66 research outputs found
A live vaccine against Neospora caninum abortions in cattle
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
CommentaryMichael P. Reichel, Dadín P. Moore, Andrew Hemphill, Luis M. Ortega-Mora, J.P. Dubey, John T. Elli
Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep
- Author
- Publication venue
- Publication date
- 01/01/2016
- Field of study
43 p.After oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii
isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a
further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions
happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in
natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies
have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and
pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the
present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in
the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some
foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen
was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the
placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase
abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence
of the isolate may play a role in their developmentS
Dog filariosis in the Lazio region (Central Italy): first report on the presence of Dirofilaria repens
- Author
- A Mantovani
- A Marconcini
- C Chauve
- C Genchi
- C Genchi
- C Genchi
- C Himonas
- CA Rawlings
- D Piergili Fioretti
- Francesco Scholl
- G Cancrini
- G Cancrini
- G Cancrini
- G Cringoli
- G Favia
- G Petruschke
- G Poglayen
- Gabriella Cancrini
- H Bucklar
- I Kanev
- J Euzeby
- J Lucientes
- JD Thompson
- JM Doby
- L Rossi
- LM Ortega-Mora
- M Pietrobelli
- Marcello Sala
- Michele Di Paolo
- O Barriga
- Paola Scaramozzino
- S Pampiglione
- Simona Gabrielli
- X Xie
- Publication venue
- BioMed Central
- Publication date
- 01/01/2005
- Field of study
BACKGROUND: Epidemiological investigations were carried out in the Lazio Region to assess the status of canine filariosis and to evaluate the actual risk for veterinary and medical public health. METHODS: Since August 2001 to June 2003, a total of 972 canine blood samples, collected in public kennels and from private owners animals of the 5 Provinces of the Region, were tested. The presence of filarial parasites was evaluated by microscopy and bio-molecular techniques; the species identification was performed by means of the same diagnostic tools. RESULTS: A total of 17/972 (1.75%; 95%CI 1.06%–2.85%) blood samples were parasitized by D. repens,13 out them drawn by dogs resident in the Province of Roma, and 4 in the other provinces. Multivariate analysis was performed in order to evaluate the association between filariosis and risk factors. The origin from coastal territories seems to be a significant risk factor to acquire the infection. CONCLUSION: This is the first report of canine filariosis in the Lazio Region, where D. repens was before reported only in foxes. The risk of human zoonotic infection is stressed, and the absence of other filarial species is discusse
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Aleppo M
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso J
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
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- Anders CF
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- Wiedenmann W
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- Wilkens HG
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- Willocq S
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- Wilson MG
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- Winkelmann S
- Winklmeier F
- Wittgen M
- Wolter MW
- Wolters H
- Wooden G
- Wosiek BK
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- Woudstra MJ
- Wraight K
- Wright C
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- Wulf E
- Wunstorf R
- Wynne BM
- Xaplanteris L
- Xella S
- Xie S
- Xie Y
- Xu C
- Xu D
- Xu G
- Yabsley B
- Yagci KD
- Yamada M
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang S
- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao W-M
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Young C
- Youssef S
- Yu D
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zdrazil M
- Zeitnitz C
- Zeller M
- Zema PF
- Zemla A
- Zendler C
