57 research outputs found
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- Author
- Abecasis Goncalo R.
- Adair Linda S.
- Afaq Saima
- Afzal Uzma
- Ahluwalia Tarunveer S.
- Ahmad Shafqat
- Alfred Tamuno
- Amin Najaf
- Bakker Stephan J. L.
- Baldassarre Damiano
- Balkau Beverley
- Bandinelli Stefania
- Barata Llilda
- Barroso Ines
- Bartz Traci M.
- Beilby John
- Bergman Richard N.
- Bergmann Sven
- Bielak Lawrence F.
- Bien Stephanie A.
- Biffar Reiner
- Blangero John
- Boehnke Michael
- Boerwinkle Eric
- Boger Carsten A.
- Bonnefond Amelie
- Bonnycastle Lori L.
- Boomsma Dorret I.
- Borecki Ingrid B.
- Bottinger Erwin
- Bouchard Claude
- Braga Daniele
- Bragg Jennifer
- Bruinenberg Marcel
- Buckley Brendan M.
- Buyske Steve
- Cadby Gemma
- Campbell Harry
- Chambers John C.
- Chasman Daniel I.
- Chen Yii-Der Ida
- Chines Peter S.
- Chittani Martina
- Chu Audrey Y.
- Coggeshall Scott
- Collins Francis S.
- Cooper Richard S.
- Corre Tanguy
- Cucca Francesco
- Cupples L. Adrienne
- Curran Joanne E.
- Cusi Daniele
- Czajkowski Jacek
- de Borst Gert J.
- de Craen Anton J. M.
- de Faire Ulf
- de Geus Eco J. C.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panagiotis
- den Ruijter Hester M.
- Deng Xuan
- Direk Nese
- Eicher John D.
- Eiriksdottir Gudny
- Eriksson Anna L.
- Eriksson Joel
- Esko Tonu
- Faul Jessica D.
- Feitosa Mary F.
- Ferrucci Luigi
- Fischer Krista
- Fisher Virginia A.
- Ford Ian
- Forrester Terrence
- Fox Caroline S.
- Franks Paul W.
- Frayling Timothy M.
- Froguel Philippe
- Gertow Karl
- Gigante Bruna
- Glorioso Nicola
- Gong Jian
- Gordon-Larsen Penny
- Gorski Mathias
- Grabe Hans-Jorgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B.
- Grarup Niels
- Gudnason Vilmundur
- Hadley David
- Haiman Christopher A.
- Haitjema Saskia
- Hallmans Goran
- Hamsten Anders
- Hansen Torben
- Harder Marie Neergaard
- Harris Tamara B.
- Hartman Catharina A.
- Hassinen Maija
- Hastie Nicholas D.
- Hayward Caroline
- Heard-Costa Nancy L.
- Heath Andrew C.
- Heid Iris M.
- Hernandez Dena
- Hindorff Lucia
- Hirschhorn Joel N.
- Hocking Lynne J.
- Hollensted Mette
- Holmen Oddgeir L.
- Homuth Georg
- Horikoshi Momoko
- Hottenga Jouke Jan
- Huang Jie
- Huang Tao
- Huffman Jennifer E.
- Hung Joseph
- Hunter David J.
- Hutri-Kahonen Nina
- Hveem Kristian
- Ingelsson Erik
- Jackson Anne U.
- James Alan L.
- Jansson John-Olov
- Jarvelin Marjo-Riitta
- Jhun Min A.
- Johnson Andrew D.
- Jorgensen Marit E.
- Jukema Wouter
- Juonala Markus
- Justesen Johanne Marie
- Justice Anne E.
- Kahonen Mika
- Kanoni Stavroula
- Kardia Sharon L. R.
- Karlsson Magnus
- Kilpelainen Tuomas O.
- Kinnunen Leena
- Kivimaki Mika
- Kleber Marcus E.
- Koistinen Heikki A.
- Kolcic Ivana
- Kolovou Genovefa
- Komulainen Pirjo
- Kooner Jaspal S.
- Kooperberg Charles
- Kramer Bernhard K.
- Kuh Diana
- Kumari Meena
- Kutalik Zoltan
- Kuusisto Johanna
- Kvaloy Kirsti
- Laakso Markku
- Lakka Timo A.
- Langenberg Claudia
- Launer Lenore J.
- Le Marchand Loic
- Leander Karin
- Lee Nanette R.
- Lehtimaki Terho
- Lim Elise
- Lim Unhee
- Lind Lars
- Lindgren Cecilia M.
- Linneberg Allan
- Liu Ching-Ti
- Lobbens Stephane
- Loh Marie
- Loos Ruth J. F.
- Lorentzon Mattias
- Luan Jian'an
- Luben Robert
- Lubke Gitta
- Ludolph-Donislawski Anja
- Lupoli Sara
- Lyytikainen Leo-Pekka
- Madden Pamela A. F.
- Mahajan Anubha
- Mangino Massimo
- Manichaikul Ani
- Mannikko Reija
- Marchini Jonathan
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Nicholas G.
- Marz Winfried
- McCarthy Mark I.
- McKenzie Colin A.
- McKnight Barbara
- Mellstrom Dan
- Menni Cristina
- Metspalu Andres
- Middelberg Rita P. S.
- Mohlke Karen L.
- Montgomery Grant W.
- Morris Andrew P.
- Mueller-Nurasyid Martina
- Musk A. W. (Bill)
- Narisu Narisu
- Nauck Matthias
- Navarro Pau
- Ngwa Julius S.
- Nolte Ilja M.
- North Kari E.
- Ohlsson Claes
- Oldehinkel Albertine J.
- Olden Matthias
- Ong Ken K.
- Padmanabhan Sandosh
- Palmer Lyle J.
- Pasterkamp Gerard
- Pedersen Oluf
- Perez Jeremiah
- Perusse Louis
- Pervjakova Natalia
- Peters Annette
- Peters Ulrike
- Peyser Patricia A.
- Pisinger Charlotta
- Polasek Ozren
- Porteous David J.
- Psaty Bruce M.
- Qi Lu
- Qi Qibin
- Raitakari Olli T.
- Rankinen Tuomo
- Rao D. C.
- Rasmussen-Torvik Laura J.
- Rauramaa Rainer
- Rawal Rajesh
- Renstrom Frida
- Rice Treva
- Ridker Paul M.
- Rose Lynda M.
- Rudan Igor
- Sanna Serena
- Sarti Cinzia
- Sarzynski Mark A.
- Sattar Naveed
- Savonen Kai
- Schlessinger David
- Scholtens Salome
- Schurmann Claudia
- Scott Robert A.
- Sennblad Bengt
- Siemelink Marten A.
- Silbernagel Gunther
- Slagboom P. Eline
- Smith Albert Vernon
- Smith Blair H.
- Smith Jennifer A.
- Snieder Harold
- Sorensen Thorkild I. A.
- Spector Tim D.
- Staessen Jan A.
- Stancakova Alena
- Stott David J.
- Strachan David P.
- Strauch Konstantin
- Strawbridge Rona J.
- Stringham Heather M.
- Sung Yun Ju
- Swertz Morris A.
- Swift Amy J.
- Tanaka Toshiko
- Taylor Kent D.
- Tayo Bamidele O.
- Teumer Alexander
- Thorand Barbara
- Thuillier Dorothee
- Tiemeier Henning
- Tremoli Elena
- Trompet Stella
- Tuomilehto Jaakko
- Tyrrell Jessica
- Uitterlinden Andre G.
- Van der Harst Pim
- van der Laan Sander W.
- van der Most Peter J.
- van Duijn Cornelia M.
- Van Vliet-Ostaptchouk Jana V.
- Vandenput Liesbeth
- Vedantam Sailaja L.
- Verweij Niek
- Vestergaard Henrik
- Vink Jacqueline M.
- Vitart Veronique
- Vohl Marie-Claude
- Vollenweider Peter
- Volzke Henry
- Vonk Judith M.
- Waeber Gerard
- Waldenberger Melanie
- Wareham Nicholas J.
- Weir David R.
- Westendorp R. G. J.
- Whitfield John B.
- Wild Sarah
- Willemsen Gonneke
- Wilson James F.
- Winkler Thomas W.
- Wolffenbuttel Bruce H. R.
- Wong Andrew
- Wright Alan F.
- Wu Joseph
- Wu Ying
- Xue Luting
- Yengo Loic
- Young Kristin
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zillikens M. Carola
- Zimmermann Martina E.
- Zubair Niha
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.Peer reviewe
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Aspelund Thor
- Aulchenko Yurii
- Bakker Stephan J.L.
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bis Joshua C.
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burton Paul R.
- Campbell Harry
- Casas Juan P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Charlotte Onland-Moret N.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Ming-Huei
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Curb J. David
- Dahgam Santosh
- Danesh John
- Day Ian N.M.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Denniff Matthew
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo P.
- Dreisbach Albert W.
- Dries Daniel L.
- Dörr Marcus
- Eaton Charles B.
- Ehret Georg B.
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Eyheramendy Susana
- Fabsitz Richard R.
- Farlow Deborah N.
- Farrall Martin
- Fava Cristiano
- Ferrucci Luigi
- Forrester Terrence
- Fowkes Gerald R.
- Fox Ervin R.
- Franceschini Nora
- Frayling Timothy M.
- Galan Pilar
- Ganesh Santhi
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Goel Anuj
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Hercberg Serge
- Hernandez Dena
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hirschorn Joel N.
- Hoffman Bolton Judith A.
- Hofman Albert
- Hopewell Jemma C.
- Howard Philip
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jackson Anne U.
- Jafar Tazeen H.
- Janipalli Charles S.
- JinGo Min
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Kang Sun J.
- Kangas Antti J.
- Kao Wen Hong Linda
- Kardia Sharon L.R.
- Kathiresan Sekar
- Keating Brendan J.
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kooner Jaspal S.
- Kranthi Kumar M.J.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumari Meena
- Kutlar Abdullah
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Li Yali
- Liu Kiang
- Liu Yongmei
- Lohman Kurt K.
- Longstreth Will T.
- Loos Ruth J.F.
- Luan Jian'an
- Lucas Gavin
- Ludwig Barbara
- Lyon Helen N.
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- MariaCorsi Anna
- Marmot Michael G.
- Martin Lisa W.
- Mattace-Raso Francesco U.S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Meschia James F.
- Miki Tetsuro
- Milaneschi Yuri
- Mohlke Karen L.
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Musani Solomon K.
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Navis Gerjan
- Newton-Cheh Christopher
- Nguyen Khanh-Dung Hoang
- Nilsson Peter
- Nyberg Fredrik
- O'Connell Jeffrey R.
- O'Donnell Chris
- O'Reilly Paul F.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ongen Halit
- Oostra Ben A.
- Org Elin
- Orru Marco
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Penman Alan D.
- Perola Markus
- Pihur Vasyl
- Platou Carl G.P.
- Plump Andrew
- Polak Josef F.
- Polasek Ozren
- Prabhakaran Dorairajan
- Pramstaller Peter P.
- Prokopenko Inga
- Psaty Bruce M.
- Radha Mani K.
- Raffel Leslie J.
- Raitakari Olli
- Ramachandran Vasan S.
- Rao Dabeeru C.
- Rasheed Asif
- Redline Susan
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rosengren Annika
- Rotimi Charles N.
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Schwartz Steven M.
- Schwarz Peter E.H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shrine Nick R.G.
- Shriner Daniel
- Shuldiner Alan R.
- Shyong Tai E.
- Sijbrands Eric J.G.
- Sim Xueling
- Singleton Andrew
- Sjögren Marketa
- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Snieder Harold
- Soininen Pasi
- SolerArtigas Maria
- Soranzo Nicole
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Swift Amy J.
- Sõber Siim
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka Toshiko
- Taylor Andrew
- Taylor Herman A.
- Tayo Bamidele O.
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Tobin Martin D.
- Tomaszewski Maciej
- Townsend Raymond R.
- Tripathy Vikal
- Tukiainen Taru
- Tuomilehto Jaakko
- Twee-Hee Ong Rick
- Tzoulaki Ioanna
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S.P.M.
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D.G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- Wichmann H.-Erich
- Wiggins Kerri L.
- Wild Sarah H.
- Wilson James F.
- Witteman Jacqueline C.M.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Wyatt Sharon B.
- Würz Peter
- Yajnik Chittaranjan S.
- Yao Jie
- Young J. Hunter
- Zelenika Diana
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- Publication date
- 02/08/2017
- Field of study
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10−8) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10−8). The top IBC association for SBP was rs2012318 (P= 6.4 × 10−6) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10−6) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexit
Non-Standard Errors
- Author
- Abad-Díaz David
- Abudy Menachem
- Adrian Tobias
- Ait-Sahalia Yacine
- Akmansoy Olivier
- Alcock Jamie T.
- Alexeev Vitali
- Aloosh Arash
- Amato Livia
- Amaya Diego
- Angel James J.
- Avetikian Alejandro T.
- Bach Amadeus
- Baidoo Edwin
- Bakalli Gaetan
- Bao Li
- Barbon Andrea
- Bashchenko Oksana
- Bindra Parampreet C.
- Bjønnes Geir H.
- Black Bernard S.
- Black Jeffrey R.
- Bogoev Dimitar
- Bohorquez Correa Santiago
- Bondarenko Oleg
- Bos Charles S.
- Bosch-Rosa Ciril
- Bouri Elie
- Brownlees Christian
- Calamia Anna
- Cao Viet Nga
- Capelle-Blancard Gunther
- Capera Romero Laura M.
- Caporin Massimiliano
- Carrion Allen
- Caskurlu Tolga
- Chakrabarty Bidisha
- Chen Jian
- Chernov Mikhail
- Cheung William
- Chincarini Ludwig B.
- Chordia Tarun
- Chow Sheung-Chi
- Clapham Benjamin
- Colliard Jean-Edouard
- Comerton-Forde Carole
- Curran Edward
- Dao Thong
- Dare Wale
- Davies Ryan J.
- De Blasis Riccardo
- De Nard Gianluca F.
- Declerck Fany
- Deev Oleg
- Degryse Hans
- Deku Solomon Y.
- Desagre Christophe
- Dim Chukwuma
- Dimpfl Thomas
- Dong Yun Jiang
- Dreber Anna
- Drummond Philip A.
- Dudda Tom
- Duevski Teodor
- Dumitrescu Ariadna
- Dyakov Teodor
- Dyhrberg Anne Haubo
- Dzielinski Michał
- Eksi Asli
- El Kalak Izidin
- Eugster Nicolas
- Evans Martin D. D.
- Farrell Michael
- Felez-Vinas Ester
- Ferrara Gerardo
- Ferrouhi El Mehdi
- Flori Andrea
- Fluharty Jonathan T.
- Foley Sean D. V.
- Fong Kingsley Y. L.
- Foucault Thierry
- Franus Tatiana
- Franzoni Francesco
- Frijns Bart
- Frömmel Michael
- Fu Servanna M.
- Füllbrunn Sascha C.
- Gan Baoqing
- Gao Ge
- Gehrig Thomas P.
- Gemayel Roland
- Gerritsen Dirk
- Gil-Bazo Javier
- Gilder Dudley
- Glosten Lawrence R.
- Gomez Thomas
- Gorbenko Arseny
- Grammig Joachim
- Grégoire Vincent
- Güçbilmez Ufuk
- Hagströmer Björn
- Hambuckers Julien
- Hapnes Erik
- Harris Jeffrey H.
- Harris Lawrence
- Hartmann Simon
- Hasse Jean-Baptiste
- Hautsch Nikolaus
- He Xue-Zhong (Tony)
- Heath Davidson
- Hediger Simon
- Hendershott Terrence
- Hibbert Ann Marie
- Hjalmarsson Erik
- Hoelscher Seth
- Hoffmann Peter
- Holden Craig W.
- Holzmeister Felix
- Horenstein Alex R.
- Huang Da
- Huang Wenqian
- Huber Juergen
- Hurlin Christophe
- Ilczuk Konrad
- Ivashchenko Alexey
- Iyer Subramanian R.
- Jahanshahloo Hossein
- Jalkh Naji P.
- Johannesson Magnus
- Jones Charles M.
- Jurkatis Simon
- Jylhä Petri
- Kaeck Andreas T.
- Kaiser Gabriel
- Karam Arzé
- Karmaziene Egle
- Kassner Bernhard
- Kaustia Markku
- Kazak Ekaterina
- Kearney Fearghal
- Kervel Vincent van
- Khan Saad A.
- Khomyn Marta K.
- Kirchler Michael
- Klein Olga
- Klein Tony
- Klos Alexander
- Koetter Michael
- Kolokolov Aleksey
- Korajczyk Robert A.
- Kozhan Roman
- Krahnen Jan P.
- Kuhle Paul
- Kwan Amy
- Lajaunie Quentin
- Lam F. Y. Eric C.
- Lambert Marie
- Langlois Hugues
- Lausen Jens
- Lauter Tobias
- Leippold Markus
- Levin Vladimir
- Li Hui
- Li Yijie
- Liew Chee Yoong
- Lindner Thomas
- Linton Oliver
- Liu Anqi
- Liu Jiacheng
- Llorente Guillermo
- Lof Matthijs
- Lohr Ariel
- Longstaff Francis
- Lopez-Lira Alejandro
- Mankad Shawn
- Mano Nicola
- Marchal Alexis
- Martineau Charles
- Mazzola Francesco
- Meloso Debrah
- Menkfeld Albert J.
- Mi Michael G.
- Mihet Roxana
- Mohan Vijay
- Moinas Sophie
- Moore David
- Mu Liangyi
- Muravyev Dmitriy
- Murphy Dermot
- Neszveda Gabor
- Neumeier Christian
- Neusüss Sebastian
- Nielsson Ulf
- Nimalendran Mahendrarajah
- Nolte Sven
- Norden Lars L.
- O'Neill Peter W.
- Obaid Khaled
- Pagnotta Emiliano
- Painter Marcus
- Palan Stefan
- Palit Imon J.
- Park Andreas
- Pascual Roberto
- Pasquariello Paolo
- Pastor Lubos
- Patel Vinay
- Patton Andrew J.
- Pearson Neil D.
- Pelizzon Loriana
- Pelli Michele
- Pelster Matthias
- Pfiffer Cameron
- Philip Richard
- Plíhal Tomáš
- Prakash Puneet
- Press Oliver-Alexander
- Prodromou Tina
- Prokopczuk Marcel
- Putnins Talis
- Pérignon Christophe
- Qian Ya
- Raizada Gaurav
- Rakowski David
- Ranaldo Angelo
- Razen Michael
- Regis Luca
- Reitz Stefan
- Renault Thomas
- Renjie Rex W.
- Reno Roberto
- Riddiough Steven J.
- Rinne Kalle
- Rintamäki Paul J.
- Riordan Ryan
- Rittmannsberger Thomas
- Rodríguez Longarela Iñaki
- Roesch Dominik
- Rognone Lavinia
- Roseman Brian
- Rosu Ioanid
- Roy Saurabh
- Rudolf Nicolas
- Rush Stephen R.
- Rzayev Khaladdin
- Rzeznik Aleksandra A.
- Sanford Anthony
- Sankaran Harikumar
- Sarkar Asani
- Sarno Lucio
- Scaillet Olivier
- Scharnowski Stefan
- Schenk-Hoppé Klaus R.
- Schertler Andrea
- Schneider Michael
- Schroeder Florian
- Schuster Philipp
- Schwarz Marco A.
- Schürhoff Norman
- Seasholes Mark S.
- Seeger Norman J.
- Shachar Or
- Shkilko Andriy
- Shui Jessica
- Sikic Mario
- Simion Giorgia
- Smales Lee A.
- Sojli Elvira
- Sokolov Konstantin
- Spokeviciute Laima
- Stefanova Denitsa
- Subrahmanyam Marti G.
- Szaszi Barnabas
- Söderlind Paul
- Sönksen Jantje
- Talavera Oleksandr
- Tang Yuehua
- Taylor Nick
- ter Ellen Saskia
- Tham Wing Wah
- Theissen Erik
- Thimme Julian
- Tonks Ian
- Tran Hai
- Trapin Luca
- Trolle Anders B.
- Vaduva M. Andreea
- Valente Giorgio
- van der Wel Michel
- van Dijk Mathijs A.
- Van Ness Robert A.
- Vasquez Aurelio
- Verousis Thanos
- Verwijmeren Patrick
- Vilhelmsson Anders
- Vilkov Grigory
- Vladimirov Vladimir
- Vogel Sebastian
- Voigt Stefan
- Wagner Wolf
- Walther Thomas
- Weiss Patrick
- Weitzel Utz
- Werner Ingrid M.
- Westerholm Joakim
- Westheide Christian
- Wika Hans C.
- Wipplinger Evert
- Wolf Michael
- Wolff Christian C. P.
- Wolk Leonard
- Wong Wink-Keung
- Wrampelmeyer Jan
- Wu Zhen-Xing
- Xia Shuo
- Xiu Dacheng
- Xu Caihong
- Xu Ke
- Yadav Pradeep K.
- Yagüe José
- Yan Cheng
- Yang Antti
- Yoo Woongsun
- Yu Shihao
- Yu Wenjia
- Yu Yihe
- Yueshen Bart Z.
- Yuferova Darya
- Zamojski Marcin
- Zareei Abalfazl
- Zeisberger Stefan M.
- Zhang Lu
- Zhang S. Sarah
- Zhang Xiaoyu
- Zhao Lu
- Zhong Zhuo
- Zhou Chen
- Zhou Zeyang (Ivy)
- Zhu Xingyu S.
- Zoican Marius
- Zwinkels Remco
- Östberg Per
- Ødegaard Bernt A.
- Publication venue
- Publication date
- 11/02/2023
- Field of study
In statistics, samples are drawn from a population in a data-generating process (DGP). Standard errors measure the uncertainty in estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence-generating process (EGP). We claim that EGP variation across researchers adds uncertainty: Non-standard errors (NSEs). We study NSEs by letting 164 teams test the same hypotheses on the same data. NSEs turn out to be sizable, but smaller for better reproducible or higher rated research. Adding peer-review stages reduces NSEs. We further find that this type of uncertainty is underestimated by participants
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
- Author
- Abecasis GR
- Abecasis Gonçalo R.
- Absher D
- Adair Linda S.
- Adeyemo Adebowale
- Aherrahrou Z
- Ahmadi KR
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler D
- Altshuler David
- Amin Najaf
- Andersen K
- Aragam J
- Arfan Ikram M.
- Arking DE
- Arking Dan E.
- Arnett D
- Arora Pankaj
- Artigas Maria Soler
- Aspelund T
- Aspelund Thor
- Assimes TL
- Atkinson EJ
- Aulchenko YS
- Aulchenko YS
- Aulchenko YS
- Aulchenko Yurii
- Badola S
- Bakker SJ
- Bakker Stephan J. L.
- Ball SG
- Balmforth AJ
- Bandinelli Stefania
- Barbalic M
- Barroso Inês
- Beckmann J
- Beckmann Jacques S.
- Beilby John P.
- Benjamin E
- Benjamin EJ
- Bergman Richard N.
- Bergmann Sven
- Bickel C
- Bilo HJ
- Bis J
- Bis JC
- Bis JC
- Bis Joshua C.
- Blankenberg S
- Blankenberg S
- Blankenberg S
- Blettner M
- Boban M
- Bochud M
- Bochud Murielle
- Boehnke Michael
- Boerwinkle E
- Boerwinkle E
- Boerwinkle E
- Boerwinkle Eric
- Bolton Judith A Hoffman
- Bonnycastle Lori L.
- Borecki I
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Brandstätter A
- Braund PS
- Braund Peter S.
- Brown MJ
- Brown Morris J.
- Bruse P
- Burnett MS
- Burton Paul R.
- Burtt N
- Böger CA
- Böhm BO
- Cambien F
- Campbell H
- Campbell S
- Campbell Harry
- Casas Juan P.
- Caulfield MJ
- Caulfield Mark J.
- Cavalieri M
- Chakravarti Aravinda
- Chambers JC
- Chambers John C.
- Chandak Giriraj R.
- Chang PP
- Chang Yen-Pei C.
- Charchar Fadi J.
- Charlotte Onland-Moret N.
- Chasman DI
- Chasman Daniel I.
- Chaturvedi Nish
- Chen IY
- Chen L
- Chen Ming-Huei
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Connell JM
- Connell John M.
- Cook HT
- Cook HT
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh J
- Coresh Josef
- Cornelis MC
- Corsi Anna Maria
- Cotlarciuc I
- Cotlarciuc I
- Couper D
- Cupples LA
- Cupples LA
- Curhan GC
- Dahgam Santosh
- Dandona S
- Danesh John
- Davey Smith G
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- de Jong PE
- de Silva R
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- Dreisbach Albert W.
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- Olden Matthias
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- Uitterlinden AG
- Uitterlinden AG
- Uitterlinden AG
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst P
- van der Harst Pim
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- Wang Xiaoling
- Wareham NJ
- Wareham Nicholas J.
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- Waterworth DM
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- Wichmann HE
- Wichmann HE
- Wichmann H. -Erich
- Wiggins Kerri L.
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- Wilensky R
- Willenborg C
- Willerson JT
- Wilson JF
- Wilson James F.
- Winkelmann BR
- Winkler K
- Witteman JC
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- Witteman JC
- Witteman Jacqueline C. M.
- Wong Andrew
- Wong Tien Y.
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- Wright BJ
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yang Q
- Yao Jie
- Zaboli G
- Zelenika Diana
- Zeller T
- Zeller T
- Zeller T
- Zemunik T
- Zerres K
- Zgaga L
- Zhai Guangju
- Zhang W
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Ziegler A
- Ziegler A
- Ziegler A
- Zillikens MC
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Zweiker R
- Publication venue
- Nature
- Publication date
- 01/01/2011
- Field of study
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Aspelund Thor
- Aulchenko Yurii
- Bakker Stephan J.L.
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bis Joshua C.
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burton Paul R.
- Campbell Harry
- Casas Juan P.
- Caulfield Mark J.
- Chakravarti Aravinda
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Charlotte Onland-Moret N.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Ming-Huei
- Cho Yoon Shin
- Clarke Robert
- Collins Francis S.
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Curb J. David
- Dahgam Santosh
- Danesh John
- Day Ian N.M.
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Denniff Matthew
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo P.
- Dreisbach Albert W.
- Dries Daniel L.
- Dörr Marcus
- Eaton Charles B.
- Ehret Georg B.
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Eyheramendy Susana
- Fabsitz Richard R.
- Farlow Deborah N.
- Farrall Martin
- Fava Cristiano
- Ferrucci Luigi
- Forrester Terrence
- Fowkes Gerald R.
- Fox Ervin R.
- Franceschini Nora
- Frayling Timothy M.
- Galan Pilar
- Ganesh Santhi
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Goel Anuj
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Hercberg Serge
- Hernandez Dena
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hirschorn Joel N.
- Hoffman Bolton Judith A.
- Hofman Albert
- Hopewell Jemma C.
- Howard Philip
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jackson Anne U.
- Jafar Tazeen H.
- Janipalli Charles S.
- JinGo Min
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Kang Sun J.
- Kangas Antti J.
- Kao Wen Hong Linda
- Kardia Sharon L.R.
- Kathiresan Sekar
- Keating Brendan J.
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kooner Jaspal S.
- Kranthi Kumar M.J.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumari Meena
- Kutlar Abdullah
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Li Yali
- Liu Kiang
- Liu Yongmei
- Lohman Kurt K.
- Longstreth Will T.
- Loos Ruth J.F.
- Luan Jian'an
- Lucas Gavin
- Ludwig Barbara
- Lyon Helen N.
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- MariaCorsi Anna
- Marmot Michael G.
- Martin Lisa W.
- Mattace-Raso Francesco U.S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- Meitinger Thomas
- Melander Olle
- Meneton Pierre
- Meschia James F.
- Miki Tetsuro
- Milaneschi Yuri
- Mohlke Karen L.
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Musani Solomon K.
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Navis Gerjan
- Newton-Cheh Christopher
- Nguyen Khanh-Dung Hoang
- Nilsson Peter
- Nyberg Fredrik
- O'Connell Jeffrey R.
- O'Donnell Chris
- O'Reilly Paul F.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ongen Halit
- Oostra Ben A.
- Org Elin
- Orru Marco
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Penman Alan D.
- Perola Markus
- Pihur Vasyl
- Platou Carl G.P.
- Plump Andrew
- Polak Josef F.
- Polasek Ozren
- Prabhakaran Dorairajan
- Pramstaller Peter P.
- Prokopenko Inga
- Psaty Bruce M.
- Radha Mani K.
- Raffel Leslie J.
- Raitakari Olli
- Ramachandran Vasan S.
- Rao Dabeeru C.
- Rasheed Asif
- Redline Susan
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Rosengren Annika
- Rotimi Charles N.
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Schwartz Steven M.
- Schwarz Peter E.H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shrine Nick R.G.
- Shriner Daniel
- Shuldiner Alan R.
- Shyong Tai E.
- Sijbrands Eric J.G.
- Sim Xueling
- Singleton Andrew
- Sjögren Marketa
- Smith Albert V.
- Smith George Davey
- Smith Nicholas L.
- Snieder Harold
- Soininen Pasi
- SolerArtigas Maria
- Soranzo Nicole
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Swift Amy J.
- Sõber Siim
- Tabara Yasuharu
- Talmud Philippa J.
- Tanaka Toshiko
- Taylor Andrew
- Taylor Herman A.
- Tayo Bamidele O.
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Tobin Martin D.
- Tomaszewski Maciej
- Townsend Raymond R.
- Tripathy Vikal
- Tukiainen Taru
- Tuomilehto Jaakko
- Twee-Hee Ong Rick
- Tzoulaki Ioanna
- Uda Manuela
- Ueshima Hirotsugu
- Uiterwaal Cuno S.P.M.
- Uitterlinden Andre G.
- Umemura Satoshi
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- Vartiainen Erkki
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D.G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- Wichmann H.-Erich
- Wiggins Kerri L.
- Wild Sarah H.
- Wilson James F.
- Witteman Jacqueline C.M.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Wyatt Sharon B.
- Würz Peter
- Yajnik Chittaranjan S.
- Yao Jie
- Young J. Hunter
- Zelenika Diana
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- Hum Mol Genet
- Publication date
- 01/01/2011
- Field of study
The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity
A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension
- Author
- Abecasis Gonçalo R.
- Adair Linda S.
