the C-D-T network, suggesting their potential as modulators for CRC metastasis. These findings propose a promising approach for developing drugs targeting specific proteins to mitigate metastasis in colorectal cancer
Gastric Fistula in the Chest After Sleeve Gastrectomy: a Systematic Review of Diagnostic and Treatment Options.
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/10/2020
- Field of study
This study aimed to establish the optimal diagnostic and treatment algorithm for the management of gastric fistula in the chest (GFIC) after sleeve gastrectomy (SG) through a systematic review of published cases. A multi-database search was performed, which produced 1182 results, of which 26 studies were included in this systematic review. The initial presentation included subphrenic collections, leaks, or (recurrent) pneumonia with associated symptoms such as persistent cough, fever, and/or dyspnea. Computed tomography (CT) scan in combination with either upper gastrointestinal (UGI) series or an esophagogastroduodenoscopy (EGD) was used to adequately diagnose the fistulas. Initial treatment was either with clips and/or clips and stents that were placed endoscopically. When unsuccessful in the majority of the cases, the surgical treatment consisted of total gastrectomy and Roux-en-Y esophagojejunostomy in a laparoscopic or open fashion
Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruit: Validating its traditional usage
- Author
- A Briend
- A Cravioto
- A-M Svennerholm
- AD Lopez
- AG Jagtap
- AK Nadkarni
- B Das
- BR Sharma
- BR Sharma
- C Parmar
- CE Kicklighter
- CG Thakkur
- CHEMEXCIL
- CJL Murray
- CK Kokate
- CP Kala
- CR Parish
- D Miranda
- FG Shoba
- G Di Carlo
- GA Agbor
- GC Jagetia
- GD Lutterodt
- GS Pandeya
- GV Satyavati
- H Mavar-Manga
- J Galvez
- J Morton
- JC Chen
- JE Oben
- JN Dhuley
- JP Nataro
- K Kambu
- K Kruawan
- K Shoaf
- L Tona
- MP Shiva
- N Kamalakkannan
- N Kamalakkannan
- N Venkatesan
- NK Ganguly
- Noshir Antia
- OA Trowell
- PA Akah
- PG Daswani
- PG Daswani
- PK Mukherjee
- Poonam Daswani
- Pundarikakshudu Tetali
- R Agarwal
- R Chopra
- RA Gianella
- RH Liu
- RL Guerrant
- RL Guerrant
- RN Greenberg
- S Ashkenazi
- S Brijesh
- S Brijesh
- S Brijesh
- S Knutton
- SD Sarker
- SK Roy
- SP Gutierrez
- T Shimamura
- T Vesikari
- Tannaz Birdi
- VSN Rao
- W Liao
- World Health Organization
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p><it>Aegle marmelos </it>(L.) Correa has been widely used in indigenous systems of Indian medicine due to its various medicinal properties. However, despite its traditional usage as an anti-diarrhoeal there is limited information regarding its mode of action in infectious forms of diarrhoea. Hence, we evaluated the hot aqueous extract (decoction) of dried unripe fruit pulp of <it>A. marmelos </it>for its antimicrobial activity and effect on various aspects of pathogenicity of infectious diarrhoea.</p> <p>Methods</p> <p>The decoction was assessed for its antibacterial, antigiardial and antirotaviral activities. The effect of the decoction on adherence of enteropathogenic <it>Escherichia coli </it>and invasion of enteroinvasive <it>E. coli </it>and <it>Shigella flexneri </it>to HEp-2 cells were assessed as a measure of its effect on colonization. The effect of the decoction on production of <it>E. coli </it>heat labile toxin (LT) and cholera toxin (CT) and their binding to ganglioside monosialic acid receptor (GM1) were assessed by GM1-enzyme linked immuno sorbent assay whereas its effect on production and action of <it>E. coli </it>heat stable toxin (ST) was assessed by suckling mouse assay.</p> <p>Results</p> <p>The decoction showed cidal activity against <it>Giardia </it>and rotavirus whereas viability of none of the six bacterial strains tested was affected. It significantly reduced bacterial adherence to and invasion of HEp-2 cells. The extract also affected production of CT and binding of both LT and CT to GM1. However, it had no effect on ST.</p> <p>Conclusion</p> <p>The decoction of the unripe fruit pulp of <it>A. marmelos</it>, despite having limited antimicrobial activity, affected the bacterial colonization to gut epithelium and production and action of certain enterotoxins. These observations suggest the varied possible modes of action of <it>A. marmelos </it>in infectious forms of diarrhoea thereby validating its mention in the ancient Indian texts and continued use by local communities for the treatment of diarrhoeal diseases.</p
Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aimo Ilaria
- Aiola Salvatore
- Ajaz Muhammad
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Armesto Perez Nestor
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Bach Matthias Jakob
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
- Baltasar Dos Santos Pedrosa Fernando
- Baral Rama Chandra
- Barbano Anastasia Maria
- Barbera Roberto
- Barile Francesco
- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
