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The soil-dwelling earthworm Allolobophora chlorotica modifies its burrowing behaviour in response to carbendazim applications
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2010
- Field of study
Carbendazim-amended soil was placed above or below unamended soil. Control tests comprised two layers of unamended soil. Allolobophora chlorotica earthworms were added to either the upper or the unamended soil. After 72 h vertical distributions of earthworms were compared between control and carbendazim-amended experiments. Earthworm distributions in the carbendazim-amended test containers differed significantly from the ‘normal’ distribution observed in the control tests. In the majority of the experiments, earthworms significantly altered their burrowing behaviour to avoid carbendazim. However, when earthworms were added to an upper layer of carbendazim-amended soil they remained in this layer. This non-avoidance is attributed to (1) the earthworms’ inability to sense the lower layer of unamended soil and (2) the toxic effect of carbendazim inhibiting burrowing. Earthworms modified their burrowing behaviour in response to carbendazim in the soil. This may explain anomalous results observed in pesticide field trials when carbendazim is used as a control substance
Формирование эмоциональной культуры как компонента инновационной культуры студентов
- Author
- A Abdellaoui
- A Garrod
- A Wright
- Abdel Abdellaoui
- Adesola Ogunniyi
- Adolfo Correa
- Alan F. Wright
- Alan R. Shuldiner
- Alanna Morrison
- Albert V. Smith
- Albertine J. Oldehinkel
- Alena Stančáková
- Alexander Drong
- Alexander Teumer
- Alice V. Stanton
- Aliki-Eleni Farmaki
- Amelie Bonnefond
- Anders Hamsten
- Andre G. Uitterlinden
- Andres Metspalu
- Andrew A. Hicks
- Andrew Bjonnes
- Andrew D. Morris
- Andrew P. Morris
- Andrew R. Wood
- Angela Matchan
- Anil K. Giri
- Anke Tönjes
- Anna Maria Töglhofer
- Annamari Lundqvist
- Anne U. Jackson
- Anni Joensuu
- Antonietta Robino
- Antti-Pekka Sarin
- Anu Loukola
- AR Wood
- Aravinda Chakravarti
- Archie Campbell
- Ashley van der Spek
- Astrid van Hylckama Vlieg
- Atsushi Takahashi
- Babatunde Salako
- Bamidele O. Tayo
- Bengt Sennblad
- Benjamin Lehne
- Beverley Balkau
- Bjarke Feenstra
- Blair H. Smith
- Bruce M. Psaty
- C Darwin
- C Darwin
- CA Rietveld
- Carole Ober
- Caroline Hayward
- Caroline S. Fox
- Cecilia M. Lindgren
- Charles Gu
- Charles N. Rotimi
- Chittaranjan S. Yajnik
- Chris Haley
- Christa Meisinger
- Christian Gieger
- Christopher J. Hammond
- Cinzia Sala
- CJ Willer
- Claude Bouchard
- Claudia Schurmann
- Clemens Baumbach
- Colin N. A. Palmer
- Constance Chen
- Cornelia M. van Duijn
- Cornelius A. Rietveld
- Corrado Masciullo
- Cristian Pattaro
- Cristina Menni
- D Charlesworth
- Daniel I. Chasman
- Daniel J. Benjamin
- Daniel Shriner
- Daniela Ruggiero
- Daniela Toniolo
- Daniele Cusi
- David A. Mackey
- David C.M. Liewald
- David J. Porteous
- David P. Strachan
- David R. Weir
- Degui Zhi
- Dhananjay Vaidya
- Dharambir K. Sanghera