- Adeyemo Adebowale
- Ala-Korpela Mika
- Alexander Myriam
- Altshuler David
- Amin Najaf
- Arfan Ikram M.
- Arking Dan E.
- Arora Pankaj
- Aspelund Thor
- Aulchenko Yurii
- Bakker Stephan J. L.
- Bandinelli Stefania
- Barroso Inês
- Beckmann Jacques S.
- Beckmann Jacques S.
- Beilby John P.
- Beilby John P.
- Bergman Richard N.
- Bergmann Sven
- Bis Joshua C.
- Bochud Murielle
- Boehnke Michael
- Boerwinkle Eric
- Bonnycastle Lori L.
- Bornstein Stefan R.
- Bots Michiel L.
- Bragg-Gresham Jennifer L.
- Brand Eva
- Brand Stefan-Martin
- Braund Peter S.
- Brown Morris J.
- Burton Paul R.
- Campbell Harry
- Carstensen Maren
- Casas Juan P.
- Chambers John C.
- Chandak Giriraj R.
- Chang Yen-Pei C.
- Charchar Fadi J.
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Brian H.
- Chen Ming-Huei
- Clarke Robert
- Collins Rory
- Connell John M.
- Cooper Jackie A.
- Cooper Matthew N.
- Cooper Richard S.
- Coresh Josef
- Courchesne Paul
- Dahgam Santosh
- Danesh John
- Davey Smith George
- Dehghan Abbas
- Deloukas Panos
- Demirkan Ayse
- Denniff Matthew
- Dominiczak Anna F.
- Dong Yanbin
- Doumatey Ayo
- Dreisbach Albert W.
- Dörr Marcus
- Dörr Marcus
- Ehret Georg B.
- Elliott Paul
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Erdmann Jeanette
- Esko Tõnu
- Eyheramendy Susana
- Fava Cristiano
- Felix Stephan B.
- Ferrucci Luigi
- Forrester Terrence
- Fowkes F. Gerald R.
- Fox Ervin R.
- Galan Pilar
- Ganesh Santhi K.
- Garcia Melissa
- Gaunt Tom R.
- Gieger Christian
- Glazer Nicole L.
- Go Min Jin
- Goel Anuj
- Grallert Harald
- Grobbee Diederick E.
- Groop Leif
- Grässler Jürgen
- Guarrera Simonetta
- Gudnason Vilmundur
- Guo Xiuqing
- Gyllensten Ulf B.
- Hadley David
- Hamsten Anders
- Han Bok-Ghee
- Hardy Rebecca
- Harris Tamara B.
- Hartikainen Anna-Liisa
- Hayward Caroline
- Heath Simon
- Heckbert Susan R.
- Hedblad Bo
- Hercberg Serge
- Herder Christian
- Hernandez Dena
- Hernandez Dena G.
- Hicks Andrew A.
- Hicks Andrew A.
- Hilton Gina
- Hingorani Aroon D.
- Hoang Nguyen Khanh-Dung
- Hoffman Bolton Judith A.
- Hofman Albert
- Hofman Albert
- Hopewell Jemma C.
- Howard Philip
- Huan Tianxiao
- Humphries Steve E.
- Hunt Steven C.
- Hveem Kristian
- Hwang Shih-Jen
- Igl Wilmar
- Isaacs Aaron
- Islam Muhammad
- Iwai Naoharu
- Jafar Tazeen H.
- Janipalli Charles S.
- Joehanes Roby
- Johnson Andrew D.
- Johnson Andrew D.
- Johnson Toby
- Järvelin Marjo-Riitta
- Järvelin Marjo-Riitta
- Kangas Antti J.
- Kao Wen Hong Linda
- Kardia Sharon L.
- Kathiresan Sekar
- Kettunen Johannes
- Khaw Kay-Tee
- Kim Hyung-Lae
- Kinra Sanjay
- Kita Yoshikuni
- Kivimaki Mika
- Kooner Jaspal S.
- Kranthi Kumar M. J.
- Kroemer Heyo K.
- Kuh Diana
- Kulkarni Smita R.
- Kumari Meena
- Kuusisto Johanna
- Kuznetsova Tatiana
- Kähönen Mika
- Köttgen Anna
- Laakso Markku
- Laan Maris
- Laitinen Jaana
- Lakatta Edward G.
- Langefeld Carl D.
- Larson Martin G.
- Lathrop Mark
- Launer Lenore
- Lawlor Debbie A.
- Lawrence Robert W.
- Lee Jong-Young
- Lee Nanette R.
- Lehtimäki Terho
- Levy Daniel
- Levy Daniel
- Li Yali
- Liu Chunyu
- Liu Poching
- Liu Yongmei
- Lohman Kurt K.
- Longstreth W. T.
- Loos Ruth J. F.
- Luan Jian’an
- Lucas Gavin
- Ludwig Barbara
- Lyytikäinen Leo-Pekka
- Mangino Massimo
- Maria AnnaCorsi
- Mattace-Raso Francesco U. S.
- Matullo Giuseppe
- McArdle Wendy L.
- McKenzie Colin A.
- Meitinger Thomas
- Meitinger Thomas
- Melander Olle
- Melzer David
- Meneton Pierre
- Meschia James F.
- Metspalu Andres
- Miki Tetsuro
- Milaneschi Yuri
- Milani Lili
- Mohlke Karen L.
- Mooser Vincent
- Morken Mario A.
- Morris Richard W.
- Morrison Alanna C.
- Mosley Thomas H.
- Munroe Patricia B.
- Munson Peter J.
- Najjar Samer
- Nalls Michael A.
- Narisu Narisu
- Navis Gerjan
- Newton-Cheh Christopher
- Nilsson Peter
- Nyberg Fredrik
- O'Donnell Christopher J.
- Ogihara Toshio
- Ohkubo Takayoshi
- Okamura Tomonori
- Olden Matthias
- Ong Rick Twee-Hee
- Ongen Halit
- Onland-Moret N. Charlotte
- Oostra Ben A.
- Org Elin
- Orru Marco
- O’Connell Jeffrey R.
- O’Donnell Chris
- O’Reilly Paul F.
- Palmas Walter
- Palmen Jutta
- Palmer Lyle J.
- Palmer Nicholette D.
- Parker Alex N.
- Parsa Afshin
- Pattaro Cristian
- Pattaro Cristian
- Peden John F.
- Peltonen Leena
- Peltonen Leena
- Perola Markus
- Peters Annette
- Peters Marjolein J.
- Pihur Vasyl
- Pilling Luke C.
- Platou Carl G. P.
- Plump Andrew
- Polasek Ozren
- Prabhakaran Dorairajan
- Pramstaller Peter P.
- Pramstaller Peter P.
- Prokisch Holger
- Prokopenko Inga
- Psaty Bruce M.
- RadhaMani K.
- Raffel Leslie J.
- Raghavachari Nalini
- Raitakari Olli
- Rao Dabeeru C.
- Rasheed Asif
- Reinmaa Eva
- Rettig Rainer
- Ricceri Fulvio
- Rice Kenneth M.
- Ridker Paul M.
- Rivadeneira Fernando
- Roden Michael
- Rosengren Annika
- Rotimi Charles
- Rotter Jerome I.
- Rudan Igor
- Rudock Megan E.
- Salako Tunde
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Schramm Katharina
- Schurmann Claudia
- Schwartz Stephen M.
- Schwarz Peter E. H.
- Scott James
- Scott Laura J.
- Scuteri Angelo
- Sehmi Joban S.
- Seielstad Mark
- Seshadri Sudha
- Sharma Pankaj
- Shaw-Hawkins Sue
- Shi Gang
- Shin Cho Yoon
- Shrine Nick R. G.
- Shriner Daniel
- Shuldiner Alan R.
- Sijbrands Eric J. G.
- Sim Xueling
- Singleton Andrew
- Singleton Andrew
- Sjögren Marketa
- Smith Albert V.
- Smith Nicholas L.
- Snieder Harold
- Soininen Pasi
- Soler Artigas Maria
- Soranzo Nicole
- Spector Tim D.
- Staessen Jan A.
- Stančáková Alena
- Steinle Nanette I.
- Strachan David P.
- Sun Yan V.
- Swift Amy J.
- Sõber Siim
- Tabara Yasuharu
- Tai E. Shyong
- Talmud Philippa J.
- Tanaka Toshiko
- Taylor Andrew
- Tayo Bamidele
- Terzic Janos
- Teumer Alexander
- Thelle Dag S.
- Tobin Martin D.
- Tomaszewski Maciej
- Tripathy Vikal
- Tukiainen Taru
- Tzoulaki Ioanna
- Ueshima Hirotsugu
- Uiterwaal Cuno S. P. M.
- Uitterlinden Andre G.
- Uitterlinden André G.
- Umemura Satoshi
- van der Harst Pim
- van der Schouw Yvonne T.
- van Duijn Cornelia M.
- van Duijn Cornelia M.
- van Gilst Wiek H.
- van Meurs Joyce B. J.
- Vartiainen Erkki
- Vasan Ramachandran
- Vasan Ramachandran S.
- Vasan Ramachandran S.
- Veldre Gudrun
- Verwoert Germaine C.
- Viigimaa Margus
- Viikari Jorma
- Vinay D. G.
- Vineis Paolo
- Vitart Veronique
- Voight Benjamin F.
- Vollenweider Peter
- Völker Uwe
- Völker Uwe
- Völzke Henry
- Wagenknecht Lynne E.
- Wain Louise V.
- Waldenberger Melanie
- Wang Richard
- Wang Thomas J.
- Wang Xiaoling
- Wareham Nicholas J.
- Watkins Hugh
- Weder Alan B.
- Whincup Peter H.
- Wichmann H. -Erich
- Wiggins Kerri L.
- Wild Sarah H.
- Wilson James F.
- Witteman Jacqueline C. M.
- Wong Andrew
- Wong Tien Y.
- Wright Alan F.
- Wu Ying
- Würtz Peter
- Yajnik Chittaranjan S.
- Yang Xia
- Yao Chen
- Yao Jie
- Ying Sai-xia
- Young J. H.
