146 research outputs found
The overlapping burden of the three leading causes of disability and death in sub-Saharan African children
- Author
- Abolhassani H
- Abosetugn AE
- Abu Gharbieh E
- Adekanmbi V
- Adetokunboh OO
- Aghaali M
- Aji B
- Al Aly Z
- Al Mekhlafi HM
- Alahdab F
- Alhassan RK
- Ali S
- Alizade H
- Aljunid SM
- Almasi Hashiani A
- Altirkawi KA
- Alvis Guzman N
- Amare AT
- Amini S
- Amugsi DA
- Ancuceanu R
- Andrei CL
- Ansari F
- Anvari D
- Appiah SCY
- Arabloo J
- Aremu O
- Atout MMW
- Ausloos F
- Ausloos M
- Ayanore MA
- Aynalem YA
- Azene ZN
- Badawi A
- Baig AA
- Banach M
- Baumann MM
- Bedi N
- Bhagavathula AS
- Bhandari D
- Bhardwaj N
- Bhardwaj P
- Bhatt S
- Bhattacharyya K
- Bhutta ZA
- Bijani A
- Birhanu TTM
- Bitew ZW
- Blacker BF
- Boloor A
- Brady OJ
- Butt ZA
- Car J
- Carvalho F
- Casey DC
- Chattu VK
- Chowdhury MAK
- Chu D
- Coelho CH
- Cook AJ
- Damiani G
- Daoud F
- Darwish AH
- Daryani A
- Das JK
- Davis Weaver N
- Deribe K
- Desalew A
- Deshpande A
- Dharmaratne SD
- Dianatinasab M
- Diaz D
- Djalalinia S
- Dorostkar F
- Dubljanin E
- Duko B
- Dwyer Lindgren L
- Earl L
- Effiong A
- El Sayed Zaki M
- El Tantawi M
- Enany S
- Fattahi N
- Feigin VL
- Fernandes E
- Ferrara P
- Fischer F
- Foigt NA
- Folayan MO
- Foroutan M
- Frostad JJ
- Fukumoto T
- Gaidhane AM
- Gebrekrstos HGGK
- Gebremeskel L
- Gebreslassie AA
- Gela JD
- Gething PW
- Gezae KE
- Ghadiri K
- Ghashghaee A
- Golechha M
- Gubari MIM
- Hadgu FB
- Hamidi S
- Handiso DW
- Hashi A
- Hassan S
- Hay SI
- Hayat K
- Herteliu C
- Ho HC
- Holla R
- Hosseinzadeh M
- Househ M
- Hussain R
- Hwang B
- Ibitoye SE
- Il Shin J
- Ilesanmi OS
- Ilic IM
- Ilic MD
- Irvani SSN
- Jaafari J
- Javaheri T
- Jha RP
- Johnson KB
- Jonas JB
- Jozwiak JJ
- Kabir A
- Kalhor R
- Kanchan T
- Karch A
- Kayode GA
- Keiyoro PN
- Khader YS
- Khalil IA
- Khan G
- Khan M
- Khan MN
- Khatab K
- Khater MM
- Khatib MN
- Kianipour N
- Kim YJ
- Kimokoti RW
- Kisa A
- Kisa S
- Kissoon N
- Kochhar S
- Koolivand A
- Kopec JA
- Koyanagi A
- Krishan K
- Kumar P
- Kurmi OP
- Kusuma D
- La Vecchia C
- Lal DK
- Lami FH
- Landires I
- Lansingh VC
- Lasrado S
- Lazzar Atwood A
- Lee PH
- LeGrand KE
- Lewycka S
- Li B
- Lim SS
- Lindstedt PA
- Liu X
- Longbottom J
- Lopez AD
- Magdy Abd El Razek H
- Mahasha PW
- Maleki A
- Mamun AA
- Mansournia MA
- Marczak LB
- Martins Melo FR
- Mayala BK
- Meharie BG
- Melese A
- Mendoza W
- Menezes RG
- Mengesha EW
- Mensah GA
- Meretoja TJ
- Mestrovic T
- Miller Petrie MK
- Miller TR
- Mirrakhimov EM
- Moazen B
- Mohammad Gholi Mezerji N
- Mohammadi S
- Mohammed S
- Mokdad AH
- Moradi M
- Moradzadeh R
- Moraga P
- Mosser JF
- Murray CJL
- Naderi M
- Nagarajan AJ
- Nazari J
- Ndejjo R
- Negoi I
- Ngunjiri JW
- Nguyen HLT
- Nguyen QP
- Nnaji CA
- Noubiap JJ
- Nuñez Samudio V
- Olagunju AT
- Olusanya BO
- Olusanya JO
- Omer MO
- Onwujekwe OE
- Otstavnov N
- Otstavnov SS
- Owolabi MO
- P A M
- Padubidri JR
- Pana A
- Peprah EK
- Pham HQ
- Pigott DM
- Pirestani M
- Postma MJ
- Pottoo FH
- Pourjafar H
- Quazi Syed Z
- Rahim F
- Rahimi Movaghar V
- Rahman MHU
- Rao PC
- Rao SJ
- Rathi P
- Rawaf DL
- Rawaf S
- Rawal L
- Rawassizadeh R
- Regassa LD
- Reiner RC
- Renzaho AMN
- Rezaei N
- Rezai MS
- Ribeiro AI
- Rickard J
- Rios González CM
- Rumisha SF
- Sabour S
- Sajadi SM
- Salomon JA
- Samadi Kafil H
- Samy AM
- Sanabria J
- Sartorius B
- Saxena D
- Schaeffer LE
- Senthilkumaran S
- Sha F
- Shaheen AA
- Shaikh MA
- Sharma R
- Sheikh A
- Shibuya K
- Shigematsu M
- Simonetti B
- Singh JA
- Smith DL
- Soheili A
- Sokhan A
- Spurlock EE
- Sreeramareddy CT
- Sufiyan MB
- Swartz SJ
- Tadesse DB
- Tamiru AT
- Tefera YG
- Temsah M
- Tessema ZT
- Titova MV
- Tran BX
- Troeger CE
- Truong PN
- Unnikrishnan B
- Upadhyay E
- Vasankari TJ
- Vasseghian Y
- Violante FS
- Vu GT
- Waheed Y
- Wamai RG
- Wassie EG
- Weiss DJ
