30 research outputs found
Antenatal endogenous and exogenous glucocorticoids and their impact on immune ontogeny and long-term immunity
The power threshold of H-mode access in mixed hydrogen–tritium and pure tritium plasmas at JET with ITER-like wall
The heating power to access the high confinement mode (H-mode), PLH, scales approximately inversely with the isotope mass of the main ion plasma species as found in (protonic) hydrogen, deuterium and tritium plasmas in many fusion facilities over the last decades. In first dedicated L–H transition experiments at the Joint European Torus (JET) tokamak facility with the ITER-like wall (ILW), the power threshold, PLH, was studied systematically in plasmas of pure tritium and hydrogen–tritium mixtures at a magnetic field of 1.8 T and a plasma current of 1.7 MA in order to assess whether this scaling still holds in a metallic wall device. The measured power thresholds, PLH, in Ohmically heated tritium plasmas agree well with the expected isotope scaling for metallic walls and the lowest power threshold was found in Ohmic phases at low density. The measured power thresholds in ion cyclotron heated plasmas of pure tritium or hydrogen–tritium mixtures are significantly higher than the expected isotope mass scaling due to higher radiation levels. However, when the radiated power is taken into account, the ion cyclotron heated plasmas exhibit similar power thresholds as a neutral beam heated plasma, and are close to the scaling. The tritium plasmas in this study tended to higher electron heating fractions and, when heated with ion cyclotron waves, to relatively higher radiation fractions compared to other isotopes potentially impeding access to sustained H-modes.The authors thank P.A. Schneider, F. Ryter, A. Nielsen, and A. Kappatou for fruitful discussions and for help with data analysis tools. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom Research and Training Programme 2014–2018 and 2019–2020 under Grant Agreement No. 633053. The views and opinions expressed herein do not necessarily reflect those of the European Commission. G. Birkenmeier received funding from the Helmholtz Association under Grant No. VH-NG-1350.Peer Reviewed"Article signat per 27 autors/es: G. Birkenmeier, E.R. Solano, E. Lerche, D. Taylor, D. Gallart, M.J. Mantsinen, E. Delabie, I.S. Carvalho, P. Carvalho, E. Pawelec, J.C. Hillesheim, F. Parra Diaz, C. Silva, S. Aleiferis, J. Bernardo, A. Boboc, D. Douai, E. Litherland-Smith, R. Henriques, K.K. Kirov, C.F. Maggi, J. Mailloux, M. Maslov, F.G. Rimini, S.A. Silburn, P. Sirén, H. Weisen and JET Contributors"Postprint (published version
The role of isotope mass and transport for H-mode access in tritium containing plasmas at JET with ITER-like wall
Special Issue Featuring the Invited Talks from the 48th EPS Conference on Plasma Physics, 27 June - 1 July 2022The required heating power, , to access the high confinement regime (H-mode) in tritium containing plasmas is investigated in JET with ITER-like wall at a toroidal magnetic field of T and a plasma current of MA. , also referred to as the L-H power threshold, is determined in plasmas of pure tritium as well as mixtures of hydrogen with tritium (H-T) and mixtures of deuterium with tritium (D-T), and is compared to the L-H power threshold in plasmas of pure hydrogen and pure deuterium. It is found that, for otherwise constant parameters, is not the same in plasmas with the same effective isotope mass, , when they differ in their isotope composition. Thus, is not sufficient to describe the isotope effect of in a consistent manner for all considered isotopes and isotope mixtures. The electron temperature profiles measured at the L-H transition in the outer half of the radius are very similar for all isotopes and isotope mixtures, despite the fact that the L-H power threshold varies by a factor of about six. This finding, together with the observation of an offset linear relation between the L-H power threshold, , and an effective heat diffusivity, , indicates that the composition-dependent heat transport in the low confinement mode (L-mode) determines, how much power is needed to reach the necessary electron temperatures at the edge, and hence PLH.This work has been carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (Grant Agreement No. 101052200—EUROfusion). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the European Commission can be held responsible for them. G Birkenmeier received funding from the Helmholtz Association under Grant No. VH-NG-1350Peer Reviewed"Article signat per 50 autors/es: G Birkenmeier, E R Solano, I S Carvalho, J C Hillesheim, E Delabie, E Lerche, D Taylor, D Gallart, M J Mantsinen, C Silva, C Angioni, F Ryter, P Carvalho, M Fontana, E Pawelec, S A Silburn, P Sirén, S Aleiferis, J Bernardo, A Boboc, D Douai, P Puglia, P Jacquet, E Litherland-Smith, I Jepu, D Kos, H J Sun, A Shaw, D King, B Viola, R Henriques, K K Kirov, M Baruzzo, J Garcia, A Hakola, A Huber, E Joffrin, D Keeling, A Kappatou, M Lennholm, P Lomas, E de la Luna, C F Maggi, J Mailloux, M Maslov, F G Rimini, N Vianello, G Verdoolaege, H Weisen, M Wischmeier and JET Contributors"Postprint (published version
Magnetic Phase transitions in Plasmas and Transport Barriers
A model of magnetic phase transitions in plasmas is presented: plasma blobs
with pressure excess or defect are dia- or para-magnets and move radially under
the influence of the background plasma magnetisation. It is found that magnetic
phase separation could be the underlying mechanism of L to H transitions and
drive transport barrier formation. Magnetic phase separation and associated
pedestal build up, as described here, can be explained by the well known
interchange mechanism, now reinterpreted as a magnetisation interchange which
remains relevant even when stable or saturated. A testable necessary criterion
for the L to H transition is presented.Comment: 3 figures, 9 pages, equations created with MathType To be published
in Nuclear Fusion, accepted August 201
Overview of recent TJ-II stellarator results
The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presentedThis work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under Grant Agreement No. 633053. It has been partially funded by the Ministerio de Ciencia, Inovación y Universidades of Spain under projects ENE2013-48109-P, ENE2015-70142-P and FIS2017-88892-P. It has also received funds from the Spanish Government via mobility grant PRX17/00425. The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by the Barcelona S.C. It has been supported as well by The Science and Technology Center in Ukraine (STCU), Project P-507F
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe
Robust estimation of bacterial cell count from optical density
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data