- Bartalini Paolo
- Barth Klaus
- Bartke Jerzy Gustaw
- Bartsch Esther
- Bashir Butt Jamila
- Basile Maurizio
- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belmont Iii Ronald John
- Belmont Moreno Ernesto
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
- Berceanu Ionela
- Bercuci Alexandru
- Berdnikov Yaroslav
- Berenyi Daniel
- Bertens Redmer Alexander
- Berzano Dario
- Betev Latchezar
- Bhasin Anju
- Bhat Inayat Rasool
- Bhati Ashok Kumar
- Bhattacharjee Buddhadeb
- Bhom Jihyun
- Bianchi Livio
- Bianchi Nicola
- Bianchin Chiara
- Bielcik Jaroslav
- Bielcikova Jana
- Bilandzic Ante
- Biswas Rathijit
- Biswas Saikat
- Bjelogrlic Sandro
- Blair Justin Thomas
- Blanco Fernando
- Blau Dmitry
- Blume Christoph
- Bock Friederike
- Boettger Stefan
- Bogdanov Alexey
- Boggild Hans
- Boldizsar Laszlo
- Bombara Marek
- Book Julian Heinz
- Borel Herve
- Borissov Alexander
- Borri Marcello
- Bossu Francesco
- Botta Elena
- Braun-Munzinger Peter
- Bregant Marco
- Breitner Timo Gunther
- Broker Theo Alexander
- Browning Tyler Allen
- Broz Michal
- Brucken Erik Jens
- Bruna Elena
- Bruno Giuseppe Eugenio
- Budnikov Dmitry
- Buesching Henner
- Bufalino Stefania
- Buncic Predrag
- Busch Oliver
- Buthelezi Edith Zinhle
- Buxton Jesse Thomas
- Cabanillas Noris Juan Carlos
- Caffarri Davide
- Cai Xu
- Caines Helen Louise
- Calero Diaz Liliet
- Caliva Alberto
- Calvo Villar Ernesto
- Camerini Paolo
- Carena Francesco
- Carena Wisla
- Carnesecchi Francesca
- Castillo Castellanos Javier Ernesto
- Castro Andrew John
- Casula Ester Anna Rita
- Cavicchioli Costanza
- Ceballos Sanchez Cesar
- Cepila Jan
- Cerello Piergiorgio
- Cerkala Jakub
- Chang Beomsu
- Chapeland Sylvain
- Chartier Marielle
- Charvet Jean-Luc Fernand
- Chattopadhyay Subhasis
- Chattopadhyay Sukalyan
- Chelnokov Volodymyr
- Cherney Michael Gerard
- Cheshkov Cvetan Valeriev
- Cheynis Brigitte
- Chibante Barroso Vasco Miguel
- Chochula Peter
- Choi Kyungeon
- Chojnacki Marek
- Choudhury Subikash
- Christakoglou Panagiotis
- Christensen Christian Holm
- Christiansen Peter
- Chujo Tatsuya
- Chung Suh-Urk
- Cicalo Corrado
- Cifarelli Luisa
- Cindolo Federico
- Cleymans Jean Willy Andre
- Colamaria Fabio Filippo
- Colella Domenico
- Collu Alberto
- Colocci Manuel
- Conesa Balbastre Gustavo
- Conesa Del Valle Zaida
- Connors Megan Elizabeth
- Contreras Nuno Jesus Guillermo
- Cormier Thomas Michael
- Corrales Morales Yasser
- Correia Zanoli Henrique Jose
- Cortes Maldonado Ismael
- Cortese Pietro
- Cosentino Mauro Rogerio
- Costa Filippo
- Crochet Philippe
- Cruz Albino Rigoberto
- Cuautle Flores Eleazar
- Cunqueiro Mendez Leticia
- D'Erasmo Ginevra
- Dahms Torsten
- Dainese Andrea
- Danu Andrea
- Das Debasish
- Das Indranil
- Das Supriya
- Dash Ajay Kumar
- Dash Sadhana
- De Caro Annalisa
- De Cataldo Giacinto
- De Cuveland Jan
- De Falco Alessandro
- De Gruttola Daniele
- De Marco Nora
- De Pasquale Salvatore
- De Sudipan
- Deisting Alexander
- Deloff Andrzej
- Denes Ervin Sandor
- Di Bari Domenico
- Di Mauro Antonio
- Di Nezza Pasquale
- Diaz Corchero Miguel Angel
- Dietel Thomas
- Dillenseger Pascal
- Diozcora Vargas Trevino Aurora
- Divia Roberto
- Djuvsland Oeystein
- Dobrigkeit Chinellato David
- Dobrin Alexandru Florin
- Dobrowolski Tadeusz Antoni
- Domenicis Gimenez Diogenes
- Donigus Benjamin
- Dordic Olja
- Drozhzhova Tatiana
- Dubey Anand Kumar
- Dubla Andrea
- Ducroux Laurent
- Dupieux Pascal
- Ehlers Iii Raymond James
- Elia Domenico
- Engel Heiko
- Erazmus Barbara Ewa
- Erdemir Irem
- Erhardt Filip
- Eschweiler Dominic
- Espagnon Bruno
- Estienne Magali Danielle
- Esumi Shinichi
- Eum Jongsik
- Evans David
- Evdokimov Sergey
- Eyyubova Gyulnara
- Fabbietti Laura
- Fabris Daniela
- Faivre Julien
- Fantoni Alessandra
- Fasel Markus
- Feldkamp Linus
- Felea Daniel
- Feliciello Alessandro
- Feofilov Grigorii
- Ferencei Jozef
- Fernandez Tellez Arturo
- Ferreira Natal Da Luz Pedro Hugo
- Ferretti Alessandro
- Festanti Andrea
- Feuillard Victor Jose Gaston
- Figiel Jan
- Filchagin Sergey
- Finogeev Dmitry
- Fionda Fiorella
- Fiore Enrichetta Maria
- Fleck Martin Gabriel
- Floris Michele
- Foertsch Siegfried Valentin
- Foka Panagiota
- Fokin Sergey
- Fragiacomo Enrico
- Francescon Andrea
- Frankenfeld Ulrich Michael
- Fuchs Ulrich
- Furget Christophe
- Furs Artur
- Fusco Girard Mario
- Gaardhoeje Jens Joergen
- Gagliardi Martino
- Gago Medina Alberto Martin
- Gallio Mauro
- Gameiro Munhoz Marcelo
- Gangadharan Dhevan Raja
- Ganoti Paraskevi
- Gao Chaosong
- Garabatos Cuadrado Jose
- Garcia-Solis Edmundo Javier
- Gargiulo Corrado
- Gasik Piotr Jan
- Germain Marie
- Gheata Andrei George
- Gheata Mihaela
- Ghosh Premomoy
- Ghosh Sanjay Kumar
- Gianotti Paola
- Giubellino Paolo
- Giubilato Piero
- Gladysz-Dziadus Ewa
- Glassel Peter
- Gomez Coral Diego Mauricio
- Gomez Ramirez Andres
- Gonzalez Ferreiro Elena
- Gonzalez Zamora Pedro
- Gorbunov Sergey
- Gorlich Lidia Maria
- Gotovac Sven
- Grabski Varlen
- Graczykowski Lukasz Kamil
