51 research outputs found
Deep Learning How to Fit an Intravoxel Incoherent Motion Model to Diffusion-Weighted MRI
Purpose: This prospective clinical study assesses the feasibility of training
a deep neural network (DNN) for intravoxel incoherent motion (IVIM) model
fitting to diffusion-weighted magnetic resonance imaging (DW-MRI) data and
evaluates its performance. Methods: In May 2011, ten male volunteers (age
range: 29 to 53 years, mean: 37 years) underwent DW-MRI of the upper abdomen on
1.5T and 3.0T magnetic resonance scanners. Regions of interest in the left and
right liver lobe, pancreas, spleen, renal cortex, and renal medulla were
delineated independently by two readers. DNNs were trained for IVIM model
fitting using these data; results were compared to least-squares and Bayesian
approaches to IVIM fitting. Intraclass Correlation Coefficients (ICC) were used
to assess consistency of measurements between readers. Intersubject variability
was evaluated using Coefficients of Variation (CV). The fitting error was
calculated based on simulated data and the average fitting time of each method
was recorded. Results: DNNs were trained successfully for IVIM parameter
estimation. This approach was associated with high consistency between the two
readers (ICCs between 50 and 97%), low intersubject variability of estimated
parameter values (CVs between 9.2 and 28.4), and the lowest error when compared
with least-squares and Bayesian approaches. Fitting by DNNs was several orders
of magnitude quicker than the other methods but the networks may need to be
re-trained for different acquisition protocols or imaged anatomical regions.
Conclusion: DNNs are recommended for accurate and robust IVIM model fitting to
DW-MRI data. Suitable software is available at (1)
Improved unsupervised physics-informed deep learning for intravoxel incoherent motion modeling and evaluation in pancreatic cancer patients
: Earlier work showed that IVIM-NET, an unsupervised
physics-informed deep neural network, was more accurate than other
state-of-the-art intravoxel-incoherent motion (IVIM) fitting approaches to DWI.
This study presents an improved version: IVIM-NET, and characterizes
its superior performance in pancreatic ductal adenocarcinoma (PDAC) patients.
: In simulations (SNR=20), the accuracy, independence and
consistency of IVIM-NET were evaluated for combinations of hyperparameters (fit
S0, constraints, network architecture, # hidden layers, dropout, batch
normalization, learning rate), by calculating the NRMSE, Spearman's , and
the coefficient of variation (CV), respectively. The best performing
network, IVIM-NET was compared to least squares (LS) and a Bayesian
approach at different SNRs. IVIM-NET's performance was evaluated in
23 PDAC patients. 14 of the patients received no treatment between scan
sessions and 9 received chemoradiotherapy between sessions. Intersession
within-subject standard deviations (wSD) and treatment-induced changes were
assessed. : In simulations, IVIM-NET outperformed
IVIM-NET in accuracy (NRMSE(D)=0.18 vs 0.20; NMRSE(f)=0.22 vs 0.27;
NMRSE(D*)=0.39 vs 0.39), independence ((D*,f)=0.22 vs 0.74) and
consistency (CV (D)=0.01 vs 0.10; CV (f)=0.02 vs 0.05;
CV (D*)=0.04 vs 0.11). IVIM-NET showed superior performance
to the LS and Bayesian approaches at SNRs<50. In vivo, IVIM-NET
sshowed significantly less noisy parameter maps with lower wSD for D and f than
the alternatives. In the treated cohort, IVIM-NET detected the most
individual patients with significant parameter changes compared to day-to-day
variations. : IVIM-NET is recommended for IVIM
fitting to DWI data
Abdominal organ motion during inhalation and exhalation breath-holds: pancreatic motion at different lung volumes compared
Contrary to what is commonly assumed, organs continue to move during breath-holding. We investigated the influence of lung volume on motion magnitude during breath-holding and changes in velocity over the duration of breath-holding. Sixteen healthy subjects performed 60-second inhalation breath-holds in room-air, with lung volumes of ∼100% and ∼70% of the inspiratory capacity, and exhalation breath-holds, with lung volumes of ∼30% and ∼0% of the inspiratory capacity. During breath-holding, we obtained dynamic single-slice magnetic-resonance images with a time-resolution of 0.6s. We used 2-dimensional image correlation to obtain the diaphragmatic and pancreatic velocity and displacement during breath-holding. Organ velocity was largest in the inferior-superior direction and was greatest during the first 10s of breath-holding, with diaphragm velocities of 0.41mm/s, 0.29mm/s, 0.16mm/s and 0.15mm/s during BH100%, BH70%, BH30% and BH0%, respectively. Organ motion magnitudes were larger during inhalation breath-holds (diaphragm moved 9.8 and 9.0mm during BH100% and BH70%, respectively) than during exhalation breath-holds (5.6 and 4.3mm during BH30% and BH0%, respectively). Using exhalation breath-holds rather than inhalation breath-holds and delaying irradiation until after the first 10s of breath-holding may be advantageous for irradiation of abdominal tumor
Contrast-agent-based perfusion MRI code repository and testing framework: ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)
Purpose
Software has a substantial impact on quantitative perfusion MRI values. The lack of generally accepted implementations, code sharing and transparent testing reduces reproducibility, hindering the use of perfusion MRI in clinical trials. To address these issues, the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI) aimed to establish a community-led, centralized repository for sharing open-source code for processing contrast-based perfusion imaging, incorporating an open-source testing framework.
