Efficient compensation handling via subjective updates

Programming abstractions for compensation handling and dynamic update are crucial in specifying reliable interacting systems, such as Collective Adaptive Systems (CAS). Compensations and updates both specify how a system reacts in response to exceptional events. Prior work showed that different semantics for compensation handling can be encoded into a calculus of adaptable processes with objective updates, in which a process is reconfigured by its context. This paper goes further by considering subjective updates, in which, intuitively, a process reconfigures itself. A calculus of adaptable processes with subjective update its introduced, and its expressivity is assessed by encoding two semantics for compensation handling. The resulting encodings are more efficient than those using objective updates: they require less computational steps

Causal consistency for reversible multiparty protocols

In programming models with a reversible semantics, computational steps can be undone. This paper addresses the integration of reversible semantics into process languages for communication-centric systems equipped with behavioral types. In prior work, we introduced a monitors-as-memories approach to seamlessly integrate reversible semantics into a process model in which concurrency is governed by session types (a class of behavioral types), covering binary (two-party) protocols with synchronous communication. The applicability and expressiveness of the binary setting, however, is limited. Here we extend our approach, and use it to define reversible semantics for an expressive process model that accounts for multiparty (n-party) protocols, asynchronous communication, decoupled rollbacks, and abstraction passing. As main result, we prove that our reversible semantics for multiparty protocols is causally-consistent. A key technical ingredient in our developments is an alternative reversible semantics with atomic rollbacks, which is conceptually simple and is shown to characterize decoupled rollbacks

Session coalgebras: A coalgebraic view on session types and communication protocols

Compositional methods are central to the development and verification of software systems. They allow breaking down large systems into smaller components, while enabling reasoning about the behaviour of the composed system. For concurrent and communicating systems, compositional techniques based on behavioural type systems have received much attention. By abstracting communication protocols as types, these type systems can statically check that programs interact with channels according to a certain protocol, whether the intended messages are exchanged in a certain order. In this paper, we put on our coalgebraic spectacles to investigate session types, a widely studied class of behavioural type systems. We provide a syntax-free description of session-based concurrency as states of coalgebras. As a result, we rediscover type equivalence, duality, and subtyping rela

On primitives for compensation handling as adaptable processes

Mechanisms for compensation handling and dynamic update are increasingly relevant in the specification of reliable communicating systems. Compensations and updates are intuitively similar: both specify how the behavior of a concurrent system changes at runtime in response to an exceptional event. However, calculi for concurrency with compensations and updates are technically quite different. We compare calculi for concurrency with compensation handling and dynamic update from the standpoint of their relative expressiveness. We develop two encodings of a process calculus with compensation handling into a calculus of adaptable processes. These encodings differ in the target language considered: the first considers adaptable processes with subjective updates in which, intuitively, a process reconfigures itself; the second considers objective updates in which a process is reconfigured by a process in its context. Our main discovery is that subjective updates are more efficient than objective ones in encoding primitives

Minimal session types for the €-calculus

Session types enable the static verification of message-passing programs. A session type specifies a channel's protocol as sequences of messages. Prior work established a minimality result: every process typable with standard session types can be compiled down to a process typable using minimal session types: session types without the sequencing construct. This result justifies session types in terms of themselves; it holds for a higher-order session €-calculus, where values are abstractions (functions from names to processes). This paper establishes a new minimality result but now for the session €-calculus, the language in which values are names and for which session types have been more widely studied. Remarkably, this new minimality result can be obtained by composing known results. We develop optimizations of our new minimality result, and establish its static and dynamic correctness

Session-based concurrency, declaratively

Session-based concurrency is a type-based approach to the analysis of message-passing programs. These programs may be specified in an operational or declarative style: the former defines how interactions are properly structured; the latter defines governing conditions for correct interaction

Ruxolitinib in refractory acute and chronic graft-versus-host disease : a multicenter survey study

Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. First-line treatment is based on the use of high doses of corticosteroids. Unfortunately, second-line treatment for both acute and chronic graft-versus-host disease, remains a challenge. Ruxolitinib has been shown as an effective and safe treatment option for these patients. Seventy-nine patients received ruxolitinib and were evaluated in this retrospective and multicenter study. Twenty-three patients received ruxolitinib for refractory acute graft-versus-host disease after a median of 3 (range 1-5) previous lines of therapy. Overall response rate was 69.5% (16/23) which was obtained after a median of 2 weeks of treatment, and 21.7% (5/23) reached complete remission. Fifty-six patients were evaluated for refractory chronic graft-versus-host disease. The median number of previous lines of therapy was 3 (range 1-10). Overall response rate was 57.1% (32/56) with 3.5% (2/56) obtaining complete remission after a median of 4 weeks. Tapering of corticosteroids was possible in both acute (17/23, 73%) and chronic graft-versus-host disease (32/56, 57.1%) groups. Overall survival was 47% (CI: 23-67%) at 6 months for patients with aGVHD (62 vs 28% in responders vs non-responders) and 81% (CI: 63-89%) at 1 year for patients with cGVHD (83 vs 76% in responders vs non-responders). Ruxolitinib in the real life setting is an effective and safe treatment option for GVHD, with an ORR of 69.5% and 57.1% for refractory acute and chronic graft-versus-host disease, respectively, in heavily pretreated patients

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

Search for H→γγ produced in association with top quarks and constraints on the Yukawa coupling between the top quark and the Higgs boson using data taken at 7 TeV and 8 TeV with the ATLAS detector

A search is performed for Higgs bosons produced in association with top quarks using the diphoton decay mode of the Higgs boson. Selection requirements are optimized separately for leptonic and fully hadronic final states from the top quark decays. The dataset used corresponds to an integrated luminosity of 4.5 fb−14.5 fb−1 of proton–proton collisions at a center-of-mass energy of 7 TeV and 20.3 fb−1 at 8 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. No significant excess over the background prediction is observed and upper limits are set on the tt¯H production cross section. The observed exclusion upper limit at 95% confidence level is 6.7 times the predicted Standard Model cross section value. In addition, limits are set on the strength of the Yukawa coupling between the top quark and the Higgs boson, taking into account the dependence of the tt¯H and tH cross sections as well as the H→γγ branching fraction on the Yukawa coupling. Lower and upper limits at 95% confidence level are set at −1.3 and +8.0 times the Yukawa coupling strength in the Standard Model