La implantació del sistema de comunicació PECS en un estudi de cas únic diagnosticat com a TEL

Treball final de Grau en Mestre o Mestra d'Educació Infantil. Codi: MI1040. Curs acadèmic 2016-2017Aquest treball es centra en la intervenció sobre un alumne de quatre anys diagnosticat com a TEL i integrat en una aula ordinària. L’objectiu és millorar la comunicació mitjançant el sistema de comunicació PECS. Per tal de dur a terme aquesta intervenció es van haver de seguir uns passos d’acord amb el manual d’aquest material. A més, hi ha altres objectius específics als quals s’ha de prestar també molta atenció, com per exemple intentar aconseguir que l’alumne augmente el seu vocabulari, millorar la seva comunicació i també treballar per tal que aquest millore l’atenció. Aquest és un treball de cas únic en el qual s’ha utilitzat una metodologia tant qualitativa com quantitativa. La posada en marxa ha tingut una durada d’un total de dos mesos i mig. Finalment s’ha observat mitjançant registres que l’alumne ha ampliat el vocabulari i també han augmentat el nombre de peticions que realitza de forma autònoma.This work focuses on the intervention on a four-year child diagnosed as SLI and integrated into a regular classroom. The aim is to improve communication through the Picture Exchange Communication System (PECS). In order to carry out this procedure it is necessary to follow a few steps in accordance with the manual of this material. In addition, there are other specific aims to which we should pay a lot of attention as well as, for example try to increase the vocabulary, improve the communication and also work for that improves attention. This is a unique case in which quantitative and qualitative methodology have been used. The intervention has had duration of a total of two months and a half. Finally, it has been observed through the registers that the student has expanded the vocabulary and he has increased the number of requests performed autonomously

Conservation of aging and cancer epigenetic signatures across human and mouse

Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. While many of these observations arise from the use of mouse models, there is a lack of systematic comparisons of human and mouse epigenetic patterns in the context of disease. However, such comparisons are significant as they allow to establish the extent to which some of the observed similarities or differences arise from pre-existing species-specific epigenetic traits. Here, we have used reduced representation bisulfite sequencing to profile the brain methylomes of young and old, tumoral and non-tumoral brain samples from human and mouse. We first characterized the baseline epigenomic patterns of the species and subsequently focused on the DNA methylation alterations associated with cancer and aging. Next, we described the functional genomic and epigenomic context associated with the alterations, and finally we integrated our data to study interspecies DNA methylation levels at orthologous CpG sites. Globally, we found considerable differences between the characteristics of DNA methylation alterations in cancer and aging in both species. Moreover, we describe robust evidence for the conservation of the specific cancer and aging epigenomic signatures in human and mouse. Our observations point towards the preservation of the functional consequences of these alterations at multiple levels of genomic regulation. Finally, our analyses reveal a role for the genomic context in explaining disease- and species-specific epigenetic traits.© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution

Tecnologías emergentes

En pos del bienestar general, el desarrollo humano se ve modelado por innovaciones tecnológicas que inciden directa e indirectamente en la forma de vida. Las Tecnologías Emergentes crecen de manera acelerada permitiendo avances en el campo de la comunicación, la medicina, la agricultura, el comercio y la educación; entre tantos otros. En el ámbito educativo particularmente, las Tecnologías Emergentes han generado un nuevo escenario para el desarrollo del proceso de enseñanza-aprendizaje, facilitando posibilidades múltiples y planteando nuevos desafíos en todos los niveles de formación. Actualmente, el espacio de educación formal trasciende el aula, gracias a la existencia de múltiples herramientas disponibles tanto en dispositivos móviles como en computadoras ocasionando la necesidad de repensar la educación. Asimismo, las Tecnologías Emergentes también permiten generar indicadores dinámicos que proporcionan nuevas métricas para el análisis del proceso de aprendizaje y la gestión educativa. El presente artículo sintetiza el plan de trabajo 2021 del ITT-UNNOBA-CIC en relación al desarrollo e impacto de las Tecnologías Emergentes al servicio de la Educación, guardando un especial hincapié en la accesibilidad a entornos virtuales de enseñanza-aprendizaje (EVEA), la inteligencia artificial y la informática en salud.Eje: Tecnología Informática aplicada en Educación.Red de Universidades con Carreras en Informátic

Salidas profesionales y desarrollo de carreras relacionadas con la titulación estudiada

El objetivo de este proyecto es la mejora de la empleabilidad de los alumnos del grado de Comercio. El proyecto consiste en un ciclo de conferencias con directivos que tienen responsabilidades en áreas comerciales de empresas, con el objetivo de que conozcan las posibilidades de trabajo y las competencias y habilidades que se exigen.Depto. de Organización de EmpresasFac. de Ciencias Económicas y EmpresarialesFALSEsubmitte

