Potencial de exportación de crema hidratante facial de aceite de sacha inchi y aloe vera hacia el mercado estadounidense

En el presente plan de negocios titulado “Potencial de exportación de crema hidratante facial de aceite de sacha inchi y aloe vera hacia el mercado estadounidense”, se busca analizar la viabilidad de la exportación de una crema hidratante de aceite de sacha inchi y aloe vera hacia Estados Unidos. Estos insumos han sido elegidos por presentar beneficios que hacen que la piel del rostro luzca más brillante e hidratada. Además, su uso es milenario, ya que nuestros ancestros solían aplicarlos directamente a su piel para sentirla más fresca y tersa. El nombre de la empresa es “KS Beaty SAC”, la cual manejará el producto bajo el nombre de “Qara Beaty SAC”, con el fin de posteriormente aplicar la estrategia de diversificación, en el momento en que la marca haya ganado experiencia y confianza entre los consumidores estadounidenses. Por otro lado, el mercado meta elegido es Nueva York puesto que es el estado que importa mayor cantidad de productos enfocados al cuidado de la piel, ya que poseen un estilo de vida orientada a una cultura saludable y preocupación constante por la calidad de los productos naturales. Por ello, es necesario cumplir con los requisitos dados por la FDA en Estados Unidos para una exportación segura y por DIGEMID (Dirección General de Medicamentos, Insumos y Drogas) en el Perú. Por ende, los proveedores han sido elegidos teniendo en cuenta sus certificaciones de calidad y comercialización en el mercado de destino.This business plan entitled “Export Potential of Facial Moisturizer based of Sacha Inchi and Aloe Vera to the US Market" pretends to analyze whether exporting this moisturizer cream to USA is feasible or not. The authors chose the natural supplies due to its great benefits to the skin such as making it smoother and shiner. Besides, the use of these products is millennial because our ancestors used to apply it directly on their skin. The company's name will be "KS Beauty Care" and will handle the product under the name of "Qara Beaty SAC”. Later, it is planned to apply the diversification strategy after the brand has earned experience and the American customers’ trust. On the other hand, the selected target is New York in behalf of being the state which imported the mayor amount of skin care products thanks to its concern of a healthy life style. Therefore, it is necessary to comply with the requirements of both, the Peruvian regulations of DIGEMID and the American regulations of the FDA. As a result, suppliers have been chosen considering its quality certifications amount others

Potencial de exportación de crema hidratante facial de aceite de sacha inchi y aloe vera hacia el mercado estadounidense

En el presente plan de negocios titulado “Potencial de exportación de crema hidratante facial de aceite de sacha inchi y aloe vera hacia el mercado estadounidense”, se busca analizar la viabilidad de la exportación de una crema hidratante de aceite de sacha inchi y aloe vera hacia Estados Unidos. Estos insumos han sido elegidos por presentar beneficios que hacen que la piel del rostro luzca más brillante e hidratada. Además, su uso es milenario, ya que nuestros ancestros solían aplicarlos directamente a su piel para sentirla más fresca y tersa. El nombre de la empresa es “KS Beaty S. A. C.”, la cual manejará el producto bajo el nombre de “Qara Beaty S. A. C.”, con el fin de posteriormente aplicar la estrategia de diversificación, en el momento en que la marca haya ganado experiencia y confianza entre los consumidores estadounidenses. Por otro lado, el mercado meta elegido es Nueva York puesto que es el estado que importa mayor cantidad de productos enfocados al cuidado de la piel, ya que poseen un estilo de vida orientada a una cultura saludable y preocupación constante por la calidad de los productos naturales. Por ello, es necesario cumplir con los requisitos dados por la FDA en Estados Unidos para una exportación segura y por DIGEMID (Dirección General de Medicamentos, Insumos y Drogas) en el Perú. Por ende, los proveedores han sido elegidos teniendo en cuenta sus certificaciones de calidad y comercialización en el mercado de destino.This business plan entitled “Export potential of facial moisturizer based of Sacha Inchi and Aloe Vera to the US Market" pretends to analyze whether exporting this moisturizer cream to USA is feasible or not. The authors chose the natural supplies due to its great benefits to the skin such as making it smoother and shiner. Besides, the use of these products is millennial because our ancestors used to apply it directly on their skin. The company's name will be "KS Beauty Care" and will handle the product under the name of "Qara Beaty S. A. C.”. Later, it is planned to apply the diversification strategy after the brand has earned experience and the American customers’ trust. On the other hand, the selected target is New York in behalf of being the state which imported the mayor amount of skin care products thanks to its concern of a healthy life style. Therefore, it is necessary to comply with the requirements of both, the Peruvian regulations of DIGEMID and the American regulations of the FDA. As a result, suppliers have been chosen considering its quality certifications amount others.Trabajo de investigaciónCampus Lima Centr

