Understanding and Modeling of Void Closure Mechanisms in Hot Metal Forming Processes: A Multiscale Approach

International audienceAfter casting, metal ingots may contain voids of different shapes and sizes which need to be eliminated in order to deliver a sound material. Hot metal forming processes are regularly used in the industry to reach this goal, but the calibration of these processes to get a complete closure of internal voids is still an issue. Existing models in the literature are either based on explicit full-field approaches or micro-analytical approaches. Both approaches have significant limitations regarding industrial issues. A new multiscale approach is thus proposed here. Based on realistic macroscopic loading conditions, extracted from the process scale, meso-scale simulations are conducted on a representative volume element containing an ellipsoidal void. The ellipsoidal void's shape factor and orientation with respect to the loading direction are considered in the void closure evolution law in addition to the classical mechanical parameters (equivalent plastic strain and stress triaxiality ratio). Several process and void morphological parameters are analyzed regarding void closure and the proposed mean field model is validated by comparison with explicit full field simulations of hot rolling

Analyse multi-échelle de la refermeture de porosités, appliquée à la mise en forme des métaux à chaud

National audienceLe comportement en refermeture de porosités est étudié par éléments finis, à l'échelle d'un volume élémentaire représentatif. Les maillages sont générés à partir de géométries réelles de porosités obtenues par tomographie aux rayons X. Les simulations sont réalisées avec des conditions aux limites représentatives des conditions industrielles réelles. Il est démontré que l'état de contraintes présente une influence de premier ordre sur le comportement en refermeture, devant d'autres paramètres mécaniques. L'impact de la géométrie de la porosité est également étudié via la génération de géométries équiva-lentes représentatives. Celle-ci présente également une influence de premier ordre sur le comportement en refermeture

Elaboration, par une approche sur VER, d’un modèle à champ moyen pour la prédiction de la refermeture de pores lors de la déformation àchaud de métaux

International audienceDans une pièce métallique, des pores résiduels non désirés sont toujours présents après les opérations de fonderie. Pour refermer ces pores de taille généralement négligeable par rapport à la taille de la pièce, les industriels utilisent des procédés à chaud tels que le forgeage libre ou le laminage. Dans la littérature, plusieurs modèles à champ moyen prédictifs en terme d'évolution du volume des pores traitent de cette problématique. Récemment un nouveau modèle à champ moyen, appelé Cicaporo4, a été élaboré et continue d'être amélioré afin de modéliser la refermeture des pores. Ce modèle se base sur une approche multi-échelles2 utilisant des simulations sur Volume Elémentaire Représentatif (VER). La plupart des modèles classiques étudient la refermeture en fonction de latriaxialité des contraintes et de la déformation plastique équivalente. Pour l'élaboration du modèle Cicaporo, les effets de la morphologie des pores et de leur orientation dans la matrice ont été investigués

Three-dimensional analysis of real void closure at the meso-scale during hot metal forming processes

International audienceIn the metal forming industry, elimination of internal defects is a prerequisite to avoid catastrophic failure of workpieces. The two different approaches used in the literature to study void closure, respectively at the process-scale and void-scale, present a certain number of limitations. In this paper, an alternative method is presented at a meso-scale. Simulations are performed using a Representative Volume Element (RVE) with real void geometries generated from 3D images obtained using computed microtomography. Complex mechanical loadings are imposed using advanced boundary conditions coming from process numerical modeling. The simulations provide very accurate results to model void closure in real industrial conditions. Equivalent spherical and ellipsoidal voids are also generated and void volume evolution is compared to the case of real geometries. It is shown that the global tendency of void closure is well respected, even though the use of a sphere underestimates void closure, whereas an ellipsoid overestimates void closure, on the final stage. A sensitivity study to mechanical parameters shows that strain-rate has no major influence, while stress triaxiality ratio exhibits a strong influence on the closure of real void. Non-uniform boundary conditions also applied to demonstrate that most existing predictive models are unable to predict void closure in non-uniform mechanical loading

Porphyromonas gingivalis Participates in Pathogenesis of Human Abdominal Aortic Aneurysm by Neutrophil Activation. Proof of Concept in Rats