- Diane M. Becker
- Diego Vozzi
- Donna K. Arnett
- Dorret I. Boomsma
- Dragana Vuckovic
- Dwaipayan Bharadwaj
- Edith Hofer
- Eero Vuoksimaa
- Efthymia Vlachopoulou
- Eleftheria Zeggini
- Eric Boerwinkle
- Erik Ingelsson
- Erika Salvi
- Erin B. Ware
- Erkki Vartiainen
- Erwin P. Bottinger
- Evelin Mihailov
- F Galton
- Folkert W. Asselbergs
- Francesca Pavani
- Francine Grodstein
- Francis S. Collins
- Frank D. Mentch
- Frank Geller
- Gail Davies
- GB Ehret
- Generation Scotland
- Georg Ehret
- Georg Homuth
- George Davey Smith
- George Dedoussis
- George T. O'Connor
- Gerard Pasterkamp
- Gianluigi Zaza
- Gibran Hemani
- Giorgia Girotto
- Giovanni Gambaro
- Giovanni Malerba
- Giriraj R. Chandak
- Gonneke Willemsen
- Grant W. Montgomery
- H Campbell
- H Lango Allen
- H Najmabadi
- H Stefansson
- Hakon Hakonarson
- Hannele Mattsson
- Hans Bisgaard
- Hao Mei
- Harri Rissanen
- Harry Campbell
- Heikki A. Koistinen
- Helen R. Warren
- Helena Schmidt
- Henning Tiemeier
- Hugoline G. de Haan
- I Rudan
- Ian Ford
- Ian J. Deary
- Igor Rudan
- IJ Deary
- Ilaria Gandin
- Ilja Demuth
- Ilja M. Nolte
- Inga Patarcic
- Inga Prokopenko
- Ingrid B. Borecki
- Irina Gillham-Nasenya
- J Gibson
- J. Wouter Jukema
- Jaakko Kaprio
- Jaakko Tuomilehto
- James B. Meigs
- James F. Wilson
- James G. Wilson
- James S. Pankow
- Jari Lahti
- Jaspal S. Kooner
- JE Powell
- Jeffrey R. O'Connel
- Jennifer A. Smith
- Jennifer E. Huffman
- Jerome I. Rotter
- Jessica D. Faul
- Jessica van Setten
- JI Hoffman
- Jie Yao
- Jing Hua Zhao
- Jinyan Huang
- Joel N. Hirschhorn
- Johan G. Eriksson
- Johanna Kuusisto
- John B. Whitfield
- John C. Chambers
- John Connell
- John M. Starr
- John R. B. Perry
- Jonathan P. Bradfield
- Josée Dupuis
- Jouke-Jan Hottenga
- JR Flynn
- Juha Sinisalo
- JV Neel
- Karen L. Mohlke
- Kari E. North
- Kauko Heikkilä
- Kent D. Taylor
- Kirsi Pietilainen
- Koichi Matsuda
- Konstantin Strauch
- KW Broman
- L Ronnegard
- L. Adrienne Cupples
- LA Weiss
- Lars Bertram
- Lars Lind
- Laura J. Scott
- Lawrence F. Bielak
- Lazaros Lataniotis
- Leanne M. Hall
- Lenore J. Launer
- Lihua Wang
- Lili Milani
- Lisa R. Yanek
- Lisbeth Carstensen
- Loic Yengo
- Lorraine Southam
- Louis Pérusse
- Luigi Ferrucci
- LV Hedges
- Lyn R. Griffiths
- Lynda M. Rose
- Lynne J. Hocking
- M Kirin
- M Soler Artigas
- M. Arfan Ikram
- MA Nalls
- Maciej Tomaszewski
- Mads Melbye
- Magnus Johannesson
- Manraj K. Kooner
- Marcus Dörr
- Margie J. Wright
- Mari Nelis
- Maria G. Stathopoulou
- Maria Pina Concas
- Marie Loh
- Marilyn C. Cornelis
- Marina Ciullo
- Mario Pirastu
- Marja-Liisa Lokki
- Mark Abney
- Mark J. Caulfield
- Markku Laakso
- Markku S. Nieminen
- Markus Perola
- Mary F. Feitosa
- Massimo Mangino
- Matthew A. Allison
- Matthew J. Suderman
- May E. Montasser
- MC Keller
- MC Keller
- Melanie Waldenberger
- Michael Boehnke
- Michela Traglia
- Michiaki Kubo
- Mika Kähönen
- Miles C. Benton
- Misa Graff
- Najaf Amin
- Nancy L. Heard-Costa
- Natalia Tšernikova
- Naveed Sattar
- Nazir M. Khan
- NE Morton
- Neil Poulter
- Nele Friedrich