- Zelenika Diana
- Zeller Tanja
- Zhai Guangju
- Zhang Feng
- Zhang Weihua
- Zhao Jing Hua
- Zhu Haidong
- Zhu Xiaofeng
- Zitting Paavo
- Zukowska-Szczechowska Ewa
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have uncovered numerous genetic variants (SNPs) that are associated with blood pressure (BP). Genetic variants may lead to BP changes by acting on intermediate molecular phenotypes such as coded protein sequence or gene expression, which in turn affect BP variability. Therefore, characterizing genes whose expression is associated with BP may reveal cellular processes involved in BP regulation and uncover how transcripts mediate genetic and environmental effects on BP variability. A meta-analysis of results from six studies of global gene expression profiles of BP and hypertension in whole blood was performed in 7017 individuals who were not receiving antihypertensive drug treatment. We identified 34 genes that were differentially expressed in relation to BP (Bonferroni-corrected p<0.05). Among these genes, FOS and PTGS2 have been previously reported to be involved in BP-related processes; the others are novel. The top BP signature genes in aggregate explain 5%–9% of inter-individual variance in BP. Of note, rs3184504 in SH2B3, which was also reported in GWAS to be associated with BP, was found to be a trans regulator of the expression of 6 of the transcripts we found to be associated with BP (FOS, MYADM, PP1R15A, TAGAP, S100A10, and FGBP2). Gene set enrichment analysis suggested that the BP-related global gene expression changes include genes involved in inflammatory response and apoptosis pathways. Our study provides new insights into molecular mechanisms underlying BP regulation, and suggests novel transcriptomic markers for the treatment and prevention of hypertension
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
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- Haritunians Talin
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- Ingelsson Erik
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- Ladouceur Martin
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- Paré Guillaume
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- Sidore Carlo
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- Trompet Stella
- Trummer Olivia
- Tryggvadottir Laufey
- Tryggvason Karl
- Trégouët David-Alexandre
- Tsaprouni Loukia
- Tsoka Sophia
- Tsui Kim
- Tukiainen Taru
- Tuomilehto Jaakko
- Turner Stephen T
- Tylavsky Frances A
- Tyrer Jonathon
- Tzoulaki Ioanna
- Tönjes Anke
- Uda Manuela
- Ueshima Hirotsugu
- Uh Hae-Won
- Uiterwaal Cuno S P M
- Uitterlinden Andre G
- Uitterlinden André G
- Ulivi Sheila
- Ulivi Shelia
- Umans Jason
- Umemura Satoshi
- Urreizti Roser
- Uusitupa Matti
- Vallejo Edgar E
- van Dam Rob M
- Van den Herik Evita G
- van der Harst Pim
- van der Klauw Melanie M
- van der Schoot C Ellen
- van der Schouw Yvonne T
- van Duijn Cornelia
- Van Duijn Cornelia
- van Gils Carla H
- van Gilst Wiek H
- van Heemst Diana
- Van Hul Wim
- van Meurs Joyce B J
- van Meurs Joyve B J
- van Nierop Peter
- van Oort Floor V A
- van Pelt L Joost
- van Schoor Natasja M
- Van Vliet-Ostaptchouk Jana V
- van Wingerden Sophie
- van Wingerden Sophie W
- Van Zuydam Natalie
- Vandenput Liesbeth
- Varga Tibor V
- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
- Visscher Peter M
- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease
- Author
- Aad van der Lugt
- Aaron Isaacs
- Aaron Isaacs
- Aaron R. Folsom
- Abbas Dehghan
- Abbas Dehghan
- Abbas Dehghan
- Adebowale Adeyemo
- Afshin Parsa
- Afshin Parsa
- Alan B. Weder
- Alan F. Wright
- Alan R. Shuldiner
- Alan R. Shuldiner
- Alanna C. Morrison
- Albert Hofman
- Albert Hofman
- Albert Hofman
- Albert V. Smith
- Albert V. Smith
- Albert W. Dreisbach
- Aldi T. Kraja
- Alena Stančáková
- Alex N. Parker
- Alexander Teumer
- Alison H. Goodall
- Amy J. Swift
- Anders Franco‐Cereceda
- Anders Hamsten
- Anders Hamsten
- Andre G. Uitterlinden
- Andre G. Uitterlinden
- Andre G. Uitterlinden
- Andre Uitterlinden
- Andreas Ziegler
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew D. Johnson
- Andrew D. Johnson
- Andrew Plump
- Andrew Singleton
- Andrew Taylor
- Andrew Wong
- Angela M. Carter
- Angela Silveira
- Angelo Scuteri
- Angelo Scuteri
- Anna F. Dominiczak
- Anna Köttgen
- Anna Maria Corsi
- Anna‐Liisa Hartikainen
- Anne B. Newman
- Anne U. Jackson
- Annette Peters
- Annika Rosengren
- Ann‐Christine Syvänen
- Antti J. Kangas
- Anuj Goel
- Anuj Goel
- Aravinda Chakravarti
- Arne Schillert
- Aroon D. Hingorani
- Asif Rasheed
- Ayo Doumatey
- Ayse Demirkan
- Bamidele Tayo
- Barbara Ludwig
- Barbara McKnight
- Ben A. Oostra
- Ben Oostra
- Bengt Sennblad
- Benjamin F. Voight
- Benjamin F. Voight
- Bernhard O. Boehm
- Bernhard R. Winkelmann
- Bo Hedblad
- Bok‐Ghee Han
- Bolli Thorsson
- Braxton D. Mitchell
- Bruce M. Psaty
- Bruce M. Psaty
- Bruce M. Psaty
- Carl D. Langefeld
- Carl G. P. Platou
- Caroline Hayward
- Caroline Hayward
- Caroline S. Fox
- Charles C. White
- Charles Rotimi
- Charles S. Janipalli
- Chittaranjan S. Yajnik
- Christa Meisinger
- Christa Meisinger
- Christian Gieger
- Christie Ballantyne
- Christopher J. O'Donnell
- Christopher Newton‐Cheh
- Ci Song
- Colin A. McKenzie
- Cornelia M. van Duijn
- Cornelia van Duijn
- Cristian Pattaro
- Cristiano Fava
- Cuno S. P. M. Uiterwaal
- D. G. Vinay
- Dabeeru C. Rao
- Dag S. Thelle
- Dan E. Arking
- Daniel H. O'Leary
- Daniel I. Chasman
- Daniel Levy
- Daniel Shriner
- Danish Saleheen
- Danish Saleheen
- David Altshuler
- David Altshuler
- David Hadley
- David J. Couper
- David M. Herrington
- David P. Strachan
- David S. Siscovick
- David Tregouet
- Debbie A. Lawlor
- Dena Hernandez
- Diana Kuh
- Diana Zelenika
- Diane M. Becker
- Diederick E. Grobbee
- Dorairaj Prabhakaran
- E. Shyong Tai
- Edward G. Lakatta
- Edward G. Lakatta
- Elin Org
- Elisabeth M. C. Schrijvers
- Eran Halperin
- Eric Boerwinkle
- Eric Boerwinkle
- Eric J. G. Sijbrands
- Erkki Vartiainen
- Ervin R. Fox
- Eva Brand
- Eva‐Maria Stoegerer
- Ewa Zukowska‐Szczechowska
- F. Gerald R. Fowkes
- Fadi J. Charchar
- Feng Zhang
- Fernando Rivadeneira
- Fernando Rivadeneira
- Florian Ernst
- Folkert W. Asselbergs
- Frances M. K. Williams
- Francesco U. S. Mattace‐Raso
- Francis S. Collins
- Francois Cambien
- Fredrik Nyberg
- Fulvio Ricceri
- Gabriel P. Krestin
- Gang Shi
- Gavin Lucas
- Geoffrey H. Tofler
- Georg B. Ehret
- Georg Homuth
- George Davey Smith
- Gerardo Heiss
- Gerjan J. Navis
- Gerjan Navis
- Germaine C. Verwoert
- Gianluca Usala
- Gina Hilton
- Giriraj R. Chandak
- Giuseppe Matullo
- Gonçalo R. Abecasis
- Gonçalo R. Abecasis
- Guangju Zhai
- Gudny Eiriksdottir
- Gudrun Veldre
- Günther Silbernagel
- H. Erich Wichmann
- H.‐Erich Wichmann
- Haidong Zhu
- Haiqing Shen
- Halit Ongen
- Hans L. Hillege
- Harold Snieder
- Harry Campbell
- Heather M. Stringham
- Helena Schmidt
- Henry Völzke
- Henry Völzke
- Heyo K. Kroemer
- Hirotsugu Ueshima
- Hugh S. Markus
- Hugh Watkins
- Hugh Watkins
- Hyung‐Lae Kim
- Ian N. M. Day
- Igor Rudan
- Inga Prokopenko
- Ingrid B. Borecki
- Inês Barroso
- Ioanna Tzoulaki
- J. Hunter Young
- Jaakko Tuomilehto
- Jaana Laitinen
- Jackie A. Cooper
- Jacqueline C. M. Witteman
- Jacqueline Witteman
- Jacques S. Beckmann
- James B. Meigs
- James F. Meschia
- James F. Wilson
- James F. Wilson
- James Scott
- Jan A. Staessen
- Jan Lüdemann
- Janos Terzic
- Jason H. Moore
- Jaspal S. Kooner
- Jaspal S. Kooner
- Jeanette Erdmann
- Jeffrey R. O'Connell
- Jeffrey R. O'Connell
- Jemma C. Hopewell
- Jemma C. Hopewell
- Jennifer E. Huffman
- Jennifer L. Bragg‐Gresham
- Jens Baumert
- Jens Baumert
- Jerome I. Rotter
- Jerome I. Rotter
- Jian'an Luan
- Jie Huang
- Jie Yao
- Jing Hua Zhao
- Jingzhong Ding
- Joachim Thiery
- Joanne M. Murabito
- Joban S. Sehmi
- Jochen Seissler
- Johanna Kuusisto
- Johannes Kettunen
- John C. Chambers
- John C. Chambers
- John D. Eicher
- John Danesh
- John Danesh
- John F. Peden
- John F. Peden
- John M. Connell
- John P. Beilby
- John Öhrvik
- Jong‐Young Lee
- Jorma Viikari
- Jorma Viikari
- Josef Coresh
- Joseph F. Polak
- Joseph M. Massaro
- Joshua C. Bis
- Joshua C. Bis
- Joshua C. Bis
- Josyf C. Mychaleckyj
- Juan P. Casas
- Judith A. Hoffman Bolton
- Julie Cunningham
- Jutta Palmen
- Jürgen Grässler
- K. Radha Mani
- Karen L. Mohlke
- Kari North
- Katja E. Petrovic
- Kay‐Tee Khaw
- Kenneth M. Rice
- Kenneth Rice
- Kent Taylor
- Kent Taylor
- Kerri L. Wiggins
- Khanh‐Dung Hoang Nguyen
- Kristian Hveem
- Kurt K. Lohman
- Kurt Lohman
- L. Adrienne Cupples
- Lasse Folkersen
- Laura J. Scott
- Lawrence F. Bielak
- Leena Peltonen
- Leena Peltonen
- Leif Groop
- Lenore J. Launer
- Lenore Launer
- Leo‐Pekka Lyytikäinen
- Leslie J. Raffel
- Lewis C. Becker