- Welay FT
- Welgan CA
- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wiysonge CS
- Wondmeneh TG
- Yamada T
- Yaya S
- Yeshitila YG
- Yip P
- Yonemoto N
- Yu C
- Yuce D
- Yusefzadeh H
- Zaidi Z
- Zamanian M
- Zangeneh A
- Zhang Y
- Zhang Z
- Ziapour A
- Publication venue
- Nature Research
- Publication date
- 01/01/2022
- Field of study
Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival. © 2022, The Author(s).Funding text 1: This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation. ; Funding text 2: This study was funded by the Bill & Melinda Gates Foundation. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The non-consortium authors have no competing interests . Competing interests for consortium authors is as follows: Robert Ancuceanu reports receiving consultancy or speaker feeds from UCB, Sandoz, Abbvie, Zentiva, Teva, Laropharm, CEGEDIM, Angelini, Biessen Pharma, Hofigal, AstraZeneca, and Stada. Jacek Jerzy Jozwiak reports personal fees from Amgen, ALAB Laboratories, Teva, Synexus, Boehringer Ingelheim, and Zentiva, all outside the submitted work. Kewal Krishan reports non-financial support from UGC Centre of Advanced Study, CAS II, Department of Anthropology, Panjab University, Chandigarh, India, outside the submitted work. Walter Mendoza is a Program Analyst in Population and Development at the United Nations Population Fund-UNFPA Country Office in Peru, which does not necessarily endorse or support these findings. Maarten J Postma reports grants and personal fees from MSD, GSK, Pfizer, Boehringer Ingelheim, Novavax, BMS, Seqirus, Astra Zeneca, Sanofi, IQVIA, grants from Bayer, BioMerieux, WHO, EU, FIND, Antilope, DIKTI, LPDP, Budi, personal fees from Novartis, Quintiles, Pharmerit, owning stock options in Health-Ecore and PAG Ltd, and being advisor to Asc Academics, all outside the submitted work. Jasviner A Singh reports personal fees from Crealta/Horizon, Medisys, Fidia, UBM LLC, Trio health, Medscape, WebMD, Clinical Care options, Clearview healthcare partners, Putnam associates, Focus forward, Navigant consulting, Spherix, Practice Point communications, the National Institutes of Health, the American College of Rheumatology, and Simply Speaking, owning stock options in Amarin, Viking, Moderna, Vaxart pharmaceuticals and Charlotte’s Web Holdings, being a member of FDA Arthritis Advisory Committee, the steering committee of OMERACT, an international organization that develops measures for clinical trials and receives arm’s length funding from 12 pharmaceutical companies, and the Veterans Affairs Rheumatology Field Advisory Committee, and acting as Editor and Director of the UAB Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis, all outside the submitted work. Era Upadhyay has a patent A system and method of reusable filters for anti-pollution mask pending, and a patent A system and method for electricity generation through crop stubble by using microbial fuel cells pending
Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000–2018
- Author
- Abady GG
- Abd-Allah F
- Abdelalim A
- Abebo ZH
- Abejie AN
- Abosetugn AE
- Abreu LG
- Abrigo MRM
- Abu-Gharbieh E
- Abushouk AI
- Adamu AL
- Adedeji IA
- Adegbosin AE
- Adekanmbi V
- Adetokunboh OO
- Agudelo-Botero M
- Aji B
- Akinyemi OO
- Alamneh AA
- Alanezi FM
- Alanzi TM
- Albright J
- Alcalde-Rabanal JE
- Alemu BW
- Alhassan RK
- Ali BA
- Ali S
- Alinia C
- Alipour V
- Amit AML
- Amugsi DA
- Anbesu EW
- Ancuceanu R
- Anjomshoa M
- Ansari F
- Antonio CAT
- Anvari D
- Arabloo J
- Arora A
- Artanti KD
- Asemahagn MA
- Asmare WN
- Atout MMW
- Ausloos M
- Awoke N
- Ayanore MA
- Aynalem YA
- Ayza MA
- Azene ZN
- Badiye AD
- Baig AA
- Bakkannavar SM
- Banach M
- Banik PC
- Basaleem H
- Bayati M
- Baye BA
- Bedi N
- Belay SA
- Bhagavathula AS
- Bhandari D
- Bhardwaj N
- Bhardwaj P
- Bhattacharjee NV
- Bhutta ZA
