Forecasting the BAO Measurements of the CSST galaxy and AGN Spectroscopic Surveys

The spectroscopic survey of the China Space Station Telescope (CSST) is expected to obtain a huge number of slitless spectra, including more than one hundred million galaxy spectra and millions of active galactic nuclei (AGN) spectra. By making use of these spectra, we can measure the Baryon Acoustic Oscillation (BAO) signals over large redshift ranges with excellent precisions. In this work, we predict the CSST measurements of the post-reconstruction galaxy power spectra at 0<z<1.2 and pre-reconstruction AGN power spectra at 0<z<4, and derive the BAO signals at different redshift bins by constraining the BAO scaling parameters using the Markov Chain Monte Carlo method. Our result shows that the CSST spectroscopic survey can provide accurate BAO measurements with precisions higher than 1% and 3% for the galaxy and AGN surveys, respectively. By comparing with current measurements in the same range at low redshifts, this can improve the precisions by a factor of $2\sim3$, and similar precisions can be obtained in the pessimistic case. We also investigate the constraints on the cosmological parameters using the measured BAO data by the CSST, and obtain stringent constraint results for the energy density of dark matter, Hubble constant, and equation of state of dark energy.Comment: 15 pages, 9 figures, 4 table

Cosmological Constraint Precision of the Photometric and Spectroscopic Multi-probe Surveys of China Space Station Telescope (CSST)

As one of Stage IV space-based telescopes, China Space Station Telescope (CSST) can perform photometric and spectroscopic surveys simultaneously to efficiently explore the Universe in extreme precision. In this work, we investigate several powerful CSST cosmological probes, including cosmic shear, galaxy-galaxy lensing, photometric and spectroscopic galaxy clustering, and number counts of galaxy clusters, and study the capability of these probes by forecasting the results of joint constraints on the cosmological parameters. By referring to real observational results, we generate mock data and estimate the measured errors based on CSST observational and instrumental designs. To study the systematical effects on the results, we also consider a number of systematics in CSST photometric and spectroscopic surveys, such as the intrinsic alignment, shear calibration uncertainties, photometric redshift uncertainties, galaxy bias, non-linear effects, instrumental effects, etc. The Fisher matrix method is used to derive the constraint results from individual or joint surveys on the cosmological and systematical parameters. We find that the joint constraints by including all these CSST cosmological probes can significantly improve the results from current observations by one order of magnitude at least, which gives $\Omega_m$ and $\sigma_8$ $<$1% accuracy, and $w_0$ and $w_a$ $<$5% and 20% accuracies, respectively. This indicates that the CSST photometric and spectroscopic multi-probe surveys could provide powerful tools to explore the Universe and greatly improve the studies of relevant cosmological problems.Comment: 17 pages, 12 figures, 3 tables. Accepted for publication in MNRA

An autophagy-related diagnostic biomarker for uterine fibroids: FOS

Uterine fibroids (UFs) are the most common benign gynecologic tumors in reproductive-aged women. The typical diagnostic strategies of UFs are transvaginal ultrasonography and pathological feature, while molecular biomarkers are considered conventional options in the assessment of the origin and development of UFs in recent years. Here, we extracted the differential expression genes (DEGs) and differential DNA methylation genes (DMGs) of UFs from the Gene Expression Omnibus (GEO) database, GSE64763, GSE120854, GSE45188, and GSE45187. 167 DEGs with aberrant DNA methylation were identified, and further Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed by the relevant R package. We next discerned 2 hub genes (FOS, and TNFSF10) with autophagy involvement by overlapping 167 DEGs and 232 autophagic regulators from Human Autophagy Database. FOS was identified as the most crucial gene through the Protein–Protein Interactions (PPI) network with the correlation of the immune scores. Moreover, the down-regulated expression of FOS in UFs tissue at both mRNA and protein levels was validated by RT-qPCR and immunohistochemistry respectively. The area under the ROC curve (AUC) of FOS was 0.856, with a sensitivity of 86.2% and a specificity of 73.9%. Overall, we explored the possible biomarker of UFs undergoing DNA—methylated autophagy and provided clinicians with a comprehensive assessment of UFs

Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder

BackgroundThe hyperarousal process model plays a central role in the physiology of chronic insomnia disorder (CID). Recent evidence has demonstrated that the habenula is involved in the arousal and sleep–wake cycle. However, whether the intrinsic habenular functional network contributes to the underlying mechanism of CID and its relationship to the arousal state in CID remains unclear.MethodsThis single-centered study included 34 patients with subjective CID and 22 matched good sleep control (GSC), and underwent a series of neuropsychological tests and resting-state functional magnetic resonance imaging scans. The habenular functional network was assessed using seed-based functional connectivity (FC) analysis. The subjective arousal state was evaluated with the hyperarousal scale (HAS). Alterations in the habenular FC network and their clinical significance in patients with CID were explored.ResultsCompared with the GSC group, the CID group showed decreased habenular FC in the left caudate nucleus and right inferior parietal lobule and increased FC in the right habenula, bilateral calcarine cortex, and posterior cingulate cortex. The decreased FC between the left habenula and caudate nucleus was associated with an increased arousal state in the CID group.ConclusionThe present results provide evidence for a dysfunctional habenular network in patients with CID. These findings extend our understanding of the neuropathological mechanisms underlying the hyperarousal model in chronic insomnia

miRNA-Based Signature Associated With Tumor Mutational Burden in Colon Adenocarcinoma

Colon adenocarcinoma (COAD) is one of the most common malignant tumors. Tumor mutation burden (TMB) has become an independent biomarker for predicting the response to immune checkpoint inhibitors (ICIs). miRNAs play an important role in cancer-related immune regulation. However, the relationship between miRNA expression and TMB in COAD remains unclear. Therefore, the transcriptome profiling data, clinical data, mutation annotation data, and miRNA expression profiles for cases of COAD were downloaded from the TCGA database. Subsequently, 323 COAD cases were randomly divided into training and test sets. The differential expression of miRNAs in the high and low TMB groups in the training set was obtained as a signature using the least absolute shrinkage and selection operator (LASSO) logistic regression and verified in the test set. Based on the LASSO method, principal component analysis (PCA), and ROC, we found that the signature was credible because it can discriminate between high and low TMB levels. In addition, the correlation between the 18-miRNA-based signature and immune checkpoints was performed, followed by qRT-PCR, to measure the relative expression of 18 miRNAs in COAD patients. The miRNA-based model had a strong positive correlation with TMB and a weak positive correlation with CTLA4 and CD274 (PD-L1). However, no correlation was observed between the model and SNCA (PD-1). Finally, enrichment analysis of the 18 miRNAs was performed to explore their biological functions. The results demonstrated that 18 miRNAs were involved in the process of immunity and cancer pathways. In conclusion, the 18-miRNA-based signature can effectively predict and discriminate between the different TMB levels of COAD and provide a guide for its treatment with ICIs

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

The lipid droplet–associated protein Fsp27 mediates lipid droplet growth by promoting directional lipid transfer from smaller to larger lipid droplets

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Research Progress on Environmental Impact Assessment of Urban Construction Activities

The process of building new construction, reconstruction, and demolition has a very significant environmental impact. As the pillar industry of the national economy, the construction industry has put tremendous pressure on the environment in its production process. This pressure is not only manifested in the consumption of resources and energy, but also in the discharge of pollutants in the three states of solid, liquid and gas. This article aims to sort out the environmental impact assessment methods of construction activities at home and abroad, and sort out the research progress of environmental impact assessment. First, start from the macro background to explain the necessity of systematic analysis and evaluation of the environmental impact in the construction field, and then briefly comb the environmental impact assessment methods in the construction field at home and abroad from the aspects of applied research, advantages and limitations, and finally summarize and look forward to the article. It can provide scholars with a little reference and reference, and promote the further expansion and improvement of environmental impact assessment methods in the construction field

Environmental costing research based on a CiteSpace analysis

Taking Scopus database as data source, CiteSpace was used to construct knowledge map of environmental cost accounting research, and the current research hotspots and future research trends in this field were analyzed. According to the research results, relevant suggestions are put forward to provide reference for the development of environmental cost accounting research