- Graham Katie Leanne
- Grelli Alessandro
- Grigoras Alina Gabriela
- Grigoras Costin
- Grigoryan Ara
- Grigoryan Smbat
- Grigoryev Vladislav
- Grion Nevio
- Grosse-Oetringhaus Jan Fiete
- Grossiord Jean-Yves
- Grosso Raffaele
- Grynyov Borys
- Guber Fedor
- Guernane Rachid
- Guerzoni Barbara
- Gulbrandsen Kristjan Herlache
- Gulkanyan Hrant
- Gunji Taku
- Gupta Anik
- Gupta Ramni
- Haake Rudiger
- Haaland Oystein Senneset
- Hadjidakis Cynthia Marie
- Haiduc Maria
- Hamagaki Hideki
- Hamar Gergoe
- Hansen Alexander
- Harris John William
- Hartmann Helvi
- Harton Austin Vincent
- Hatzifotiadou Despina
- Hayashi Shinichi
- Heckel Stefan Thomas
- Heide Markus Ansgar
- Helstrup Haavard
- Herghelegiu Andrei Ionut
- Herrera Corral Gerardo Antonio
- Hess Benjamin Andreas
- Hetland Kristin Fanebust
- Hilden Timo Eero
- Hillemanns Hartmut
- Hippolyte Boris
- Hosokawa Ritsuya
- Hristov Peter Zahariev
- Huang Meidana
- Humanic Thomas
- Hussain Nur
- Hussain Tahir
- Hutter Dirk
- Hwang Dae Sung
- Ilkaev Radiy
- Ilkiv Iryna
- Inaba Motoi
- Ippolitov Mikhail
- Irfan Muhammad
- Ivanov Marian
- Ivanov Vladimir
- Izucheev Vladimir
- Jacobs Peter Martin
- Jadlovska Slavka
- Jahnke Cristiane
- Jang Haeng Jin
- Janik Malgorzata Anna
- Jena Chitrasen
- Jena Satyajit
- Jimenez Bustamante Raul Tonatiuh
- Jones Peter Graham
- Jung Hyungtaik
- Jusko Anton
- Kalinak Peter
- Kalweit Alexander Philipp
- Kamin Jason Adrian
- Kang Ju Hwan
- Kaplin Vladimir
- Kar Somnath
- Karasu Uysal Ayben
- Karavichev Oleg
- Karavicheva Tatiana
- Karayan Lilit
- Karpechev Evgeny
- Kebschull Udo Wolfgang
- Keidel Ralf
- Keijdener Darius Laurens
- Keil Markus
- Khan Kamal
- Khan Mohammed Mohisin
- Khan Palash
- Khan Shuaib Ahmad
- Khanzadeev Alexei
- Kharlov Yury
- Kileng Bjarte
- Kim Beomkyu
- Kim Do Won
- Kim Dong Jo
- Kim Hyeonjoong
- Kim Jinsook
- Kim Mimae
- Kim Minwoo
- Kim Se Yong
- Kim Taesoo
- Kirsch Stefan
- Kisel Ivan
- Kiselev Sergey
- Kisiel Adam Ryszard
- Kiss Gabor
- Klay Jennifer Lynn
- Klein Carsten
- Klein Jochen
- Klein-Boesing Christian
- Kluge Alexander
- Knichel Michael Linus
- Knospe Anders Garritt
- Kobayashi Taiyo
- Kobdaj Chinorat
- Kofarago Monika
- Kollegger Thorsten
- Kolozhvari Anatoly
- Kondratev Valerii
- Kondratyeva Natalia
- Kondratyuk Evgeny
- Konevskikh Artem
- Kopcik Michal
- Kour Mandeep
- Kouzinopoulos Charalampos
- Kovalenko Oleksandr
- Kovalenko Vladimir
- Kowalski Marek
- Koyithatta Meethaleveedu Greeshma
- Kral Jiri
- Kralik Ivan
- Kravcakova Adela
- Kretz Matthias
- Krivda Marian
- Krizek Filip
- Kryshen Evgeny
- Krzewicki Mikolaj
- Kubera Andrew Michael
- Kucera Vit
- Kugathasan Thanushan
- Kuhn Christian Claude
- Kuijer Paulus Gerardus
- Kumar Ajay
- Kumar Jitendra
- Kurashvili Podist
- Kurepin Alexander
- Kurepin Alexey
- Kuryakin Alexey
- Kushpil Svetlana
- Kweon Min Jung
- Kwon Youngil
- La Pointe Sarah Louise
- La Rocca Paola
- Lagana Fernandes Caio
- Lakomov Igor
- Langoy Rune
- Lara Martinez Camilo Ernesto
- Lardeux Antoine Xavier
- Lattuca Alessandra
- Laudi Elisa
- Lea Ramona
- Leardini Lucia
- Lee Graham Richard
- Lee Seongjoo
- Legrand Iosif
- Lehas Fatiha
- Lemmon Roy Crawford
- Lenti Vito
- Leogrande Emilia
- Leon Monzon Ildefonso
- Leoncino Marco
- Levai Peter
- Li Shuang
- Li Xiaomei
- Lien Jorgen Andre
- Lietava Roman
- Lindal Svein
- Lindenstruth Volker
- Lippmann Christian
- Lisa Michael Annan
- Ljunggren Hans Martin
- Lodato Davide Francesco
- Loginov Vitaly
- Loizides Constantinos
- Lokesh Kumar
- Lonne Per-Ivar
- Lopez Torres Ernesto
- Lopez Xavier Bernard
- Lowe Andrew John
- Luettig Philipp Johannes
- Lunardon Marcello
- Luparello Grazia
- Maevskaya Alla
- Mager Magnus
- Mahajan Sanjay
- Mahmood Sohail Musa
- Maire Antonin
- Majka Richard Daniel
- Mal'Kevich Dmitry
- Malaev Mikhail
- Maldonado Cervantes Ivonne Alicia
- Malinina Liudmila
- Malzacher Peter
- Mamonov Alexander
- Manko Vladislav
- Manso Franck
- Manzari Vito
- Marchisone Massimiliano
- Mares Jiri
- Margagliotti Giacomo Vito
- Margotti Anselmo
- Margutti Jacopo
- Marin Ana Maria
- Markert Christina
- Marquard Marco
- Martin Blanco Javier
- Martin Nicole Alice
- Martinengo Paolo
- Martinez Hernandez Mario Ivan
- Martinez Pedreira Miguel
- Martinez-Garcia Gines
- Martynov Yevgen
- Mas Alexis Jean-Michel
- Masciocchi Silvia
- Masera Massimo
- Masoni Alberto
- Massacrier Laure Marie
- Mastroserio Annalisa
- Masui Hiroshi
- Matyja Adam Tomasz
- Mayer Christoph
- Mazer Joel Anthony
- Mazzoni Alessandra Maria
- Mcdonald Daniel
- Meddi Franco
- Melikyan Yuri
- Menchaca-Rocha Arturo Alejandro
- Meninno Elisa
- Mercado-Perez Jorge
- Meres Michal
- Miake Yasuo
- Mieskolainen Matti Mikael
- Mikhaylov Konstantin
- Milano Leonardo
- Millan Almaraz Jesus Roberto
- Milosevic Jovan
- Minervini Lazzaro Manlio
- Mischke Andre
- Mishra Aditya Nath
- Miskowiec Dariusz Czeslaw
- Mitra Jubin
- Mitu Ciprian Mihai
- Mohammadi Naghmeh
- Mohanty Bedangadas
- Molnar Levente
- Montano Zetina Luis Manuel
