30 research outputs found
Genome-wide microRNA screening in Nile tilapia reveals pervasive isomiRs’ transcription, sex-biased arm switching and increasing complexity of expression throughout development
- Author
- A Brummer
- A Cnaani
- A Juanchich
- A Khvorova
- A Kozomara
- A Loytynoja
- A Marco
- AJ Kriegel
- AM Heimberg
- B Giardine
- B Yan
- C Cheng
- C Huang
- C Sangokoya
- CP Petersen
- CT Amemiya
- CT Neilsen
- D Brawand
- DP Bartel
- E Berezikov
- E Berezikov
- E Wienholds
- E Wienholds
- E Wit de
- EJ Thatcher
- EP Nawrocki
- F Christodoulou
- F Hassan
- F Xu
- G Mathonnet
- G Santpere
- G-Q Tang
- GM Schratt
- H Kitano
- H Kuang
- H Wu
- H Zhang
- H Zhou
- J Giusti
- J Hausser
- J Mazzuchelli
- J Meunier
- J Xiao
- JM Romao
- JP Broughton
- JR Neilson
- JS Taylor
- K Okamura
- K Prufer
- KP Lai
- L Guo
- L He
- L Pase
- L Penso-Dolfin
- LCG Hinske
- LF Sempere
- M Ha
- M Kearse
- M Pignatelli
- MB Stocks
- MJ Hubisz
- MK McGahon
- MR Fabian
- MR Friedlander
- N Cloonan
- O Eshel
- P Franchini
- P Paczynska
- PA Sharp
- R Andreassen
- RC Edgar
- RH Plasterk
- S Tam
- SB Chakraborty
- SH Bernhart
- SS Lakshmi
- T Bizuayehu
- W Filipowicz
- WJ Kent
- Y Lee
- Y-HE Loh
- Z Su
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
MicroRNAs (miRNAs) are key regulators of gene expression in multicellular organisms. The elucidation of miRNA function and evolution depends on the identification and characterization of miRNA repertoire of strategic organisms, as the fast-evolving cichlid fishes. Using RNA-seq and comparative genomics we carried out an in-depth report of miRNAs in Nile tilapia (Oreochromis niloticus), an emergent model organism to investigate evo-devo mechanisms. Five hundred known miRNAs and almost one hundred putative novel vertebrate miRNAs have been identified, many of which seem to be teleost-specific, cichlid-specific or tilapia-specific. Abundant miRNA isoforms (isomiRs) were identified with modifications in both 5p and 3p miRNA transcripts. Changes in arm usage (arm switching) of nine miRNAs were detected in early development, adult stage and even between male and female samples. We found an increasing complexity of miRNA expression during ontogenetic development, revealing a remarkable synchronism between the rate of new miRNAs recruitment and morphological changes. Overall, our results enlarge vertebrate miRNA collection and reveal a notable differential ratio of miRNA arms and isoforms influenced by sex and developmental life stage, providing a better picture of the evolutionary and spatiotemporal dynamics of miRNAs
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
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- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
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- Agliozzo C
- Agudo I
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- Aguilar JA
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- Albuquerque IFM
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- Allekotte I
- Allen B
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- Array LWA Long Wavelength
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- Ziegler A
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- Zimnukhov DS
- Ziolkowski M
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- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Localization and broadband follow-up of the gravitational-wave transient GW150914
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- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
The second Sandia Fracture Challenge: predictions of ductile failure under quasi-static and moderate-rate dynamic loading
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- A. A. Brown
