56 research outputs found
Perturbative non uniform black strings in
We construct the non uniform AdS black string solution with a perturbation
theory in six dimensions, focusing on the backreacting second order correction.
The backreactions at second order give the first relevant corrections to the
thermodynamical quantities. Our results show that for configurations with
horizon radius and length in the extradimension small compared to the AdS
radius, the properties of the non uniform black string are similar to the
locally asymptotically flat case. For black strings with small horizon radial
coordinate but large length in the extradimension, the thermodynamical
properties of the solutions are affected by the AdS curvature.Comment: 10 pages, 2 figure
Planning for Emerging Threats: Rethinking the Presidential Line of Succession
From the COVID-19 pandemic to the Ukraine war, recent events have highlighted possible threats to the continuity of presidential leadership. The presidential line of succession in the Presidential Succession Act of 1947 has several flaws. Some of the successors it designates might be ill-suited to discharge the powers of the presidency. Others concerns include its constitutionality, inappropriate incentives it might create, and the democratic legitimacy of outcomes it might produce. This report proposes several reforms to the line of succession for pre- and post-inaugural succession contingencies.https://ir.lawnet.fordham.edu/rule_of_law_clinic/1002/thumbnail.jp
The Constitutent Quark as a Topological Soliton
Recently it was proposed that the constituent quark is a topological soliton.
I investigate this soliton, calculating its mass, radius, magnetic moment,
color magnetic moment, and spin structure function. Within the approximations
used, the magnetic moments and spin structure function cannot simultaneously be
made to agree with the constituent quark model. Some discussion of what to
expect from better approximations is included.Comment: 21 pages, LBL-3510
Early results and lessons learned from a multicenter, randomized, double-blind trial of bone marrow aspirate concentrate in critical limb ischemia
ObjectivesDespite advances in endovascular therapies, critical limb ischemia (CLI) continues to be associated with high morbidity and mortality. Patients without direct revascularization options have the worst outcomes. We sought to explore the feasibility of conducting a definitive trial of a bone marrow-derived cellular therapy for CLI in this “no option” population.MethodsA pilot, multicenter, prospective, randomized, double-blind, placebo-controlled trial for “no option” CLI patients was performed. The therapy consisted of bone marrow aspirate concentrate (BMAC), prepared using a point of service centrifugation technique and injected percutaneously in 40 injections to the affected limb. Patients were randomized to BMAC or sham injections (dilute blood). We are reporting the 12-week data.ResultsForty-eight patients were enrolled. The mean age was 69.5 years (range, 42-93 years). Males predominated (68%). Diabetes was present in 50%. Tissue loss (Rutherford 5) was present in 30 patients (62.5%), and 18 (37.5%) had rest pain without tissue loss (Rutherford 4). Patients were deemed unsuitable for conventional revascularization based on multiple prior failed revascularization efforts (24 [50%]), poor distal targets (43 [89.6%]), and medical risk (six [12.5%]). Thirty-four patients were treated with BMAC and 14 with sham injections. There were no adverse events attributed to the injections. Renal function was not affected. Effective blinding was confirmed; blinding index of 61% to 85%. Subjective and objective outcome measures were effectively obtained with the exception of treadmill walking times, which could only be obtained at baseline and follow-up in 15 of 48 subjects. This pilot study was not powered to demonstrate statistical significance but did demonstrate favorable trends for BMAC versus control in major amputations (17.6% vs 28.6%), improved pain (44% vs 25%), improved ankle brachial index (ABI; 32.4% vs 7.1%), improved Rutherford classification (35.3% vs 14.3%), and quality-of-life scoring better for BMAC in six of eight domains.ConclusionsIn this multicenter, randomized, double-blind, placebo-controlled trial of autologous bone marrow cell therapy for CLI, the therapy was well tolerated without significant adverse events. The BMAC group demonstrated trends toward improvement in amputation, pain, quality of life, Rutherford classification, and ABI when compared with controls. This pilot allowed us to identify several areas for improvement for future trials and CLI studies. These recommendations include elimination of treadmill testing, stratification by Rutherford class, and more liberal inclusion of patients with renal insufficiency. Our strongest recommendation is that CLI studies that include Rutherford 4 patients should incorporate a composite endpoint reflecting pain and quality of life
A scalar field instability of rotating and charged black holes in (4+1)-dimensional Anti-de Sitter space-time
We study the stability of static as well as of rotating and charged black
holes in (4+1)-dimensional Anti-de Sitter space-time which possess spherical
horizon topology. We observe a non-linear instability related to the
condensation of a charged, tachyonic scalar field and construct "hairy" black
hole solutions of the full system of coupled Einstein, Maxwell and scalar field
equations. We observe that the limiting solution for small horizon radius is
either a hairy soliton solution or a singular solution that is not a regular
extremal solution. Within the context of the gauge/gravity duality the
condensation of the scalar field describes a holographic
conductor/superconductor phase transition on the surface of a sphere.Comment: 16 pages including 8 figures, v2: discussion on soliton solutions
extended; v3: matches version accepted for publication in JHE
Rotating black holes with equal-magnitude angular momenta in d=5 Einstein-Gauss-Bonnet theory
We construct rotating black hole solutions in Einstein-Gauss-Bonnet theory in
five spacetime dimensions. These black holes are asymptotically flat, and
possess a regular horizon of spherical topology and two equal-magnitude angular
momenta associated with two distinct planes of rotation. The action and global
charges of the solutions are obtained by using the quasilocal formalism with
boundary counterterms generalized for the case of Einstein-Gauss-Bonnet theory.
We discuss the general properties of these black holes and study their
dependence on the Gauss-Bonnet coupling constant . We argue that most
of the properties of the configurations are not affected by the higher
derivative terms. For fixed the set of black hole solutions terminates
at an extremal black hole with a regular horizon, where the Hawking temperature
vanishes and the angular momenta attain their extremal values. The domain of
existence of regular black hole solutions is studied. The near horizon geometry
of the extremal solutions is determined by employing the entropy function
formalism.Comment: 25 pages, 7 figure
Einstein-Gauss-Bonnet black strings
We construct uniform black-string solutions in Einstein-Gauss-Bonnet gravity
for all dimensions between five and ten and discuss their basic properties.
Closed form solutions are found by taking the Gauss-Bonnet term as a
perturbation from pure Einstein gravity. Nonperturbative solutions are
constructed by solving numerically the equations of the model. The
Gregory-Laflamme instability of the black strings is explored via linearized
perturbation theory. Our results indicate that new qualitative features occur
for , in which case stable configurations exist for large enough values of
the Gauss-Bonnet coupling constant. For other dimensions, the black strings are
dynamically unstable and have also a negative specific heat. We argue that this
provides an explicit realization of the Gubser-Mitra conjecture, which links
local dynamical and thermodynamic stability. Nonuniform black strings in
Einstein-Gauss-Bonnet theory are also constructed in six spacetime dimensions.Comment: 33 pages, 11 figure
New AdS solitons and brane worlds with compact extra-dimensions
We construct new static, asymptotically AdS solutions where the conformal
infinity is the product of Minkowski spacetime and a sphere . Both
globally regular, soliton-type solutions and black hole solutions are
considered. The black holes can be viewed as natural AdS generalizations of the
Schwarzschild black branes in Kaluza-Klein theory. The solitons provide new
brane-world models with compact extra-dimensions. Different from the
Randall-Sundrum single-brane scenario, a Schwarzschild black hole on the Ricci
flat part of these branes does not lead to a naked singularity in the bulk.Comment: 28 pages, 4 figure
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
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