Gestión y Aplicación de Metadatos Asociados al Tráfico Multimedia en Videoconferencia 3D

En los terminales multimedia de nueva generación se están incorporando cada vez más funcionalidades capaces de generar información adicional que enriquece la comunicación audiovisual en sí misma. Esta nueva información adicional, metainformación o metadatos, deberán poder ser gestionados y transmitidos de forma independiente pero sincronizados con el propio flujo multimedia. En este trabajo se presenta una arquitectura que permite resolver el problema identificado y que ha sido implementada con éxito en el proyecto CENIT VISION, dando soporte a diversos servicios de valor añadido asociados a una Videoconferencia 3D inmersiva: interacción con el usuario, grabación de sesiones, gestión de calidad, etc. La misma solución también tiene aplicación en otros entornos del sector multimedia como publicidad personalizada para IPTV, y de otros, como videovigilancia

Engineered Contrast Agents in a Single Structure for T1-T2 Dual Magnetic Resonance Imaging

[EN] The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T-1-T-2 dual-mode relaxivity requires the accurate assembly of T-1 and T-2 magnetic centers in a single structure. In this context, we have synthesized a novel hybrid material by monitoring the formation of Prussian Blue analogue Gd(H2O)(4)[Fe(CN)(6)] nanoparticles with tailored shape (from nanocrosses to nanorods) and size, and further protection with a thin and homogeneous silica coating through hydrolysis and polymerization of silicate at neutral pH. The resulting Gd(H2O)(4)[Fe(CN)(6)]@SiO2 magnetic nanoparticles are very stable in biological fluids. Interestingly, this combination of Gd and Fe magnetic centers closely packed in the crystalline network promotes a magnetic synergistic effect, which results in significant improvement of longitudinal relaxivity with regards to soluble Gd3+ chelates, whilst keeping the high transversal relaxivity inherent to the iron component. As a consequence, this material shows excellent activity as MRI CA, improving positive and negative contrasts in T-1- and T-2-weighted MR images, both in in vitro (e.g., phantom) and in vivo (e.g., Sprague-Dawley rats) models. In addition, this hybrid shows a high biosafety profile and has strong ability to incorporate organic molecules on the surface with variable functionality, displaying great potential for further clinical application.Financial support of the Spanish Ministry of Economy and Competitiveness (projects TEC2016-80976-R and SEV-2016-0683) is gratefully acknowledged. Dr E. M. Rivero thanks the Cursol Foundation for a post-doctoral scholarship. A. C. G. also thanks the La Caixa Foundation for a Ph.D. scholarship. We fully appreciate the assistance of the Electron Microscopy Service of the UPV and INSCANNER S.L.Cabrera-García, A.; Checa-Chavarria, E.; Pacheco-Torres, J.; Bernabeu-Sanz, A.; Vidal Moya, JA.; Rivero-Buceta, EM.; Sastre Navarro, GI.... (2018). 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Tunable T1and T2contrast abilities of manganese-engineered iron oxide nanoparticles through size control. Nanoscale, 6(17), 10404. doi:10.1039/c4nr02680bPerrier, M., Kenouche, S., Long, J., Thangavel, K., Larionova, J., Goze-Bac, C., … Guari, Y. (2013). Investigation on NMR Relaxivity of Nano-Sized Cyano-Bridged Coordination Polymers. Inorganic Chemistry, 52(23), 13402-13414. doi:10.1021/ic401710jPerera, V. S., Yang, L. D., Hao, J., Chen, G., Erokwu, B. O., Flask, C. A., … Huang, S. D. (2014). Biocompatible Nanoparticles of KGd(H2O)2[Fe(CN)6]·H2O with Extremely HighT1-Weighted Relaxivity Owing to Two Water Molecules Directly Bound to the Gd(III) Center. Langmuir, 30(40), 12018-12026. doi:10.1021/la501985pCai, X., Gao, W., Ma, M., Wu, M., Zhang, L., Zheng, Y., … Shi, J. (2015). A Prussian Blue-Based Core-Shell Hollow-Structured Mesoporous Nanoparticle as a Smart Theranostic Agent with Ultrahigh pH-Responsive Longitudinal Relaxivity. 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BARD1 Pathogenic Variants are Associated with Triple-Negative Breast Cancer in a Spanish Hereditary Breast and Ovarian Cancer Cohort

