23 research outputs found
Opera and Hypnosis: Victor Maurelâs Experiments with Verdiâs Otello
One day in his private home on the avenue Bugeaud, in Parisâs sixteenth arrondissement, the famous baritone Victor Maurel hosted a meeting which combined music with hypnotism of a young woman
Vocal Culture in the Age of Laryngoscopy
For several months beginning in 1884, readers of Life, Science, Health, the Atlantic Monthly and similar magazines would have encountered half-page advertisements for a newly patented medical device called the âammoniaphoneâ (Figure 2.1). Invented and promoted by a Scottish doctor named Carter Moffat and endorsed by the soprano Adelina Patti, British Prime Minister William Gladstone and the Princess of Wales, the ammoniaphone promised a miraculous transformation in the voices of its users. It was recommended for âvocalists, clergymen, public speakers, parliamentary men, readers, reciters, lecturers, leaders of psalmody, schoolmasters, amateurs, church choirs, barristers, and all persons who have to use their voices professionally, or who desire to greatly improve their speaking or singing tonesâ. Some estimates indicated that Moffat sold upwards of 30,000 units, yet the ammoniaphone was a flash in the pan as far as such things go, fading from public view after 1886
Unsound Seeds
With this image of a curtain hiding and at the same time heightening some terrible secret, Max Kalbeck began his review of the first Viennese performance of Richard Straussâs Salome. Theodor W. Adorno picked up the image of the curtain in the context of Straussâs fabled skill at composing non-musical events, when he identified the opening flourish of Straussâs Salome as the swooshing sound of the rising curtain. If this is so, the succĂšs de scandale of the opera was achieved, in more than one sense, as soon as the curtain rose at Dresdenâs Semperoper on 10 December 1905.
Critics of the premiere noted that the opera set âboundless wildness and degeneration to musicâ; it brought âhigh decadenceâ onto the operatic stage; a âcomposition of hysteriaâ, reflecting the âdisease of our timeâ, Salome is âhardly music any moreâ.The outrage did not end there
Science, Technology and Love in Late Eighteenth-Century Opera
It is a tale told by countless operas: young love, thwarted by an old manâs financially motivated marriage plans, triumphs in the end thanks to a deception that tricks the old man into blessing the young loversâ union. Always a doddering fool, the old man is often also an enthusiast for knowledge. Such is the case, for instance, in Carlo Goldoniâs comic opera libretto Il mondo della luna (1750), in which Buonafedeâs interest in the moon opens him to an elaborate hoax that has him believe he and his daughters have left Earth for the lunar world; and also in the Singspiel Die LuftbĂ€lle, oder der Liebhaber Ă la Montgolfier (1788), wherein the apothecary Wurm trades Sophie, the ward he intended to marry himself, for a technological innovation that will make him a pioneering aeronaut
Operatic Fantasies in Early Nineteenth-Century Psychiatry
In his celebrated essay on insanity in the Dictionnaire des sciences mĂ©dicales (1816), French psychiatrist Ătienne Esquirol marvelled at the earlier custom of allowing asylum inmates to attend theatrical productions at Charenton
Estimated economic benefits from low-frequency administration of atypical antipsychotics in treatment of schizophrenia: a decision model
<p>Abstract</p> <p>The objective of this study was to quantify the direct medical resources used and the corresponding burden of disease in the treatment of patients with schizophrenia. Because low-frequency administration (LFA) of risperidone guarantees adherence during treatment intervals and offers fewer opportunities to discontinue, adherence and persistence were assumed to improve, thereby reducing relapses of major symptoms.</p> <p>A decision tree model including Markov processes with monthly cycles and a five-year maximum timeframe was constructed. Costs were adapted from the literature and discounted at a 3% annual rate. The population is a demographically homogeneous cohort of patients with schizophrenia, differentiated by initial disease severity (mildly ill, moderately ill, and severely ill). Treatment parameters are estimated using published information for once-daily risperidone standard oral therapy (RIS-SOT) and once-monthly risperidone long-acting injection (RIS-LAI) with LFA therapy characteristics derived from observed study trends. One-year and five-year results are expressed as discounted direct medical costs and mean number of relapses per patient (inpatient, outpatient, total) and are estimated for LFA therapies given at three, six, and nine month intervals.</p> <p>The one-year results show that LFA therapy every 3 months (LFA-3) (10,721) or RIS-LAI ($9,450) with similar trends in the 5-year results. Moreover, the model predicts that LFA-3 vs. RIS-SOT vs. RIS LAI therapy will reduce costly inpatient relapses (0.16 vs. 0.51 vs. 0.41). Extending the interval to six (LFA-6) and nine (LFA-9) months resulted in further reductions in relapse and costs.</p> <p>Limitations include the fact that LFA therapeutic options are hypothetical and do not yet exist and limited applicability to compare one antipsychotic agent versus another as only risperidone therapy is evaluated. However, study results have quantified the potential health state improvements and potential direct medical cost savings achievable with the development and use of LFA medication delivery technologies.</p
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.</p