- Bijani A
- Birhan TA
- Birihane BM
- Bitew ZW
- Bohlouli S
- Bohluli M
- Bojia HA
- Boloor A
- Brady OJ
- Bragazzi NL
- Brunoni AR
- Budhathoki SS
- Butt ZA
- Bärnighausen TW
- Castaldelli-Maia JM
- Castro F
- Cernigliaro A
- Charan J
- Chatterjee P
- Chatterjee S
- Chattu VK
- Chaturvedi S
- Chowdhury MAK
- Chu D-T
- Collison ML
- Cook AJ
- Cork MA
- Couto RAS
- Cárdenas R
- Dagnew B
- Dai H
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Darshan BB
- Darwesh AM
- Darwish AH
- Daryani A
- Das JK
- Davis AC
- de Hidru, HD
- Denova-Gutiérrez E
- Deribe K
- Desalew A
- Deshpande A
- Dessie A
- Deuba K
- Dharmaratne SD
- Dhimal M
- Dhungana GP
- Diaz D
- Didarloo A
- Dipeolu IO
- Doan LP
- Donkers KM
- Duko B
- Duraes AR
- Dwyer-Lindgren L
- Dávila-Cervantes CA
- Earl L
- El-Jaafary SI
- Elema TB
- Elhabashy HR
- Faris PS
- Faro A
- Farzadfar F
- Feigin VL
- Feleke BE
- Ferede TY
- Fischer F
- Foigt NA
- Folayan MO
- Franklin RC
- Gad MM
- Gaidhane S
- Gardner WM
- Geberemariyam BS
- Gebregiorgis BG
- Gebremedhin KB
- Gebremichael B
- Ghaffarpasand F
- Gilani SA
- Ginindza TG
- Glagn M
- Golechha M
- Gonfa KB
- Goulart BNG
- Gudi N
- Guido D
- Guled RA
- Guo Y
- Gupta RD
- Hamidi S
- Handiso DW
- Hasaballah AI
- Hassan A
- Hay SI
- Hay SI
- Hayat K
- Hegazy MI
- Heidari B
- Henry NJ
- Herteliu C
- Ho HC
- Hoang CL
- Holla R
- Hon J
- Hosseini M
- Hosseinzadeh M
- Househ M
- Hsairi M
- Hu G
- Huda TM
- Hwang B-F
- Ibitoye SE
- Ilesanmi OS
- Ilic IM
- Ilic MD
- Inbaraj LR
- Iqbal U
- Irvani SSN
- Islam MM
- Iwu CCD
- Iwu CJ
- Jain A
- Janodia MD
- Javaheri T
- John-Akinola YO
- Johnson KB
- Joukar F
- Jozwiak JJ
- Jr
- Kabir A
- Kalankesh LR
- Kalhor R
- Kamath A
- Kamyari N
- Kanchan OT
- Kapoor N
- Karimi SE
- Karyani AK
- Kasaye HK
- Kassahun G
- Kassebaum NJ
- Kayode GA
- Keiyoro PN
- Kelkay B
- Khalid N
- Khan MN
- Khaneghah AM
- Khatab K
- Khater AM
- Khater MM
- Khatib MN
- Kim YJ
- Kimokoti RW
- Kinyoki DK
- Kisa A
- Kisa S
- Kosen S
- Krishan K
- Kulkarni V
- Kumar GA
- Kumar M
- Kumar N
- Kumar P
- Kurmi OP
- Kusuma D
- Lad SD
- Lami FH
- Landires I
- Lansingh VC
- Lasrado S
- Lazzar-Atwood A
- Lee PH
- LeGrand KE
- Letourneau ID
- Lewycka S
- Li B
- Li M-C
- Li S
- Liu X
- Local Burden of Disease Exclusive Breastfeeding Collaborators
- Lodha R
- Lopez JCF
- Louie C
- Lu D
- Machado DB
- Mahesh PA
- Maled V
- Maleki S
- Malta DC
- Mamun AA
- Manafi N
- Mansournia MA
- Mapoma CC
- Marczak LB
- Martins-Melo FR
- Matin BK
- Mehndiratta MM
- Mejia-Rodriguez F
- Mekonnen TC
- Mendoza W
- Menezes RG
- Mengesha EW
- Mersha AM
- Miller TR
- Mini GK
- Mirrakhimov EM
- Misra S
- Moghadaszadeh M
- Mohammad DK
- Mohammadian-Hafshejani A
- Mohammed JA
- Mohammed S
- Mokdad AH
- Montero-Zamora PA
- Moradi M
- Moradzadeh R
- Moraga P
- Mosser JF
- Mousavi SM
- Munro SB
- Muriithi MK
- Mustafa G
- Muthupandian S
- Nagaraja SB
- Nagarajan AJ
- Naik G
- Naimzada MD
- Nangia V
- Nascimento BR
- Nayak VC
- Ndejjo R
- Ndwandwe DE
- Negoi I
- Nguefack-Tsague G
- Ngunjiri JW
- Nguyen CT
- Nguyen DN
- Nguyen HLT
- Nigussie SN
- Nigussie TTN
- Nikbakhsh R
- Nnaji CA
- Nunez-Samudio V
- Oancea B
- Oghenetega OB
- Olagunju AT
- Olusanya BO
- Olusanya JO
- Omer MO
- Onwujekwe OE
- Ortega-Altamirano DV
- Osgood-Zimmerman AE
- Otstavnov N
- Otstavnov SS
- Owolabi MO
- Padubidri JR
- Pana A
- Pandey A
- Pandi-Perumal SR
- Pangaribuan HU
- Parsekar SS
- Pasupula DK
- Patel UK
- Pathak A
- Pathak M
- Pattanshetty SM
- Patton GC
- Paulos K
- Pepito VCF
- Pickering BV
- Pinheiro M
- Piwoz EG
- Pokhrel KN
- Pourjafar H
- Prada SI
- Pribadi DRA
- Quintanilla BPA
- Rabiee M
- Rabiee N
- Rahim F
- Rahimzadeh S
- Rahman A
- Rahman MHU
- Rahmani AM
- Rai RK
- Ranabhat CL
- Rao SJ
- Rastogi P
- Rathi P
- Rawaf DL
- Rawaf S
- Rawassizadeh R
- Rawat R
- Rawat R
- Regassa LD
- Rego MAS
- Reiner RC
- Reshmi B
- Rezapour A