Only a small fraction of hereditary breast and/or ovarian cancer (HBOC) cases are caused by germline variants in the high-penetrance breast cancer 1 and 2 genes (BRCA1 and BRCA2). BRCA1-associated ring domain 1 (BARD1), nuclear partner of BRCA1, has been suggested as a potential HBOC risk gene, although its prevalence and penetrance are variable according to populations and type of tumor. We aimed to investigate the prevalence of BARD1 truncating variants in a cohort of patients with clinical suspicion of HBOC. A comprehensive BARD1 screening by multigene panel analysis was performed in 4015 unrelated patients according to our regional guidelines for genetic testing in hereditary cancer. In addition, 51,202 Genome Aggregation Database (gnomAD) non-Finnish, non-cancer European individuals were used as a control population. In our patient cohort, we identified 19 patients with heterozygous BARD1 truncating variants (0.47%), whereas the frequency observed in the gnomAD controls was 0.12%. We found a statistically significant association of truncating BARD1 variants with overall risk (odds ratio (OR) = 3.78; CI = 2.10-6.48; p = 1.16 x 10(-5)). This association remained significant in the hereditary breast cancer (HBC) group (OR = 4.18; CI = 2.10-7.70; p = 5.45 x 10(-5)). Furthermore, deleterious BARD1 variants were enriched among triple-negative BC patients (OR = 5.40; CI = 1.77-18.15; p = 0.001) compared to other BC subtypes. Our results support the role of BARD1 as a moderate penetrance BC predisposing gene and highlight a stronger association with triple-negative tumors

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

re-habitar El Carmen : Un proyecto sobre patrimonio contemporáneo

El proyecto _re-HABITAR suponía para el propio proceder de la institución un avance más allá del reconocimiento, registro, inventario o protección patrimonial de la arquitectura del siglo XX y del Movimiento Moderno para posicionarse en la acción preventiva y conservativa de ese legado contemporáneo. Para ello, la praxis patrimonial se aferraba a un modelo: el de la vivienda social en España en la segunda mitad del siglo XX; a un caso concreto: el de la barriada de Nuestra Señora del Carmen (Recasens Méndez-Queipo de Llano, 1958); y a un requisito fundamental: analizar un objeto vivo y en uso, aún con la presencia de quienes lo vivieron y usaron desde su origen

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Procedimiento de extracción de derivados bioinsecticidas de la planta Artemisia Absinthium L.

Procedimiento de extracción de derivados bioinsecticidas de la planta Artemisia absinthium L., caracterizado por unos parámetros agronómicos y económicos de producción orgánica de la planta con un quimiotipo específico con el fin de producir extractos orgánicos consistentes en aceite esencial y extracto no volátil, y en otra fase extractos supercríticos de composición química caracterizada, obtenidos con CO2 a presión como disolvente mayoritario, siendo las principales aplicaciones industriales de los extractos y aceites así extraídos su uso como materia base para formulaciones de insecticidas naturales, de especial aplicación en agricultura ecológica para el control de insectos plaga, especialmente áfidos y lepidópteros, así como su uso como ingrediente para formulaciones mixtas, en combinaciones sinergistas junto con otros componentes activos naturales.Peer reviewedCentro de investigación y Tecnología Agroalimentaria (Aragón), Consejo Superior de Investigaciones Científicas (España), Universidad de ZaragozaA1 Solicitud de patente con informe sobre el estado de la técnic

Programas de diversificación curricular : de la teoría a la práctica

Contiene: t. I. Fundamentación teórica - t. II. Bases para el desarrollo de programas - t. III. Análisis de casos, informes y propuestas - t. IV. Materiales de apoyoGuía legal, teórica y práctica para los centros de educación secundaria dividida en cuatro tomos, cuyo objetivo es el de facilitar el desarrollo de las medidas de atención a la diversidad contempladas en la LOGSE, en sus dimensiones de enseñanza comprensiva y diversificada. El primer tomo analiza los principios del actual sistema educativo a partir de la interpretación de la legislación existente. El tomo II aborda los criterios para diseñar un programa de diversificación curricular, las estrategias de intervención educativa, los criterios de selección de alumnos y sugerencias para el desarrollo curricular. Se analizan los instrumentos de evaluación socio-psicopedagógica para su posterior concreción en el informe de evaluación. Cuatro análisis de casos basados en experiencias de las práctica profesional componen el tomo III que también incluye un ejemplo de programa de diverisificación curricular de dos años propuesto para el Instituto de Educación Secundaria Buero Vallejo de Guadalajara durante el curso 1995-1996. El tomo IV es un conjunto de materiales de apoyo de carácter experimental para los procesos de evaluación sociopsicopedagógica siguiendo el modelo descrito en el tomo II.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5; 28014 Madrid; Tel. +34917748000; [email protected]