Examining the impacts of constructive controversy on a community of inquiry and open-mindedness in an asynchronous online discussion format

The community of inquiry (COI) framework is a theoretical and practical model for creating deep, meaningful online learning experiences through three essential and interconnected elements: teaching presence, social presence, and cognitive presence. Asynchronous online discussions (AODs) are the typical communication medium in a COI; therein, a sense of community (i.e., social presence) is designed and facilitated (i.e., teaching presence) to develop and foster critical inquiry (i.e., cognitive presence). The construct of cognitive presence is based on the practical inquiry model, which includes four phases—a triggering event, exploration, integration, and resolution—to foster critical thinking skills through knowledge generation and confirmation. However, a persistent finding in COI research is that learners experience difficulty in moving beyond the exploration phase. Across a variety of AOD types, learners demonstrate low engagement levels in integration and little or no resolution, which are the phases associated with higher-order critical thinking processes and skills. This problem of practice may be symptomatic of the focus of the COI framework on developing learners’ critical thinking skills and the inattention to critical thinking dispositions, such as open-mindedness and truth seeking. Thus, this quantitative, experimental posttest-only control group study investigates the impact of the constructive controversy (CC)-AOD learning strategy on learners’ perceptions of the COI, their actively open-minded thinking about evidence (AOT-E), and AOD rubric scores. Those in the treatment group participated in the CC-AOD learning strategy, a collaborative argumentation process in which learners worked in pairs and utilized perspective-switching to reach a consensus position on a controversial issue; learners in the control group worked independently. The treatment group had higher mean scores in every self-reported dependent variable, but the between-groups differences were nonsignificant. Learners in the treatment group, furthermore, exhibited significantly higher cognitive presence and social presence rubric scores in weekly AODs during the intervention period compared to the control group. Practical and theoretical implications are discussed, with a focus on the unique cultural context of the study and the potential conceptual mismatch between the COI and AOT-E

Center on Disability Studies eNewsletter, September 2023

Welcome to the September 2023 CDS Quarterly eNewsletter. Special highlights in this issue include: Maui Response Director’s Message Featured Artist Alexandra McClurg, MACL Educators Scholarship, Spark Aloha! H-PEP Inclusive First Aid/CPR/AED Upcoming Classes Nā Hōkū Newsletter Release, Project Hoʻokuʻi V Mia Ives-Rublee and Justice Shorter #PacRim 2024 Keynotes Hōkūlani Insider Newsletter Release, Project Hōkūlani Swim Safe: ASD Program Upcoming Classes Scholarships Opportunities, #PacRim2024 Sponsor and Exhibitor Invitations, #PacRim2024 Hawaiʻi Inclusive Early Childhood Professional Prep Project Soccer Classes, Wellness Matters Program Webinar with Dr. Jun Yaeda, University of Tsukuba, Japan September Events, Access to Independence Featured Film Release on KHON, The Power of Hoʻokuʻ

Center on Disability Studies eNewsletter, December 2023

As the year draws to a close and the holiday season is upon us, I want to extend my gratitude to our partners, collaborators, participants, students, and stakeholders on behalf of CDS. We genuinely appreciate the collective efforts that continually contribute to the success of our projects and initiatives. Looking ahead, we're gearing up for our Pac Rim Conference in February 2024, centered around the theme "Beyond Access: Building a Culture of Belonging," a concept we're deeply passionate about. This ethos guides our efforts within our unit and throughout our projects. Additionally, I encourage you to read about Dr. Steve Brown and his impactful legacy on CDS, within the AUCD network, and on Disability Culture. We celebrate his life and honor his memory

Center on Disability Studies eNewsletter, June 2023

Welcome to our summer newsletter. In this issue we highlight many events and happenings sponsored by CDS during June and July that you don’t want to miss out on. Disability Pride Month is also celebrated each year in July. Disability Pride initially started as a day of celebration in 1990, the year that the Americans with Disabilities Act (ADA) was signed into law. It is also an opportunity to raise awareness about improving access and inclusion. The first official Disability Pride celebration occurred in 2015 to commemorate the ADA’s 25th anniversary and the Disability Pride Flag was originally designed in 2019 by Ann Magill, who with feedback within the disabled community, refined its visual elements in 2021 to be more accessible. You can read more about how the disability pride flag helps increase the community’s visibility at https://go.hawaii.edu/qEX

Results from the centers for disease control and prevention's predict the 2013-2014 Influenza Season Challenge

Background: Early insights into the timing of the start, peak, and intensity of the influenza season could be useful in planning influenza prevention and control activities. To encourage development and innovation in influenza forecasting, the Centers for Disease Control and Prevention (CDC) organized a challenge to predict the 2013-14 Unites States influenza season. Methods: Challenge contestants were asked to forecast the start, peak, and intensity of the 2013-2014 influenza season at the national level and at any or all Health and Human Services (HHS) region level(s). The challenge ran from December 1, 2013-March 27, 2014; contestants were required to submit 9 biweekly forecasts at the national level to be eligible. The selection of the winner was based on expert evaluation of the methodology used to make the prediction and the accuracy of the prediction as judged against the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet). Results: Nine teams submitted 13 forecasts for all required milestones. The first forecast was due on December 2, 2013; 3/13 forecasts received correctly predicted the start of the influenza season within one week, 1/13 predicted the peak within 1 week, 3/13 predicted the peak ILINet percentage within 1 %, and 4/13 predicted the season duration within 1 week. For the prediction due on December 19, 2013, the number of forecasts that correctly forecasted the peak week increased to 2/13, the peak percentage to 6/13, and the duration of the season to 6/13. As the season progressed, the forecasts became more stable and were closer to the season milestones. Conclusion: Forecasting has become technically feasible, but further efforts are needed to improve forecast accuracy so that policy makers can reliably use these predictions. CDC and challenge contestants plan to build upon the methods developed during this contest to improve the accuracy of influenza forecasts. © 2016 The Author(s)

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Center on Disability Studies eNewsletter, March 2024

Welcome to the March 2024 issue of the CDS Quarterly eNewsletter. Join us in celebrating a Developmental Disability Awareness Month (DDAM) and recapping our 39th Annual Pacific Rim International Conference on Disability and Diversity. This issue includes special features that include: DD Council Day at the Capitol; CDS Annual Report (FY 2023); and CDS Project Highlights and Events

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

Summary: Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors. Mice deficient for the essential autophagy genes Atg5, Atg14, or Atg16L1 display a dramatic impairment in the growth of syngeneic tumors. Moreover, T cells lacking Atg5 have a profound shift to an effector memory phenotype and produce greater amounts of interferon-γ (IFN-γ) and tumor necrosis factor α (TNF-α). Mechanistically, Atg5−/− CD8+ T cells exhibit enhanced glucose metabolism that results in alterations in histone methylation, increases in H3K4me3 density, and transcriptional upregulation of both metabolic and effector target genes. Nonetheless, glucose restriction is sufficient to suppress Atg5-dependent increases in effector function. Thus, autophagy-dependent changes in CD8+ T cell metabolism directly regulate anti-tumor immunity. : DeVorkin et al. show that loss of autophagy enhances CD8+ T-cell-mediated rejection of tumors. Mechanistically, suppression of autophagy shifts T cells to a glycolytic phenotype and causes a reduction in S-adenosylmethionine. As a consequence, autophagy-deficient T cells transcriptionally reprogram immune response genes to an effector memory state. Keywords: autophagy, CD8+ T cells, anti-tumor immunity, glycolysis, lactate, SAM, methylatio