- Ribeiro AI
- Rickard J
- Roever L
- Rumisha SF
- Rwegerera GM
- Sagar R
- Sajadi SM
- Salem MR
- Samy AM
- Santric-Milicevic MM
- Saraswathy SYI
- Sarker AR
- Sartorius B
- Sathian B
- Saxena D
- Sbarra AN
- Schaeffer LE
- Schipp MF
- Sengupta D
- Senthilkumaran S
- Sha F
- Shafaat O
- Shaheen AA
- Shaikh MA
- Shalash AS
- Shannawaz M
- Sheikh A
- Shetty BSK
- Shetty RS
- Shibuya K
- Shiferaw WS
- Shin JI
- Silva DAS
- Singh NP
- Singh P
- Singh S
- Sintayehu Y
- Skryabin VY
- Skryabina AA
- Soheili A
- Soltani S
- Sorrie MB
- Spurlock EE
- Steuben KM
- Sudaryanto A
- Sufiyan MB
- Swartz SJ
- Syed ZQ
- Tadesse EG
- Tamiru AT
- Tantawi ME
- Tapak L
- Tareque MI
- Tarigan IU
- Tesema GA
- Tesfay FH
- Teshome A
- Tessema ZT
- Thankappan KR
- Thapar R
- Thomas N
- Topor-Madry R
- Tovani-Palone MR
- Traini E
- Tran BX
- Truong PN
- Tsegaye BTBT
- Ullah I
- Umeokonkwo CD
- Unnikrishnan B
- Upadhyay E
- Uzochukwu BSC
- VanderHeide JD
- Vecchia CL
- Violante FS
- Vo B
- Wado YD
- Waheed Y
- Wamai RG
- Wang F
- Wang Y
- Wang Y-P
- Weaver ND
- Wickramasinghe ND
- Wiens KE
- Wiysonge CS
- Woyczynski L
- Wu A-M
- Wu C
- Yamada T
- Yaya S
- Yeshaneh A
- Yeshaw Y
- Yeshitila YG
- Yilma MT
- Yip P
- Yonemoto N
- Yosef T
- Younis MZ
- Yousuf AY
- Yu C
- Yu Y
- Yuce D
- Zafar S
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamanian M
- Zar HJ
- Zastrozhin MS
- Zastrozhina A
- Zelellw DA
- Zhang Y
- Zhang Z-J
- Zhao X-JG
- Zodpey S
- Zuniga YMH
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Exclusive breastfeeding (EBF)-giving infants only breast-milk for the first 6 months of life-is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here we present a geospatial analysis of EBF prevalence estimates from 2000 to 2018 across 94 LMICs mapped to policy-relevant administrative units (for example, districts), quantify subnational inequalities and their changes over time, and estimate probabilities of meeting the World Health Organization's Global Nutrition Target (WHO GNT) of ≥70% EBF prevalence by 2030. While six LMICs are projected to meet the WHO GNT of ≥70% EBF prevalence at a national scale, only three are predicted to meet the target in all their district-level units by 2030.This work was primarily supported by grant no. OPP1132415 from the Bill & Melinda Gates Foundation. Co-authors used by the Bill & Melinda Gates Foundation (E.G.P. and R.R.3) provided feedback on initial maps and drafts of this manuscript. L.G.A. has received support from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES), Código de Financiamento 001 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (grant nos. 404710/2018-2 and 310797/2019-5). O.O.Adetokunboh acknowledges the National Research Foundation, Department of Science and Innovation and South African Centre for Epidemiological Modelling and Analysis. M.Ausloos, A.Pana and C.H. are partially supported by a grant from the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project no. PN-III-P4-ID-PCCF-2016-0084. P.C.B. would like to acknowledge the support of F. Alam and A. Hussain. T.W.B. was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. K.Deribe is supported by the Wellcome Trust (grant no. 201900/Z/16/Z) as part of his international intermediate fellowship. C.H. and A.Pana are partially supported by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project no. PN-III-P2-2.1-SOL-2020-2-0351. B.Hwang is partially supported by China Medical University (CMU109-MF-63), Taichung, Taiwan. M.Khan acknowledges Jatiya Kabi Kazi Nazrul Islam University for their support. A.M.K. acknowledges the other collaborators and the corresponding author. Y.K. was supported by the Research Management Centre, Xiamen University Malaysia (grant no. XMUMRF/2020-C6/ITM/0004). K.Krishan is supported by a DST PURSE grant and UGC Centre of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M.Kumar