Broad band flux-density monitoring of radio sources with the Onsala twin telescopes

The Onsala twin telescopes (OTT) are two 13 m telescopes located at the Onsala Space Observatory in Sweden. With dual linear polarized broad-band (3-14 GHz) receivers, they are part of the next generation Very Long Baseline Interferometry (VLBI) Global Observing System (VGOS) for geodesy and astrometry. In addition to purely geodetic data products, VGOS will regularly produce full-polarisation images of hundreds of radio sources. These rich monitoring data will be valuable for both astronomy and geodesy. In this pilot study we aimed at monitoring ten bright radio sources to search for flares or similar activity, and at testing the instrument calibration on long (months) and short (hours) time scales. Using the OTT as a standalone instrument, we observed and analysed 91 short (<30 min) sessions spanning seven months. We monitored seven potentially variable radio sources (0059+581, 0552+398, 1144+402, 1156+295, 1617+229, 3C418, OJ287) and three reference calibrators (3C147, 3C286, 3C295). We used the Common Astronomy Software Applications (CASA) package to fringe-fit, bandpass-correct and scale the data to obtain flux densities in the four standard VGOS bands: 3.0-3.5 GHz (band 1), 5.2-5.7 GHz (band 2), 6.3-6.8 GHz (band 3), and 10.2-10.7 GHz (band 4). We obtained simultaneous multi-frequency light curves for ten radio sources. A bright multi-frequency flare is observed in the radio source 0059+581. OJ287 and 1156+295 show significant long-term variability in their light curves. After correcting for instrumental biases, we determine the empirical flux density uncertainty as similar to 5 %

Espaces et lieux de la musique

Michael Werner, directeur d’étudesKarine Le Bail, chargée de recherche au CNRSPatrice Veit, directeur de recherche au CNRS Espaces et lieux de musique : le musicien, l’architecte, le spectateur et le politique Ce séminaire bimensuel, à raison de séances de trois heures, a engagé depuis trois ans une réflexion sur la figuration de l’espace dans le champ scénique et musical. Durant l’année écoulée, Marie-Madeleine Mervant-Roux, directrice de recherche au CNRS (Arias, atelier de recherche sur l’..

Lieux et espaces de la musique

Michael Werner, directeur d’étudesKarine Le Bail, chargée de recherche au CNRSPatrice Veit, directeur de recherche au CNRS Espaces et lieux de musique : le musicien, l’architecte, le spectateur et le politique Dans le cadre de ce séminaire mensuel, à raison de séances de quatre heures, nous avons poursuivi l’exploration des différents aspects liés à l’espace qui structurent l’exécution et l’écoute de la musique. Pendant l’année 2009-2010, le séminaire était plus particulièrement centré sur la..

Telomeres and Genomic Instability from Precancerous Lesions to Advanced Cancer – Understanding Through Ovarian Cancer

Genetic instability plays an important role in ovarian carcinogenesis. Genetic instability is one of the characteristics shared by most human cancers and seems to exist (at various levels) at all stages of the disease, from precancerous lesions to advanced cancer. It is possible that this instability is one of the first trigger events, which would facilitate the subsequent establishment of all the other cancer hallmarks. Telomere shortening appears to take place in most human preinvasive epithelial lesions: short telomeres are found in up to 88% of early precancerous conditions of the bladder, cervix, colon, esophagus, or prostate. However, little is known about ovarian carcinogenesis and telomere shortening. Recent evidence has shown that the fallopian tube may be the origin of ovarian cancer. A new tubal carcinogenic sequence has been described with precancerous lesions that could metastasize to the ovary and result in invasive ovarian cancer. In this review, we will describe the degree of telomere shortening and genomic instability (estimated by the expression of DNA damage response proteins, such as H2AX, Chk2, ATM, 53BP1, p53, and TRF2, and by array comparative genomic hybridization) in early preinvasive stages of ovarian cancer (serous tubal intraepithelial carcinoma (STIC)), ovarian high-grade serous carcinoma, and benign controls. Given that STICs have the shortest telomeres, they could be in a telomere crisis phase preceding genomic stabilization due to telomerase activation (see appended diagram). Concordant results were obtained in immunohistochemical and molecular studies. The expression of all DNA damage proteins increased from benign fallopian tubes to STICs suggesting an early activation of the DNA damage response (DDR) pathways in STICs and indicating that genomic instability may occur early in the precancerous lesions of high-grade serous ovarian cancer (HGSC). In this chapter, we propose to review current knowledge about the function of human telomeres and telomerase and their relevance in genomic instability in cancer and to focus on specific results for ovarian cancer

GSFC VLBI Analysis Center

This report presents the activities of the GSFC VLBI Analysis Center during 2012. The GSFC VLBI Analysis Center analyzes all IVS sessions, makes regular IVS submissions of data and analysis products, and performs research and software development aimed at improving the VLBI technique

CRIA – Centre de recherches interdisciplinaires sur l’Allemagne

Christophe Duhamelle, Michael Werner, Pierre Monnet, directeurs d’étudesFalk Bretschneider, maître de conférencesBernd Klesmann, chercheur de l’Institut historique allemand, ParisChristine Lebeau, professeure à l’Université Paris-I/Panthéon-SorbonnePatrice Veit, directeur de recherche au CNRS Les mots de l’histoire : historiens allemands et français face à leurs concepts et à leurs outils Ce séminaire, organisé en partenariat avec l’Institut historique allemand de Paris et soutenu depuis 2008..

CRIA – Centre de recherches interdisciplinaires sur l’Allemagne

Christophe Duhamelle, Michael Werner, Pierre Monnet, directeurs d’étudesFalk Bretschneider, maître de conférencesBernd Klesmann, chercheur de l’Institut historique allemand, ParisChristine Lebeau, professeure à l’Université Paris-I/Panthéon-SorbonnePatrice Veit, directeur de recherche au CNRS Les mots de l’histoire : historiens allemands et français face à leurs concepts et à leurs outils Ce séminaire, organisé en partenariat avec l’Institut historique allemand de Paris et soutenu depuis 2008..

Centre de recherches interdisciplinaires sur l’Allemagne – CRIA

Jean-Louis Georget, maître de conférences à l’Université Paris-XIII/Nord L’ethnologie allemande de la Seconde Guerre mondiale à l’École de Tübingen Le travail a porté cette année sur l’étrange oubli de contextualisation de l’émergence de la discipline des sciences de la culture qu’est la Volkskunde, produit d’un long refoulement depuis la fin du XIXe siècle. Bernhard Tschofen, directeur de l’institut Ludwig Uhland de Tübingen, est venu parler, dans le cadre d’une invitation faite par le Centr..

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

La radio et la professionnalisation des métiers de la musique en France dans les années trente

International audienc