Attitudes and training of research fellows in surgery: national questionnaire survey

We examined the views of research fellows towards research and investigated whether the recommendations of the Calman report on research and surgical training had been adhered to

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events42Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases

自由3 霊長類の喉頭軟骨の関節形態(VI 共同利用研究 2.研究成果)

10.1016/0020-1383(95)93500-HInjury263187-190INJU

The influence of emotion on lexical processing: Insights from RT distributional analysis

10.3758/s13423-013-0525-xPsychonomic Bulletin and Review212526-53

Robust non-line-of-sight localisation system in indoor environment

A robust wireless localisation system that is able to locate a mobile device in a non-line-of-sight indoor environment using only the time of arrival and angle of arrival of multipath signals received at the reference device is presented. By resolving the error variances owing to multipath signals into mutually perpendicular components, and applying weighting factors for each of these components, the location accuracy is greatly improved, especially at large distances and at high levels of angle measurement noise

Lung cancer incidence in Singapore: Ethnic and gender differences

10.1016/j.lungcan.2014.01.007Lung Cancer84123-30LUCA

HOXA9 is a novel myopia risk gene

10.1186/s12886-019-1038-9BMC Ophthalmology19128GUSTO (Growing up towards Healthy Outcomes