87 research outputs found
Hidden costs of attending Manhattan Public High School
- Author
- Publication venue
- Publication date
- 01/01/1951
- Field of study
Call number: LD2668 .R4 1951 D75
Community Memories: A Glimpse of African American Life in Frankfort, Kentucky
- Publication venue
- UKnowledge
- Publication date
- 01/01/2003
- Field of study
Community Memories is a fascinating look into life recalled by African Americans who consider Frankfort their home. Featuring unique oral history recollections and over two hundred candid personal photographs collected from community residents, the book provides an enlightening expression of the black experience in Kentuckyâs capital. The memories focus on the elusive concept of communityâthat which binds together individuals in the living of everyday life. A satisfying blend of public history and local accounts, Community Memories explores the neighborhood, familial, religious, occupational, social, and educational components of the daily community experience of twentieth-century African Americans in Frankfort.
Published by the Kentucky Historical Society and distributed by the University Press of Kentucky
Senior Editor Winona L. Fletcher is professor emerita of theater and drama at Indiana University.
Associate Editor Sheila Mason Burton is assistant director for research coordination at the Kentucky Legislative Research Commission.
Associate Editor James E. Wallace is assistant director of the Kentucky Historical Society.
Photographs Editor Mary E. Winter is special collections branch manager and photographs archivist at the Kentucky Historical Society.
Oral History Editor Douglas A. Boyd is oral history and folklife archivist at the Kentucky Historical Society.https://uknowledge.uky.edu/upk_african_american_studies/1024/thumbnail.jp
Governo dos escravos na mina de Morro Velho 1835-1888
- Author
- ALEXANDRE Valentin
- Alisson EugĂȘnio
- BARBOSA Keith Valéria de Oliveira
- BURTON Richard
- BURTON Richard Francis
- BURTON Richard Francis
- BURTON Richard Francis
- EUGENIO Alisson
- EUGĂNIO Alisson
- Ferreira LuĂs Gomes
- FOUCAULT Michel
- FOUCAULT Michel
- FRANCO Maria Sylvia de Carvalho
- KARASH Mary
- KENNETH Kiple F
- KLEIN Hebert S.
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LIBBY Douglas Cole
- LUNA Francisco Vidal
- MARIOSA Rosilene Maria
- MARQUESE Rafael de Bivar
- MARQUESE Rafael de Bivar
- MELO Ciro FlĂĄvio de Castro Bandeira de
- OUCAULT Michel
- SOUZA Rafael de Freitas
- TEUSCHER Reinhold
- Tuesher Reinhold
- VAINFAS Ronaldo
- VILHENA Mathias AntĂŽnio Moinho de
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Scholarship on Gender and Sport in Sex Roles and Beyond
- Author
- A Bruin De
- A Fausto-Sterling
- A Knoppers
- A Knoppers
- A Schrack-Walters
- A Smiler
- Annelies Knoppers
- AT Klomsten
- AT Klomsten
- B Carrington
- B Fielding-Lloyd
- C Greenleaf
- C Ingen Van
- C Koca
- C Palmer
- C Wrisberg
- CL Cole
- D Anderson
- D Corbett
- D Kleiber
- D Shaffer
- D Shogun
- DD Douglas
- DL Andrews
- DL Andrews
- DL Andrews
- DL Andrews
- DP Johns
- E Anderson
- E Roper
- G Chapman
- G Coulomb-Cabagno
- G Cunningham
- G Cunningham
- G Cunningham
- G Lewis
- G Lippe Von der
- G Rail
- GS Desertrain
- H Hendy
- H Lenskyj
- H Marsh
- H Sykes
- H Sykes
- H Thorpe
- I Claringbould
- I Claringbould
- I Claringbould
- IH Frieze
- IH Frieze
- J Butler
- J Croxton
- J Felshin
- J Kay
- J McDowell
- J Miller
- J Parks
- J Parks
- J Young
- JA Hargreaves
- JA Hargreaves
- JC Caudwell
- K Jamieson
- K Jamieson
- K Jamieson
- K Linderman
- K Russell
- K Walseth
- K Young
- KW Crenshaw
- L Burton
- L Chase
- L Harrison
- L Hoeber
- L Hoeber
- M Boutilier
- M Boutilier
- M Hardin
- M Hart
- M Hebl
- M Helstein
- M Hoferek
- M Messner
- M Messner
- M Sagas
- M Sartore
- M Weiss
- MA Hall
- MA Hall
- MA Messner
- MA Messner
- Mary McDonald
- MC Duncan
- MC Duncan
- MG McDonald
- MJ Kane
- N Koivula
- N Theberge
- N Theberge
- N Trujillo
- P Griffin
- P Markula
- P Markula
- P Willis
- PH Collins
- R Colker
- R Connell
- RM Kanter
- RW Connell
- RW Connell
- RW Connell
- S Banet-Weiser
- S Birrell
- S Birrell
- S Cahn
- S Franzoi
- S Greendorfer
- S King
- S King
- S King
- S Laberge
- S Matteo
- S Matteo
- S Mills
- S Ross
- S Scraton
- S Scraton
- S Shaw
- SL Greendorfer
- SR Guthrie
- T Kay
- T Miller
- V Krane
- VVP Rao
- W Whisenant
- W Whisenant
- W Whisenant
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
In this paper we critically review how research on girls or women and sport has developed over the last 35Â years. We use a post-positivist lens to explore the content of the papers published in Sex Roles in the area of women, gender and sport and examine the shifts in how gender and sport have been conceptualized in these accounts. In order to initiate a broader dialogue about the scholarly analysis of gender and sport, we subsequently explore ideas inspired by feminist theorizing that have dominated/guided related research in other outlets over this time period but have received relatively little attention in papers published in Sex Roles. We conclude by briefly making suggestions for further research in this area
Inclusive fitness theory and eusociality
- Author
- Alan Grafen
- Alex Kacelnik
- Alpedrinha Joao A. C.
- Andrew Cockburn
- Andrew Zink
- Andy Gardner
- Angus Buckling
- Bernard Crespi
- Bernard Voelkl
- Beukeboom Leo W.
- Beverly Strassmann
- Biernaskie Jay M.
- Bruce Lyon
- Burley Nancy T.
- Burton Chellew Max N.
- Cant Michael A.
- Charnov Eric L.
- Claire El Mouden
- Cole Blaine J.
- Couzin Iain D.
- Coyne Jerry A.
- Curry Robert L.
- Dall Sasha R. X.
- Daniel Kronauer
- Darryl Gwynne
- David Pfennig
- Denis Roze
- Dickinson Janis L.
- Douglas Mock
- Emlen Stephen T.
- Foster William A.
- Fox Charles W.
- Francisco Ú
- Francois Balloux
- Francois Rousset
- Gardner Michael G.
- Geoff Wild
- Gerald Borgia
- Gilbert Roberts
- Goodisman Michael A. D.
- Graham Thompson
- Grozinger Christina M.
- Hanna Kokko
- Harvey Paul H.
- Hatchwell Ben J.
- Heikki Helantera
- Helms Ken R.
- Ido Pen
- Jü
- Jan Komdeur
- Janet Shellmann Sherman
- Jay Evans
- Jean Baptiste Andre
- Jeff Smith
- Jeremy Field
- John Alcock
- John Tooby
- Johnstone Rufus A.
- Judith Korb
- Juergen Gadau
- Jun Abe
- Kazuki Tsuji
- Kevin Foster
- Kim Hill
- Laurent Lehmann
- Leda Cosmides
- Lee Alan Dugatkin
- Linksvayer Timothy A.
- Liselotte Sundströ
- Lorenzo Santorelli
- Malte Andersson
- Marshall James A. R.
- Mary Jane West Eberhard
- Max Reuter
- Michael Breed
- Michael Taborsky
- Michel Chapuisat
- Michod Richard E.
- Minus van Baalen
- Moore Allen J.
- Mueller Ulrich G.
- Natalie Jiricny
- Nick Barton
- Nick Colegrave
- Olav Rueppell
- Parker Geoff A.
- Patrick Abbot
- Paul Schmid Hempel
- Pedersen Jes S.
- Pekka Pamilo
- Peter Taylor
- Pierre Henri Gouyon
- Queller David C.
- Rankin Daniel J.
- Redouan Bshary
- Reece Sarah E.
- Reeve Hudson K.
- Regis Ferriere
- Richard McElreath
- Richard Wrangham
- Rick Grosberg
- Robert Montgomerie
- Robson Simon K. A.
- Rolf Kü
- Ronald Noë
- Sé
- Sachs Joel L.
- Sam Brown
- Samir Okasha
- Samuel Alizon
- Schwarz Michael P.
- Scott Creel
- Sherman Paul W.
- Shuker David M.
- Sigal Balshine
- Spagna Joseph C.
- Suarez Andrew V.
- Susanne Foitzik
- Sylvain Gandon
- Thibaud Monnin
- Thomas Getty
- Tim Clutton Brock
- Toby Kiers E.
- Tom Scott Phillips
- Tom Wenseleers
- Trine Bilde
- Troy Day
- Tsutsui Neil D.
- Turillazzi Stefano
- Vargo Edward L.
- West Stuart A.
- Westneat David F.
- Wiernasz Diane C.
- Yannis Michalakis
- Young Andrew J.
- Zeh David W.
- Zeh Jeanne A.
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
- Author
- Adams Mark J
- Adan Roger A H
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Alda Martin
- Alexander Madeline
- Alfredsson Lars
- Als Thomas D
- Andlauer Till F M
- Ando Tetsuya
- Andreassen Ole A
- Androutsos Christos
- Anjorin Adebayo
- Anney Richard J L
- Anttila Verneri
- Arking Dan E
- Arnold Paul D
- Arranz M. J.
- Artigas Maria Soler
- Aschauer Harald
- Asherson Philip
- Backlund Lena
- Baker Jessica H
- Baldursson GĂsli
- Banaschewski Tobias
- Barr Cathy L
- Barta Csaba
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Belangero Sintia
- Bellgrove Mark
- Belliveau Richard A
- Bellivier Frank
- Bencko Vladimir
- Bergen Andrew W
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Bettella Francesco
- Bey Katharina
- Bienvenu O Joseph
- Biernacka Joanna M
- Binder Elisabeth B
- BirgegÄrd Andreas
- Black Donald W
- Blackwood Douglas H R
- Boomsma Dorret I
- Bramon Elvira
- Brandt Harry
- Breen Gerome
- Brown Lawrence W
- Buccola Nancy G
- Budde Monika
- Budman Cathy
- Buitelaar Jan
- Bulik Cynthia M
- Bunney William
- Burghardt Roland
- Burmeister Margit
- Burton Christie L
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- BĂŠkvad-Hansen Marie
- BĂžen Erlend
- BĂžrglum Anders D
- Cairns Murray J
- Campion Dominique
- Carlberg Laura
- Carr Vaughan J
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Cath Danielle
- Cerrato Felecia
- Chambert Kimberly
- Cheon Keun-Ah
- Christensen Jane H
- Churchhouse Claire
- Cichon Sven
- Ciullo Valentina
- Clarke Toni-Kim
- Clementi Maurizio
- Cloninger C Robert
- Coffey Barbara J
- Cohen David
- Coleman Jonathan R I
- Collier David A
- Collins Ryan L
- Colodro-Conde LucĂa
- Cook Edwin H
- Coon Hilary
- Coppola Giovanni
- Cormand Bru
- Corvin Aiden
- Courtet Philippe
- Craddock Nicholas
- Crawford Steven
- Crosbie Jennifer
- Crow Scott
- Crowley James J
- Curtis David
- Cusi Daniele
- Czerski Piotr M
- Dale Anders M
- Dalkner Nina
- Dalsgaard SĂžren
- Daly Mark J
- Danner Unna N
- Dannlowski Udo
- Davis Lea K
- Davis Oliver S P
- de Geus E. J. C.
- De Rubeis Silvia
- Degenhardt Franziska
- Degortes Daniela
- DeLisi Lynn E
- Delorme Richard
- Demontis Ditte
- Denys Damiaan
- Depienne Christel
- Derks Eske M
- DeSocio Janiece E
- Di Florio Arianna
- Dick Danielle M
- Dietrich Andrea
- Dina Christian
- Direk Nese
- Docampo Elisa
- Docherty Anna R
- Domenici Enrico
- Domschke Katharina
- Donohoe Gary
- Doyle Alysa E
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E
- Dunn Erin C
- Eapen Valsamma
- Edenberg Howard J
- Egberts Karin
- Ehrenreich Hannelore
- Ehrlich Stefan
- Elia Josephine
- ElvsÄshagen TorbjÞrn
- Espeseth Thomas
- Etain Bruno
- Falkai Peter
- Fanous Ayman H
- Faraone Stephen V
- Feng Yen-Chen A
- Fernandez Thomas V
- FernĂĄndez-Aranda Fernando
- Fichter Manfred M
- Fischer Sascha B
- Foo Jerome C
- Foretova Lenka
- Forstner Andreas J
- Forty Liz
- Forzan Monica
- Frank Josef
- Franke Barbara
- Freedman Robert
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gambaro Giovanni
- Garcia-Delgar Blanca
- Gaspar Héléna A
- Ge Tian
- Gejman Pablo V
- Gelernter Joel
- Geller Daniel A
- Gershon Elliot S
- Geschwind Daniel H
- Giegling Ina
- Gilbert Donald L
- Gill Michael
- Godard Stephanie
- Goes Fernando S
- Golimbet Vera
- Gonidakis Fragiskos
- Gordon Scott D
- Gordon-Smith Katherine
- Gorwood Philip
- Grabe Hans J
- Grados Marco A
- Green Melissa J
- Greenberg Erica
- Greenwood Tiffany A
- Grice Dorothy E
- Grigoroiu-Serbanescu Maria
- Grotzinger Andrew D
- Grove Jakob
- GrĂŒnblatt Edna
- Gudmundsson Olafur O
- Guo Yiran
- Guzman-Parra José
- Haavik Jan
- HagstrĂžm Julie
- Hakonarson Hakon
- Halmi Katherine A
- Hamilton Steven P
- Hanna Gregory L
- Hansen Christine S
- Hansen Thomas F
- Hartman Catharina A
- Hartmann Andreas
- Hartmann Annette M
- Hatzikotoulas Konstantinos
- Hauser Joanna
- Hautzinger Martin
- Hawi Ziarih
- Hebebrand Johannes
- Hedderly Tammy
- Heilbronner Urs
- Heiman Gary A
- Helder Sietske G
- Henskens Frans A
- Herms Stefan
- Herpertz-Dahlmann Beate
- HervĂĄs Amaia
- Herzog Wolfgang
- Heyman Isobel
- Hinney Anke
- Hoekstra Pieter J
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Hong Hyun Ju
- Hope Sigrun
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Howard David
- Howrigan Daniel P
- Huang Alden
- Huang Hailiang
- Hultman Christina M
- Huyser Chaim
- Ibanez-Gomez Laura
- Ikeda Masashi
- Imgart Hartmut
- Ising Marcus
- Iwata Nakao
- Jablensky Assen V
- Jamain Stéphane
- Jiménez-Murcia Susana
- Joa Inge
- Joachim Oedegaard Ketil
- Johnson Craig
- Jones Ian
- Jones Lisa A
- Jordan Jennifer
- JuliĂ Antonio
- Jönsson Erik G
- KaminskĂĄ Deborah
- Kandaswamy Radhika
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J H
- Kaye Walter H
- Kelly Brian J
- Kelsoe John R
- Kendler Kenneth S
- Kennedy James L
- Kennedy Martin A
- Keski-Rahkonen Anna
- Khramtsova Ekaterina A
- Kim Youl-Ri
- Kim Young Key
- Kim Young-Shin
- King Robert A
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klei Lambertus
- Kloiber Stefan
- Klump Kelly L
- Knight Jo
- Knudsen Gun Peggy S
- Kogevinas Manolis
- Koh Yun-Joo
- Koller Anna C
- Konstantinidis Anastasios
- Konte Bettina
- Kook Sodahm
- Kranzler Henry R
- Kuntsi Jonna
- Kuperman Samuel