Methods
A repository was established on the OSIPI GitHub website. Python was chosen as the target software language. Calls for code contributions were made to OSIPI members, the ISMRM Perfusion Study Group, and publicly via OSIPI websites. An automated unit-testing framework was implemented to evaluate the output of code contributions, including visual representation of the results.
Results
The repository hosts 86 implementations of perfusion processing steps contributed by 12 individuals or teams. These cover all core aspects of DCE- and DSC-MRI processing, including multiple implementations of the same functionality. Tests were developed for 52 implementations, covering five analysis steps. For T1 mapping, signal-to-concentration conversion and population AIF functions, different implementations resulted in near-identical output values. For the five pharmacokinetic models tested (Tofts, extended Tofts-Kety, Patlak, two-compartment exchange, and two-compartment uptake), differences in output parameters were observed between contributions.
Conclusions
The OSIPI DCE-DSC code repository represents a novel community-led model for code sharing and testing. The repository facilitates the re-use of existing code and the benchmarking of new code, promoting enhanced reproducibility in quantitative perfusion imaging
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
Model-based reconstructions for intravoxel incoherent motion and diffusion-tensor imaging parameter map estimations
PURPOSE: Intravoxel incoherent motion (IVIM) imaging and diffusion-tensor imaging (DTI) facilitate non-invasive quantification of tissue perfusion and diffusion. Both are promising biomarkers in various diseases and a combined acquisition is therefore desirable. This comes with challenges, including noisy parameter maps and long scan times, especially for the perfusion fraction f and pseudo-diffusion coefficient D*. A model-based reconstruction has the potential to overcome these challenges. As a first step, our goal was to develop a model-based reconstruction framework for IVIM and combined IVIM-DTI parameter estimation. METHODS: The IVIM and IVIM-DTI models were implemented in the PyQMRI model-based reconstruction framework and validated with simulations and in vivo data. Commonly used voxel-wise nonlinear least-squares fitting was used as reference. Simulations with the IVIM and IVIM-DTI models were performed with 100 noise realizations to assess accuracy and precision. Diffusion-weighted data were acquired for IVIM-reconstruction in the liver (n=5) as well as for IVIM-DTI in the kidneys (n=5) and lower-leg muscles (n=6) of healthy volunteers. The median and interquartile range (IQR) values of the IVIM and IVIM-DTI parameters were compared to assess bias and precision. RESULTS: With model-based reconstruction, the parameter maps exhibit less noise, which was most pronounced in the f and D* maps both in the simulations and in vivo. The bias values in the simulations were comparable between model-based reconstruction and the reference method. The IQR was lower with model-based reconstruction compared to the reference for all parameters. CONCLUSION: Model-based reconstruction is feasible for IVIM and IVIM-DTI and improves the precision of the parameter estimates, particularly for f and D* maps
Dynamic MRI of swallowing: real-time volumetric imaging at 12 frames per second at 3 T
Objective: Dysphagia or difficulty in swallowing is a potentially hazardous clinical problem that needs regular monitoring. Real-time 2D MRI of swallowing is a promising radiation-free alternative to the current clinical standard: videofluoroscopy. However, aspiration may be missed if it occurs outside this single imaged slice. We therefore aimed to image swallowing in 3D real time at 12 frames per second (fps). Materials and methods: At 3 T, three 3D real-time MRI acquisition approaches were compared to the 2D acquisition: an aligned stack-of-stars (SOS), and a rotated SOS with a golden-angle increment and with a tiny golden-angle increment. The optimal 3D acquisition was determined by computer simulations and phantom scans. Subsequently, five healthy volunteers were scanned and swallowing parameters were measured. Results: Although the rotated SOS approaches resulted in better image quality in simulations, in practice, the aligned SOS performed best due to the limited number of slices. The four swallowing phases could be distinguished in 3D real-time MRI, even though the spatial blurring was stronger than in 2D. The swallowing parameters were similar between 2 and 3D. Conclusion: At a spatial resolution of 2-by-2-by-6 mm with seven slices, swallowing can be imaged in 3D real time at a frame rate of 12 fps