- Montes Prado Esther
- Morando Maurizio
- Moreira De Godoy Denise Aparecida
- Moretto Sandra
- Morreale Astrid
- Morsch Andreas
- Muccifora Valeria
- Mudnic Eugen
- Muhlheim Daniel Michael
- Muhuri Sanjib
- Mukherjee Maitreyee
- Mulligan James Declan
- Murray Sean
- Musa Luciano
- Musinsky Jan
- Nandi Basanta Kumar
- Nania Rosario
- Nappi Eugenio
- Naru Muhammad Umair
- Nattrass Christine
- Nayak Kishora
- Nayak Tapan Kumar
- Nazarenko Sergey
- Nedosekin Alexander
- Nellen Lukas
- Ng Fabian
- Nicassio Maria
- Niculescu Mihai
- Niedziela Jeremi
- Nielsen Borge Svane
- Nikolaev Sergey
- Nikulin Sergey
- Nikulin Vladimir
- Noferini Francesco
- Nomokonov Petr
- Nooren Gerardus
- Norman Jaime
- Nyanin Alexander
- Nystrand Joakim Ingemar
- Oeschler Helmut Oskar
- Oh Saehanseul
- Oh Sun Kun
- Ohlson Alice Elisabeth
- Okatan Ali
- Okubo Tsubasa
- Olah Laszlo
- Oleniacz Janusz
- Oliveira Da Silva Antonio Carlos
- Oliver Michael Henry
- Onderwaater Jacobus
- Oppedisano Chiara
- Orava Risto
- Ortiz Velasquez Antonio
- Oskarsson Anders Nils Erik
- Otwinowski Jacek Tomasz
- Oyama Ken
- Ozdemir Mahmut
- Pachmayer Yvonne Chiara
- Pagano Paola
- Pahula Hewage Sandun
- Paic Guy
- Pajares Vales Carlos
- Pal Susanta Kumar
- Pan Jinjin
- Pandey Ashutosh Kumar
- Pant Divyash
- Papcun Peter
- Papikyan Vardanush
- Pappalardo Giuseppe
- Pareek Pooja
- Park Woojin
- Parmar Sonia
- Passfeld Annika
- Paticchio Vincenzo
- Patra Rajendra Nath
- Paul Biswarup
- Peitzmann Thomas
- Pereira Da Costa Hugo Denis Antonio
- Pereira De Oliveira Filho Elienos
- Peresunko Dmitry Yurevich
- Perez Lara Carlos Eugenio
- Perez Lezama Edgar
- Peskov Vladimir
- Pestov Yury
- Petracek Vojtech
- Petrov Viacheslav
- Petrovici Mihai
- Petta Catia
- Piano Stefano
- Pikna Miroslav
- Pillot Philippe
- Pinazza Ombretta
- Pinsky Lawrence
- Piyarathna Danthasinghe
- Planinic Mirko
- Ploskon Mateusz Andrzej
- Pluta Jan Marian
- Pochybova Sona
- Podesta Lerma Pedro Luis Manuel
- Poghosyan Martin
- Polishchuk Boris
- Poljak Nikola
- Poonsawat Wanchaloem
- Pop Amalia
- Porteboeuf Sarah Julie
- Porter R Jefferson
- Pospisil Jan
- Prasad Sidharth Kumar
- Preghenella Roberto
- Prino Francesco
- Pruneau Claude Andre
- Pshenichnov Igor
- Puccio Maximiliano
- Puddu Giovanna
- Pujahari Prabhat Ranjan
- Punin Valery
- Putschke Jorn Henning
- Qvigstad Henrik
- Rachevski Alexandre
- Raha Sibaji
- Rajput Sonia
- Rak Jan
- Rakotozafindrabe Andry Malala
- Ramello Luciano
- Rami Fouad
- Ramillien Barret Valerie
- Raniwala Rashmi
- Raniwala Sudhir
- Rasanen Sami Sakari
- Rascanu Bogdan Theodor
- Rathee Deepika
- Read Kenneth Francis
- Real Jean-Sebastien
- Redlich Krzysztof
- Reed Rosi Jan
- Rehman Attiq Ur
- Reichelt Patrick Simon
- Reidt Felix
- Ren Xiaowen
- Renfordt Rainer Arno Ernst
- Reolon Anna Rita
- Reshetin Andrey
- Rettig Felix Vincenz
- Revol Jean-Pierre
- Reygers Klaus Johannes
- Riabov Viktor
- Ricci Renato Angelo
- Richert Tuva Ora Herenui
- Richter Matthias Rudolph
- Riedler Petra
- Riegler Werner
- Riggi Francesco
- Ristea Catalin-Lucian
- Rivetti Angelo
- Rocco Elena
- Rodriguez Cahuantzi Mario
- Rodriguez Manso Alis
- Roeed Ketil
- Roehrich Dieter
- Rogochaya Elena
- Rohr David Michael
- Romita Rosa
- Ronchetti Federico
- Ronflette Lucile
- Rosnet Philippe
- Rossi Andrea
- Roukoutakis Filimon
- Roy Ankhi
- Roy Christelle Sophie
- Roy Pradip Kumar
- Rubio Montero Antonio Juan
- Rui Rinaldo
- Russo Riccardo
- Ryabinkin Evgeny
- Ryabov Yury
- Rybicki Andrzej
- Sadovskiy Sergey
- Safarik Karel
- Sahlmuller Baldo
- Sahoo Pragati
- Sahoo Raghunath
- Sahoo Sarita
- Sahu Pradip Kumar
- Saini Jogender
- Sakai Shingo
- Saleh Mohammad Ahmad
- Salgado Lopez Carlos Alberto
- Salzwedel Jai Samuel Nielsen
- Sambyal Sanjeev Singh
- Samsonov Vladimir
- Sanchez Castro Xitzel
- Sandor Ladislav
- Sandoval Andres
- Sano Masato
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- Zhalov Mikhail
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- Zhang Haitao
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- Zhang Yonghong
- Zhao Chengxin
- Zhigareva Natalia
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- Zhou You
- Zhou Zhuo
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- Publication venue
- Publication date
- 26/06/2015
- Field of study
Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe
Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aimo Ilaria
- Aiola Salvatore
- Ajaz Muhammad
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Armesto Perez Nestor
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Bach Matthias Jakob
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
- Bala Renu
- Baldisseri Alberto
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- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
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- Bellwied Rene
- Belmont Iii Ronald John
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- Sambyal Sanjeev Singh
- Samsonov Vladimir