- Nicholas D. Hastie
- Nicholas G. Martin
- Nicholas J. Timpson
- Nicholas J. Wareham
- Nicola Pirastu
- Nicole Soranzo
- Niek Verweij
- Niina Eklund
- Nikhil Tandon
- Nilesh J. Samani
- Nona Sotoodehnia
- Nora Franceschini
- Olga McLeod
- Olli Raitakari
- Omri Gottesman
- Ozren Polašek
- Panos Deloukas
- Paolo Gasparini
- Patricia A. Peyser
- Patricia B. Munroe
- Patrik K. E. Magnusson
- Pau Navarro
- Paul Knekt
- Paul M. Ridker
- Paul Redmond
- Pedro Marques-Vidal
- Pekka Jousilahti
- Penelope A. Lind
- Peter J. van der Most
- Peter K. Joshi
- Peter Kraft
- Peter Sever
- Peter Vollenweider
- Philipp Koellinger
- Philippe Froguel
- Pim van der Harst
- Pirro G. Hysi
- R McQuillan
- R McQuillan
- R. Graham Barr
- RA Scott
- Rajiv Nadukuru
- Rany M. Salem
- Rasika A. Mathias
- RE Marioni
- RE Marioni
- Reedik Mägi
- Reinhold Schmidt
- Richa Saxena
- Richard H. Myers
- Richard Rose
- Richard S. Cooper
- Robert A. Scott
- Rodney A. Lea
- Rona J. Strawbridge
- Ruth J. F. Loos
- S Purcell
- S Wright
- S Wright
- Sailaja Vedantam
- Saira S. Mirza
- Sander W. van der Laan
- Sandosh Padmanabhan
- Sarah E. Harris
- Sarah E. Medland
- Sarah Wild
- Sarju Ralhan
- Satu Männistö
- Sebastian E. Baumeister
- Seyhan Yazar
- Sharon L. R. Kardia
- Sheila Ulivi
- Shona M. Kerr
- Sian-Tsun Tang
- Smeeta Shrestha
- Sonja I. Berndt
- Stavroula Kanoni
- Stefan Enroth
- Stefania Cappellani
- Stella Trompet
- Stephan J. L. Bakker
- Stephanie J. London
- Stephanie J. Loomis
- Stephen B. Ellis
- Stephen J. Chanock
- Stephen S. Rich
- Steven C. Hunt
- Struan F.A. Grant
- Sudha Seshadri
- Suraj S. Nongmaithem
- Sven Bergmann
- Tamara B. Harris
- Tanguy Corre
- Tarunveer S. Ahluwalia
- Teresa Nutile
- Terho Lehtimäki
- Thomas Lumley
- Thomas Meitinger
- Thorkild I. A. Sørensen
- Tian Liu
- Tim D. Spector
- Tim Kacprowski
- Timothy M. Frayling
- TJ Pemberton
- Tonu Esko
- Traci M. Bartz
- Tugce Karaderi
- Tuula Vasankari
- Ulf Gyllensten
- Ulman Lindenberger
- Ulrich Broeckel
- Uzma Afzal
- Veikko Salomaa
- Veronique Vitart
- Vilmundur Gudnason
- Walter R. Palmas
- Wei Zhao
- Weihua Meng
- Weihua Zhang
- William R. Scott
- William Wentworth-Shields
- Xiaofeng Zhu
- Xiuqing Guo
- Y.-D. Ida Chen
- Ying Wu
- Yingchang Lu
- Yingleong Chan
- Yoichiro Kamatani
- YS Aulchenko
- YS Aulchenko
- Yukinori Okada
- Yuning Chen
- Zhaoming Wang
- Åsa Johansson
- Publication venue
- Российский государственный профессионально-педагогический университет
- Publication date
- 01/01/2009
- Field of study
Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been
HE-LHC: The High-Energy Large Hadron Collider – Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- Alía R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- Apolinário L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
- Apyan A.
- Apyan A.
- Arbey A.
- Arbuzov A.
- Arduini G.
- Arı V.
- Arias S.
- Armesto N.
- Arnaldi R.
- Arsenyev S. A.
- Arzeo M.
- Asai S.
- Aslanides E.
- Astapovych D.
- Atanasov M.
- Atieh S.
- Attié D.
- Auchmann B.
- Audurier A.
- Aull S.
- Aumon S.
- Aune S.
- Avino F.