- Zenin AV
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Seropositivity rates for agents of canine vector-borne diseases in Spain : a multicentre study
- Author
- A Portillo
- A Sainz
- A Sainz
- A Sainz
- A Sainz
- AL Garcia-Perez
- Ana Montoya
- Angel Sainz
- B Menn
- B Oporto
- B Skotarczak
- C Ballart
- C Ballart
- CE Atkins
- CE Greene
- CG Couto
- D Bowman
- D Molyneux
- D Otranto
- D Otranto
- D Otranto
- D Otranto
- D Otranto
- D Otranto
- D Rodes
- D Stanneck
- DD Bowman
- DJ Rogers
- E Zaffaroni
- F Beugnet
- F Morillas
- F Simón
- F Simón
- F Simón
- FJ Merino
- FT Liang
- G Baneth
- G Baneth
- G Baneth
- G Miró
- G Miró
- G Miró
- Guadalupe Miró
- H Jin
- H Sprong
- I Amusategui
- I Amusategui
- I Amusátegui
- J Alvar
- J Guerrero
- J Martín-Sánchez
- J Rojo Vázquez
- JA Montoya
- JA Montoya-Alonso
- JA Oteo
- JC García
- JC McClure
- JC Semenza
- JF Barandika
- JM González
- JM Medlock
- JW McCall
- KE Hovius
- L Cardoso
- L Solano-Gallego
- L Solano-Gallego
- L Solano-Gallego
- LM Ortega-Mora
- M Aguado
- MC Pou Barreto
- MD Tabar
- MJ Ciudad
- MJ Day
- N Sosa
- R Chandrashekar
- R Fisa
- R Gálvez
- R Gálvez
- R Killick-Kendrick
- R Molina
- R Molina
- R Morchón
- R Morchón
- Rosa Gálvez
- RW Stich
- S Delgado
- S Mañas
- S Speck
- SE Randolph
- TG Jaenson
- V Foglia Manzillo
- WL Nicholson
- Xavier Roura
- Z Fishman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Background: Controlling canine vector-borne diseases (CVBD) is a major concern, since some of these diseases are serious zoonoses. This study was designed to determine seropositivity rates in Spain for agents causing the following five CVBD: leishmaniosis (Leishmania infantum: Li), heartworm (Dirofilaria immitis: Di), ehrlichiosis (Ehrlichia canis: Ec), anaplasmosis (Anaplasma phagocytophilum/Anaplasma platys: An) and Lyme disease (Borrelia burgdorferi: Bb). Methods: Anti-An, -Bb, and -Ec antibodies and the Di antigen were determined using the 4DX SNAP® Test (IDEXX Laboratories) and anti-L. infantum (Li) antibodies using the Leishmania SNAP® Test (IDEXX Laboratories) in blood and/or serum samples. Results: Among 1100 dogs examined, overall seropositivity rates were: Li (15.7%), Ec (5%), An (3.1%), Di (1.25%) and Bb (0.4%). While seropositivity towards Bb and Di was similar in all geographic regions, rates were significantly higher in the east of Spain (8.3%) for An, significantly higher in the north (20%) for Ec, and significantly higher in the Southeast (46.6%) and South (27.4%), and significantly lower in the north (0%) for Li. No statistical associations were observed between sex and the CVBD analyzed (p ≥ 0.05) while the following associations with other variables were detected: a higher seropositivity to Ec (40%) and Bb (6.7%) in dogs under one year of age compared with adults (p < 0.05); and a higher seropositivity to An and Li in dogs that lived outdoors versus indoors (p = 0.01; p < 0.001, respectively). Seropositivity rates of 2.1%, 0%, 1.7%, 0.5% and 4.2% were recorded respectively for An, Bb, Ec, Di and Li in dogs with no clinical signs (n = 556) versus 3.8%, 0.6%, 7.5%, 1.8% and 25.9% for those with signs (n = 507) suggestive of a CVBD. Conclusion: The data obtained indicate a risk for dogs in Spain of acquiring any of the five CVBD examined. Veterinarians in the different regions should include these diseases in their differential diagnoses and recommend the use of repellents and other prophylactic measures to prevent disease transmission by arthropod vectors. Public health authorities also need to become more involved in the problem, since some of the CVBD examined here also affect humans
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
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- ENVIN-HELICS Study Group
- Erb J
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- FINNRESUSCI Study Group
- Fischer G
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Hung WT
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- Ignacio ML
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- Imanaka H
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- Ince C
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
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- Jensen JU
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Juliarena A