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- Sandoval Andres
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- Sarkar - Sinha Tinku
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- Scapparone Eugenio
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- Seger Janet Elizabeth
- Sekiguchi Yuko
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- Selyuzhenkov Ilya
- Senosi Kgotlaesele
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- Serradilla Rodriguez Eulogio
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- Shabanov Arseniy
- Shabetai Alexandre
- Shadura Oksana
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- Sharma Monika
- Sharma Natasha
- Shigaki Kenta
- Shtejer Diaz Katherin
- Sibiryak Yury
- Siddhanta Sabyasachi
- Sielewicz Krzysztof Marek
- Siemiarczuk Teodor
- Silvermyr David Olle Rickard
- Silvestre Catherine Micaela
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- Snellings Raimond
- Snellman Tomas Wilhelm
- Soegaard Carsten
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- Song Myunggeun
- Song Zixuan
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- Spacek Michal
- Spiriti Eleuterio
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- Spyropoulou-Stassinaki Martha
- Srivastava Brijesh Kumar
- Stachel Johanna
- Stan Ionel
- Stefanek Grzegorz
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- Stenlund Evert Anders
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- Suire Christophe Pierre
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- Symons Timothy
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- Szanto De Toledo Alejandro
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- Tapia Takaki Daniel Jesus
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- Tarhini Mohamad
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- Tarzila Madalina-Gabriela
- Tauro Arturo
- Tejeda Munoz Guillermo
- Telesca Adriana
- Terasaki Kohei
- Terrevoli Cristina
- Teyssier Boris
- Thaeder Jochen Mathias
- Thomas Deepa
- Tieulent Raphael Noel
- Timmins Anthony Robert
- Toia Alberica
- Trogolo Stefano
- Trubnikov Victor
- Trzaska Wladyslaw Henryk
- Tsuji Tomoya
- Tumkin Alexandr
- Turrisi Rosario
- Tveter Trine Spedstad
- Ullaland Kjetil
- Uras Antonio
- Usai Gianluca
- Utrobicic Antonija
- Vajzer Michal
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- Van Hoorne Jacobus Willem
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- Viinikainen Jussi Samuli
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- Villalobos Baillie Orlando
- Vinogradov Alexander
- Vinogradov Leonid
- Vinogradov Yury
- Virgili Tiziano
- Vislavicius Vytautas
- Viyogi Yogendra
- Vodopyanov Alexander
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- Voloshin Sergey
- Volpe Giacomo
- Von Haller Barthelemy
- Vorobyev Ivan
- Vranic Danilo
- Vrlakova Janka
- Vulpescu Bogdan
- Vyushin Alexey
- Wagner Boris
- Wagner Jan
- Wang Hongkai
- Wang Mengliang
- Wang Yifei
- Watanabe Daisuke
- Watanabe Yosuke
- Weber Michael
- Weber Steffen Georg
- Wessels Johannes Peter
- Westerhoff Uwe
- Wiechula Jens
- Wikne Jon
- Wilde Martin Rudolf
- Wilk Grzegorz Andrzej
- Wilkinson Jeremy John
- Williams Crispin
- Windelband Bernd Stefan
- Winn Michael Andreas
- Yaldo Chris G
- Yang Hongyan
- Yang Ping
- Yano Satoshi
- Yin Zhongbao
- Yokoyama Hiroki
- Yoo In-Kwon
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
- Zaccolo Valentina
- Zaman Ali
- Zampolli Chiara
- Zaporozhets Sergey
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Chunhui
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zhu Xiangrong
- Zichichi Antonino
- Zimmermann Alice
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zyzak Maksym
- Publication venue
- Publication date
- 22/07/2015
- Field of study
Peer reviewe
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akombi Blessing
- Akunna Chisom Joyqueenet
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad Mashhour
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline Elizabeth
- Alema Niguse Meles
- Alemu Biresaw Wassihun
- Alemu Yihun Mulugeta
- Alhabib Khalid F.
- Alhassan Robert Kaba
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed Mohamed
- Alla Francois
- Allebeck Peter
- Almadi Majid Abdulrahman Hamad
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
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- Aremu Olatunde
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- Armoon Bahram
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- Asadi-Aliabadi Mehran
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- Bicer Burcu Kucuk
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- Bikbov Boris
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- Bisignano Catherine
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- Bjorge Tone
- Bockarie Moses John
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- Bohluli Mehdi
- Bojia Hunduma Amensisa
- Bolla Srinivasa Rao
- Boloor Archith
- Boon-Dooley Alexandra S.