Methodological Strategies That Benefit Students With ADHD

El abordaje de las necesidades educativas especiales (NEE) dentro del aula es un gran desafío para los docentes en la actualidad, ya que al querer generar mayor inclusión dentro de la educación se hace un poco más dificil al momento de escoger estrategias que vayan acorde a cada necedidad específica de los estudiantes; especialmente en los estudiantes que presentan TDAH ya que al ser un trastorno del neurodesarrollo tan extenso, se presenta en una amplia gama de dimensiones que hace que cada niño presente una peculiaridad. En este último tiempo se ha tomado muy a consideración el implementar diferentes estrategias metodológicas para reforzar y motivar el aprendizaje y complementarlo. Por ello, el objetivo principal es analizar y desarrollar estrategias metodológicas efectivas que beneficien a estudiantes con Trastorno por Déficit de Atención e Hiperactividad (TDAH) en su proceso de aprendizaje, promoviendo un entorno educativo inclusivo y facilitando su participación activa en el séptimo de básica de la Unidad Educativa XXX. La metodología utilizada fue de tipo descriptiva y documental. Se aplicó a una muestra no probabilística de diez docentes los cuales respondieron una encuesta para poder medir la aplicación de diferentes estrategias metodológicas dentro del aula en los estudiantes con TDAH y evidenciar si los docentes los utilizan de una manera adecuada e inclusiva. Los resultados obtenidos fueron que las diferentes estrategias metodológicas son herramientas de gran utlidad para reforzar y motivar el aprendizaje de estudiantes con TDAH.Addressing special educational needs (SEN) within the classroom is a great challenge for teachers today, since wanting to generate greater inclusion within education makes it a little more difficult when choosing strategies that are in accordance with each specific need of the students; especially in students who have ADHD since it is such an extensive neurodevelopmental disorder, it occurs in a wide range of dimensions that makes each child present a peculiarity. In recent times, great consideration has been given to implementing different methodological strategies to reinforce and motivate learning and complement it. Therefore, the main objective is to analyze and develop effective methodological strategies that benefit students with Attention Deficit Hyperactivity Disorder (ADHD) in their learning process, promoting an inclusive educational environment and facilitating their active participation in the seventh grade of basic education. Educational Unit XXX. The methodology used was descriptive and documentary. It was applied to a non-probabilistic sample of ten teachers who responded to a survey to measure the application of different methodological strategies within the classroom in students with ADHD and to demonstrate whether teachers use them in an appropriate and inclusive way. The results obtained were that the different methodological strategies are very useful tools to reinforce and motivate the learning of students with ADHD

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Geographic patterns of tree dispersal modes in Amazonia and their ecological correlates

Unidad de excelencia María de Maeztu CEX2019-000940-MAim: To investigate the geographic patterns and ecological correlates in the geographic distribution of the most common tree dispersal modes in Amazonia (endozoochory, synzoochory, anemochory and hydrochory). We examined if the proportional abundance of these dispersal modes could be explained by the availability of dispersal agents (disperser-availability hypothesis) and/or the availability of resources for constructing zoochorous fruits (resource-availability hypothesis). Time period: Tree-inventory plots established between 1934 and 2019. Major taxa studied: Trees with a diameter at breast height (DBH) ≥ 9.55 cm. Location: Amazonia, here defined as the lowland rain forests of the Amazon River basin and the Guiana Shield. Methods: We assigned dispersal modes to a total of 5433 species and morphospecies within 1877 tree-inventory plots across terra-firme, seasonally flooded, and permanently flooded forests. We investigated geographic patterns in the proportional abundance of dispersal modes. We performed an abundance-weighted mean pairwise distance (MPD) test and fit generalized linear models (GLMs) to explain the geographic distribution of dispersal modes. Results: Anemochory was significantly, positively associated with mean annual wind speed, and hydrochory was significantly higher in flooded forests. Dispersal modes did not consistently show significant associations with the availability of resources for constructing zoochorous fruits. A lower dissimilarity in dispersal modes, resulting from a higher dominance of endozoochory, occurred in terra-firme forests (excluding podzols) compared to flooded forests. Main conclusions: The disperser-availability hypothesis was well supported for abiotic dispersal modes (anemochory and hydrochory). The availability of resources for constructing zoochorous fruits seems an unlikely explanation for the distribution of dispersal modes in Amazonia. The association between frugivores and the proportional abundance of zoochory requires further research, as tree recruitment not only depends on dispersal vectors but also on conditions that favour or limit seedling recruitment across forest types