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- Kolnikova I
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- Kumari BK
- Kumbamu A
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- Kwon WY
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- Kyle UG
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- Lortat-Jacob B
- Lotay R
- Loudet CI
- Louf-Durier A
- Louf-Durier A
- Louis B
- Lourido CM
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- Lozano JA
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- Lucinio NM
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- Lukaszewicz AC
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- López AR
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- MacKay A
- MacKay A
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- Mackey G
- MacPhee I
- Macrì M
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- Maekawa K
- Maekawa K
- Maekawa K
- Maekawa K
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- Maghsoudi B
- Magnanimi E
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- Maistry N
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- Manca T
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- Mancebo J
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- Marcos-Zambrano LJ
- Mariani M
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- Marin-Mateos H
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- Martín-Loeches I
- Martín-Loeches I
- Martínez F
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- Martínez MP
- Martínez MV
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- Martínez-Carmona JF
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- Mejías CR
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- Melo N
- Mendes A
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- Mendonca AV
- Mendsaikhan N
- Menendez R
- Mengelle C
- Mercat A
- Mercat A
- Mercat A
- Mergulhão PJ
- Merino-Vega D
- Messenger D
- Mezidi M
- Mezidi M
- Michel L
- Midwinter MJ
- Mignot T
- Miguelena PR
- Mihara Y
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- Okamoto H
- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Ostermann M
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- Rodríguez FG
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- Romero I
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- Su L
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- Tabei SH
- Taccone F
- Taccone FS
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- Tapponnier R
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- Temprano-Gómez I
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- van Putten MJ
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- WIND study group
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- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
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- Yonis H
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- Yoon SZ
- Yoruk F
- Yoshida K
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- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
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- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Cancer Biomarker Discovery: The Entropic Hallmark
- Author
- A Alcaraz
- A Arabzadeh
- A Bagri
- A Balbin
- A Bantis
- A Ben-Naim
- A Bolander
- A Buhmeida
- A Burykin
- A Chetcuti
- A de Baey
- A Efeyan
- A Eroglu
- A Fabarius
- A Forget
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- A Geirsson
- A Geirsson
- A Geirsson
- A Guffanti
- A Hugel
- A Inoue
- A Isidoro
- A Jang
- A Kollara
- A Kuzmanov
- A Lundqvist
- A Maria McCrohan
- A Marreiros
- A Mendes
- A Mitra
- A Nassar
- A Petitjean
- A Petitjean
- A Pinzon-Charry
- A Richmond
- A Roesch
- A Santinelli
- A Schmidt
- A Shapiro
- A Sreekumar
- A Takeno
- A Urbanucci
- A Winter
- A Yemelyanov
- AA Babiker
- AA Babiker
- AA Tarhini
- AC Dudley
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- AD Ortega
- AG Puebla-Mora
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- AJ Liu
- AK Meeker
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- B Cinar
- B Gao
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- B Wu
- B Wu
- BD Dimitrov
- BF Gilmore
- BF Goncalves
- BF Skinnider
- BK Zehentner
- BL Adamsen
- BL de Groot
- BR Johnson