- Borges Guilherme
- Borzi Antonio Maria
- Borzouei Shiva
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- Bosetti Cristina
- Boston Sofia
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- Braithwaite Dejana
- Brauer Michael
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- Chang Angela Y.
- Chang Jung-Chen
- Chang Kai-Lan
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- Chattu Vijay Kumar
- Chaturvedi Sarika
- Cherbuin Nicolas
- Chimed-Ochir Odgerel
- Chin Ken Lee
- Chirinos-Caceres Jesus Lorenzo
- Cho Daniel Youngwhan
- Choi Jee-Young Jasmine
- Christensen Hanne
- Chu Dinh-Toi
- Chung Michael T.
- Chung Sheng-Chia
- Cicuttini Flavia M.
- Ciobanu Liliana G.
- Cirillo Massimo
- Cislaghi Beniamino
- Classen Thomas Khaled Dwayne
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- Comfort Haley
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- Conti Sara
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- Cortesi Paolo Angelo
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- Cruz Jessica A.
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- D'Amico Emanuele
- da Silva Diana Dias
- Dahlawi Saad M. A.
- Dai Haijiang
- Dai Hancheng
- Damasceno Albertino Antonio Moura
- Damiani Giovanni
- Dandona Lalit
- Dandona Rakhi
- Daneshpajouhnejad Parnaz
- Dangel William James
- Danielsson Anna-Karin
- Dargan Paul I.
- Darshan B. B.
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- Das Gupta Rajat
- Das Neves Jose
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- Davis Adrian C.
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- De Neve Jan-Walter
- Dean Frances E.
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- Deen Amanda
- Defo Barthelemy Kuate
- Degenhardt Louisa
- DeLang Marissa
- Dellavalle Robert Paul
- Demeke Feleke Mekonnen
- Demoz Gebre Teklemariam
- Demsie Desalegn Getnet
- Denova-Gutierrez Edgar
- Dereje Nebiyu Dereje
- Deribe Kebede
- Dervenis Nikolaos
- Desai Rupak
- Desalew Assefa
- Dessie Getenet Ayalew
- Deuba Keshab
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- Dianatinasab Mostafa
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- El Tantawi Maha
- El-Jaafary Shaimaa I.
- Elbarazi Iffat
- Elgendy Islam Y.
- Elhabashy Hala Rashad
- Elsharkawy Aisha
- Elyazar Iqbal R. F.
- Emamian Mohammad Hassan
- Emmons-Bell Sophia
- Erskine Holly E.
- Eshrati Babak
- Eskandari Khalil
- Eskandarieh Sharareh
- Esmaeilnejad Saman
- Esmaeilzadeh Firooz
- Esteghamati Alireza
- Esteghamati Sadaf
- Estep Kara
- Etemadi Arash
- Etisso Atkilt Esaiyas
- Ezekannagha Oluchi
- Fanzo Jessica
- Farag Tamer
- Farahmand Mohammad
- Faraj Anwar
- Faraon Emerito Jose A.
- Fareed Mohammad
- Faridnia Roghiyeh
- Farinha Carla Sofia e Sa
- Farioli Andrea
- Faris Pawan Sirwan
- Faro Andre
- Faruque Mithila
- Farzadfar Farshad
- Fattahi Nazir
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- Feldman Rachel
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- Fernandes Eduarda
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- Fischer Florian
- Fisher James L.
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- Foigt Nataliya A.
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- Force Lisa M.
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- Fox Jack T.
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- Frank Tahvi D.
- Franklin Richard Charles
- Freitas Marisa
- Fu Weijia
- Fukumoto Takeshi
- Fukutaki Kai
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- Fullman Nancy
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- Gebremeskel Leake G.
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- Gebreslassie Assefa Ayalew Ayalew Ayalew
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- Gesesew Hailay Abrha
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- Goulart Alessandra C.
- Goulart Barbara Niegia Garcia
- Grada Ayman
- Greaves Felix
- Grivna Michal
- Grosso Giuseppe
- Gubari Mohammed Ibrahim Mohialdeen
- Gudi Nachiket
- Gugnani Harish Chander
- Guimaraes Andre Luiz Sena
- Guimaraes Rafael Alves
- Guled Rashid Abdi
- Gultie Teklemariam
- Guo Gaorui
- Guo Yuming
- Gupta Rahul
- Gupta Rajeev
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- Hasan Md Mehedi
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- Hasanzadeh Amir
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- Hayoon Anna Gershberg
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- Hollingsworth Bruce
- Hoogar Praveen
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- Hosgood H. Dean
- Hossain Naznin
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- Hosseinzadeh Mehdi
- Hostiuc Mihaela
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- Yusefzadeh Hasan
- Zadey Siddhesh
- Zahabi Saleh Salehi
- Zaidi Syed Saoud
- Zaki Leila
- Zaki Maysaa El Sayed
- Zakzuk Josefina
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zangeneh Alireza
- Zarafshan Hadi
- Zastrozhin Mikhail Sergeevich
- Zewdie Kaleab Alemayehu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Jeff T.
- Zhao Xiu-Ju George
- Zhao Yingxi
- Zheleva Bistra
- Zheng Peng
- Zhou Maigeng
- Zhu Cong
- Ziapour Arash
- Zimsen Stephanie R. M.
- Zlavog Bianca S.
