Daily risk of adverse outcomes in patients undergoing complex lesions revascularization: a subgroup analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life)

Introduction: Percutaneous coronary intervention (PCI) for complex lesions, including unprotected left main (ULM) and bifurcations, is gaining a relevant role in treating coronary artery disease with good outcomes, also thanks to new generation stents. The daily risk of adverse cardiovascular events and their temporal distribution after these procedures is not known.Methods: All consecutive patients presenting with a critical lesion of ULM or bifurcation treated with very thin struts stents, enrolled in the RAIN-Cardiogroup VII study, were analyzed. The daily risk of major acute cardiovascular events (MACE), target lesion revascularization (TLR) and stent thrombosis (ST) and their temporal distribution in the first year of follow-up was the primary endpoint. Differences among subgroups (ULM, patient presentation, kind of stent polymer) were the secondary endpoint.Results: 2745 patients were included, mean age 68 ± 11 years, 33.3% diabetics, 54.5% had an acute coronary syndrome (ACS); 88.5% of treated lesions were bifurcations, 27.2% ULM. Average daily risk was 0.022% for MACE, 0.005% for TLR and 0.004% for ST, in the first year. Bimodal distribution of adverse events, especially TLR, with an early peak in the first 50 days and a late one after 150 days, was observed. Patients with ULM presented a significantly higher daily risk of events, and ACS patients presented higher MACE risk. No difference emerged according to the type of stent polymer.Conclusions: The daily risk of adverse events in the first year after complex PCI in our study is acceptably low. PCI on ULM carries a higher risk of complications

Comparing Notes: Recording and Criticism

This chapter charts the ways in which recording has changed the nature of music criticism. It both provides an overview of the history of recording and music criticism, from the advent of Edison’s Phonograph to the present day, and examines the issues arising from this new technology and the consequent transformation of critical thought and practice

Wider Still and Wider: British Music Criticism since the Second World War

This chapter provides the first historical examination of music criticism in Britain since the Second World War. In the process, it also challenges the simplistic prevailing view of this being a period of decline from a golden age in music criticism

AC Losses Measurement of the DISCORAP Model Dipole Magnet for the SIS 300 Synchrotron at FAIR

Considerable attention has been paid in the last years to the development of fast-cycled superconducting magnets for future accelerators, leading to the design and construction by INFN and GSI of a 3.8-m-long prototype of a 4.5 T, 1 T/s, dipole magnet, for the SIS300 synchrotron of the FAIR facility (Darmstadt, Germany). This ramp-rate is 20-100 times higher than the one used in other superconducting synchrotrons like RHIC or LHC. Being operated at rather large dI/dt, these magnets are subjected to a wide spectrum of ac dissipation, taking place in the superconductor as well as in the metallic components of the mechanical structure, requiring the development of specialized superconducting cables and a careful consideration of the other aspects of the structural design. Between July and September 2012, the dipole magnet prototype has been subjected to a test at LASA laboratory (INFN Milan, Italy), during which it was successfully operated at current ramp rates as high as 0.7 T/s (the power supply limit). In this paper, we describe the V-I apparatus used to assess the dissipations within the magnet during the ac regime, the measurement results, and their comparison with the values expected from the design and on the basis of superconducting cable qualification results

Una metodologia per la formulazione di scenari di danno a scala comunale: applicazione pilota su 24 centri urbani della Valdaso (Marche)

Il Progetto Valdaso, promosso dalla Regione Marche, dalle Province di Ascoli Piceno e Fermo, e coordinato sul piano scientifico dal Dipartimento della Protezione Civile, è volto alla valutazione del rischio sismico di 24 Comuni della Valdaso. L‟obiettivo ultimo è la valutazione sul territorio comunale degli effetti prodotti su edifici e popolazione (in termini di edifici inagibili, crolli, vittime e senzatetto), conseguenti ad un sisma di data severità. La metodologia prevede la valutazione della pericolosità e della vulnerabilità sismica di ciascun centro urbano, partendo dai dati disponibili o da limitate integrazioni degli stessi, ottenute con rilievi in loco e anche con il supporto degli Uffici Tecnici Comunali. Il risultato di tali elaborazioni è sintetizzato in mappe di ciascun insediamento in cui sono evidenziate le zone a pericolosità e vulnerabilità omogenee, le quali, una volta sovrapposte, individuano le zone caratterizzate dall‟omogeneità di pericolosità e vulnerabilità e quindi di danno omogeneo. Il vantaggio di tale procedura consta nel fatto che gli scenari, formulati con maggior aderenza alle problematiche del territorio e del costruito locali, sono differenziati per le varie zone del centro urbano in cui questo viene preliminarmente suddiviso e pertanto possono rivelarsi un importante strumento di supporto alla pianificazione, con particolare riferimento a quella di emergenza. L'articolo descrive la metodologia adottata facendo riferimento ad alcuni centri urbani particolarmente significativi nell‟ambito del campione studiato

Construction and Cold Test of the Superferric Octupole for the LHC Luminosity Upgrade

INFN is developing the prototypes of five corrector magnets, from skew quadrupole to dodecapole, which will equip the high-luminosity interaction regions of the high luminosity-LHC (HL-LHC) at LASA lab (Milano, Italy). These magnets are based on a superferric design, which allows a relatively simple, modular, and easy to construct magnet. This activity takes place within the framework of a collaboration agreement between CERN and INFN. The first prototype, a sextupole, has been tested in 2016. We present here the results of the cold tests of the octupole, including the training performed at 4.2 K and the qualification at 2.17 K, that has been assembled and tested in 2017. We report also on the overall experience gained during constructions and tests and the improvements toward the series production. Other important results concern inductance measurements and quench studies

Status of the Activity for the Construction of the HL-LHC Superconducting High Order Corrector Magnets at LASA-Milan

INFN is developing at LASA Laboratory (Milano, Italy) the prototypes of five corrector magnets, from skew quadrupole to dodecapole, which will equip the high-luminosity interaction regions (IRs) of the High Luminosity-LHC (HL-LHC). These magnets are based on a superferric design, to allow a relatively simple, modular, and easy to construct magnet. This program takes place within the framework of a collaboration agreement between CERN and INFN. In this paper, we present an overview of the activity, from the design, to the construction and test at the operation condition