would like to acknowledge FIC/NIH K43 TW010716-03. I.L. is a member of the Sistema Nacional de Investigación (SNI), which is supported by the Secretaría Nacional de Ciencia, Tecnología e Innovación (SENACYT), Panamá. M.L. was supported by China Medical University, Taiwan (CMU109-N-22 and CMU109-MF-118). W.M. is currently a programme analyst in Population and Development at the United Nations Population Fund (UNFPA) Country Office in Peru, which does not necessarily endorses this study. D.E.N. acknowledges Cochrane South Africa, South African Medical Research Council. G.C.P. is supported by an NHMRC research fellowship. P.Rathi acknowledges support from Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India. Ramu Rawat acknowledges the support of the GBD Secretariat for supporting the reviewing and collaboration of this paper. B.R. acknowledges support from Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal. A.Ribeiro was supported by National Funds through FCT, under the programme of ‘Stimulus of Scientific Employment—Individual Support’ within the contract no. info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND/02386/2018/CP1538/CT0001/PT. S.Sajadi acknowledges colleagues at Global Burden of Diseases and Local Burden of Disease. A.M.S. acknowledges the support from the Egyptian Fulbright Mission Program. F.S. was supported by the Shenzhen Science and Technology Program (grant no. KQTD20190929172835662). A.Sheikh is supported by Health Data Research UK. B.K.S. acknowledges Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal for all the academic support. B.U. acknowledges support from Manipal Academy of Higher Education, Manipal. C.S.W. is supported by the South African Medical Research Council. Y.Z. was supported by Science and Technology Research Project of Hubei Provincial Department of Education (grant no. Q20201104) and Outstanding Young and Middle-aged Technology Innovation Team Project of Hubei Provincial Department of Education (grant no. T2020003). The funders of the study had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. All maps presented in this study are generated by the authors and no permissions are required to publish them
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
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- Alexander KD
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- Allekotte I
- Allen B
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- Angus CR
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- Arcavi I
- Arceo R
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- Array MWA Murchison Widefield
- Arrieta M
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- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
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- Furusawa H
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A
- Author
- Abbott BP
- Abbott R
- Abbott TD
- Acernese F
- Ackley K
- Adams C
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
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- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17, the gravitational-wave event GW170817 was observed by the Advanced LIGO and Virgo detectors, and the gamma-ray burst (GRB) GRB 170817A was observed independently by the Fermi Gamma-ray Burst Monitor, and the Anti-Coincidence Shield for the Spectrometer for the International Gamma-Ray Astrophysics Laboratory. The probability of the near-simultaneous temporal and spatial observation of GRB 170817A and GW170817 occurring by chance is 5.0×10−8. We therefore confirm binary neutron star mergers as a progenitor of short GRBs. The association of GW170817 and GRB 170817A provides new insight into fundamental physics and the origin of short GRBs. We use the observed time delay of (+1.74±0.05)s between GRB 170817A and GW170817 