- Avrillaud G.
- Aydın G.
- Azatov A.
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- Azzi P.
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- Aßmann R. W.
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- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider – Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
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- Altmannshofer W.
- Alía R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
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- Attié D.
- Auchmann B.
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- Aumon S.
- Aune S.
- Avino F.
- Avrillaud G.
- Aydın G.
- Azatov A.
- Azuelos G.
- Azzi P.
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- Aßmann R. W.
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- Springer Verlag
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- 14/11/2019
- Field of study
Prevalence and architecture of de novo mutations in developmental disorders.
- Author
- Ahmed Munaza
- Aitken Stuart
- Akawi Nadia
- Alvi Mohsan
- Ambridge Kirsty
- Anjum Uruj
- Archer Hayley
- Armstrong Ruth
- Awada Jana
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Batstone Paul
- Baty David
- Bayzetinova Tanya
- Bennett Chris
- Berg Jonathan
- Bernhard Birgitta
- Bevan A. Paul
- Bitner-Glindzicz Maria
- Blair Edward
- Blyth Moira
- Bohanna David
- Bourdon Louise
- Bourn David
- Bradley Lisa
- Brady Angela
- Brent Simon
- Brewer Carole
- Brunstrom Kate
- Bunyan David J.
- Burn John
- Canham Natalie
- Castle Bruce
- Chandler Kate
- Chatzimichali Elena
- Cilliers Deirdre
- Clarke Angus
- Clasper Susan
- Clayton Stephen
- Clayton-Smith Jill
- Clowes Virginia
- Coates Andrea
- Cole Trevor
- Colgiu Irina
- Collins Amanda
- Collinson Morag N.
- Connell Fiona
- Cooper Nicola
- Cox Helen
- Cresswell Lara
- Cross Gareth
- Crow Yanick
- D'Alessandro Mariella
- Dabir Tabib
- Davidson Rosemarie
- Davies Sally
- de Vries Dylan
- Dean John
- Deshpande Charu
- Devlin Gemma
- Dixit Abhijit
- Dobbie Angus
- Donaldson Alan
- Donnai Dian
- Donnelly Carina
- Donnelly Deirdre
- Douglas Angela
- Douzgou Sofia
- Duncan Alexis
- Eason Jacqueline
- Ellard Sian
- Ellis Ian
- Elmslie Frances
- Evans Karenza
- Everest Sarah
- Fendick Tina
- Firth Helen V.
- Fisher Richard
- Fitzgerald Tomas W.
- FitzPatrick David R.
- Flinter Frances
- Foulds Nicola
- Fry Andrew
- Fryer Alan
- Gardiner Carol
- Gaunt Lorraine
- Ghali Neeti
- Gibbons Richard
- Gill Harinder
- Goodship Judith
- Goudie David
- Gray Emma
- Green Andrew
- Greene Philip
- Greenhalgh Lynn
- Gribble Susan
- Harrison Lucy
- Harrison Rachel
- Harrison Victoria
- Hawkins Rose
- He Liu
- Hellens Stephen
- Henderson Alex
- Hewitt Sarah
- Hildyard Lucy
- Hobson Emma
- Holden Simon
- Holder Muriel
- Holder Susan
- Hollingsworth Georgina
- Homfray Tessa
- Humphreys Mervyn
- Hurles Matthew E.
- Hurst Jane
- Hutton Ben
- Ingram Stuart
- Irving Melita
- Islam Lily
- Jackson Andrew
- Jarvis Joanna
- Jenkins Lucy
- Johnson Diana
- Jones Elizabeth
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- Jones Wendy D.
- Josifova Dragana
- Joss Shelagh
- Kaemba Beckie
- Kaplanis Joanna
- Kazembe Sandra
- Kelsell Rosemary
- Kerr Bronwyn
- King Daniel
- Kingston Helen
- Kini Usha
- Kinning Esther
- Kirby Gail
- Kirk Claire
- Kivuva Emma
- Kraus Alison
- Krishnappa Netravathi
- Kumar Dhavendra
- Kumar V. K. Ajith
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- Lampe Anne
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- Lowther Gordon
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- Mansour Sahar
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- McGowan Ruth
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- Mehta Sarju
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- Miedzybrodzka Zosia
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- Mohammed Shehla
- Montgomery Tara
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- Morton Jenny
- Mugalaasi Hood
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- Naik Swati
- Nellåker Chris
- Nemeth Andrea
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- Ong Kai-Ren
- Park Soo-Mi
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- Patel Chirag
- Paterson Joan
- Payne Stewart
- Perrett Daniel
- Phipps Julie
- Pilz Daniela T.