- Linda S. Adair
- Lisa R. Yanek
- Lori L. Bonnycastle
- Louise V. Wain
- Luigi Ferrucci
- Lyle J. Palmer
- Lynne E. Wagenknecht
- M. Arfan Ikram
- M. V. Kranthi Kumar
- Maciej Tomaszewski
- Mahir Karakas
- Manuela Uda
- Manuela Uda
- Marco Orru
- Marco Orru
- Marcus Dörr
- Marcus Dörr
- Marcus E. Kleber
- Margus Viigimaa
- Maria Grazia Franzosi
- Maria Sabater‐Lleal
- Maria Soler Artigas
- Mario A. Morken
- Maris Laan
- Mariza de Andrade
- Marjo‐Riitta Järvelin
- Mark J. Caulfield
- Mark Lathrop
- Mark Seielstad
- Marketa Sjögren
- Markku Laakso
- Markus Perola
- Martin D. Tobin
- Martin Farrall
- Martin G. Larson
- Martina Müller‐Nurasyid
- Mary Cushman
- Mary F. Feitosa
- Maryam Kavousi
- Massimo Mangino
- Matthew Denniff
- Matthew N. Cooper
- Matthias Olden
- Matthias Sitzer
- Matthijs Oudkerk
- Meena Kumari
- Megan E. Rudock
- Melissa Garcia
- Michael A. Nalls
- Michael A. Province
- Michael Boehnke
- Michael G. Marmot
- Michael Nalls
- Michiel L. Bots
- Mika Ala‐Korpela
- Mika Kivimaki
- Mika Kähönen
- Mika Kähönen
- Min Jin Go
- Ming‐Huei Chen
- Ming‐Huei Chen
- Mohammad A. Ikram
- Morris J. Brown
- Muhammad Islam
- Muredach P. Reilly
- Muredach P. Reilly
- Murielle Bochud
- Myriam Alexander
- N. Charlotte Onland‐Moret
- Najaf Amin
- Nanette I. Steinle
- Nanette R. Lee
- Naoharu Iwai
- Narisu Narisu
- Nena Matijevic
- Nicholas J. Wareham
- Nicholas L. Smith
- Nicholas L. Smith
- Nicholette D. Palmer
- Nick R. G. Shrine
- Nicole L. Glazer
- Nicole L. Glazer
- Nicole Soranzo
- Nicole Soranzo
- Nilesh J. Samani
- Nish Chaturvedi
- Nora Franceschini
- Norman Klopp
- Norman Klopp
- null null
- null null
- Olle Melander
- Olli Raitakari
- Olli Raitakari
- Ozren Polasek
- Paavo Zitting
- Pankaj Arora
- Pankaj Sharma
- Panos Deloukas
- Paolo Vineis
- Pasi Soininen
- Patricia A. Peyser
- Patricia B. Munroe
- Paul Elliott
- Paul F. O'Reilly
- Paul M. Ridker
- Paul R. Burton
- Per Eriksson
- Per Lundmark
- Peter E. H. Schwarz
- Peter H. Whincup
- Peter J. Grant
- Peter Nilsson
- Peter P. Pramstaller
- Peter S. Braund
- Peter Vollenweider
- Peter Würtz
- Philip A. Wolf
- Philip Howard
- Philipp S. Wild
- Philippa J. Talmud
- Pierre Meneton
- Pierre‐Emmanuel Morange
- Pilar Galan
- Pim van der Harst
- Pim van der Harst
- Qiong Yang
- Qunyuan Zhang
- Rainer Rettig
- Ralph B. D'Agostino
- Ramachandran S. Vasan
- Ravi Kumar Chilukoti
- Rebecca Hardy
- Reinhold Schmidt
- Renate B. Schnabel
- Renate B. Schnabel
- Richard N. Bergman
- Richard S. Cooper
- Richard W. Morris
- Rick Twee‐Hee Ong
- Robert Clarke
- Robert Clarke
- Robert W. Lawrence
- Roberto Elosua
- Roberto Elosua
- Rona J. Strawbridge
- Rory Collins
- Russell P. Tracy
- Ruth J. F. Loos
- Samer Najjar
- Sanjay Kinra
- Santhi K. Ganesh
- Santosh Dahgam
- Saonli Basu
- Sarah H. Wild
- Satoshi Umemura
- Scott M. Williams
- Sekar Kathiresan
- Sekar Kathiresan
- Sekar Kathiresan
- Serena Sanna
- Serge Hercberg
- Serkalem Demissie
- Sharon L. Kardia
- Sharon L. R. Kardia
- Shelly Smith
- Shih‐Jen Hwang
- Shih‐Jen Hwang
- Sigurdur Sigurdsson
- Siim Sõber
- Simon Heath
- Simonetta Guarrera
- Smita R. Kulkarni
- So‐Youn Shin
- Stefan Blankenberg
- Stefan R. Bornstein
- Stefania Bandinelli
- Stefan‐Martin Brand
- Stephan J. L. Bakker
- Stephen Burgess
- Stephen M. Schwartz
- Stephen M. Schwartz
- Steve Bevan
- Steve E. Humphries
- Steven C. Hunt
- Sudha Seshadri
- Sue Shaw‐Hawkins
- Susan R. Heckbert
- Susan R. Heckbert
- Susana Eyheramendy
- Suzette E. Elias‐Smale
- Sven Bergmann
- Takayoshi Ohkubo
- Tamara B. Harris
- Tamara B. Harris
- Tamara B. Harris
- Tanja Zeller
- Taru Tukiainen
- Tatiana Kuznetsova
- Tazeen H. Jafar
- Terho Lehtimäki
- Terho Lehtimäki
- Terrence Forrester
- Tetsuro Miki
- Thomas H. Mosley
- Thomas Illig
- Thomas J. Wang
- Thomas Meitinger
- Thomas Münzel
- Thor Aspelund
- Thor Aspelund
- Tien Y. Wong
- Tim D. Spector
- Timothy D. Howard
- Timothy D. Spector
- Timothy M. Frayling
- Tiphaine Oudot‐Mellakh
- Toby Johnson
- Tom R. Gaunt
- Tomonori Okamura
- Toshiko Tanaka
- Toshio Ogihara
- Tunde Salako
- Udo Hoffmann
- Udo Seedorf
- Ulf B. Gyllensten
- Ulf Schminke
- Uwe Völker
- Valur Emilsson
- Vasyl Pihur
- Veikko Salomaa
- Veikko Salomaa
- Veronique Vitart
- Vijay Nambi
- Vikal Tripathy
- Vilmundur Gudnason
- Vilmundur Gudnason
- Vincent Mooser
- Vinh Truong
- W. T. Longstreth
- Walter Palmas
- Weihong Tang
- Weihua Zhang
- Wen Hong Linda Kao
- Wendy L. McArdle
- Wendy S. Post
- Wiek H. van Gilst
- Wiek H. van Gilst
- Wilmar Igl
- Winfried März
- Wolfgang Koenig
- Wolfgang Koenig
- Wolfgang Rathmann
- Xia Li
- Xiaofeng Zhu
- Xiaoling Wang
- Xiuqing Guo
- Xueling Sim
- Yali Li
- Yan V. Sun
- Yan V. Sun
- Yanbin Dong
- Yasuharu Tabara
- Yen‐Pei C. Chang
- Ying Wu
- Yongmei Liu
- Yongmei Liu
- Yongmei Liu
- Yoon Shin Cho
- Yoshikuni Kita
- Yuri Milaneschi
- Yurii Aulchenko
- Yu‐Ching Cheng
- Yvonne T. van der Schouw
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2017
- Field of study
Background--Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. Methods and Results--To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD using a Mendelian randomization approach using summary statistics from large genome-wide association studies. Finally, we explored the causal effect of PAI-1 on cardiovascular risk factors including metabolic and subclinical atherosclerosis measures. In the systematic meta-analysis, the highest quantile of blood PAI-1 level was associated with higher CHD risk comparing with the lowest quantile (odds ratio=2.17; 95% CI: 1.53, 3.07) in an age- and sex-adjusted model. The effect size was reduced in studies using a multivariable-adjusted model (odds ratio=1.46; 95% CI: 1.13, 1.88). The Mendelian randomization analyses suggested a causal effect of increased PAI-1 level on CHD risk (odds ratio=1.22 per unit increase of log-transformed PAI-1; 95% CI: 1.01, 1.47). In addition, we also detected a causal effect of PAI-1 on elevating blood glucose and high-density lipoprotein cholesterol. Conclusions--Our study indicates a causal effect of elevated PAI-1 level on CHD risk, which may be mediated by glucose dysfunction
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
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- Blomstrom David B.
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- Bloom Toby
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- Blyth Peter R.
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- Brandriff Brigitte F.
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- Brettin Thomas
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- DeArellano Kurt
- Deaven Larry I.
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- Kruchowski Scott S.
- Kube Michael
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- Lou Yunian
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- Lowenstein Michael G.
- Lowry Stephen
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- Lynch Daniel
- Löhnert Tschong-Hun
- Ma Cheng
- Ma Gary
- Ma Jiao
- Ma Jie
- Ma Peter
- Ma Qingmei
- Ma Xiaohui
- Maas Jason
- Mabbitt Richard
- Macdonald Pendexter
- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
- Mahmoodi Venus
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- Major John
- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Marsh Victoria
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- Martin Joel
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- Maslen Gareth
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- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- McLay Kirsten
- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
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- McVicker Graham
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- Meidi Patrick
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- Mejima Mio
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- Meneus Louis
- Meng Shanshan
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- Mercer Simon
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- Mu Feng
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- Mulrain Leon
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- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
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- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
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- Oinn Tom
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
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- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
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- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
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- Oragunye Njideka
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- Oviedo Rodolfo J.
