Effect of endometrial polyps, histology, intrauterine localization and the technique of polypectomy On Fertility

KAL

Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model

The aim of this study was to visualize the tumor propagation and surrounding mucosal field in radiography-based 3D model for advanced stage HNSCC and combine it with HPV genotyping and miRNA expression characterization of the visualized area. 25 patients with T1-3 clinical stage HNSCC were enrolled in mapping biopsy sampling. Biopsy samples were evaluated for HPV positivity and miR-21-5p, miR-143, miR-155, miR-221-5p expression in Digital Droplet PCR system. Significant miRNA expression differences of HPV positive tumor tissue biopsies were found for miR-21-5p, miR-143 and miR-221-5p compared to the HPV negative tumor biopsy series. Peritumoral mucosa showed patchy pattern alterations of miR-21-5p and miR-155 in HPV positive cases, while gradual change of miR-21-5p and miR-221-5p was seen in HPV negative tumors. In our study we found differences of the miRNA expression patterns among the HPV positive and negative tumorous tissues as well as the surrounding mucosal fields. The CT based 3D models of the cancer field and surrounding mucosal surface can be utilized to improve proper preoperative planning. Complex evaluation of HNSCC tissue organization field can elucidate the clinical and molecular differentiation of HPV positive and negative cases, and enhance effective organ saving therapeutic strategies

Szülés módja és neonatális eredmények: terminuson túl szinguláris fejvégű magzattal spontán vajúdó, először szülő nők körében

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Large fetal weight alone in Robson-1 parturients doesn't translate into a risk of Caesarean delivery higher then that of a vaginal birth

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Increased Short-Term Beat-to-Beat QT Interval Variability in Patients with Impaired Glucose Tolerance

Prediabetic states and diabetes are important risk factors for cardiovascular morbidity and mortality. Determination of short-term QT interval variability (STVQT) is a non-invasive method for assessment of proarrhythmic risk. The aim of the study was to evaluate the STVQT in patients with impaired glucose tolerance (IGT). 18 IGT patients [age: 63 +/- 11 years, body mass index (BMI): 31 +/- 6 kg/m2, fasting glucose: 6.0 +/- 0.4 mmol/l, 120 min postload glucose: 9.0 +/- 1.0 mmol/l, hemoglobin A1c (HbA1c): 5.9 +/- 0.4%; mean +/- SD] and 18 healthy controls (age: 56 +/- 9 years, BMI: 27 +/- 5 kg/m2, fasting glucose: 5.2 +/- 0.4 mmol/l, 120 min postload glucose: 5.5 +/- 1.3 mmol/l, HbA1c: 5.4 +/- 0.3%) were enrolled into the study. ECGs were recorded, processed, and analyzed off-line. The RR and QT intervals were expressed as the average of 30 consecutive beats, the temporal instability of beat-to-beat repolarization was characterized by calculating STVQT as follows: STVQT = Sigma|QTn + 1 - QTn| (30x radical2)-1. Autonomic function was assessed by means of standard cardiovascular reflex tests. There were no differences between IGT and control groups in QT (411 +/- 43 vs 402 +/- 39 ms) and QTc (431 +/- 25 vs 424 +/- 19 ms) intervals or QT dispersion (44 +/- 13 vs 42 +/- 17 ms). However, STVQT was significantly higher in IGT patients (5.0 +/- 0.7 vs 3.7 +/- 0.7, P < 0.0001). The elevated temporal STVQT in patients with IGT may be an early indicator of increased instability of cardiac repolarization during prediabetic conditions

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Territorial Differences in Hungary's Residential Property Market

Investigations related to residential real estate can still be considered topical issues today. During our research, on the one hand, we drew conclusions based on long-term data series, and on the other hand, with the help of horizontal, territorial investigations, we revealed spatial correlations regarding the events of the past decade. In our article, firstly we reviewed some concepts related to real estate, with special attention to the domestic literature. With the help of long time series data, we examined the relationship between the change in the residential population and the stock of residential real estate. We have revealed connections, or we specified the number of built residential properties and the real income per capita, as well as examined the distribution of apartments according to comfort in the regions of our country. During our research, we also looked at how the concentration of housing transactions between private individuals changed in relation to the Central Hungarian region and the countryside. Using the 2010 and 2020 data, the Moran I index and based on the territorial autocorrelation, we clarified our correlations regarding the number of built residential real estates