- Pollard Martin
- Pottinger Caroline
- Poulton Joanna
- Pratt Norman
- Prescott Katrina
- Price Sue
- Pridham Abigail
- Prigmore Elena
- Procter Annie
- Purnell Hellen
- Quarrell Oliver
- Ragge Nicola
- Rahbari Raheleh
- Rajan Diana
- Randall Josh
- Rankin Julia
- Raymond Lucy
- Rice Debbie
- Robert Leema
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- Roberts Gillian
- Roberts Jonathan
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- Rosser Elisabeth
- Saggar Anand
- Samant Shalaka
- Sampson Julian
- Sandford Richard
- Sarkar Ajoy
- Schweiger Susann
- Scott Richard
- Scurr Ingrid
- Selby Ann
- Seller Anneke
- Sequeira Cheryl
- Shannon Nora
- Sharif Saba
- Shaw-Smith Charles
- Shearing Emma
- Shears Debbie
- Sheridan Eamonn
- Sifrim Alejandro
- Simonic Ingrid
- Singh Tarjinder
- Singzon Roldan
- Skitt Zara
- Smith Audrey
- Smith Kath
- Smithson Sarah
- Sneddon Linda
- Splitt Miranda
- Squires Miranda
- Stewart Fiona
- Stewart Helen
- Straub Volker
- Suri Mohnish
- Sutton Vivienne
- Swaminathan Ganesh Jawahar
- Sweeney Elizabeth
- Tatton-Brown Kate
- Taylor Cat
- Taylor Rohan
- Tein Mark
- Temple I. Karen
- Thomson Jenny
- Tischkowitz Marc
- Tivey Adrian R.
- Tomkins Susan
- Torokwa Audrey
- Treacy Becky
- Turner Claire
- Turnpenny Peter
- Tysoe Carolyn
- Vandersteen Anthony
- Varghese Vinod
- Vasudevan Pradeep
- Vijayarangakannan Parthiban
- Vogt Julie
- Wakeling Emma
- Wallwark Sarah
- Waters Jonathon
- Weber Astrid
- Wellesley Diana
- Whiteford Margo
- Widaa Sara
- Wilcox Sarah
- Wilkinson Emily
- Williams Denise
- Williams Nicola
- Wilson Louise
- Woods Geoff
- Wragg Christopher
- Wright Caroline F.
- Wright Michael
- Yates Laura
- Yau Michael
- Publication venue
- Nature
- Publication date
- 01/01/2017
- Field of study
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important genes. Here we have sequenced the exomes of 4,293 families containing individuals with developmental disorders, and meta-analysed these data with data from another 3,287 individuals with similar disorders. We show that the most important factors influencing the diagnostic yield of DNMs are the sex of the affected individual, the relatedness of their parents, whether close relatives are affected and the parental ages. We identified 94 genes enriched in damaging DNMs, including 14 that previously lacked compelling evidence of involvement in developmental disorders. We have also characterized the phenotypic diversity among these disorders. We estimate that 42% of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. We estimate that developmental disorders caused by DNMs have an average prevalence of 1 in 213 to 1 in 448 births, depending on parental age. Given current global demographics, this equates to almost 400,000 children born per year
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
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- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
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- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
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- Alexahin Y
- Alia RG
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- Appleby RB
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- Wienands H-U
- Wilkinson G
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- Wojton T
- Wollmann D
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- Woog D
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- Wulzer A
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- Yanehsari MK
- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appelo D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
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- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Behr JK
- Bellafont I
- Bellagamba L
- Bellegarde N
- Belli E
- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
- Bermudez SI
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
- Bernini C
- Berriaud C
- Bertarelli A
- Bertolucci S
- Besana MI
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- Beznosov O
- Bhat C
- Bhat P
- Biagini ME
- Biarrotte J-L
- Bielert ER
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- Bilei GM
- Bilki B
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- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
- Bluemlein J
- Boccali T
- Boels R
- Bogacz SA
- Bogomyagkov A
- Boine-Frankenheim O
