465 research outputs found
Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model
- Author
- A Ristimaki
- AB Hollingsworth
- B Arun
- B Fisher
- B Wang
- B Wang
- B Wang
- Bob Mau
- C Gerlach
- CH Liu
- D Pereg
- ES Díaz-Cruz
- GEP Box
- J Gerdes
- J Laborda
- Jill D Haag
- K Subbaramaiah
- LR Howe
- MB Terry
- Michael N Gould
- NL Barnes
- P Nanni
- RE Harris
- Ronald A Lubet
- RW Brueggemeier
- S Lanza-Jacoby
- S Lu
- S Rozen
- S Woditschka
- Stephan Woditschka
- TA Thompson
- TJ Jang
- Y Gavrieli
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
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- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
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- Adamek L
- Adelman J
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- Aguilar-Saavedra JA
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- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
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- Alimonti G
- Allaire C
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- Alviggi MG
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- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
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- Yamamoto S
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- Yamanaka T
- Yamazaki T
- Yamazaki Y
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- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Smit GVY
- Ye J
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at s√=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles R
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Arfaoui S
- Arguin J-F
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Atkinson M
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Avramidou R
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Balek P
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- Banfi D
- Bangert A
- Bansal V
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- Barajas CAC
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- Battaglia A
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- Beauchemin PH
- Beccherle R
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- Beckingham M
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 01/01/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral Z′ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/γ bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fb−1 in the e + e − channel and 5.0 fb−1 in the μ + μ −channel. A Z ′ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal Z′ Models
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Wilson JA
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- Winkelmann S
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- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yanush S
- Yao L
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- Yen AL
- Yilmaz M
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- Yoshihara K
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- Young CJ
- Youssef S
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- Yuan L
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- Zaidan R
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- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- Zenis T
- Zerwas D
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- Zhang H
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- Zhang X
- Zhang Z
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- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
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- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or τ lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, φ, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Counter-Gradient Variation in Respiratory Performance of Coral Reef Fishes at Elevated Temperatures
- Author
- AL Perry
- AP Farrell
- AS Brierley
- C Parmesan
- CA Deutsch
- DO Conover
- DO Conover
- EM Goolish
- ES Poloczanska
- G Gerlach
- G-R Walther
- GA Meehl
- GE Nilsson
- GE Nilsson
- GE Nilsson
- GE Nilsson
- GR Allen
- GR Allen
- Göran E. Nilsson
- HO Pörtner
- HO Pörtner
- HO Pörtner
- HO Pörtner
- HO Pörtner
- J Sollid
- JC Lai
- JE Randall
- JJ Tewksbury
- JL Gardner
- JM Grebmeier
- JM Lough
- LJ Chapman
- LK Bay
- M Schroer
- MJ Angilletta
- NA Fangue
- Naomi M. Gardiner
- NL Bindoff
- NM Gardiner
- Philip L. Munday
- PJ Doherty
- PL Munday
- PM Schulte
- R Levins
- RJ Gonzalez
- S Schaak
- S Östlund-Nilsson
- SB Munch
- Tamara Natasha Romanuk
- TL Root
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
The response of species to global warming depends on how different populations are affected by increasing temperature throughout the species' geographic range. Local adaptation to thermal gradients could cause populations in different parts of the range to respond differently. In aquatic systems, keeping pace with increased oxygen demand is the key parameter affecting species' response to higher temperatures. Therefore, respiratory performance is expected to vary between populations at different latitudes because they experience different thermal environments. We tested for geographical variation in respiratory performance of tropical marine fishes by comparing thermal effects on resting and maximum rates of oxygen uptake for six species of coral reef fish at two locations on the Great Barrier Reef (GBR), Australia. The two locations, Heron Island and Lizard Island, are separated by approximately 1200 km along a latitudinal gradient. We found strong counter-gradient variation in aerobic scope between locations in four species from two families (Pomacentridae and Apogonidae). High-latitude populations (Heron Island, southern GBR) performed significantly better than low-latitude populations (Lizard Island, northern GBR) at temperatures up to 5°C above average summer surface-water temperature. The other two species showed no difference in aerobic scope between locations. Latitudinal variation in aerobic scope was primarily driven by up to 80% higher maximum rates of oxygen uptake in the higher latitude populations. Our findings suggest that compensatory mechanisms in high-latitude populations enhance their performance at extreme temperatures, and consequently, that high-latitude populations of reef fishes will be less impacted by ocean warming than will low-latitude populations