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb-Pb collisions at root s(NN)=2.76TeV
- Author
- Adam Jaroslav
- Adamova Dagmar
- Aggarwal Madan Mohan
- Aglieri Rinella Gianluca
- Agnello Michelangelo
- Agrawal Neelima
- Ahammed Zubayer
- Ahn Sang Un
- Aiola Salvatore
- Akindinov Alexander
- Alam Sk Noor
- Alarcon Do Passo Suaide Alexandre
- Aleksandrov Dmitry
- Alessandro Bruno
- Alexandre Didier
- Alfaro Molina Jose Ruben
- ALICE Collaboration
- Alici Andrea
- Alkin Anton
- Alme Johan
- Alt Torsten
- Altinpinar Sedat
- Altsybeev Igor
- Alves Garcia Prado Caio
- Andrei Cristian
- Andronic Anton
- Anguelov Venelin
- Anielski Jonas
- Anticic Tome
- Antinori Federico
- Antonioli Pietro
- Aphecetche Laurent Bernard
- Appelshaeuser Harald
- Araujo Silva Figueredo Marcel
- Arcelli Silvia
- Armesto Perez Nestor
- Arnaldi Roberta
- Arsene Ionut Cristian
- Arslandok Mesut
- Audurier Benjamin
- Augustinus Andre
- Averbeck Ralf Peter
- Azmi Mohd Danish
- Bach Matthias Jakob
- Badala Angela
- Baek Yong Wook
- Bagnasco Stefano
- Bailhache Raphaelle Marie
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- Baltasar Dos Santos Pedrosa Fernando
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- Barbano Anastasia Maria
- Barbera Roberto
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- Barnafoldi Gergely Gabor
- Barnby Lee Stuart
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- Barth Klaus
- Bartke Jerzy Gustaw
- Bartsch Esther
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- Bastid Nicole
- Basu Sumit
- Bathen Bastian
- Batigne Guillaume
- Batista Camejo Arianna
- Batyunya Boris
- Batzing Paul Christoph
- Bearden Ian Gardner
- Beck Hans
- Bedda Cristina
- Behera Nirbhay Kumar
- Belikov Iouri
- Bellini Francesca
- Bello Martinez Hector
- Bellwied Rene
- Belmont Iii Ronald John
- Belmont Moreno Ernesto
- Belyaev Vladimir
- Bencedi Gyula
- Beole Stefania
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- Berdnikov Yaroslav
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- Berzano Dario
- Betev Latchezar
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- Blume Christoph
- Bock Friederike
- Boettger Stefan
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- Cerkala Jakub
- Chang Beomsu
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- Chelnokov Volodymyr
- Cherney Michael Gerard
- Cheshkov Cvetan Valeriev
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- Chibante Barroso Vasco Miguel
- Chochula Peter
- Choi Kyungeon
- Chojnacki Marek
- Choudhury Subikash
- Christakoglou Panagiotis
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- Christiansen Peter
- Chujo Tatsuya
- Chung Suh-Urk
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- Haaland Oystein Senneset
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- Harton Austin Vincent
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- Yaldo Chris G
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- Yang Ping
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- Yoo In-Kwon
- Yurchenko Volodymyr
- Yushmanov Igor
- Zaborowska Anna
- Zaccolo Valentina
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- Zaporozhets Sergey
- Zardoshti Nima
- Zarochentsev Andrey
- Zavada Petr
- Zavyalov Nikolay
- Zbroszczyk Hanna Paulina
- Zgura Sorin Ion
- Zhalov Mikhail
- Zhang Chunhui
- Zhang Haitao
- Zhang Xiaoming
- Zhang Yonghong
- Zhang Zuman
- Zhao Chengxin
- Zhigareva Natalia
- Zhou Daicui
- Zhou You
- Zhou Zhuo
- Zhu Hongsheng
- Zhu Jianhui
- Zichichi Antonino
- Zimmermann Alice
- Zimmermann Markus Bernhard
- Zinovjev Gennady
- Zyzak Maksym
- Publication venue
- Publication date
- 11/07/2015
- Field of study
The elliptic flow, v(2), of muons from heavy-flavour hadron decays at forward rapidity (2.5 <y <4) is measured in Pb-Pb collisions at root s(NN)= 2.76TeVwith the ALICE detector at the LHC. The scalar product, two- and four-particle Q cumulants and Lee-Yang zeros methods are used. The dependence of the v(2) of muons from heavy-flavour hadron decays on the collision centrality, in the range 0-40%, and on transverse momentum, p(T), is studied in the interval 3 <p(T)<10 GeV/c. A positive v(2) is observed with the scalar product and two-particle Q cumulants in semi-central collisions (10-20% and 20-40% centrality classes) for the p(T) interval from 3 to about 5GeV/c with a significance larger than 3 sigma, based on the combination of statistical and systematic uncertainties. The v(2) magnitude tends to decrease towards more central collisions and with increasing pT. It becomes compatible with zero in the interval 6 <p(T)<10 GeV/c. The results are compared to models describing the interaction of heavy quarks and open heavy-flavour hadrons with the high-density medium formed in high-energy heavy-ion collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
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- Antoine Studer
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- Kremling Julius
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- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
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- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
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- Leaf David E.
- Lean Richard
- Leaver Susannah
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- Leblond Julie
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- Lewis Sarah
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- Linstrum Kelsey M.
- Litton Ed
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- Liu Theresa
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- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
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- Martin Emma
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- Maxime Virginie
- Mayak Katelyn
- Mayangao Irving
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- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
- McConnochie Rachael
- McCracken Phoebe
- McCreary Erin
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- McCullagh Liz
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- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
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- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
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- Morrison Lynette
- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
- Mtuwa Shelia
- Mukherjee Dipak
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- Mulier Jelle
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- Newlands Jessica
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- Ng Anthony
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- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
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- Nierhaus Axel
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- O Rourke Kate
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- O'Neill Lorraine
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- O?Brien Neale
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- O?Kane Cecilia
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- Orlikowska Izabela
- Orlikowski David
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- Osagie Rawlings
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- Ottens Thomas
- Owen David R. J.