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- C. A. Jones
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- CA Schneider
- CHM Simha
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- M. K. Neilsen
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- O Cazacu
- P Follansbee
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- WA Wickelgren
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- X. Fang
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- ZP Bazant
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Analysis of transcripts differentially expressed between fruited and deflowered ‘Gala’ adult trees: a contribution to biennial bearing understanding in apple
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- A Franceschini
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- AM Brunner
- B Guitton
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- N Kotoda
- N Kotoda
- N Mimida
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- O Arrigoni
- O Arrigoni
- P Robles
- PE Lauri
- Q Lu
- QH Zhu
- R Blanvillain
- R Core Development Team
- R Velasco
- RA Stern
- RM Fulford
- S Chaikiattiyos
- S Scofield
- SI Gibson
- SJ Liljegren
- SJ Yoo
- SK Sung
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- SP Monselise
- T Barrett
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- T Foster
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- T Schmidt
- V Wahl
- X. Sabau
- YH Song
- YX Hu
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- ZR Sung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
First Measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary-Black-hole Merger GW170814
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- Blair CD
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- van den Brand JFJ
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- Wade AR
- Wade LE
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- Williams PKG
- Williamson AR
- Willis JL
- Willke B
- Wimmer MH
- Winkler W
- Wipf CC
- Wittel H
- Woan G
- Woehler J
- Wofford JK
- Worden J
- Wright JL
- Wu DS
- Wysocki DM
- Xiao L
- Yamamoto H
- Yancey CC
- Yang L
- Yap MJ
- Yazback M
- Yeeles DW
- Yu H
- Yu H
- Yuen SHR
- Yvert M
- Zadrozny AK
- Zanolin M
- Zelenova T
- Zendri J-P
- Zertuche LM
- Zevin M
- Zhang J
- Zhang L
- Zhang T
- Zhao C
- Zhou M
- Zhou Z
- Zhu XJ
- Zimmerman A
- Zucker ME
- Zuntz J
- Zweizig J
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/05/2019
- Field of study
We present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in H0=75−32+40kms−1Mpc−1, which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find {H}_{0 {78}_{-24}^{+96}\,\mathrm{km}\,{{\rm{s}}}^{-1}\,{\mathrm{Mpc}}^{-1} (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0
The panorama of miRNA-mediated mechanisms in mammalian cells
- Author
- A Azuma-Mukai
- A Dueck
- A Eulalio
- A Eulalio
- A Eulalio
- A Eulalio
- A Eulalio
- A Fiszer
- A Fiszer
- A Grimson
- A Helwak
- A Khvorova
- A Kozomara
- A Krek
- A Lal
- A Lal
- A Lingel
- A Nykänen
- A Rinck
- A Yamashita
- A Zdanowicz
- AD Haase
- AE Pasquinelli
- Agnieszka Fiszer
- AKL Leung
- aM Burroughs
- AM Burroughs
- AM Denli
- AM Duursma
- Anna Stroynowska-Czerwinska
- B Czech
- B Czech
- B Gentner
- B John
- B Shen
- B Wang
- B Wang
- B Wang
- B Wightman
- BL Davidson
- BP Lewis
- BSE Heale
- C Chu
- C Kanellopoulou
- C Shin
- CL Jopling
- CL Noland
- CL Noland
- CP Petersen
- CT Neilsen
- D Cazalla
- D Cifuentes
- D Incarnato
- D Kaul
- D Lazzaretti
- D Long
- D O’Carroll
- D Wang
- D Zheng
- DC Giammartino Di
- DD Scott
- DJ Luciano
- DP Bartel
- DP Bartel
- DS Schwarz
- DS Schwarz
- DT Humphreys
- DW Thomson
- E Berezikov
- E Bernstein
- E Elkayam
- E Huntzinger
- E Koscianska