International Society of Human and Animal Mycology (ISHAM)-ITS reference DNA barcoding database - the quality controlled standard tool for routine identification of human and animal pathogenic fungi

Human and animal fungal pathogens are a growing threat worldwide leading to emerging infections and creating new risks for established ones. There is a growing need for a rapid and accurate identification of pathogens to enable early diagnosis and targeted antifungal therapy. Morphological and biochemical identification methods are time-consuming and require trained experts. Alternatively, molecular methods, such as DNA barcoding, a powerful and easy tool for rapid monophasic identification, offer a practical approach for species identification and less demanding in terms of taxonomical expertise. However, its wide-spread use is still limited by a lack of quality-controlled reference databases and the evolving recognition and definition of new fungal species/complexes. An international consortium of medical mycology laboratories was formed aiming to establish a quality controlled ITS database under the umbrella of the ISHAM working group on "DNA barcoding of human and animal pathogenic fungi." A new database, containing 2800 ITS sequences representing 421 fungal species, providing the medical community with a freely accessible tool at http://www.isham.org and http://its.mycologylab.org/ to rapidly and reliably identify most agents of mycoses, was established. The generated sequences included in the new database were used to evaluate the variation and overall utility of the ITS region for the identification of pathogenic fungi at intra-and interspecies level. The average intraspecies variation ranged from 0 to 2.25%. This highlighted selected pathogenic fungal species, such as the dermatophytes and emerging yeast, for which additional molecular methods/genetic markers are required for their reliable identification from clinical and veterinary specimens.This study was supported by an National Health and Medical Research Council of Australia (NH&MRC) grant [#APP1031952] to W Meyer, S Chen, V Robert, and D Ellis; CNPq [350338/2000-0] and FAPERJ [E-26/103.157/2011] grants to RM Zancope-Oliveira; CNPq [308011/2010-4] and FAPESP [2007/08575-1] Fundacao de Amparo Pesquisa do Estado de So Paulo (FAPESP) grants to AL Colombo; PEst-OE/BIA/UI4050/2014 from Fundacao para a Ciencia e Tecnologia (FCT) to C Pais; the Belgian Science Policy Office (Belspo) to BCCM/IHEM; the MEXBOL program of CONACyT-Mexico, [ref. number: 1228961 to ML Taylor and [122481] to C Toriello; the Institut Pasteur and Institut de Veil le Sanitaire to F Dromer and D Garcia-Hermoso; and the grants from the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and the Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG) to CM de Almeida Soares and JA Parente Rocha. I Arthur would like to thank G Cherian, A Higgins and the staff of the Molecular Diagnostics Laboratory, Division of Microbiology and Infectious Diseases, Path West, QEII Medial Centre. Dromer would like to thank for the technical help of the sequencing facility and specifically that of I, Diancourt, A-S Delannoy-Vieillard, J-M Thiberge (Genotyping of Pathogens and Public Health, Institut Pasteur). RM Zancope-Oliveira would like to thank the Genomic/DNA Sequencing Platform at Fundacao Oswaldo Cruz-PDTIS/FIOCRUZ [RPT01A], Brazil for the sequencing. B Robbertse and CL Schoch acknowledge support from the Intramural Research Program of the NIH, National Library of Medicine. T Sorrell's work is funded by the NH&MRC of Australia; she is a Sydney Medical School Foundation Fellow.info:eu-repo/semantics/publishedVersio

Estimating the global conservation status of more than 15,000 Amazonian tree species

Estimates of extinction risk for Amazonian plant and animal species are rare and not often incorporated into land-use policy and conservation planning. We overlay spatial distribution models with historical and projected deforestation to show that at least 36% and up to 57% of all Amazonian tree species are likely to qualify as globally threatened under International Union for Conservation of Nature (IUCN) Red List criteria. If confirmed, these results would increase the number of threatened plant species on Earth by 22%. We show that the trends observed in Amazonia apply to trees throughout the tropics, and we predict thatmost of the world’s >40,000 tropical tree species now qualify as globally threatened. A gap analysis suggests that existing Amazonian protected areas and indigenous territories will protect viable populations of most threatened species if these areas suffer no further degradation, highlighting the key roles that protected areas, indigenous peoples, and improved governance can play in preventing large-scale extinctions in the tropics in this century

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p <1 x 10(-4)) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.Peer reviewe

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity