Negative childhood events and the development of the anorexic voice: A grounded theory

Abstract: Background: Many individuals diagnosed with anorexia nervosa (AN) describe their disorder as being represented by an internal ‘anorexic voice’ (AV). Previous studies have identified associations between eating psychopathology and multifarious forms of adverse life experiences. Aims: This study explores the relationship between adverse experiences in childhood and the development of the AV. Materials and Methods: Twelve women who had the experience of the AV in the context of a diagnosis of AN took part in semi‐structured interviews. The interview data were analysed using a constructivist grounded theory methodology. Results: Participants recalled feeling unsafe in a variety of relationships and a theory was constructed in which the AV provides a sense of conditional safety, becoming increasingly hostile and belittling when it is disobeyed, revealing similar characteristics to abusers and bullies in childhood. Discussion: Findings are related to the broader literature on the link between trauma and eating disorders, and to existing theories of internal voices. Conclusions: The findings have implications for a trauma‐focused approach when working with the AV

Functional MRI and Diffusion Tensor Imaging of Brain Reorganization After Experimental Stroke

The potential of the adult brain to reorganize after ischemic injury is critical for functional recovery and provides a significant target for therapeutic strategies to promote brain repair. Despite the accumulating evidence of brain plasticity, the interaction and significance of morphological and physiological modifications in post-stroke brain tissue remain mostly unclear. Neuroimaging techniques such as functional MRI (fMRI) and diffusion tensor imaging (DTI) enable in vivo assessment of the spatial and temporal pattern of functional and structural changes inside and outside ischemic lesion areas. This can contribute to the elucidation of critical aspects in post-stroke brain remodeling. Task/stimulus-related fMRI, resting-state fMRI, or pharmacological MRI enables direct or indirect measurement of neuronal activation, functional connectivity, or neurotransmitter system responses, respectively. DTI allows estimation of the structural integrity and connectivity of white matter tracts. Together, these MRI methods provide an unprecedented means to (a) measure longitudinal changes in tissue structure and function close by and remote from ischemic lesion areas, (b) evaluate the organizational profile of neural networks after stroke, and (c) identify degenerative and restorative processes that affect post-stroke functional outcome. Besides, the availability of MRI in clinical institutions as well as research laboratories provides an optimal basis for translational research on stroke recovery. This review gives an overview of the current status and perspectives of fMRI and DTI applications to study brain reorganization in experimental stroke models

Long-Term Aircraft Noise Exposure and Risk of Hypertension in Postmenopausal Women [2022]

13-C-AJFE-BU-002This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license https://creativecommons.org/licenses/by/4.0/. Please cite this article as: Daniel D. Nguyen, Eric A. Whitsel, Gregory A. Wellenius, Jonathan I. Levy, Jessica H. Leibler, Stephanie T. Grady, James D. Stewart, Matthew P. Fox, Jason M. Collins, Melissa N. Eliot, Andrew Malwitz, JoAnn E. Manson, Junenette L. Peters, Long-term aircraft noise exposure and risk of hypertension in postmenopausal women, Environmental Research, Volume 218, 2023, 115037, ISSN 0013-9351, https://doi.org/10.1016/j.envres.2022.115037.Background: Studies of the association between aircraft noise and hypertension are complicated by inadequate control for potential confounders and a lack of longitudinal assessments, and existing evidence is inconclusive. Objectives: We evaluated the association between long-term aircraft noise exposure and risk of hypertension among post-menopausal women in the Women\u2019s Health Initiative Clinical Trials, an ongoing prospective U.S. cohort

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

A Stratospheric Chemical Instability

The equations which determine partitioning of Clx in steady state have multiple (three) solutions under conditions which might arise in the high-latitude winter stratosphere. Two of these solutions are stable, one is unstable, to infinitesimal perturbations. The relative stability of solutions is examined by subjecting the system to finite perturbations. The more stable solution is found to eliminate the less stable when semi-infinite volumes of the two solutions are placed in contact. The high-ClO, low-NO2 solution is more stable under most conditions. Transitions from less to more stable states are slow in winter but may occur more rapidly when the seasonal variation of insolation is taken into account