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- BS Strauss
- C Adami
- C Bastide
- C Cao
- C Cybulski
- C Haqq
- C Hayashi
- C Hornig
- C Ivorra
- C Kumar-Sinha
- C Langner
- C Magi-Galluzzi
- C Magi-Galluzzi
- C Muller-Tidow
- C Nessler-Menardi
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- C Xu
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- CG Pham
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- E Beitz
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- E Kikuchi
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- G Benga
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- G Kaic
- G Kristiansen
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- G Sardana
- G Stirling
- G Tscheudschilsuren
- G Untergasser
- G Venkataraman
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- GF Azzone
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- H Chang-zheng
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- JT Bishoff
- JT Chang
- JW Denham
- K Armstrong
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- K Ishibashi
- K Ishitani
- K Kami
- K Kasuno
- K Kumagai
- K Mizutani
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- K Ruan
- K Ruan
- K Shilo
- K Sircar
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- K Tani
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- KA Tasken
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- KP Porkka
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- L Capparuccia
- L Carlsson
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- LA Diaz-Martinez
- LB Mora
- LE Clarke
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- LF Brown
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- LM Godsel
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- M Aalamian-Matheis
- M Aghaei
- M Bakhanashvili
- M Boury-Jamot
- M Boury-Jamot
- M Buxade
- M Chellaiah
- M Cimitan
- M Craig
- M Dumas
- M Dundr
- M Esteller
- M Estler
- M Fabbri
- M Fukunaga-Kalabis
- M Fukunaga-Kalabis
- M Furuno
- M Gilbert
- M Hara-Chikuma
- M Hara-Chikuma
- M Hara-Chikuma
- M Hara-Chikuma
- M Hatzfeld
- M Hatzfeld
- M Heenen
- M Ismail
- M Karaivanov
- M Kashani-Sabet
- M Kato
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- M Moghaddami
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- N Bahamontes-Rosa
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- O Bettendorf
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- P Agre
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- P Berthon
- P Boukamp
- P Cossu-Rocca
- P Dhawan
- P Dhawan
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- P Duesberg
- P Duesberg
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- PT Went
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- PW Kuchel
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- Q Lu
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- R Agarwal
- R Berretta
- R Birnie
- R Bordoni
- R Casalini
- R Das
- R Dobson
- R Halaban
- R Horuk
- R Klimek
- R Klimek
- R Kuefer
- R Lin
- R Mazzucchelli
- R Mukherjee
- R Radosavljevic
- R Rai
- R Sougrat
- RA Craven
- RA Hegele
- RA Sturm
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- RC Lee
- RD Ballal
- RD Loberg
- RD Loberg
- RD Loberg
- RD Loberg
- Regina Berretta
- RG Uzzo
- RJ Jin
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- RMH Lopez-Ruiz
- RP Ciavarra
- RP Ciavarra
- RP Singh
- RS Weinstein
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- RW DeVere White
- S Ashida
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- S Jhavar
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- S Kyle
- S Landreville
- S Makovets
- S Morohashi
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- S Philip
- S Philip
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- S Rankin
- S Rankin
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- S Sur
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- S Takahashi
- S Tancharoen
- S Verdier-Sevrain
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- T Dalmay
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- T Yu
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- V Molinie
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- V Molinie
- V Molinie
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- V Samanna