- E Kozlowska
- E Lund
- E Maniataki
- E Song
- E Wahle
- EP Murchison
- EP Ricci
- F Frank
- F Moretti
- FV Karginov
- FV Rivas
- G Hutvágner
- G Kudla
- G Mathonnet
- G Meister
- G Meister
- G Meister
- GM Borchert
- GM Borchert
- H Guo
- H Iizasa
- H Liang
- H Min
- H Su
- H Wang
- H Wu
- Ha Meijer
- HLA Janssen
- HR Chiang
- HY Hu
- HY Lee
- I Behm-Ansmant
- I Elcheva
- I Heo
- I Heo
- IJ MacRae
- IJ MacRae
- J Azevedo
- J Brennecke
- J Béthune
- J Han
- J Hauptmann
- J Houseley
- J Hu
- J Hu
- J Hu
- J Höck
- J Höck
- J Krol
- J Krol
- J Krüger
- J König
- J Liu
- J Liu
- J Liu
- J Martinez
- J Pfaff
- J Starega-Roslan
- J Ule
- J Ule
- J Winter
- J-B Ma
- J-J Song
- J-S Yang
- Ja Broderick
- JA Gredell
- JA Kruk
- JCR Politz
- JE Braun
- JE Braun
- JG Betancur
- JG Doench
- JG Ruby
- JI Henke
- JJ Forman
- JR Lytle
- JT Zipprich
- J–J Song
- K Nishi
- K Okamura
- K Takimoto
- KH Kok
- KQ Luo
- KT Gagnon
- L Cerutti
- L Poliseno
- L Salmena
- L Sinkkonen
- L Stalder
- L Weinmann
- L Wu
- LP Lim
- M Ameyar-Zazoua
- M Arribas-Layton
- M Cesana
- M Chekulaeva
- M Chekulaeva
- M Doyle
- M Fenger-Grøn
- M Ghildiyal
- M Hafner
- M Hafner
- M Jinek
- M Kedde
- M Kedde
- M Kertesz
- M Kiriakidou
- M Lu
- M Morita
- M Morlando
- M Nowotny
- M Overhoff
- M Rehmsmeier
- M Thomas
- M Yoda
- MJ Blow
- MK Meshesha
- MM Janas
- MR Fabian
- MR Fabian
- MR Fabian
- MS Ebert
- MS Ebert
- N Siddiqui
- N-P Tsai
- NT Schirle
- O Flores
- P Jin
- P Kundu
- P Landgraf
- P Saetrom
- P Smibert
- P Sumazin
- PA Maroney
- PB Kwak
- PH Olsen
- R Elkon
- R Thermann
- R Yi
- RC Friedman
- RD Morin
- RD Mortensen
- RE Lanford
- RI Gregory
- RL Boudreau
- RS Muddashetty
- RS Pillai
- RW Carthew
- S Chatterjee
- S Cheloufi
- S Diederichs
- S Griffiths-Jones
- S Gu
- S Gu
- S Memczak
- S Nottrott
- S Ozgur
- S Ro
- S Schubert
- S Srikantan
- S Till
- S Vasudevan
- S Vasudevan
- S Yekta
- SC Boutet
- SL Ameres
- SW Chi
- SW Chi
- T Eystathioy
- T Eystathioy
- T Katoh
- T Kawamata
- T Kawamata
- T Lai
- T Nishihara
- TB Hansen
- TE Mullen
- TM Rana
- TM Witkos
- TP Chendrimada
- TP Chendrimada
- UA Ørom
- V Glorian
- V Huang
- V Libri
- W Yang
- Wlodzimierz J. Krzyzosiak
- WM Gommans
- X Cai
- X Liu
- X Yang
- Y Chen
- Y Kawahara
- Y Kawahara
- Y Kawahara
- Y Lee
- Y Lee
- Y Lee
- Y Tay
- Y Tay
- Y Tomari
- Y-K Kim
- Y-K Kim
- Y-T Chan
- Z Wang
- ZS Kai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Localization and broadband follow-up of the gravitational-wave transient GW150914
- Author
- Abbott BP
- Abbott FTBOOTESCTMC
- Abdalla FB
- Abe FTINF
- Ackermann FTFGBMCM
- Ackley K
- Adame JA
- Adams C
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Agathos M
- Agatsuma K
- Aggarwal N
- Aguiar OD
- Aiello L
- Ain A
- Ajello M
- Ajith P
- Albert A
- Allam S
- Allen B
- Allen WH
- Allison TVCJ
- Allocca A
- Altin PA
- Amati L
- Anderson B
- Anderson JP
- Anderson SB
- Anderson WG
- Annis J
- Antonelli LA
- Aptekar RL
- Arai K
- Araya MC
- Arceneaux CC
- Areeda JS
- Armstrong R
- Arnaud N
- Array FTLF
- Array FTMW-F
- Arun KG
- Ascenzi S
- Ashton G
- Ast M
- Aston SM
- Astone P
- Atwood WB
- Aufmuth P
- Aulbert C
- Axelsson M
- Babak S
- Bacon P
- Bader MKM
- Bai J
- Baiardi LC
- Bakel NV
- Baker PT
- Balanutsa P
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Baltay FTJ-GEMCC
- Banerji M
- Bannister K
- Barayoga JC
- Barbiellini G
- Barclay SE
- Barish BC
- Barker D
- Barlow T
- Barone F
- Barr B
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy S
- Bartlett J
- Bartos I
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Baune C
- Bavigadda V
- Bazzan M
- Bazzano A
- Behnke B
- Bejger M
- Bell AS
- Bell CJ
- Bell ME
- Bellazzini R
- Bellm E
- Benacquista M
- Benoit-Lévy A
- Berger BK
- Berger E
- Bergman J
