Séfer sibhé ha-`Ari

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 201

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Sub-millimeter Size Sensors for Measurements in Cryogenic Turbulence

Abstract. Classical turbulence research is advancing by utilizing MEMS temperature and pressure fluctuation sensor technology. Turbulence research at cryogenic temperatures has many advantages over the classical approach, such as extreme stability of control parameters and very high Reynolds numbers in small apparatus. However, changes in material properties from room temperature to 1 K (and below) make most sensors unusable at low temperature. A new type of thermistor, incorporating a Ge-film deposited on a GaAs substrate, has been designed. It provides high sensitivity in the range of 20 mK to 5 K. In this paper, the design and characteristics of these sensors is discussed, and experimental data from three thermistors is presented. Progress on a miniature pressure transducer is also describe

Transboundary Air-Quality Effects from Urbanization

Introduction: The structure ofthe green house gas inventory follows the order established in the" Revised 1996 IPCC Guidelines-Greenhouse Gas Inventory Workbook, Volume 2", which has identified six major economic sectors, as fonows

Recueil de textes cabbalistiques

Contient : Isaac ben Salomon Luria (1534-1572). Ṣipraʾ dṣniyʿwtaʾ . ספרא דצניעותא ; Vital, Ḥayyîm ben Joseph (1542?-1620). Drwš nišmat ʾadam. דרוש נשמת האדםNumérisation effectuée à partir d'un document original.Mécénat : Numérisé en coopération avec la Bibliothèque nationale d'Israël et la Friedberg Jewish Manuscript Society dans le cadre du projet Ktiv.Recueil d'oeuvres d'Isaac ben Salomon Luria (1534-1572) et de Vital, Ḥayyîm ben Joseph (1542?-1620)En tête du manuscrit la date 29 mai 1896 pourrait être la date d'achat. Ex-libris aux initiales J.P

MiR-192 directly binds and regulates Dicer1 expression in neuroblastoma.

Neuroblastoma (NB) arises from the embryonic neural crest and is the most common extracranial solid tumor in children under 5 years of age. Reduced expression of Dicer1 has recently been shown to be in correlation with poor prognosis in NB patients. This study aimed to investigate the mechanisms that could lead to the down-regulation of Dicer1 in neuroblastoma. We used computational prediction to identify potential miRs down-regulating Dicer1 in neuroblastoma. One of the miRs that were predicted to target Dicer1 was miR-192. We measured the levels of miR-192 in 43 primary tumors using real time PCR. Following the silencing of miR-192, the levels of dicer1 cell viability, cell proliferation and migration capability were analyzed. Multivariate analysis identified miR-192 as an independent prognostic marker for relapse in neuroblastoma patients (p=0.04). We were able to show through a dual luciferase assay and side-directed mutational analysis that miR-192 directly binds the 3' UTR of Dicer1 on positions 1232-1238 and 2282-2288. An increase in cell viability, proliferation and migration rates were evident in NB cells transfected with miR-192-mimic. Yet, there was a significant decrease in proliferation when NB cells were transfected with an miR-192-inhibitor We suggest that miR-192 might be a key player in NB by regulating Dicer1 expression

Sefer Yefeh nof : [electronic resource] ... kol ha-tsarikh le-tiḳun sofrim ʻal pi ha-Ran ṿeha-Rashba ... : gam tefilah ... asher tiḳen ha-Ramban : ṿe-gam tefilah ... Mosheh n. Alashḳar ... : ʻim baḳashot ... Yitsḥaḳ Ashkenazi.

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