- Oza Deepali
- Padmakumar Anand
- Page Shannon
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- Paneru Hem
- Panjwani Ashok
- Panwar Rakshit
- Pappa Evita
- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
- Parker Lorraine
- Parker Natasha
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- Parry-Billings Karen
- Parsons Penny
- Pasieka Bastian
- Patanwala Asad
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- Patch Sarah
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- Pathak Shreya
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- Pegler Suzannah
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- Pereira Tiago Nuno Alfaro Lima
- Perez Jane
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- Petros Sirak
- Pettilä Leena
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- Phalod Gunjan
- Philbin Jennifer
- Philip Annlin
- Philippe Rigaud
- Phillips Barbara
- Phillips Matt
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- Phull Mandeep-Kaur
- Phuyal Aarti
- Pickering Charlotte
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- Pietersma Mario
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- Pinder Meredith
- Pinnell Jez
- Pinto Marta
- Pitts Sally
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- Pletz Mathias
- Plummer Bethany
- Plummer Mark
- Pogreban Tatiana
- Pogson David
- Polfliet Margot
- Polgarova Petra
- Polley Grace
- Pollock Katrina M.
- Pomeroy Fiona
- Poojara Latesh
- Pooni Jagtar- Singh
- Porteous Rebecca
- Porter David
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- Postma Douwe
- Potter Alison
- Potter Sarah
- Poulter Amber-Louise
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- Powell Elizabeth
- Prabakaran Rajalakshmi
- Pradel Gael
- Pratheema Ramachandran
- Prebeg Katharina
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- Puskarich Michael
- Putensen Daniel
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- Pérez-Terán Purificación
- Põldots Liisi
- Qiu Shan
- Qiu Xinyi
- Quayle Rachael
- Quenot Jean Pierre
- Quinn Alison
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- Rad Laura
- Rademaker Emma
- Rahmani Hassene
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- Raithatha Ajay
- Raj Ashok
- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
- Ramamurthi Balaji
- Ramanan Mahesh
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- Randell Georgina
- Rangan Ritika
- Ranganathan Lakshmi
- Rao Deepak
- Rashan Aasiyah
- Rashan Sumayyah
- Ratcliffe Megan
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- Reay Michael
- Rebello Rashmi
- Reddy Amie
- Reddy Harsha
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- Rees Stephanie
- Reeve Brenda
- Regli Adrian
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- Reid Andrew
- Reid Liadain
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- Reill Lorenz
- Reinhard Veronika
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- Reverté-Villarroya Silvia
- Revill Adam
- Rewa Oleksa
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- Reynolds Bob
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- Rhodes Jonathan
- Richards Carol
- Richards Suzanne
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- Richardson Angus
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- Ricketts Dan
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- Riepe Ansgar
- Rietveld Ilse
- Rimmer Dominic
- Ripa Marco
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- Ritzema Jenny
- Rivett Justine
- Rizzoni Damiano
- Roberts Belinda
- Roberts David
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- Robertson Debra
- Robinson Matt
- Roche Lisa
- Roche-Campo Ferran
- Rochwerg Bram
- Rodden Natalie
- Rodriguez Marina
- Rodríguez-Gómez Jorge
- Roebers Harald
- Roedl Kevin
- Rohde Gernot
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- Rosaroso Lace
- Rosborough Brian
- Rose Steve
- Rosenstein-Sisson Rachel
- Ross Elizabeth
- Rostron Anthony
- Roth Jason
- Rouge Patrick
- Roumen Rudy
- Rounds Charles
- Rovere-Querini Patrizia
- Rowan Kathryn M.
- Rowe-Leete Louise
- Rowland Matthew
- Roy Alistair
- Roynon-Reed Anna
- Rueß-Paterno Giusi
- Ruiz Winningtom
- Runge Isabelle
- Ruselli Giovanna
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- Ryan Lucy
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- Sadera Girendra
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- Salberg Armorel
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- Salvati Stefano
- Sampson Julia
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- Sandhu Gyan
- Sanghavi Ritesh
- Santamaria John
- Santos Filipa
- Santos Marlene S.
- Sapsford David
- Sara Treena
- Saran Anita
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- Sathianathan Kushaharan
- Sathianathan Prasannakumari
- Saull Michelle
- Saunders Christina T.
- Saunderson Paula
- Sauras-Colón Esther
- Saxena Manoj
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- Seaman Rebecca
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- Senya Ho
- Seppelt Ian
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- Serri Karim
- Sevilla Chanthou
- Seymour Christopher W.
- Shah Faraaz
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- Shaikh Arif
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- Shaw David
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- Slaughter Melanie
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- Sligl Wendy
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- Smyth Michelle
- Smyth Naoise
- Soar Natalie
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- Spiers Catriona
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- Stanley Timothy
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- Stapleton Liana
- Starke Lisa
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- Stedman Roger
- Steffen Melanie
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- Stephens Deanna
- Stevenson Lesley
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- Stone Sarah
- Stowe Bethan
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- Stronach Lucy
- Suber Tomeka
- Sukuraman Anila
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- Sundaram Radha
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- Sutherland Helen
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- Sven?ek Franc
- Svit?kar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szawarski Piotr
- Tai Charlotte
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- Thomas Amy
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- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tirot Patrice
- Tlayjeh Haytham
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- Touma Omar
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- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
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- Truman Nicholas
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- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
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- Tung Raymond
- Tupper-Carey Daryl
- Turgeon Alexis F.
- Turki Salah
- Turner Anne M.
- Turner Elizabeth
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- TV Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Ullmann Hannah
- Umrani Zulfiqar
- Unsworth Adam
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- Van Der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Haren Frank
- Van Hecke Jolien
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Zanten Arthur
- van Zuylen Tamara
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- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
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- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
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- Manangi Mallikarjuna
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- Mannan Syed
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- Mayo-Yáñez Miguel
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- McPherson Duncan
- Meara John G.
- Meead Adullah
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- Peral Ana
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- Su Yu-Xiong
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- Subramani Yamini
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- Sue-Chue-Lam Colin
- Suer Muhammed Salih
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- Sultania Mahesh
- Sundarraju Shalini
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- Vincent Elizabeth
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- Vohra Lubna
- Vokshi Ismail
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- Vázquez Gil
- Vázquez Irene Ortega
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- Wade Ryckie
- Wafi Omar
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- Wallis Christopher
- Wanjara Samuel
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- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
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- Watson Matthew
- Weber Clemens
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- Wheeler James
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- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
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- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Clinicopathological correlation in cutaneous tuberculosis
- Publication venue
- Wolters Kluwer Medknow Publications
- Publication date
- 01/01/2012
- Field of study
- …