- V Wessagowit
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- VD Acevedo
- VK Vanguri
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- W Chen
- W Cosme-Blanco
- W Gade
- W Ritchie
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- W Wang
- W Weichert
- W Weichert
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- WD Dunsmuir
- WE Naugler
- William C. S. Cho
- WK Kaufmann
- WK Lee
- X Chen
- X Cheng
- X Dong
- X Dong
- X Huang
- X Li
- X Liu
- X Liu
- X Meng
- X Ouyang
- X Tang
- X Wu
- X Zhang
- XJ Yang
- XQ Wang
- Y Bu
- Y Cai
- Y Deng
- Y Ito
- Y Katagiri
- Y Kozuka
- Y Lai
- Y Liu
- Y Lu
- Y Lu
- Y Ohyama
- Y Shav-Tal
- Y Sugiyama
- Y Sun
- Y Wang
- Y Wang
- Y Wu
- Y Yamamoto
- Y Yang
- Y Zhou
- YB Lim
- YC Chao
- YJ Ko
- YL Liu
- YN Liu
- YT Sasaki
- YT Sasaki
- YU Katagiri
- Z Jiang
- Z Jiang
- Z Jiang
- Z Jiang
- Z Jiang
- Z Rudzki
- ZA Dotan
- ZR Yurkovetsky
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
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- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
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- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
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- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
- Author
- Abantanga FA
- Abatli SJ
- Abbas W
- Abbo O
- Abd Elmenam M
- Abd Razak RB
- Abdelbaqi R
- Abdelhady DS
- Abdelhafez MOM
- Abdelhamid SS
- Abdelmaksoud S
- Abdelmoumen R
- Abdelmutalib F
- Abdul-Mumin A
- Abduljawad FM
- Abdullah F
- Abdulraheem N
- Abdulrahman A
- Abdulsalam MA
- Abdunomonovich DA
- Abib SDCV
- Aboelela A
- Abouheba M
- Abrahamsson K
- Abu Ajwa AE
- Abu Al-saleem HSH
- Abu Alamrain AA
- Abu Bakar AH
- Abu Farha MS
- Abu Jamie N
- Abu Jamie YMK
- Abu Jayyab M
- Abu Mayaleh A
- Abu Shiha E
- Abu Za'nouneh FJ
- Abu-Nejmah F
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- Ba'baa' B
- Badr H
- Baertschiger R
- Bagbio D
- Bah A
- Bai Q
- Bai YZ
- Baistrocchi V
- Baker W
- Ballah AM
- Ballouhey Q
- Balousha AG
- Bamanga A
- Baniowda MAM
- Bao X
- Barauskas V
- Barbosa PR
- Barcelos FZ
- Baron JDJC
- Barreto JJS
- Barros BS
- Baseggio N
- Bashir F
- Bashir MK
- Bataineh ZA
- Batal MM
- Bazozi HM
- Beasley S
- Becker K
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- Beltran NS
- Ben Enbaya M
- Benaskeur Y-I
- Benavente CM
- Beres A
- Berkova K
- Bernaus M
- Berzanskis M
- Beshtawi DMS
- Besir A
- Bianchin E
- Bibas F
- Biber E
- bin Abdullah MY
- Bin Amjad M
- bin Bujarimin AS
- bin Hassan MR
- Bin Othman MY
- bin Zahari Z
- bin Zarwawi AZ
- Bischoff C
- Blain OE
- Blanc T
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- Blom MD
- Bode C
- Bonnard A
- Boonthai A
- Borbonet D
- Borges CG
- Bouhadiba N
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- Bragagnini P
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- Broch A
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- Bruxel CL
- Bsisu I
- Bucaram E
- Burgos CM
- Burks SS
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- Caamal LJ
- Cai D
- Calancea C
- Calderon LO
- Calistus N
- Calle CS
- Cama J
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- Camp L
- Canozer A
- Caouette-Laberge L
- Carbajal LF
- Carloni ICS
- Carrasco AL
- Carrasco-Ortega C
- Carrillo I
- Casado FT
- Caseb P
- Casquero V
- Castaneda FDMD
- Castillo MN
- Cavaiuolo S
- Cekic B
- Celik M
- Centen SV
- Cepeda R
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- Chipalavela RF
- Chipana CLA
- Chiriboga E
- Chiroque CM
- Chitiavi SW
- Chitnis M
- Cho SH
- Choo CSC
- Chukwu I
- Chukwuemeka AL-J
- Chung JH
- Cino EL
- Cletus C
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- Contreras CS
- Coon J
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- Correa C
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- Cosoreanu V
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- Cripovich A
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- Cunningham A
- Cury EK
- Czauderna P
- da Cunha AG
- da Silva EAD
- da Silva JAN
- da Silva KI
- Dagilyte R
- Daher AP
- Dahman NBH
- Dalek NFRA
- Dallegre MB
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- de Almeida TL
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- de Holanda FC
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- de Oliveira DF