A tri-exponential model for intravoxel incoherent motion analysis of the human kidney: In silico and during pharmacological renal perfusion modulation
icorrelated to glomerular filtration rate (R=0.39, p=0.026). We validated a kidney-specific method for IVIM analysis using a tri-exponential model. The model is able to track renal perfusion changes induced by Angiotensin I
Deep Learning for Automated Elective Lymph Node Level Segmentation for Head and Neck Cancer Radiotherapy
Depending on the clinical situation, different combinations of lymph node (LN) levels define the elective LN target volume in head-and-neck cancer (HNC) radiotherapy. The accurate auto-contouring of individual LN levels could reduce the burden and variability of manual segmentation and be used regardless of the primary tumor location. We evaluated three deep learning approaches for the segmenting individual LN levels I–V, which were manually contoured on CT scans from 70 HNC patients. The networks were trained and evaluated using five-fold cross-validation and ensemble learning for 60 patients with (1) 3D patch-based UNets, (2) multi-view (MV) voxel classification networks and (3) sequential UNet+MV. The performances were evaluated using Dice similarity coefficients (DSC) for automated and manual segmentations for individual levels, and the planning target volumes were extrapolated from the combined levels I–V and II–IV, both for the cross-validation and for an independent test set of 10 patients. The median DSC were 0.80, 0.66 and 0.82 for UNet, MV and UNet+MV, respectively. Overall, UNet+MV significantly (p < 0.0001) outperformed other arrangements and yielded DSC = 0.87, 0.85, 0.86, 0.82, 0.77, 0.77 for the combined and individual level I–V structures, respectively. Both PTVs were also significantly (p < 0.0001) more accurate with UNet+MV, with DSC = 0.91 and 0.90, respectively. The accurate segmentation of individual LN levels I–V can be achieved using an ensemble of UNets. UNet+MV can further refine this result
Minimizing the Acquisition Time for Intravoxel Incoherent Motion Magnetic Resonance Imaging Acquisitions in the Liver and Pancreas
OBJECTIVES: The aim of this study was to determine the combination of b-values and signal averages for diffusion-weighted image acquisitions that render the minimum acquisition time necessary to obtain values of the intravoxel incoherent motion (IVIM) model parameters in vivo in the pancreas or liver with acceptable reproducibility. MATERIALS AND METHODS: For 16 volunteers, diffusion-weighted images, with 14 b-values and 9 acquisitions per b-value, were acquired in 2 scan sessions. The IVIM model was fitted to data from lesion-sized regions of interest (ROIs) (1.7 cm(3)) as well as organ-sized ROIs in the pancreas and liver. By deleting data during analyzes, the IVIM model parameters, D and f, could be determined as a function of the number of b-values as well as the number of measurements per b-value taken along. For the IVIM model parameters, we examined the behavior reproducibility, in the form of the within-subject coefficient of variation (CVw), as a function of the amount of data taken along in the fits. Finally, we determined the minimum acquisition time required as a function of CVw. RESULT: For the lesion-sized ROI, the intersession CVws were 8%/46% and 13%/55% for D/f in the pancreas and liver, respectively, when all data were taken along. For 1.2 times larger CVws, acquisition in the pancreas could be done in 5:15 minutes using 9 acquisitions per b-value at b = 0, 30, 50, 65, 100, 375, and 500 mm(-2)s and for the liver in 2:15 using 9 acquisitions per b-value at b = 0, 40, and 500 mm(-2)s. CONCLUSIONS: Acquiring 7 b-values in the pancreas and 3 b-values in the liver only decreases the reproducibility by 20% compared with an acquisition with 14 b-values. The understanding of the behavior of reproducibility as a function of b-values and acquisitions per b-values scanned will help researchers select the shortest IVIM protocol
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