to: (i) constrain the difference between the speed of gravity and the speed of light to be between −3×10−15 and +7×10−16 times the speed of light, (ii) place new bounds on the violation of Lorentz invariance, (iii) present a new test of the equivalence principle by constraining the Shapiro delay between gravitational and electromagnetic radiation. We also use the time delay to constrain the size and bulk Lorentz factor of the region emitting the gamma-rays. GRB 170817A is the closest short GRB with a known distance, but is between 2 and 6 orders of magnitude less energetic than other bursts with measured redshift. A new generation of gamma-ray detectors, and subthreshold searches in existing detectors, will be essential to detect similar short bursts at greater distances. Finally, we predict a joint detection rate for the Fermi Gamma-ray Burst Monitor and the Advanced LIGO and Virgo detectors of 0.1-1.4 per year during the 2018-2019 observing run and 0.3-1.7 per year at design sensitivity
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
- Abbott Bp
- Abbott R
- Abbott Td
- Abraham S
- Acernese F
- Ackley K
- Adams C
- Adhikari Rx
- Adya Vb
- Affeldt C
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar Od
- Aiello L
- Ain A
- Ajith P
- Allen G
- Allocca A
- Aloy Ma
- Altin Pa
- Amato A
- Anand S
- Ananyeva A
- Anderson Sb
- Anderson Wg
- Angelova Sv
- Antier S
- Appert S
- Arai K
- Araya Mc
- Areeda Js
- Arene M
- Arnaud N
- Aronson Sm
- Ascenzi S
- Ashton G
- Aston Sm
- Astone P
- Aubin F
- Aufmuth P
- AultONeal K
- Austin C
- Avendano V
- Avila-Alvarez A
- Babak S
- Bacon P
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO's second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h095%=3.47×10-25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering. © 2019 American Physical Society
Search for gravitational waves from Scorpius X-1 in the second Advanced LIGO observing run with an improved hidden Markov model
- Author
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- Willke B
- Winkler W
- Wipf Cc
- Wittel H
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- Woehler J
- Wofford Jk
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- Wu Ds
- Wysocki Dm
- Xiao S
- Xu R
- Yamamoto H
- Yancey Cc
- Yang L
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- Yap Mj
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- Zadrozny A
- Zadrozny Ak
- Zanolin M
- Zelenova T
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- Zimmerman Ab
- Zucker Me
- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
We present results from a semicoherent search for continuous gravitational waves from the low-mass x-ray binary Scorpius X-1, using a hidden Markov model (HMM) to track spin wandering. This search improves on previous HMM-based searches of LIGO data by using an improved frequency domain matched filter, the J-statistic, and by analyzing data from Advanced LIGO’s second observing run. In the frequency range searched, from 60 to 650 Hz, we find no evidence of gravitational radiation. At 194.6 Hz, the most sensitive search frequency, we report an upper limit on gravitational wave strain (at 95% confidence) of h95%0=3.47×10−25 when marginalizing over source inclination angle. This is the most sensitive search for Scorpius X-1, to date, that is specifically designed to be robust in the presence of spin wandering
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Aakvaag E
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboelela M
- Aboulhorma A
- Abramowicz H
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- Akiyama D
- Akolkar NN
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- Albert J
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- Albouy GL
- Alderweireldt S
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- Aleksa M
- Aleksandrov IN
