Dual-purpose self-deliverable lunar surface PV electrical power system

A safe haven and work supported PV power systems on the lunar surface will likely be required by NASA in support of the manned outpost scheduled for the post-2000 lunar/Mars exploration and colonization initiative. Initial system modeling and computer analysis shows that the concept is workable and contains no major high risk technology issues which cannot be resolved in the circa 2000 to 2025 timeframe. A specific selection of the best suited type of electric thruster has not been done; the initial modeling was done using an ion thruster, but Rocketdyne must also evaluate arc and resisto-jets before a final design can be formulated. As a general observation, it appears that such a system can deliver itself to the Moon using many system elements that must be transported as dead payload mass in more conventional delivery modes. It further appears that a larger power system providing a much higher safe haven power level is feasible if this delivery system is implemented, perhaps even sufficient to permit resource prospecting and/or lab experimentation. The concept permits growth and can be expanded to include cargo transport such as habitat and working modules. In short, the combined payload could be manned soon after landing and checkout. NASA has expended substantial resources in the development of electric propulsion concepts and hardware that can be applied to a lunar transport system such as described herein. In short, the paper may represent a viable mission on which previous investments play an invaluable role. A more comprehensive technical paper which embodies second generation analysis and system size will be prepared for near-term presentation

On the use of Jargon and Word Embeddings to Explore Subculture within the Reddit’s Manosphere

Understanding the identities, needs, realities and development of subcultures has been a long term target of sociology and cultural studies. Socio-cultural linguistics, in particular, examines the use of language and, in particular, the existence and use of neologisms, slang and jargon. These terms capture concepts and expressions that are not in common use and represent the new realities, norms and values of subcommunities. Identifying and understanding such terms, however, is a very complex task, particularly considering the vast amount of content that is currently available online for many such groups. In this paper, we propose a combination of computational and socio-linguistic methods to automatically extract new terminology from large amounts of data, using word-embeddings to semantically contextualise their meaning. As a use case, we explore subculture on the platform Reddit. More specifically, we investigate groups considered part of the manosphere, a loose online community where men’s perspectives, gripes, frustrations and desires are explicitly expressed and where women are typically targets of hostility. Characterisations of this group as a subculture are then provided, based on an in-depth analysis of the identified jargon

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

Cancer immunoediting is the process whereby immune cells protect against cancer formation by sculpting the immunogenicity of developing tumors. Although the full process depends on innate and adaptive immunity, it remains unclear whether innate immunity alone is capable of immunoediting. To determine whether the innate immune system can edit tumor cells in the absence of adaptive immunity, we compared the incidence and immunogenicity of 3'methylcholanthrene-induced sarcomas in syngeneic wild-type, RAG2, and RAG2x γc mice. We found that innate immune cells could manifest cancer immunoediting activity in the absence of adaptive immunity. This activity required natural killer (NK) cells and interferon γ (IFN-γ), which mediated the induction of M1 macrophages. M1 macrophages could be elicited by administration of CD40 agonists, thereby restoring editing activity in RAG2x γc mice. Our results suggest that in the absence of adaptive immunity, NK cell production of IFN-γ induces M1 macrophages, which act as important effectors during cancer immunoediting

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Jack Flood to Elizabeth Cisney Smith

Letter from Jack Flood, a man hired by the Cisney family, to Elizabeth Cisney Smith regarding Cisney Smith's marriage plans. Elizabeth Cisney Smith graduated from the Woman's Medical College of Pennsylvania in 1911. She practiced medicine for 35 years in Pennsylvania, Ohio, North Dakota and Maryland; and was active in the women's rights and suffrage movement

Incorporation of Automated Ball Indentation Methodology for Studying Powder Bed Fabricated 304L Stainless Steel

Automated Ball Indentation (ABI) is a viable method for estimating the ductility, yield stress, and ultimate stress, among other metrics, in different metallic materials. Currently, ABI data analysis utilizes Holloman’s Power Law to model the plastic region of the true stress-true strain curve. While this formulation is accurate for some materials, its relevance for additively manufactured austenitic stainless steels, such as 304L, needed investigation. The deviation of the material’s plastic behavior from the Power Law was investigated. In order to better model this behavior, both the Voce and Ludwigson formulation were investigated. These formulations were tested for both wrought and additively manufactured 304L stainless steel. Regression analysis was used to choose the appropriate fit. The chosen formulation was then used to generate a material model to simulate the ABI process. These simulations were validated through experimental analysis.Mechanical Engineerin