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- Delforge X
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- Dieudonne L
- Dimatatac DM
- Djordjevic I
- do Nascimento SD
- Dogar S
- Doheim MF
- Dominguez D
- Dominguez MA
- dos Santos CS
- dos Santos MSF
- Dosselman LJ
- Douiri A
- Drah W
- Dube AM
- Duchesne C
- Duggan E
- Dure C
- Ebeido A
- Echegaray MD
- Egbuchulem IK
- Ejinkeonye EC
- Ekenze SO
- Ekwunife OH
- El Tallaa MA
- El-Ghazaly M
- Elassall GMH
- Elayeb A
- Elebute OA
- Elewaily M
- Elfiky M
- Elgammudi M
- Elghazaly SM
- Elhadi A
- Elhadi M
- Elhajjaji YA
- Elhattab A
- Elias RA
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- Elzohiri M
- Elzowawi F
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- Emil S
- Ensar N
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- Espineda B
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- Essa TM
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- Gee O
- Gerus S
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- Ghaly KAE
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- Ghazzawi I
- Ghorab IA
- Ghosh D
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- Giovanoni LS
- Goddard L
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- Gohil H
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- Guinsburg R
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- Gutierrez NT
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- Hasan S
- Hasan S
- Hasanain DK
- Hashim HHB
- Hashim I
- Hashim S
- Hassan MA
- Hassan MYM
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- Hery G
- Hinojosa AS
- Hinostroza D
- Hisham I
- Hodgman E
- Honhar M
- Horacio B
- Horozic D
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- Hussain SR
- Hussein OG
- Hussien M
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- Ibrahim EAA
- Ibrahim F
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- Ibukunolu O
- Igoche M
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- Imamoglu M
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- Iriondo M
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- Jester I
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- Joharifard S
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- Jonuzi A
- Jooma U
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- Juhasz L
- Julio L
- Junes MDC
- Juricic M
- Jusabani M
- Jyun KWY
- Kader S
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- Kamel TM
- Kamilovski M
- Kannessan H
- Kano Y
- Kapihya C
- Karabulut R
- Karakus SC
- Karamustafic A
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- Karim S
- Karim S
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- Kayed YIO
- Kayibanda E
- Kchiche N
- Kcomt SG
- Kelay A
- Keles E
- Keshtgar A
- Khaled A
- Khalel WIA
- Khalid HM
- Khamag O
- Khatatba LZA
- Khattak MAK
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- Kihiko D
- Kim H-Y
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- Koszutski T
- Kowalewsk G
- Krause H
- Krayem Y
- Krisanova D
- Krishnaswami S
- Kufeji D
- Kukkady A
- Kumar V
- Kumolalo FO
- Kunfah SMP
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- Kurt G
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- Lapouble F
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- Lawalbarau A
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- Laymouna MA
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- Leal PO
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- Lechmiannandan A
- Lee JY
- Lee S
- Leech M
- Leite MTC
- Leles KDDP
- Leon CD
- Leon JLA
- Leon NRM
- Lerma S
- Letic E
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- Levitt M
- Leyba MF
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- Liang L
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- Liubsys A
- Liukitithara S
- Liyenzero PO
- Ljuhar D
- Lobos P
- Lodhia J
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- Losty P
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- Lubbad W
- Lucio P
- Lui Y
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- Luo W
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- Lv Z
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- Machado ABS
- Machemedze S
- Madieh J
- Madziba S
- Magro NMH
- Mahmoud AM
- Mahmud K
- Mahmud R
- Mairami AB