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- Alimonti G
- Alkakhi W
- Allaire C
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- Allport PP
- Aloisio A
- Alonso F
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- Alvarez Estevez M
- Alvarez Fernandez A
- Alves Cardoso M
- Alviggi MG
- Aly M
- Amaral Coutinho Y
- Ambler A
- Amelung C
- Amerl M
- Ames CG
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- Zhemchugov A
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Observation of electroweak production of two jets and a Z-boson pair
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- Zhemchugov A
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- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
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- Zwalinski L
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/02/2023
- Field of study
Electroweak symmetry breaking explains the origin of the masses of elementary particles through their interactions with the Higgs field. Besides the measurements of the Higgs boson properties, the study of the scattering of massive vector bosons with spin 1 allows the nature of electroweak symmetry breaking to be probed. Among all processes related to vector-boson scattering, the electroweak production of two jets and a Z-boson pair is a rare and important one. Here we report the observation of this process from proton–proton collision data corresponding to an integrated luminosity of 139 fb−1 recorded at a centre-of-mass energy of 13 TeV with the ATLAS detector at the Large Hadron Collider. We consider two different final states originating from the decays of the Z-boson pair: one containing four charged leptons and another containing two charged leptons and two neutrinos. The hypothesis of no electroweak production is rejected with a statistical significance of 5.7σ, and the measured cross-section for electroweak production is consistent with the Standard Model prediction. In addition, we report cross-sections for inclusive production of a Z-boson pair and two jets for the two final states
Binary Black Hole Mergers in the first Advanced LIGO Observing Run
- Author
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- Zweizig J
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2016
- Field of study
The first observational run of the Advanced LIGO detectors, from September 12, 2015 to January 19, 2016, saw the first detections of gravitational waves from binary black hole mergers. In this paper we present full results from a search for binary black hole merger signals with total masses up to 100M⊙ and detailed implications from our observations of these systems. Our search, based on general-relativistic models of gravitational wave signals from binary black hole systems, unambiguously identified two signals, GW150914 and GW151226, with a significance of greater than 5σ over the observing period. It also identified a third possible signal, LVT151012, with substantially lower significance, which has a 87% probability of being of astrophysical origin. We provide detailed estimates of the parameters of the observed systems. Both GW150914 and GW151226 provide an unprecedented opportunity to study the two-body motion of a compact-object binary in the large velocity, highly nonlinear regime. We do not observe any deviations from general relativity, and place improved empirical bounds on several high-order post-Newtonian coefficients. From our observations we infer stellar-mass binary black hole merger rates lying in the range 9−240Gpc−3yr−1. These observations are beginning to inform astrophysical predictions of binary black hole formation rates, and indicate that future observing runs of the Advanced detector network will yield many more gravitational wave detections
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