- Bergmann G
- Bernstein RA
- Beroiz CCM
- Berry CPL
- Bersanetti D
- Bersier D
- Bertin E
- Bertolini A
- Betzwieser J
- Beuzekom MV
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhat PN
- Bilenko IA
- Billingsley G
- Birch J
- Birney R
- Biscans S
- Bisht A
- Bissaldi E
- Bissaldi E
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blair CD
- Blair DG
- Blair RM
- Blandford RD
- Bloemen S
- Bloom ED
- Bock O
- Bode MF
- Bodiya TP
- Boer M
- Bogaert G
- Bogan C
- Bohe A
- Bojtos P
- Bond C
- Bondu F
- Bonino R
- Bonnand R
- Boom BA
- Bork R
- Boschi V
- Bose S
- Bottacini E
- Botticella MT
- Bouffanais Y
- Bozzi A
- Bozzo E
- Bradaschia C
- Brady PR
- Braginsky VB
- Branchesi M
- Brand JFJVD
- Brandt S
- Brandt TJ
- Brau JE
- Briant T
- Briggs MS
- Brillet A
- Brinkmann M
- Brisson V
- Brocato FTFLATCE
- Brockill P
- Broeck CVD
- Brooks AF
- Brout D
- Brown DA
- Brown DD
- Brown NM
- Bruel P
- Buchanan CC
- Buckley D
- Buckley-Geer E
- Budnev NM
- Buikema A
- Bulik T
- Bulten HJ
- Buonanno A
- Burke DL
- Burns E
- Burrows DN
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- Conte A
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- Cook D
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- Corbitt TR
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- Vikram V
- Vinciguerra S
- Vine DJ
- Vinet J-Y
- Virgilio AD
- Vitale S
- Vitek S
- Vo T
- Vocca H
- Voronkov MA
- Vorvick C
- Voss D
- Vousden WD
- Vrech R
- Vyatchanin SP
- Wade AR
- Wade LE
- Wade M
- Walker AR
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- Wallace L
- Walsh S
- Wang C
- Wang G
- Wang H
- Wang M
- Wang X
- Wang Y
- Ward RL
- Warner J
- Was M
- Waters C
- Watson D
- Wayth RB
- Weaver B
- Wechsler RH
- Wei L-W
- Weinert M
- Weinstein AJ
- Weiss R
- Welborn T
- Wen L
- Wester W
- Westphal T
- Wette K
- Weßels P
- Whelan JT
- White DJ
- Whiting BF
- Whiting MT
- Wiersema K
- Wijers RAMJ
- Williams A
- Williams RD
- Williamson AR
- Willis JL
- Willke B
- Willman M
- Wilson-Hodge CA
- Wimmer MH
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- Wittel H
- Woan G
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- Worden J
- Wright DE
- Wright JL
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- Yam W
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- Yancey CC
- Yang S
- Yanny B
- Yap MJ
- Yock PC
- Yoshida M
- Young DR
- Yu H
- Yu H-F
- Yuan F
- Yurkov V
- Yvert M
- Zadko
- Zadrożny A
- Zangrando L
- Zanolin M
- Zaremba M
- Zendri J-P
- Zevin M
- Zhang B-B
- Zhang B-B
- Zhang F
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- Zhang X
- Zhang Y
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- Zhou M
- Zhou Z
- Zhu S
- Zhu XJ
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- Ćwiek FTPESSTOCA
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- Żarnecki AF
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- Field of study
A gravitational-wave transient was identified in data recorded by the Advanced LIGO detectors on 2015 September 14. The event candidate, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the gravitational wave data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network Circulars, giving an overview of the participating facilities, the gravitational wave sky localization coverage, the timeline and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the electromagnetic data and results of the electromagnetic follow-up campaign will be disseminated in the papers of the individual teams
Thermal Fatigue and Failure Analysis of Cu-Plated Through Hole Solder Joints
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Study on damage bifurcation and instability of rock-like materials
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study