Transport lattice models of heat transport in skin with spatially heterogeneous, temperature-dependent perfusion
- Author
- A Huch
- A Vladimirescu
- AJ Welch
- AM Stoll
- AM Stoll
- AR Moritz
- B Erdmann
- B Mochnacki
- BI Tropea
- C ABalanis
- C Mudd
- CJ Diederich
- CL Chan
- CR Davies
- CTW Moonen
- CW Song
- CW Song
- D Hess
- D Walz
- DA Nelson
- DA Stewart
- DA Torvi
- DC Mikulecky
- Donald A Stewart
- DT Tompkins
- EC Fear
- EH Wissler
- F Gustrau
- G Kron
- G Rooth
- Gregory T Martin
- GT Martin
- GT Martin
- GT Martin
- H Arkin
- H Pennes
- HF Bowman
- HS Carslaw
- J Lang
- J Liu
- J Utoh
- JA Pearce
- JA Surrell
- James C Weaver
- JC Bischof
- JH Lienhard
- KR Diller
- KR Diller
- KR Diller
- KR Diller
- KR Foster
- KR Foster
- MH Falk
- NL Gershfeld
- NT Wright
- P Gerlach
- P Wust
- PD Tyréus
- PJ Riu
- R Seip
- RC Lee
- RC Lee
- RT Brouillette
- S Bhowmick
- S Puccini
- SC Jiang
- TE Dudar
- TR Gowrishankar
- TR Gowrishankar
- ZS Deng
- Publication venue
- BioMed Central
- Publication date
- 17/11/2004
- Field of study
BACKGROUND: Investigation of bioheat transfer problems requires the evaluation of temporal and spatial distributions of temperature. This class of problems has been traditionally addressed using the Pennes bioheat equation. Transport of heat by conduction, and by temperature-dependent, spatially heterogeneous blood perfusion is modeled here using a transport lattice approach. METHODS: We represent heat transport processes by using a lattice that represents the Pennes bioheat equation in perfused tissues, and diffusion in nonperfused regions. The three layer skin model has a nonperfused viable epidermis, and deeper regions of dermis and subcutaneous tissue with perfusion that is constant or temperature-dependent. Two cases are considered: (1) surface contact heating and (2) spatially distributed heating. The model is relevant to the prediction of the transient and steady state temperature rise for different methods of power deposition within the skin. Accumulated thermal damage is estimated by using an Arrhenius type rate equation at locations where viable tissue temperature exceeds 42°C. Prediction of spatial temperature distributions is also illustrated with a two-dimensional model of skin created from a histological image. RESULTS: The transport lattice approach was validated by comparison with an analytical solution for a slab with homogeneous thermal properties and spatially distributed uniform sink held at constant temperatures at the ends. For typical transcutaneous blood gas sensing conditions the estimated damage is small, even with prolonged skin contact to a 45°C surface. Spatial heterogeneity in skin thermal properties leads to a non-uniform temperature distribution during a 10 GHz electromagnetic field exposure. A realistic two-dimensional model of the skin shows that tissue heterogeneity does not lead to a significant local temperature increase when heated by a hot wire tip. CONCLUSIONS: The heat transport system model of the skin was solved by exploiting the mathematical analogy between local thermal models and local electrical (charge transport) models, thereby allowing robust, circuit simulation software to obtain solutions to Kirchhoff's laws for the system model. Transport lattices allow systematic introduction of realistic geometry and spatially heterogeneous heat transport mechanisms. Local representations for both simple, passive functions and more complex local models can be easily and intuitively included into the system model of a tissue
Nicotine delivery to users from cigarettes and from different types of e-cigarettes
- Author
- Anna Phillips
- AR Vansickel
- AR Vansickel
- B Caldwell
- C Bullen
- Dunja Przulj
- E Kralikova
- G St Helen
- G Sutherland
- H Digard
- H McRobbie
- Hayden McRobbie
- KE Farsalinos
- KE Farsalinos
- KK Gerlach
- L Dawkins
- LE Dawkins
- MJ Schroeder
- ML Goniewicz
- ML Goniewicz
- ML Trehy
- N Douptcheva
- NK Cobb
- NL Benowitz
- P Hajek
- Peter Hajek
- Public Health England
- R Pellegrino
- Rebecca Anderson
- TR McAuley
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 21/12/2016
- Field of study
BACKGROUND: Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS: Twelve participants (‘dual users’ of EC and cigarettes) used their own brand cigarette and nine different EC brands. Blood samples were taken at baseline and at 2-min intervals for 10 min and again at 30 min. RESULTS: Eleven smokers provided usable data. None of the EC matched cigarettes in nicotine delivery (C (max) = 17.9 ng/ml, T (max) = 4 min and AUC(0–>30) = 315 ng/ml/min). The EC with 48 mg/ml nicotine generated the closest PK profile (C (max) = 13.6 ng/ml, T (max) = 4 min, AUC(0–>30) = 245 ng/ml/min), followed by a third generation EC using 20 mg/ml nicotine (C (max) = 11.9 ng/ml, T (max) = 6 min, AUC(0–>30) = 232 ng/ml/min), followed by the tank system using 20 mg/ml nicotine (C (max) = 9.9 ng/ml, T (max) = 6 min, AUC(0–>30) = 201 ng/ml/min). Cig-a-like PK values were similar, ranging from C (max) 7.5 to 9.7 ng/ml, T (max) 4-6 min, and AUC(0–>30) 144 to 173 ng/ml/min. Moderate differences in e-liquid nicotine concentrations had little effect on nicotine delivery, e.g. the EC with 24 mg/ml cartridge had the same PK profile as ECs with 16 mg/ml cartridges. Using similar strength e-liquid, the tank EC provided significantly more nicotine than cig-a-like ECs. CONCLUSIONS: EC brands we tested do not deliver nicotine as efficiently as cigarettes, but newer EC products deliver nicotine more efficiently than cig-a-like brands. Moderate variations in nicotine content of e-liquid have little effect on nicotine delivery. Smokers who are finding cig-a-like EC unsatisfactory should be advised to try more advanced systems
Is the meiofauna a good indicator for climate change and anthropogenic impacts?
- Author
- A Ahnert
- A Borja
- A Carpentier
- A Forchino
- A Guerrini
- A Mazzola
- A McIntyre-Wressnig
- A Piot
- A Pusceddu
- A Pusceddu
- A Pusceddu
- A Pusceddu
- A Rose
- AA Cook
- AD Kennedy
- AH Parulekar
- AJ Gooday
- AJ Gooday
- AJ Gooday
- AJ Gooday
- AJ Gooday
- AJ Radwell
- Alexandre Arvigo
- Andrew J. Gooday
- Ann Vanreusel
- Antoine Rio-Cabello
- AP Covich
- AR Thurber
- AW Decho
- AWG Wurff van der
- B Buchardt
- B Freedman
- B Górska
- B Lebreton
- BC Coull
- BC Coull
- BD Wigham
- BE Hopper
- BK Sen Gupta
- BR Kuipers
- BS Ingole
- BS Ingole
- BT Hentschel
- C Alsterberg
- C Bussau
- C Bussau
- C Colen Van
- C Fontanier
- C Heip
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- Julien Thébault
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- RM Warwick
- RN Arieli
- Roxanne Langonne-Augen
- RR Hessler
- S Amjad
- S Bonaglia
- S Gollasch
- S Gollasch
- S Jennings
- S Laakmann
- S Mirto
- S Mirto
- S Oron
- S Somot
- S Wang
- S Widdicombe
- SA Gerlach
- SA Gerlach
- SA Gerlach
- SA Netto
- Sarah Seite
- SC Doney
- SC Doney
- SG Bolam
- SI Rogers
- SJ Forster
- SL Dashfield
- SM Burton
- SR Ernst
- T Bongers
- T Irizuki
- T Kang
- T Mascart
- T Mascart
- T Moens
- T Radziejewska
- T Radziejewska
- T Wernberg
- T Yamanaka
- TA Scambos
- Tangi Le Bot
- TF Sutherland
- Thomas Andro
- Thomas Van Der Stegen
- TK Gyedu-Ababio
- TK Gyedu-Ababio
- TK Pinto
- Tristan James
- U Braeckman
- V Bouchet
- V Cadre Le
- Valentin Foulon
- VB Pogrebov
- VG Fonseca
- Viatcheslav N. Ivanenko
- Vivien Hulot
- VMP Bouchet
- VV Galtsova
- WP Sijp
- WS Liu
- WS Liu
- X Sun
- XQ Ngo
- ZA Ansari
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Our planet is changing, and one of the most pressing challenges facing the scientific community revolves around understanding how ecological communities respond to global changes. From coastal to deep-sea ecosystems, ecologists are exploring new areas of research to find model organisms that help predict the future of life on our planet. Among the different categories of organisms, meiofauna offer several advantages for the study of marine benthic ecosystems. This paper reviews the advances in the study of meiofauna with regard to climate change and anthropogenic impacts. Four taxonomic groups are valuable for predicting global changes: foraminifers (especially calcareous forms), nematodes, copepods and ostracods. Environmental variables are fundamental in the interpretation of meiofaunal patterns and multistressor experiments are more informative than single stressor ones, revealing complex ecological and biological interactions. Global change has a general negative effect on meiofauna, with important consequences on benthic food webs. However, some meiofaunal species can be favoured by the extreme conditions induced by global change, as they can exhibit remarkable physiological adaptations. This review highlights the need to incorporate studies on taxonomy, genetics and function of meiofaunal taxa into global change impact research
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
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