АНАЛИЗ УПРАВЛЯЕМЫХ ГЕНЕРАТОРОВ СИСТЕМ ФАЗОВОЙ СИНХРОНИЗАЦИИ

A technique for determining the main characteristics of the generators is proposed. The method is based on computer simulations of device’s electrical circuits.Рассмотрена методика определения основных характеристик управляемых генераторов, основывающаяся на компьютерном моделировании электрических схем устройств

Анализ импульсных устройств фазовой синхронизации с накачкой заряда

A mathematical model of impulse devices of phase locking with charge pumping has been developed in state space. The paper proposes an algorithm of modeling transient processes. An analytical expression for parasitic deviation of frequency in steady-state conditions has been obtained. An analysis of stability has been carried out.В пространстве состояний получена математическая модель импульсных устройств фазовой синхронизации с накачкой заряда. Предложен алгоритм моделирования переходных процессов. Получено аналитическое выражение для паразитной девиации частоты в установившемся режиме. Проведен анализ устойчивости

ПРИНЦИПЫ ПОСТРОЕНИЯ МАТЕМАТИЧЕСКИХ МОДЕЛЕЙ СИСТЕМ ФАЗОВОЙ СИНХРОНИЗАЦИИ

The results of various embodiments study of the hardware and software phase-locked loops, suggesting possible variants of generalized mathematical models of the multi-systems as well as devices with a cyclic interrupt mode-locked are presented. One of the possible algorithms of phase-locked loops software functioning is offered.Приведены результаты исследования различных вариантов реализации аппаратных и программных систем фазовой синхронизации, предложены возможные варианты построения обобщенных математических моделей многокольцевых систем, а также устройств с циклическим прерыванием режима автоподстройки. Предложен один из возможных алгоритмов функционирования программной системы фазовой синхронизации

High-power ultrasonic synthesis and magnetic-field-assisted arrangement of nanosized crystallites of cobalt-containing layered double hydroxideu

High-quality stoichiometric Co2Al–NO3 and Co2Al–CO3 layered double hydroxides (LDHs) have been obtained by precipitation followed by anion exchange, both high-power sonication assisted. Application of high-power ultrasound has been demonstrated to result in a considerable acceleration of the crystallization process and the anion-exchange reaction. Two independent approaches were used to form bulk and 2-D samples of Co2Al–NO3 with the oriented crystallites, namely uniaxial pressing of deposits from sonicated LDH slurries and magnetic field assisted arrangement of LDH crystallites precipitating on glass substrates. A convenient way of preparation of semi-transparent compacts with relatively big blocks of oriented crystallites have been demonstrated. Thin dense transparent films of highly-ordered crystallites of Co2Al–NO3 LDH have been produced and characterized.publishe

Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway

<p>Abstract</p> <p>Background</p> <p>Dozens of Traditional Chinese Medicine (TCM) formulas have been used for promotion of "blood production" for centuries, and we are interested in developing novel thrombopoietic medicines from these TCMs. Our previous studies have demonstrated the hematopoietic effects of DangGui BuXue Tong (DBT), a formula composed of <it>Radix Angelicae Sinensis </it>and <it>Radix Astragali </it>in animal and cellular models. As a step further to identify and characterize the active chemical components of DBT, we tested the hematopoietic and particularly, thrombopoietic effects of polysaccharide-enriched fractions from the root of <it>Radix Angelicae Sinensis </it>(APS) in this study.</p> <p>Methods</p> <p>A myelosuppression mouse model was treated with APS (10 mg/kg/day). Peripheral blood cells from APS, thrombopoietin and vehicle-treated samples were then counted at different time-points. Using the colony-forming unit (CFU) assays, we determined the effects of APS on the proliferation and differentiation of hematopoietic stem/progenitor cells and megakaryocytic lineages. Using a megakaryocytic cell line M-07e as model, we analyzed the cellular apoptosis progression with and without APS treatment by Annexin V, Mitochondrial Membrane Potential and Caspase 3 assays. Last, the anti-apoptotic effect of APS on cells treated with Ly294002, a Phosphatidylinositol 3-Kinse inhibitor (PI3K) was also tested.</p> <p>Results</p> <p>In animal models, APS significantly enhanced not only the recovery of platelets, other blood cells and their progenitor cells, but also the formation of Colony Forming Unit (CFU). In M-07e cells, we observed the anti-apoptotic effect of APS. Treatment by Ly294002 alone increased the percentage of cells undergoing apoptosis. However, addition of APS to Ly294002-treated cells significantly reduced the percentage of cells undergoing apoptosis.</p> <p>Conclusions</p> <p>APS promotes hematopoiesis and thrombopoiesis in the mouse model. This effect likely resulted from the anti-apoptosis activity of APS and is likely to involve the PI3K/AKT pathway.</p

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

ANALySIS OF PHASE-LOCKED SYSTEM VOLTAGE CONTROLLED OSCILLATORS

A technique for determining the main characteristics of the generators is proposed. The method is based on computer simulations of device’s electrical circuits

Analysis of Impulse Devices of Phase Locking with Charge Pumping

A mathematical model of impulse devices of phase locking with charge pumping has been developed in state space. The paper proposes an algorithm of modeling transient processes. An analytical expression for parasitic deviation of frequency in steady-state conditions has been obtained. An analysis of stability has been carried out

PRINCIPLES OF PHASE-LOCKED LOOPS MATHEMATICAL MODELS CONSTRUCTION

The results of various embodiments study of the hardware and software phase-locked loops, suggesting possible variants of generalized mathematical models of the multi-systems as well as devices with a cyclic interrupt mode-locked are presented. One of the possible algorithms of phase-locked loops software functioning is offered