Informática y tecnologías emergentes

Las tecnologías emergentes son innovaciones en desarrollo que como su nombre lo dice en un futuro cambiarán la forma de vivir del ser humano brindándole mayor facilidad a la hora de realizar sus actividades. Estas tecnologías innegablemente están modelando nuestra sociedad, nuestras costumbres, la forma de relacionarnos y comunicarnos, la forma en la que las empresas producen, la forma en la que se educa. Hemos pasado de un modelo de sociedad industrial a un modelo de producción del conocimiento donde las demandas de las tanto de las empresas como de la sociedad, han cambiado. Incluso el modo de interactuar con esta tecnología está cambiando. Hoy en día esa interacción es mucho más dinámica dando al usuario un rol activo, convirtiendo al mismo usuario en parte de la tecnología. El proyecto descripto en este documento tiene como propósito identificar, contextualizar, evaluar, desarrollar y aplicar diversas herramientas informáticas en tecnologías emergentes, las cuales tendrán un impacto en forma directa en áreas tales como: telecomunicaciones, salud, seguridad, gobierno, educación, industria, entre otras. El trabajo se cimentará en cuatro ejes fundamentales: tecnologías exponenciales (IT), tratamiento masivo de datos (big data), tecnología en educación (e-tecnología), y robótica e interacción hombre-máquina (HCI).Eje: Innovación en Sistemas de Software.Red de Universidades con Carreras en Informática (RedUNCI

Post-Franco Theatre

In the multiple realms and layers that comprise the contemporary Spanish theatrical landscape, “crisis” would seem to be the word that most often lingers in the air, as though it were a common mantra, ready to roll off the tongue of so many theatre professionals with such enormous ease, and even enthusiasm, that one is prompted to wonder whether it might indeed be a miracle that the contemporary technological revolution – coupled with perpetual quandaries concerning public and private funding for the arts – had not by now brought an end to the evolution of the oldest of live arts, or, at the very least, an end to drama as we know it

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

TFG 2012/2013

Amb aquesta publicació, EINA, Centre universitari de Disseny i Art adscrit a la Universitat Autònoma de Barcelona, dóna a conèixer el recull dels Treballs de Fi de Grau presentats durant el curs 2012-2013. Voldríem que un recull com aquest donés una idea més precisa de la tasca que es realitza a EINA per tal de formar nous dissenyadors amb capacitat de respondre professionalment i intel·lectualment a les necessitats i exigències de la nostra societat. El treball formatiu s’orienta a oferir resultats que responguin tant a paràmetres de rigor acadèmic i capacitat d’anàlisi del context com a l’experimentació i la creació de nous llenguatges, tot fomentant el potencial innovador del disseny.Con esta publicación, EINA, Centro universitario de diseño y arte adscrito a la Universidad Autónoma de Barcelona, da a conocer la recopilación de los Trabajos de Fin de Grado presentados durante el curso 2012-2013. Querríamos que una recopilación como ésta diera una idea más precisa del trabajo que se realiza en EINA para formar nuevos diseñadores con capacidad de responder profesional e intelectualmente a las necesidades y exigencias de nuestra sociedad. El trabajo formativo se orienta a ofrecer resultados que respondan tanto a parámetros de rigor académico y capacidad de análisis, como a la experimentación y la creación de nuevos lenguajes, al tiempo que se fomenta el potencial innovador del diseño.With this publication, EINA, University School of Design and Art, ascribed to the Autonomous University of Barcelona, brings to the public eye the Final Degree Projects presented during the 2012-2013 academic year. Our hope is that this volume might offer a more precise idea of the task performed by EINA in training new designers, able to speak both professionally and intellectually to the needs and demands of our society. The educational task is oriented towards results that might respond to the parameters of academic rigour and the capacity for contextual analysis, as well as to considerations of experimentation and the creation of new languages, all the while reinforcing design’s innovative potential

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p &lt; 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

RNA-Binding Proteins as Targets to Improve Salt Stress Tolerance in Crops

© 2020 by the authors.Salt stress drastically reduce crop productivity. In order to identify genes that could improve crop salt tolerance, we randomly expressed a cDNA library of the halotolerant sugar beet in a sodium-sensitive yeast strain. We identified six sugar beet genes coding for RNA binding proteins (RBP) able to increase the yeast Na+-tolerance. Two of these genes, named Beta vulgaris Salt Tolerant 3 (BvSATO3) and BvU2AF35b, participate in RNA splicing. The other four BvSATO genes (BvSATO1, BvSATO2, BvSATO4 and BvSATO6) are putatively involved in other processes of RNA metabolism. BvU2AF35b improved the growth of a wild type yeast strain under salt stress, and also in mutant backgrounds with impaired splicing, thus confirming that splicing is a target of salt toxicity. To validate the yeast approach, we characterized BvSATO1 in sugar beet and Arabidopsis. BvSATO1 expression was repressed by salt treatment in sugar beet, suggesting that this gene could be a target of salt toxicity. Expression of BvSATO1 in Arabidopsis increased the plant salt tolerance. Our results suggest that not only RNA splicing, but RNA metabolic processes such as such as RNA stability or nonsense-mediated mRNA decay may also be affected by salt stress and could be biotechnological targets for crop improvement.This research was funded by the Spanish Government and the European Union (grant number FEDER/BFU2015-64204R to R.R., and BFU2016-77728-C3-3-P to P.A.), by the ERI BIOTECMED (ISIC/2013/004) and by the Valencian Government (APOSTD 2017/118).Peer reviewe