- Boland MJ
- Bologna S
- Bolukbasi O
- Bomben M
- Bondarenko S
- Bonvini M
- Boos E
- Bordini B
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- Borghello G
- Borgonovi L
- Borowka S
- Bortoletto D
- Boscherini D
- Boscolo M
- Boselli S
- Bosley RR
- Bossu F
- Botta C
- Bottura L
- Boughezal R
- Boutin D
- Bovone G
- Bozbey A
- Bozzi C
- Bozzini D
- Braccini V
- Braibant-Giacomelli S
- Bramante J
- Braun-Munzinger P
- Briffa JA
- Britzger D
- Brodsky SJ
- Brooke JJ
- Bruce R
- Bruna E
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- Brunner O
- Bruzual HM
- Bruzzone P
- Buffat X
- Bulyak E
- Burkart F
- Burkhardt H
- Burnet J-P
- Butin F
- Buttazzo D
- Butterworth A
- Caccia M
- Cai Y
- Caiffi B
- Cairo V
- Cakir IT
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- Calaga R
- Calame CMC
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- Calderini G
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- Camalich JM
- Camalich JM
- Camarri P
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- Camporesi T
- Canbay AC
- Canepa A
- Cantergiani E
- Canton GG
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- Cardella U
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- Casalbuoni S
- Casas J
- Cascella M
- Castelnovo P
- Castorina G
- Catalano G
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- Chaikovska I
- Chakrabortty J
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- Chanal D
- Chanal H
- Chance A
- Chance S
- Charitos P
- Charles J
- Charles TK
- Chattopadhyay S
- Chehab R
- Chekanov SV
- Chen N
- Chernoded A
- Chetvertkova V
- Chevalier AB
- Chevalier L
- Chiarelli G
- Chiarello G
- Chiesa M
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- Childers JT
- Chmielinska A
- Cholakian A
- Chomaz P
- Chorowski M
- Chou W
- Chrzaszcz M
- Chyhyrynets E
- Cibinetto G
- Ciftci AK
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- Ciuchini M
- Clark PJ
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- Coccaro A
- Codina EP
- Cogan J
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- Collamati F
- Colldelram C
- Collier P
- Collot J
- Contino R
- Conventi F
- Cook CTA
- Cooley L
- Corcella G
- Cornell AS
- Corral GH
- Correia-Rodrigues H
- Costa MG
- Costanza F
- Couderc F
- Coupard J
- Craig N
- Crespo Garrido I
- Crivellin A
- Croteau JF
- Crouch M
- Cure B
- Curti J
- Curtin D
- Czech M
- D'Agnolo RT
- D'Ambrosio G
- D'Auria S
- D'Auria V
- d'Enterria D
- D'Onofrio M
- da Costa JBG
- da Silva HFP
- da Silva PF
- da Silva W
- da Silveira GG
- Dachauer C
- Daibo M
- Dainese A
- Dalena B
- Daljevec A
- Dallapiazza W
- Dam M
- Das SP
- DasBakshi S
- David A
- Davidek T
- de Blas J
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- Yang G
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- Yao W-M
- Yazgan E
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- Yilmaz A
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- Yoo H-D
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- Zadeh SG
- Zadeh SG
- Zahnd M
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- Zhong Y-M
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- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Barranco Garcia J
- Barreiro Guimaraes da Costa J
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
- Baudouy B
- Bauer F
- Bauer M
- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Bellafont I
- Bellagamba L
- Bellegarde N
- Belli E
- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
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- Yao W-M
- Yazgan E
- Yermolchik V
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoeldi GG
- Barnes MJ
- Barr A
- Barranco Garcia J
- Barreiro Guimaraes da Costa J
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
- Baudouy B
- Bauer F
- Bauer M
- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Bellafont I
- Bellagamba L
- Bellegarde N
- Belli E
- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
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- Blekman F
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- Bogomyagkov A
- Boine-Frankenheim O
- Boland MJ
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
HE-LHC: The High-Energy Large Hadron Collider
- Author
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- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
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