- Ow David
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- Palazzolo Michael
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- Parkin Kim
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- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
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- Patrick James
- Paul Heidie A.
- Paul Shelia
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- Perez Agapito
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- Perito Andrew
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- Rodriguez Alex
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- Sarmiento R.
- Sasaki Takashi
- Satpathy Suraj
- Saunders David
- Saunders Elizabeth H.
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- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
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- Silk Richard
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- Song Liping
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- Sougnez Carrie
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- Su Xiaohu
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- Subramanian Sandhya
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- Sulston John
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- Sun Min
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- Swann Mark
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- Ségurens Béatrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
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- Tahara Takashi
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- Takaoka Tori
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- Tam Serena
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- Tamirisa Aparna
- Tan Olivia
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- Tang Hongli
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- Tansey Jennifer
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- Tatsuyama Miho
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- Taudien Stefan
- Taylor Amy
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- Tesmer Judith G.
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- Thomas Ruth
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- Thorne Rachel Diane
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- Tian Chaoguang
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- Tin-Wollam Aye M.
- Tinsley Emma
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- Togashi Naoko
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- Tomlinson Chad
- Tong Jingli
- Topham Kerri
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- Wang Ying
- Wang Yuanyuan
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- Wangdi Tsering
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- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
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- Waterston Robert H.
- Watson Andy
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- Webb Anthony
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- Wehri Edward
- Wei Shulin
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- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
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- Woyke Tanja
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- Wu Chungen
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- Xi Yan
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- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
- Author
- Aaron Folsom
- Aaron Isaacs
- Abbas Dehghan
- Adebowale Adeyemo
- Adrienne Tin
- Afshin Parsa
- Aida Karina Dieffenbach
- Alan B. Weder
- Alan B. Zonderman
- Alan F. Wright
- Alan Go
- Alan R. Shuldiner
- Alanna C. Morrison
- Albert Hofman
- Albert V. Smith
- Albert W. Dreisbach
- Alena Stancakova
- Alex N. Parker
- Alexander Teumer
- Alexandre F. R. Stewart
- Alistair Hall
- Amy J. Swift
- Anders Hamsten
- Andre Franke
- Andre G. Uitterlinden
- Andreas Meinitzer
- Andreas Tomaschitz
- Andreas Ziegler
- Andres Metspalu
- Andrew A. Hicks
- Andrew D. Johnson
- Andrew Plump
- Andrew Singleton
- Andrew Taylor
- Andrew Wong
- Angela Doering
- Angelo Scuteri
- Anika Grosshennig
- Anja Medack
- Anke Tonjes
- Anna F. Dominiczak
- Anna Köttgen
- Anna Maria Corsi
- Anna-Liisa Hartikainen
- Anne U. Jackson
- Annette Peters
- Annika Rosengren
- Anthony J. Balmforth
- Antonietta Robino
- Antonio Lupo
- Anuj Goel
- Aravinda Chakravarti
- Arne Schillert
- Arnika K. Wagner
- Aroon D. Hingorani
- Asif Rasheed
- Atsushi Takahashi
- Aude Saint-Pierre
- Audrey Y. Chu
- Augustine Kong
- Augusto D. Pichard
- Ayo Doumatey
- Ayse Demirkan
- Bamidele Tayo
- Barbara Kollerits
- Barbara Ludwig
- Barry I. Freedman
- Belen Ponte
- Ben A. Oostra
- Benedicte Stengel
- Benjamin F. Voight
- Benjamin J. Wright
- Bernhard K. Krämer
- Bernhard O. Böhm
- Bernhard Paulweber
- Bernhard R. Winkelmann
- Bo Hedblad
- Bok-Ghee Han
- Braxton D. Mitchell
- Brenda W. Penninx
- Brendan M. Buckley
- Bruce M. Psaty
- Bruno H. Stricker
- Candace Guiducci
- Carl D. Langefeld
- Carl G. P. Platou
- Carlos Iribarren
- Carmen A. Peralta
- Carole Proust
- Caroline Hayward
- Caroline S. Fox
- Carsten A. Böger
- Catherine Helmer
- Charles N. Rotimi
- Charles S. Janipalli
- Chien-Hsiun Chen
- Chittaranjan S. Yajnik
- Christa Meisinger
- Christian Fuchsberger
- Christian Gieger
- Christian Hengstenberg
- Christian M. Shaffer
- Christian Müller
- Christina Loley
- Christina Willenborg
- Christoph Bickel
- Christoph Sinning
- Christopher J. O’Donnell
- Christopher Newton-Cheh
- Christopher P. Nelson
- Christopher W. Knouff
- Cinzia Sala
- Claire Perret
- Colin A. McKenzie
- Cornelia M. van Duijn
- Cristian Pattaro
- Cristiano Fava
- Cuno S. P. M. Uiterwaal
- D. G. Vinay
- Dabeeru C. Rao
- Daehee Kang
- Dag S. Thelle
- Dan E. Arking
- Daniel Ackermann
- Daniel I. Chasman
- Daniel J. Rader
- Daniel Levy
- Daniel Shriner
- Daniel Taliun
- Daniela Ruggiero
- Daniela Toniolo
- Daniele Cusi
- Danish Saleheen
- Darina Czamara
- David Altshuler
- David Couper
- David Ellinghaus
- David Hadley
- David P. Strachan
- David S. Siscovick
- Dawn M. Waterworth
- Debbie A. Lawlor
- Dena Hernandez
- Devin Absher
- Diana Kuh
- Diana Zelenika
- Diederick E. Grobbee
- Dongfeng Gu
- Donna K. Arnett
- Dorairajan Prabhakaran
- Douglas Ruderfer
- E-Shyong Tai
- Edward G. Lakatta
- Elena Rochtchina
- Elin Org
- Elizabeth G. Holliday
- Elizabeth J. Atkinson
- Emelia Benjamin
- Eran Halperin
- Eric Boerwinkle
- Eric J. G. Sijbrands
- Erik Ingelsson
- Erika Salvi
- Erkki Vartiainen
- Ervin R. Fox
- Erwin P. Bottinger
- Eva Albrecht
- Eva Brand
- Ewa Zukowska-Szczechowska
- F. Gerald R. Fowkes
- Fadi J. Charchar
- Federico Murgia
- Feng Zhang
- Fernando Rivadeneira
- Florian Ernst
- Florian Kronenberg
- Francesco U. S. Mattace-Raso
- Francis S. Collins
- Francois Cambien
- Frank B. Hu
- Fredrik Nyberg
- Fulvio Ricceri
- Fumihiko Takeuchi
- Fuu-Jen Tsai
- Gang Shi
- Gary C. Curhan
- Gary F. Mitchell
- Gavin Lucas
- Georg Homuth
- George A. Wells
- George B. Ehret
- George Davey Smith
- Gerjan J. Navis
- Germaine C. Verwoert
- Gian-Andri Thun
- Gina Hilton
- Giorgio Pistis
- Giovanni Gambaro
- Giovanni Malerba
- Giriraj R. Chandak
- Giuseppe Matullo
- Goncalo R. Abecasis
- Grant W. Montgomery
- Guangju Zhai
- Gudmar Thorleifsson
- Gudmundur Thorgeirsson
- Gudny Eiriksdottir
- Gudrun Veldre
- Gunnar Jacobs
- Guo Li
- H-Erich Wichmann
- Haidong Zhu
- Hakon H. Hakonarson
- Halit Ongen
- Hans J. Rupprecht
- Hao Mei
- Harald Dobnig
- Harald Grallert
- Harold Snieder
- Harry Campbell
- Heather M. Stringham
- Helena Schmidt
- Henri Wallaschofski
- Henry Völzke
- Heribert Schunkert
- Hermann Brenner
- Heyo K. Kroemer
- Hilma Holm
- Hirotsugu Ueshima
- Holly Kramer
- Honghuang Lin
- Hua Tang
- Hubert Scharnagl
- Hugh Watkins
- Hyung-Lae Kim
- I. Mateo Leach
- Ian Ford
- Ian H. de Boer
- Ian N. M. Day
- Ida Yii-Der Chen
- Idris Guessous
- Iftikhar Kullo
- Igor Rudan
- Ilja M. Nolte
- Ines Barroso
- Inga Prokopenko
- Ingrid Borecki
- Inke R. König
- Ioanna Tzoulaki
- Iris M. Heid
- Ivana Kolcic
- Ivana Persico
- J. H. Young