- Maistry N
- Makepeace LM
- Makhmud A
- Malaga FPD
- Malcius D
- Maldonado JEG
- Malik J
- Malik S
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- Manjira E
- Manni F
- Mansfield S
- Mansour I
- Mansour MA
- Manteola ER
- Marcos D
- Marianella D
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- Marta O
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- Martinez-Leo B
- Martins BMR
- Matias MA
- Matos JPV
- Matour BM
- Mazzuca RB
- Mbonicura JC
- Mbonisweni A
- Mccluney S
- Medard P
- Meftah A
- Mellado DH
- Meloche-Dumas L
- Mena A
- Mendizabal DB
- Menin FA
- Mercado P
- Mert MK
- Mesic A
- Meyer KF
- Michael V
- Middlesworth W
- Middleton T
- Mieres C
- Mikneviciute A
- Milisic E
- Millan C
- Miranda CT
- Miriam A
- Mironescu A
- Mirza MB
- Misk RA
- Mitul A
- Mitul AR
- Modekwe V
- Modi V
- Mohammad MA
- Mohammed A
- Mohammed AA
- Mohammed HM
- Mohammed KA
- Mohammed MM
- Mohammed OAA
- Moitt N
- Molina M
- Molinelli M
- Monawar AB
- Montoya D
- Moore AC
- Mora M
- Moraes M
- Morales A
- Morales LB
- Morales O
- Morejon VJ
- Moreno ME
- Mori FT
- Moriya E
- Morjan M
- Mose M
- Motee J
- Motter SB
- Motter SB
- Mounira BNEI
- Mouti MB
- Mouttalib S
- Mshelbwala PM
- Msuya D
- Mugambi S
- Mugo R
- Muhic A
- Mulu J
- Mumtaz U
- Munoz G
- Muntean L
- Murad AMI
- Muradi T
- Muragijimana JDD
- Muraveji Q
- Murillo IVE
- Murshidi RM
- Murtadi HM
- Murzaie MY
- Muslimovich AM
- Mussein HM
- Mustufa H
- Mutlu M
- Mvukiyehe JP
- Mwai T
- Nageh M
- Nah SA
- Naidoo R
- Naim NABM
- Naim SRR
- Naranjo K
- Nassar I
- Nataraja RM
- Naumeri F
- Naunova VC
- Ndata A
- Ndayishimiye I
- Ndungu J
- Negash S
- Negida A
- Negrete A
- Nemer AA
- Nemer R
- Neyra MSL
- Nezerwa YC
- Ngerncham M
- Ngwenya S
- Nisar MU
- Niyukuri A
- Nkuliza D
- Nkunzimana E
- Nofal AH
- Noor WR
- Nor MTM
- Nour I
- Nour IR
- Nour IR
- Novotny N
- Nuntasunti W
- Nwangwu EI
- Nwankwo EP
- Nwosu DC
- O'Connor J
- O'Connor Z
- Obeso AS
- Obianyo NE
- Ochieng K
- Ochieng R
- Odi AA-NB
- Ogundoyin O
- Ojeda AG
- Olabisi OO
- Olanrewaju M
- Olayade K
- Olori S
- Olulana DI
- Omari RY
- Omling E
- Ortiz RS
- Osagie O
- Osazuwa M
- Oshiba AM
- Osman M
- Osowicka M
- Osuigwe AN
- Osuoji RI
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- Oviedo JJM
- Owiwi Y
- Owusu S
- Owusu-Sekyere F
- Oyebanji L
- Oyinloye A
- Ozcelik Z
- Ozen MA
- Pachl M
- Padilla CP
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- Palacios N
- Palomino AG
- Pandit GS
- Papa A
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- Pardo LM
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- Paredes VS
- Parigi GB
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- Parmentier B
- Pasaoglu M
- Pasierbek M
- Pasqua N
- Patel A
- Patkowski D
- Patzer L
- Pauzi SFM
- Peraza JL
- Perez JO
- Perez MO
- Perez RD
- Pernik MN
- Pesara LMH
- Petel MR
- Peycelon M
- Phannua R
- Philipo GS
- Piche N
- Picon CMDJT
- Pigeolet M
- Pilkington M
- Pinar B
- Piotrowska A
- Planka L
- Poenaru D
- Poocharoen W
- Popovic N
- Porras JD
- Portilla EF
- Pos L
- Prabhu PS
- Prat J
- Puentes MC
- Puglia P
- Puig MG
- Puligandla P
- Putruele D
- Qabaja MM
- Qadomi AB
- Qawwash A
- Qi TTH
- Qudah HA
- Quevedo LMB
- Quinteros EFD
- Quiroz NH
- Qunaibi MAF
- Qureshi T
- Qutishat H
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- Raboe E
- Rackova T
- Radwan AS
- Raffaele A
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- Raymond KJ
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- Rehman WU
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- Rex D
- Reyes GY
- Rhodes H
- Ribas B
- Riboni C
- Rieth A
- Rincon LC
- Rissmann A
- Risteski T
- Rite S
- Rivarola NI
- Rivera AC
- Rivera JRCC
- Roberts CA
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- Rojas N
- Rolle U
- Romano PG
- Rosa BR
- Rosas FA
- Roszkiewicz A
- Ruan W
- Rudolfson N
- Ruzgar N
- Rygl M
- Saad AM
- Saad MM
- Sabbatini S
- Sabic A
- Sabti S
- Sadagurschi M
- Sadek K
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- Safa N
- Safus A
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- Sahuanay VRC
- Salah M
- Salawu MM
- Salazar K
- Saldana L
- Saleem A
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- Saleh A
- Saleh M
- Salem HK
- Salha AAS
- Salim JM
- Salinas V
- Salo M
- Samad L
- Samadi AZ
- Samarah YA
- Samarakkody U
