Nursing Advising Using a MOOC: A Case Study

Advanced technology has moved online courses from being available to exclusively to elite students to literally being open to the general public. The proliferation of Massive Open Online Courses (MOOCs) has led to expanding public access to a wide range of information including careers in health care fields. Our group developed a MOOC to assist people from around the world who are interested in pursuing a career in nursing get the information they need to be successful in the nursing program and in the profession of nursing. In this article, we describe course content, who the students were who enrolled in the free MOOC, and the course outcomes we developed. In addition, we discuss lessons learned and provide recommendations to assist others seeking to develop a MOOC for career advising

Circadian influences on myocardial infarction

Components of circadian rhythm maintenance, or “clock genes,� are endogenous entrainable oscillations of about 24 h that regulate biological processes and are found in the suprachaismatic nucleus (SCN) and many peripheral tissues, including the heart. They are influenced by external cues, or Zeitgebers, such as light and heat, and can influence such diverse phenomena as cytokine expression immune cells, metabolic activity of cardiac myocytes, and vasodilator regulation by vascular endothelial cells. While it is known that the central master clock in the SCN synchronizes peripheral physiologic rhythms, the mechanisms by which the information is transmitted are complex and may include hormonal, metabolic, and neuronal inputs. Whether circadian patterns are causally related to the observed periodicity of events, or whether they are simply epi-phenomena is not well established, but a few studies suggest that the circadian effects likely are real in their impact on myocardial infarct incidence. Cycle disturbances may be harbingers of predisposition and subsequent response to acute and chronic cardiac injury, and identifying the complex interactions of circadian rhythms and myocardial infarction may provide insights into possible preventative and therapeutic strategies for susceptible populations.ECU Open Access Publishing Support Fun

A continent-wide detailed geological map dataset of Antarctica

Abstract A dataset to describe exposed bedrock and surficial geology of Antarctica has been constructed by the GeoMAP Action Group of the Scientific Committee on Antarctic Research (SCAR) and GNS Science. Our group captured existing geological map data into a geographic information system (GIS), refined its spatial reliability, harmonised classification, and improved representation of glacial sequences and geomorphology, thereby creating a comprehensive and coherent representation of Antarctic geology. A total of 99,080 polygons were unified for depicting geology at 1:250,000 scale, but locally there are some areas with higher spatial resolution. Geological unit definition is based on a mixed chronostratigraphic- and lithostratigraphic-based classification. Description of rock and moraine polygons employs the international Geoscience Markup Language (GeoSciML) data protocols to provide attribute-rich and queryable information, including bibliographic links to 589 source maps and scientific literature. GeoMAP is the first detailed geological map dataset covering all of Antarctica. It depicts ‘known geology’ of rock exposures rather than ‘interpreted’ sub-ice features and is suitable for continent-wide perspectives and cross-discipline interrogation

Notch signaling: its roles and therapeutic potential in hematological malignancies

Notch is a highly conserved signaling system that allows neighboring cells to communicate, thereby controlling their differentiation, proliferation and apoptosis, with the outcome of its activation being highly dependent on signal strength and cell type. As such, there is growing evidence that disturbances in physiological Notch signaling contribute to cancer development and growth through various mechanisms. Notch was first reported to contribute to tumorigenesis in the early 90s, through identification of the involvement of the Notch1 gene in the chromosomal translocation t(7;9)(q34;q34.3), found in a small subset of T-cell acute lymphoblastic leukemia. Since then, Notch mutations and aberrant Notch signaling have been reported in numerous other precursor and mature hematological malignancies, of both myeloid and lymphoid origin, as well as many epithelial tumor types. Of note, Notch has been reported to have both oncogenic and tumor suppressor roles, dependent on the cancer cell type. In this review, we will first give a general description of the Notch signaling pathway, and its physiologic role in hematopoiesis. Next, we will review the role of aberrant Notch signaling in several hematological malignancies. Finally, we will discuss current and potential future therapeutic approaches targeting this pathway

The GeoMAP (v.2022-08) continent-wide detailed geological dataset of Antarctica

A dataset describing exposed bedrock and surficial geology of Antarctica constructed by the GeoMAP Action Group of SCAR (The Scientific Committee on Antarctic Research) and GNS Science, New Zealand. Legacy geological map data have been captured into a geographic information system (GIS), refining its spatial reliability, harmonising classification, then improving representation of glacial sequences and geomorphology. A total 99,080 polygons have been unified for depicting geology at 1:250,000 scale, but locally there are some areas with higher spatial precision. Geological definition in GeoMAP v.2022-08 is founded on a mixed chronostratigraphic- and lithostratigraphic-based classification. Description of rock and moraine polygons employs international GeoSciML data protocols to provide attribute-rich and queriable data; including bibliographic links to 589 source maps and scientific literature. Data are provided under CC-BY License as zipped ArcGIS geodatabase, QGIS geopackage or GoogleEarth kmz files. GeoMAP is the first detailed geological dataset covering all of Antarctica. GeoMAP depicts 'known geology' of rock exposures rather than 'interpreted' sub-ice features and is suitable for continent-wide perspectives and cross-discipline interrogation