- J. Wouter Jukema
- Jaakko Tuomilehto
- Jaana Laitinen
- Jaap W. Deckers
- Jackie A. Cooper
- Jacqueline C. M. Witteman
- Jacques S. Beckmann
- James E. Hixson
- James F. Meschia
- James F. Wilson
- James Scott
- James T. Willerson
- Jan A. Staessen
- Jan Stritzke
- Janine F. Felix
- Janja Nahrstedt
- Janos Terzic
- Jasmin Divers
- Jaspal S. Kooner
- Jayashri Aragam
- Jean-Charles Lambert
- Jean-Michel Gaspoz
- Jeanette Erdmann
- Jeanette M. Stafford
- Jeffrey R. Gulcher
- Jeffrey R. O’Connell
- Jemma C. Hopewell
- Jennifer A. Smith
- Jennifer L. Bragg-Gresham
- Jer-Yuarn Wu
- Jerome I. Rotter
- Jessica D. Faul
- Jiang He
- Jianjun Liu
- Jian’an Luan
- Jie Jin Wang
- Jie Yao
- Jing Hua Zhao
- Jingzhong Ding
- Joanne Murabito
- Joban S. Sehmi
- Joe Devaney
- Joel N. Hirschhorn
- Johanna Kuusisto
- Johanne Tremblay
- Johannes H. Smit
- Johannes Haerting
- John Attia
- John B. Whitfield
- John C. Chambers
- John Chalmers
- John Danesh
- John F. Peden
- John M. Connell
- John P. Beilby
- John R. Thompson
- John S. Gottdiener
- Jong-Young Lee
- Jorma Viikari
- Josef Coresh
- Joseph M. Lindsay
- Joshua C. Bis
- Joshua C. Denny
- Joshua Knowles
- Juan P. Casas
- Judith A Hoffman Bolton
- Juha Karjalainen
- Jutta Palmen
- Jyotika K. Fernandes
- Jürgen Grässler
- K. Radha Mani
- Karen L. Mohlke
- Kari Stefansson
- Karin Halina Greiser
- Karl Andersen
- Karl J. Lackner
- Karl Werdan
- Karl Winkler
- Karlhans Endlich
- Katalin Susztak
- Katja Butterbach
- Kay-Tee Khaw
- Kazuhiko Yamamoto
- Keith L. Keene
- Kelly Volcik
- Kenneth M. Kent
- Kenneth M. Rice
- Kent D. Taylor
- Kerri L. Wiggins
- Khanh-Dung Hoang Nguyen
- Kiran Musunuru
- Klaus Stark
- Kristian Hveem
- Kristin Marciante
- Kurt Lohman
- L. Adrienne Cupples
- Lars Lind
- Laura J. Scott
- Laura Portas
- Laura R. Loehr
- Laurence Tiret
- Leena Peltonen
- Leif Groop
- Lenore J. Launer
- Leo-Pekka Lyytikäinen
- Leslie J. Raffel
- Li Chen
- Li-Ching Chang
- Liming Qu
- Linda S. Adair
- Loic Yengo
- Lori L. Bonnycastle
- Louise V. Wain
- Lowell Satler
- Lude Franke
- Luigi Ferrucci
- Lyle J. Palmer
- Lynda M. Rose
- Lynne E. Wagenknecht
- Lyudmyla Kedenko
- M. Arfan Ikram
- M. J. Kranthi Kumar
- Maciej Tomaszewski
- Madhumathi Rao
- Maija Garnaas
- Maja Barbalic
- Maksim Struchalin
- Man Li
- Manuela Uda
- Marco Orru
- Marcus Dörr
- Marcus E. Kleber
- Marcus Fischer
- Margaret M. Redfield
- Margherita Cavalieri
- Margot Haun
- Margus Viigimaa
- Maria Blettner
- Maria Soler Artigas
- Marie Metzger
- Marilyn C. Cornelis
- Marina Ciullo
- Mario A. Morken
- Mario Pirastu
- Maris Laan
- Mariza de Andrade
- Marjo-Riitta Jarvelin
- Mark A. McEvoy
- Mark Hlatky
- Mark J. Caulfield
- Mark Lathrop
- Mark Seielstad
- Mark Woodward
- Marketa Sjögren
- Markku Laakso
- Markus Perola
- Martin Adam
- Martin D. Tobin
- Martin Farrall
- Martin G. Larson
- Mary F. Feitosa
- Mary Susan Burnett
- Masato Isono
- Massimiliano Cocca
- Massimo Mangino
- Mathias Gorski
- Matthew Denniff
- Matthew N. Cooper
- Matthias Nauck
- Matthias Olden
- Max C. Walker
- Medea Imboden
- Meena Kumari
- Megan E. Rudock
- Melanie Waldenberger
- Melissa Garcia
- Menno Pruijm
- Meredith Foster
- Michael Boehnke
- Michael G. Marmot
- Michael M. Hoffmann
- Michael Nalls
- Michael Preuss
- Michael Stumvoll
- Michele K. Evans
- Michele M. Sale
- Michiaki Kubo
- Michiel L. Bots
- Mika Kivimaki
- Mika Kähönen
- Min Jin Go
- Ming-Huei Chen
- Mingyao Li
- Mladen Boban
- Morris J. Brown
- Muhammad Islam
- Muredach P Reilly
- Murielle Bochud
- Myriam Alexander
- Myriam Rheinberger
- N. Charlotte Onland-Moret
- Nabila Bouatia-Naji
- Najaf Amin
- Nanette I. Steinle
- Nanette R. Lee
- Naoharu Iwai
- Naoyuki Kamatani
- Narisu Narisu
- Neil Risch
- Nele Friedrich
- Nicholas G. Martin
- Nicholas J. Wareham
- Nicholas L. Smith
- Nicholette D. Palmer
- Nick Hastie
- Nick R. G. Shrine
- Nicole L. Glazer
- Nicole Probst-Hensch
- Nicole Soranzo
- Niek Verweij
- Nilesh J. Samani
- Nish Chaturvedi
- Noel Burtt
- Norbert Watzinger
- Norihiro Kato
- Norman Klopp
- null null
- null null
- null null
- null null
- null null
- Olga Jarinova
- Olivier Devuyst
- Olle Melander
- Olli Raitakari
- Omri Gottesman
- Oscar H. Franco
- Ozren Polasek
- Paavo Zitting
- Pankaj Arora
- Pankaj Sharma
- Panos Deloukas
- Paolo Gasparini
- Paolo Vineis
- Patricia B. Munroe
- Patricia P. Chang
- Patrick Diemert
- Patrick Linsel-Nitschke
- Paul Elliott
- Paul F. O’Reilly
- Paul M. Ridker
- Paul Mitchell
- Paul Muntner
- Paul R. Burton
- Pavel Hamet
- Peng Chen
- Peter E. H. Schwarz
- Peter H. Whincup
- Peter J. van der Most
- Peter Kovacs
- Peter Nilsson
- Peter P. Pramstaller
- Peter S. Braund
- Peter Vollenweider
- Petra Bruse
- Philip Howard
- Philipp S. Wild
- Philippa J. Talmud
- Philippe Froguel
- Pierre Meneton
- Pilar Galan
- Pim van der Harst
- Pio d’Adamo
- Qiong Yang
- Rainer Rettig
- Ramachandran S. Vasan
- Rebecca Hardy
- Reedik Mägi
- Reijo Laaksonen
- Reiner Biffar
- Reinhold Schmidt
- Renate Schnabel
- Richard J. Rodeheffer
- Richard Myers
- Richard N. Bergman
- Richard S. Cooper
- Richard W. Morris
- RickTwee-Hee Ong
- Rita P. S. Middelberg
- Robert Clarke
- Robert J. Carroll
- Robert Roberts
- Robert W. Lawrence
- Robert Wilensky
- Robert Zweiker
- Roberto Elosua
- Rodney J. Scott
- Ron Waksman
- Ronit Katz
- Rory Collins
- Rossella Sorice
- Ruth J. F. Loos
- Ruth McPherson
- S. -J. Cathy Fann
- Samer Najjar
- Sanaz Sedaghat
- Sanjay Kinra
- Santhi K. Ganesh
- Santosh Dahgam
- Sarah H. Wild
- Satoshi Umemura
- Sekar Kathiresan
- Serge Hercberg
- Serkalem Demissie-Banjaw
- Sharon L. R. Kardia
- Sheila Ulivi
- Shih-Jen Hwang
- Shiro Maeda
- Shufeng Chen
- Siim Sõber
- Simon Heath
- Simonetta Guarrera
- Smita R. Kulkarni
- Solveig Gretarsdottir
- Sonny Dandona
- Stacey B. Gabriel
- Stefan Blankenberg
- Stefan Coassin
- Stefan Enroth
- Stefan Kloiber
- Stefan Pilz
- Stefan R. Bornstein
- Stefan Schreiber
- Stefan-Martin Brand
- Stefania Bandinelli
- Stella Trompet
- Stephan B. Felix
- Stephan J. L. Bakker
- Stephen E. Epstein
- Stephen Fortmann
- Stephen G. Ball
- Stephen J. Hancock
- Stephen T. Turner
- Steve E. Humphries
- Steven C. Hunt
- Steven M. Schwartz
- Steven Sidney
- Su-Chi Lim
- Sudha Seshadri
- Sue Shaw-Hawkins
- Susan R. Heckbert
- Susana Eyheramendy
- Sven Bergmann
- Sylvia E. Rosas
- Sylvia Stracke
- Takayoshi Ohkubo
- Talin Haritunians
- Tamara B. Harris
- Tanja B. Grammer
- Tanja Zeller
- Tatiana Kuznetsova
- Tatijana Zemunik
- Tatjana Stojakovic
- Tatsuhiko Tsunoda
- Tazeen H. Jafar
- Terho Lehtimäki
- Terrence Forrester
- Terri L. Young
- Tetsuro Miki
- Themistocles L. Assimes
- Thomas F. Münzel
- Thomas H. Mosley
- Thomas Illig
- Thomas J. Wang
- Thomas Lumley
- Thomas Meitinger
- Thomas Quertermous
- Thor Aspelund
- Thorsten Reffelmann
- Tien-Yin Wong
- Tiit Nikopensius
- Tim D. Spector
- Timothy M. Frayling
- Tin Aung
- Toby Johnson
- Tom R. Gaunt
- Tomohiro Katsuya
- Tomonori Okamura
- Tonu Esko
- Toshihiro Tanaka
- Toshiko Tanaka
- Toshio Ogihara
- Tunde Salako
- Tune H. Pers
- Ulf Gyllensten
- Unnur Thorsteinsdottir
- Uwe Völker
- Valur Emilsson
- Vasyl Pihur
- Veikko Salomaa
- Veronique Vitart
- Vikal Tripathy
- Ville Aalto
- Vilmundur Gudnason
- Vincent Chouraki
- Vincent Mooser
- Viviane Nicaud
- Vladan Mijatovic
- W. H. Linda Kao
- Walter Palmas
- Wayne D. Rosamond
- Wei-Min Chen
- Weihua Zhang
- Wendy L. McArdle
- Wiek H. van Gilst
- Wilfried Renner
- Will T. Longstreth
- William Matthai
- Wilmar Igl
- Winfried März
- Wolfgang Koenig
- Wolfgang Lieb
- Wolfram Goessling
- Xiaofeng Zhu
- Xiaoling Wang
- Xiuqing Guo
- Xueling Sim
- Yali Li
- Yan V. Sun
- Yanbin Dong
- Yasuharu Tabara
- Yen-Pei C. Chang
- Yi-An Ko
- Yik-Ying Teo
- Ying A. Wang
- Ying Wu
- Yingchang Lu
- Yong Li
- Yongmei Liu
- Yoon Shin Cho
- Yoshikuni Kita
- Young Jin Kim
- Yuan-Tsong Chen
- Yukinori Okada
- Yuri Milaneschi
- Yurii Aulchenko
- Yusuke Nakamura
- Yvonne T. van der Schouw
- Zouhair Aherrahrou
- Åsa Johansson
- Publication venue
- Springer Nature America, Inc
- Publication date
- 27/10/2015
- Field of study
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways
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