IOT based Health Monitoring System

So we propose an innovative system that automated this task with ease. Our system puts forward a smart patient health tracking system that uses Sensors to track patient health and uses internet to inform their loved ones in case of any issues. Our system uses temperature as well as heartbeat sensing to keep track of patient health. The sensors are connected to a microcontroller to track the status which is in turn interfaced to an LCD display as well as wifi connection in order to transmit alerts. If system detects any abrupt changes in patient heartbeat or body temperature. Also system gives graphical representation of Patient’s “ECG". The system automatically alerts the user about the patient’s status over IOT and also shows details of heartbeat and temperature of patient live over the internet

Study of Vibration Behaviour of Stiffened Polymer Composite Shells for Underwater Structural Applications

This paper presents vibration behavior of ring stiffened polymer composite thick shells used for underwater structures. Filament wound shells stiffened with internal and external rings and with hemispherical ends were tested for vibration in air and water in free-free boundary condition using roving hammer and fixed response method. Modal testing of the shells was performed under hydrostatic loading in a custom designed buckling tester for determining natural frequency at higher sea depths. Accelerometer was mounted on the inner surface of the shell. It was excited using a plumbob, rope and pulley arrangement. Experimental results were validated by modal analysis using Hyperworks and ANSYS. Vibration behavior in water was simulated by Fluid structure interaction approach. Experimental first natural frequency in water was lesser than that in air. With increase in hydrostatic pressure, the shell showed moderate variation in natural frequency. The experimental and numerical results of natural frequency and mode shapes were in good agreement with each other. Natural frequencies were lower in long and thick shells

Anticataleptic activity of various extracts of the aerial parts of Achyranthes aspera

Achyranthes aspera is traditionally used in the treatment of cough and bronchitis and therefore it was our objective to study the effect various extracts of the plant on clonidine and haloperidol induced catalepsy to study its antihistaminic effect. Petroleum ether extract (200 mg/kg, i.p.) of the plant significantly inhibited clonidine-induced catalepsy but not inhibited haloperidol-induced catalepsy. This proves the antihistaminic activity of the plant. The extract was standardized by HPTLC in presence of standard β-sitosterol, which proves that the antihistaminic activity may be due to β-sitosterol.Colegio de Farmacéuticos de la Provincia de Buenos Aire

In vitro studies of antistress and antiallergic effects of semecarpus anacardium fruit in asthma

Semicarpus anacardium Linn. (Anacardiaceae) is a deciduous moderate sized tree. The plant is commonly known as Ballataka (Sanskrit), Bhela (Hindi) and marking nut in English. Fruits are acrid and sweet and used traditionally in the treatment of asthma. Allergy and stress are important contributing factors in asthma; hence, our objective was to study the effect of plant extracts on milk-induced leucocytosis (antistress) and milk-induced eosinophilia (antiallergic) as no work is done in this direction and to check a possible antiasthmatic role of the plant. Extracts were given at the dose of 50 and 100 mg/kg, p.o., to mice. Ethyl acetate and ethanol extracts showed significant decrease in leukocytes and eosinophils count. These results confirm the use of S. anacardium fruits as antistress and antiallergic agents in the treatment asthma.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Prevalence of glutathione S-transferase M1 null polymorphism in tobacco users, oral leukoplakia and oral squamous cell carcinoma patients in South Indian population: A polymerase chain reaction study

Context: Tobacco abuse is a well-known risk factor for potentially malignant disorders as well as oral squamous cell carcinoma (SCC). Factors that influence tobacco-exposed individuals developing a malignancy may include a combination of total tobacco exposure and genetic susceptibility. Aim: This study was undertaken to determine the prevalence of the glutathione S-transferase M1 (GSTM1) null polymorphism in oral leukoplakia and oral SCC patients in South Indian population. Settings and Design: This case-control study was conducted in hospital setting on South Indian population. Materials and Methods: Totally, 280 subjects with a history of tobacco use, oral leukoplakia, oral SCC were included in this study. Three milliliter of blood was collected and transported under cold cycle and taken for evaluation of GSTM1 null polymorphism using Multiplex Polymerase Chain Reaction. Results and Discussion: On comparing the prevalence of GSTM1 null polymorphism among the group with subjects with habits and no oral lesions, oral leukoplakia and oral SCC, it was observed that there was a statistically significant association between GSTM1 null polymorphism and the different groups (P < 0.01). Conclusion: The lack of GSTM1 activity would make the oral tissues more susceptible to action of tobacco carcinogens and to the development of a high-grade level of dysplasia in oral leukoplakia and thereby increases the susceptibility of lesion to undergo malignant changes

Ultrasensitive real-time detection of Pb²⁺ ions using g-C₄N₄ nanosheets

The quick and easy monitoring of heavy metals in drinking water is utmost important due to their harmful effects on human health. In this work, a GaN-based high-electron-mobility transistor (HEMT) sensor has been fabricated using optical lithography and explored as a prospective sensor for the determination of trace Pb2+ ions present in the water. Graphitic carbon nitride (g-C3N4) was synthesized by a single-step combustion method. The g-C3N4 nanosheets were used to functionalize the gate area of the fabricated GaN HEMT sensor to investigate the presence of Pb2+ metal ions in water. The g-C3N4 functionalized sensor exhibited a sensitivity of around 0.46A /ppb with 0.32 ppb, as the limit of detection (LoD) is much below the international set standards. Moreover, the real-time measurements on lake water were performed using the developed GaN HEMT sensor to detect the presence of Pb2+ ions in real samples in a fast and ultrasensitive manner. We anticipate that the reported work will certainly serve as a proof-of-concept to develop heavy metal ion sensors.This work was supported by the Abdul Kalam Technology Innovation Fellowship under Grant INAE/121/AKF/46

Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents

Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxyhdeneamino)-3-(2-phenyl)-1,2-dihydroquinazoli n-4(3H)-one (L) were synthesized and characterized The structure of ligand is confirmed by single crystal X-ray diffraction studies The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand (C) 2010 Elsevier Masson SAS All rights reserved