- Sambo YT
- Samy D
- San Miguel DO
- Sanchez A
- Sanchez B
- Sanchez CIA
- Sanchez J
- Sanchez JS
- Sanchez N
- Saousen B
- Sara N
- Saracevic A
- Sarhan OAK
- Sarihan H
- Sarkaz TL
- Sayeed F
- Sbaih MF
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- Scherl H
- Schmedding A
- Schopf LF
- Sehic A
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- Shehu I
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- Sherzad A
- Shikha A
- Shinondo P
- Shnishah AE
- Shokri HA
- Shonubi A
- Shoubaki A
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- Sidler D
- Sigalet D
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- Silva E
- Silva J
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- Sim M
- Simeon T
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- Singer G
- Singh M
- Sivaraj J
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- Siyotula T
- Skvaril J
- Slavkovi A
- Slavkovic M
- Smith ER
- Sobrero H
- Soccorso G
- Sokolovic E
- Sola J
- Solanki M
- Soldan CP
- Soliman NA
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- Song ES
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- Soomro A
- Sotelo LO
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- Soula E
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- St-Louis E
- St-Vil D
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- Stichhauer R
- Stojanovic M
- Stringer M
- Strumila A
- Sueiras I
- Suleiman F
- Sultana S
- Sundeep PT
- Suradi HH
- Sutcliffe J
- Suzen A
- Svensson E
- Svirsky A
- Swessi H
- Syed S
- Syovata F
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- Tababa O
- Tabari AK
- Tabiri S
- Tadesse A
- Tahyneh AAA
- Takrouney MH
- Talat N
- Tamada H
- Tamaddun HFB
- Tang W
- Tanimola AG
- Tanming P
- Tanny ST
- Tantush SA
- Tarabishi AS
- Tarek A
- Tarmohamed M
- Tarniba SA
- Tarrado X
- Tasker D
- Tauffer MG
- Teague W
- Telles L
- Temilade BB
- Teo R
- Teran A
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- Testoni D
- Thaiwatcharamas K
- Thiessen J
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- Thomas G
- Thomas MC
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- Till H
- Tillig B
- Tobor S
- Toczewski K
- Tom A
- Toplicic D
- Toral E
- Torres-Canchala L
- Toselli L
- Touabti S
- Toufik IA
- Trainba S
- Trein CS
- Trojanova B
- Trypens A
- Tumi M
- Turkyilmaz C
- Turkyilmaz Z
- Tuyishime E
- Ubhi H
- Ugwu JO
- Ugwunne CA
- Ulasi I
- Ullrich S
- Unchon GL
- Urquizo MML
- Vacek J
- Vaitkiene A
- Valencia S
- Valeria P
- Valerio-Vazquez R
- Valladares PS
- Vanis N
- Vaquila J
- Varela MF
- Vargas OP
- Vatta F
- Vazquez MEM
- vd Merwe E
- Velana J
- Velasco JJCR
- Vellusamy VMM
- Venant N
- Venkatraman SS
- Verdeata R
- Verduga L
- Vergara C
- Verkauskas G
- Veronica S
- Vervoort D
- Vianney BJM
- Vida L
- Vidal CRZ
- Vierboom L
- Villalba AV
- Vinskaite A
- von Bismarck S
- von Delft D
- Vosoughi A
- Wafa T
- Walker G
- Wang D
- Wang J
- Wang J
- Wang P
- Waseem B
- Weeratunga N
- Weiszewsk A
- Wen G
- Wester T
- Wijekoon N
- Wilke A
- Williams I
- Williams O
- Williams R
- Wilson MDF
- Win WSP
- Wishah BDM
- Wishah N
- Wissanji H
- Wolak P
- Wolny A
- Wong J
- Wong M
- Wright NJ
- Wu G
- Wyrzykowski D
- Xie H
- Yacoub MA
- Yaghi B
- Yaghi DH
- Yalcinkaya A
- Yang H-B
- Yanis AH
- Yao Y
- Yapo B
- Yeniay AO
- Yola MM
- Yong F
- Youn JK
- Yousuf H
- Yu M
- Yu R
- Yuen QS
- Yuldashev RZ
- Yunus A
- Zaghlol LY
- Zain M
- Zaman ASK
- Zanellato JB
- Zea-Salazar LE
- Zeinelabdeen A
- Zelada JA
- Zhao X
- Zhu J
- Zhu L
- Zidan M
- Zivanovic D
- Zreeg DAS
- Zurikat RO
- Zvizdic N
- Zvizdic Z
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 24/07/2021
- Field of study
Background: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. // Methods: We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. // Findings: We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. // Interpretation: Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
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- Agostinis P
- Agrewala JN
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- Aguilar PV
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- Aizawa S
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- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
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