Lifting Slepton Masses with a Non-universal, Non-anomalous U(1)'_{NAF} in Anomaly Mediated SUSY breaking

We extend the Minimum Supersymmetry Standard Model by a non-anomalous family (NAF) U(1)'_{NAF} gauge symmetry. All gauge anomalies are cancelled with no additional exotics other than the three right-handed neutrinos. The FI D-terms associated with the U(1)'_{NAF} symmetry lead to additional positive contributions to slepton squared masses. In a RG invariant way, this thus solves the tachyonic slepton mass problem in Anomaly Mediated Supersymmetry Breaking. In addition, the U (1)'_{NAF} symmetry naturally gives rise to the fermion mass hierarchy and mixing angles, and determines the mass spectrum of the sparticles.Comment: 13 pages; v2: version to appear in Phys. Lett.

Realistic Anomaly Mediation with Bulk Gauge Fields

We present a simple general framework for realistic models of supersymmetry breaking driven by anomaly mediation. We consider a 5-dimensional "brane universe" where the visible and hidden sectors are localized on different branes, and the standard model gauge bosons propagate in the bulk. In this framework there can be charged scalar messengers that have contact interactions with the hidden sector, either localized in the hidden sector or in the bulk. These scalars obtain soft masses that feed into visible sector scalar masses at two loop order via bulk gauge interactions. This contribution is automatically flavor-blind, and can be naturally positive. If the messengers are in the bulk this contribution is automatically the same order of magnitude as the anomaly mediated contribution, independent of the brane spacing. If the messengers are localized to a brane the two effects are of the same order for relatively small brane spacings. The gaugino masses and A terms are determined completely by anomaly mediation. In order for anomaly mediation to dominate over radion mediation the radion must be is stabilized in a manner that preserves supersymmetry, with supergravity effects included. We show that this occurs in simple models. We also show that the mu problem can be solved by the vacuum expectation value of a singlet in this framework.Comment: 16 pages, LaTeX2e, no figure

TeV-Scale Horizontal Symmetry and the Slepton Mass Problem of Anomaly Mediation

We propose a new scenario for solving the tachyonic slepton mass problem of anomaly mediated supersymmetry breaking models with a non-Abelian horizontal gauge symmetry broken at the TeV scale. A specific model based on SU(3)_{H} horizontal symmetry is presented wherein the sleptons receive positive mass-squared from the asymptotically free SU(3)_{H} gauge sector. Approximate global symmetries present in the model strongly suppress flavor changing processes induced by the horizontal vector gauge bosons. The model predicts m_{h} < 120 GeV for the lightest Higgs boson mass, tan{beta} nearly equal to 4, and M_V = 1-4 TeV for the SU(3)_{H} gauge boson masses. The lightest SUSY particle is found to be the neutral Wino, which is a candidate for cold dark matter.Comment: 25 pages in LaTeX, 2 eps figure

Jazz Guitar Ensemble and Jazz Combos

Kennesaw State University School of Music presents Jazz Guitar Ensemble and Jazz Combos.https://digitalcommons.kennesaw.edu/musicprograms/1353/thumbnail.jp

Jazz Guitar Ensemble and Jazz Combos

Kennesaw State University School of Music presents Jazz Guitar Ensemble and Jazz Combos.https://digitalcommons.kennesaw.edu/musicprograms/1422/thumbnail.jp

Signals of anomaly mediated supersymmetry breaking in an e^- gamma collider

We study the signatures of minimal anomaly mediated supersymmetry breaking in an e^- gamma collider. We demonstrate that the associated production of a sneutrino with the lightest chargino leads to a substantially large signal size. The background is negligibly small, though. Even more interestingly, a measurement of the fundamental supersymmetry breaking parameters could be possible.Comment: 25 pages, LaTex, 7 PS figures and 1 table (included

IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System

PURPOSE: To improve persistence of adoptively transferred T-cell receptor (TCR)-engineered T cells and durable clinical responses, we designed a clinical trial to transplant genetically-modified hematopoietic stem cells (HSCs) together with adoptive cell transfer of T cells both engineered to express an NY-ESO-1 TCR. Here, we report the preclinical studies performed to enable an investigational new drug (IND) application. EXPERIMENTAL DESIGN: HSCs transduced with a lentiviral vector expressing NY-ESO-1 TCR and the PET reporter/suicide gene HSV1-sr39TK and T cells transduced with a retroviral vector expressing NY-ESO-1 TCR were coadministered to myelodepleted HLA-A2/Kb mice within a formal Good Laboratory Practice (GLP)-compliant study to demonstrate safety, persistence, and HSC differentiation into all blood lineages. Non-GLP experiments included assessment of transgene immunogenicity and in vitro viral insertion safety studies. Furthermore, Good Manufacturing Practice (GMP)-compliant cell production qualification runs were performed to establish the manufacturing protocols for clinical use. RESULTS: TCR genetically modified and ex vivo-cultured HSCs differentiated into all blood subsets in vivo after HSC transplantation, and coadministration of TCR-transduced T cells did not result in increased toxicity. The expression of NY-ESO-1 TCR and sr39TK transgenes did not have a detrimental effect on gene-modified HSC's differentiation to all blood cell lineages. There was no evidence of genotoxicity induced by the lentiviral vector. GMP batches of clinical-grade transgenic cells produced during qualification runs had adequate stability and functionality. CONCLUSIONS: Coadministration of HSCs and T cells expressing an NY-ESO-1 TCR is safe in preclinical models. The results presented in this article led to the FDA approval of IND 17471

Supersymmetry on the Run: LHC and Dark Matter

Supersymmetry, a new symmetry that relates bosons and fermions in particle physics, still escapes observation. Search for SUSY is one of the main aims of the recently launched Large Hadron Collider. The other possible manifestation of SUSY is the Dark Matter in the Universe. The present lectures contain a brief introduction to supersymmetry in particle physics. The main notions of supersymmetry are introduced. The supersymmetric extension of the Standard Model - the Minimal Supersymmetric Standard Model - is considered in more detail. Phenomenological features of the MSSM as well as possible experimental signatures of SUSY at the LHC are described. The DM problem and its possible SUSY solution is presented.Comment: Latex, 37 pages, 35 figures. Lectures given at 48 Schladming School on Theoretical Physics, March 201

Physics searches at the LHC

With the LHC up and running, the focus of experimental and theoretical high energy physics will soon turn to an interpretation of LHC data in terms of the physics of electroweak symmetry breaking and the TeV scale. We present here a broad review of models for new TeV-scale physics and their LHC signatures. In addition, we discuss possible new physics signatures and describe how they can be linked to specific models of physics beyond the Standard Model. Finally, we illustrate how the LHC era could culminate in a detailed understanding of the underlying principles of TeV-scale physics.Comment: 184 pages, 55 figures, 14 tables, hundreds of references; scientific feedback is welcome and encouraged. v2: text, references and Overview Table added; feedback still welcom

Status of Muon Collider Research and Development and Future Plans

The status of the research on muon colliders is discussed and plans are outlined for future theoretical and experimental studies. Besides continued work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy collider, many studies are now concentrating on a machine near 0.1 TeV (CoM) that could be a factory for the s-channel production of Higgs particles. We discuss the research on the various components in such muon colliders, starting from the proton accelerator needed to generate pions from a heavy-Z target and proceeding through the phase rotation and decay ($\pi \to \mu \nu_{\mu}$) channel, muon cooling, acceleration, storage in a collider ring and the collider detector. We also present theoretical and experimental R & D plans for the next several years that should lead to a better understanding of the design and feasibility issues for all of the components. This report is an update of the progress on the R & D since the Feasibility Study of Muon Colliders presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A. Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics (Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics, Accelerators and Beam