International audienceBACKGROUND: Abdominal Aortic Aneurysms (AAAs) represent a particular form of atherothrombosis where neutrophil proteolytic activity plays a major role. We postulated that neutrophil recruitment and activation participating in AAA growth may originate in part from repeated episodes of periodontal bacteremia. METHODS AND FINDINGS: Our results show that neutrophil activation in human AAA was associated with Neutrophil Extracellular Trap (NET) formation in the IntraLuminal Thrombus, leading to the release of cell-free DNA. Human AAA samples were shown to contain bacterial DNA with high frequency (11/16), and in particular that of Porphyromonas gingivalis (Pg), the most prevalent pathogen involved in chronic periodontitis, a common form of periodontal disease. Both DNA reflecting the presence of NETs and antibodies to Pg were found to be increased in plasma of patients with AAA. Using a rat model of AAA, we demonstrated that repeated injection of Pg fostered aneurysm development, associated with pathological characteristics similar to those observed in humans, such as the persistence of a neutrophil-rich luminal thrombus, not observed in saline-injected rats in which a healing process was observed. CONCLUSIONS: Thus, the control of periodontal disease may represent a therapeutic target to limit human AAA progression

Verbal and Visual Memory Impairments Among Young Offspring and Healthy Adult Relatives of Patients With Schizophrenia and Bipolar Disorder: Selective Generational Patterns Indicate Different Developmental Trajectories

Objective: Memory deficits have been shown in patients affected by schizophrenia (SZ) and bipolar (BP)/mood disorder. We recently reported that young high-risk offspring of an affected parent were impaired in both verbal episodic memory (VEM) and visual episodic memory (VisEM). Understanding better the trajectory of memory impairments from childhood to adult clinical status in risk populations is crucial for early detection and prevention. In multigenerational families densely affected by SZ or BP, our aim was to compare the memory impairments observed in young nonaffected offspring with memory functioning in nonaffected adult relatives and patients. Methods: For 20 years, we followed up numerous kindreds in the Eastern Québec population. After having characterized the Diagnostic and Statistical Manual of Mental Disorders phenotypes, we assessed cognition (N = 381) in 3 subsamples in these kindreds and in controls: 60 young offspring of a parent affected by SZ or BP, and in the adult generations, 92 nonaffected adult relatives and 40 patients affected by SZ or BP. VEM was assessed with the California Verbal Learning Test and VisEM with the Rey figures. Results: The VEM deficits observed in the offspring were also found in adult relatives and patients. In contrast, the VisEM impairments observed in the young offspring were present only in patients, not in the adult relatives. Conclusion: Implications for prevention and genetic mechanisms can be drawn from the observation that VEM and VisEM would show distinct generational trajectories and that the trajectory associated with VisEM may offer a better potential than VEM to predict future risk of developing the disease

Trends in SAVR with biological vs. mechanical valves in middle-aged patients: results from a French large multi-centric survey

Background/introductionCurrently, despite continued issues with durability ( 1), biological prosthetic valves are increasingly chosen over mechanical valves for surgical aortic valve replacement (SAVR) in adult patients of all ages, at least in Western countries. For younger patients, this choice means assuming the risks associated with a redo SAVR or valve-in-valve procedure.PurposeTo assess the use of mechanical vs. biological valve prostheses for SAVR relative to patient's age and implant time in a large population extracted from the French National Database EPICARD.MethodsPatients in EPICARD undergoing SAVR from 2007 to 2022 were included from 22 participating public or private centers chosen to represent a balanced representation of centre sizes and geographical discrepancies. Patients with associated pathology of the aorta (aneurysm or dissection) and requiring a vascular aortic prosthesis were excluded. Comparisons were made amongst centers, valve choice, implant date range, and patient age.ResultsWe considered 101,070 valvular heart disease patients and included 72,375 SAVR (mean age 71.4 ± 12.2 years). We observed a mechanical vs. biological prosthesis ratio (MBPR) of 0.14 for the overall population. Before 50 years old (y-o), MBPR was >1.3 (p < 0.001) while patients above 60 years-old received principally biological SAVR (p < 0.0001). Concerning patients between 50 and 60 years-old patients, MPVR was 1.04 (p = 0.03). Patients 50–60 years-old from the first and second study duration quartile (before August 2015) received preferentially mechanical SAVR (p < 0.001). We observed a shift towards more biological SAVR (p < 0.001) for patients from the third and fourth quartile to reach a MBPR at 0.43 during the last years of the series. Incidentally, simultaneous mitral valve replacement were more common in case of mechanical SAVR (p < 0.0001), while associated CABGs were more frequent in case of biological SAVR (p < 0.0001).ConclusionIn a large contemporary French patient population, real world practice showed a recent shift towards a lower age-threshold for biological SAVR as compared to what would suggest contemporary guidelines

ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.Peer reviewe

ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.Peer reviewe