- Ladd-Acosta Christine
- Landén Mikael
- Langley Kate
- Laurent-Levinson Claudine
- Lavebratt Catharina
- Le Hellard Stephanie
- Lee Jimmy
- Lee Phil H
- Lencz Todd
- Lerer Bernard
- Lesch Klaus-Peter
- Leung Patrick W L
- Leventhal Bennett L
- Levinson Douglas F
- Levitan Robert D
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Dong
- Li Qingqin S
- Lichtenstein Paul
- Lissowska Jolanta
- Lochner Christine
- Loo Sandra K
- Loohuis Loes M O
- Loughland Carmel M
- Lucae Susanne
- Ludolph Andrea G
- Luykx Jurjen J
- Maaser Anna
- Madruga-Garrido Marcos
- Magnusson Pall
- Magnusson Patrik K E
- Maj Mario
- Malaty Irene
- Malhotra Anil K
- Mallet Jacques
- Malt Ulrik F
- Maras Athanasios
- Marsal Sara
- Martin Alicia R
- Martin Joanna
- Martin Nicholas G
- Martinsson Lina
- Mathews Carol A
- Mattheisen Manuel
- Mayora Monica Gratacos
- Mbarek Hamdi
- McCracken James T
- McDevitt Sara
- McDonald Colm
- McElroy Susan L
- McGough James J
- McIntosh Andrew M
- McMahon Francis J
- McQuillin Andrew
- Medland Sarah E
- Meijer Inge A
- Melle Ingrid
- Metspalu Andres
- Middeldorp Christel M
- Millischer Vincent
- Mir Pablo
- Mitchell James
- Mitchell Karen S
- Mitchell Philip B
- Mitjans Marina
- Monteleone Alessio Maria
- Monteleone Palmiero
- Montgomery Grant W
- Moran Jennifer L
- Morer Astrid
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mortensen Preben B
- Mostafavi Sara
- Mowry Bryan J
- Mullins Niamh
- Munn-Chernoff Melissa A
- Murphy Kieran C
- Murphy Tara L
- Murray Robin M
- Myers Richard M
- MĂŒller-Myhsok Bertram
- MĂŒller-Vahl Kirsten R
- MĂŒnchau Alexander
- Naarden Allan
- Nacmias Benedetta
- Nagy Peter
- Navratilova Marie
- Neale Benjamin M
- Neale Michael C
- Nestadt Gerald
- Nestadt Paul S
- Nicolini Humberto
- Nievergelt Caroline M
- Nivard Michel G
- Nordentoft Merete
- Nurmi Erika L
- Nurnberger John I
- Nyegaard Mette
- Nyholt Dale R
- NĂŠrland Terje
- Nöthen Markus M
- O'Donovan Michael C
- O'Neill F Anthony
- O'Toole Julie K
- Oades Robert D
- Oh Sang-Yun
- Okun Michael S
- Ophoff Roel A
- Owen Michael J
- Paciga Sara A
- Padyukov Leonid
- Palmer Duncan S
- Palotie Aarno
- Pantel Jacques
- Pantelis Christos
- Papezova Hana
- Paschou Peristera
- Pato Carlos N
- Pato Michele T
- Pedersen Carsten B
- Pedersen Marianne G
- Penninx Brenda Wjh
- Perica Vesna Boraska
- Perlis Roy H
- Perry Amy
- Peters Triinu
- Peterson Roseann E
- Petryshen Tracey L
- Pinto Dalila
- Piras Fabrizio
- Piras Federica
- Pistis Giorgio
- Pittenger Christopher
- Plessen Kerstin J
- Porteous David J
- Posthuma Danielle
- Potash James B
- Poterba Timothy
- Poulsen Jesper B
- Preisig Martin
- Pulver Ann E
- Quested Digby J
- Quiroz Jorge A
- Qvist Per
- Rabionet Raquel
- Raevuori Anu
- Ramos-Quiroga Josep Antoni
- Ramoz Nicolas
- Rehnström Karola
- Reichborn-Kjennerud Ted
- Reichenberg Abraham
- Reichert Jennifer
- Reif Andreas
- Reinbold CĂ©line S
- Ribasés Marta
- Ricca Valdo
- Richter Margaret A
- Rietschel Marcella
- Riley Brien
- Ripke Stephan
- Rivera Margarita
- Rizzo Renata
- Roberson Mary
- Roberts Marion
- Robertson Mary
- Roeder Kathryn
- Roessner Veit
- Rohde Luis A
- Rosenthal Jacob
- Rothenberger Aribert
- Rouleau Guy A
- Rovira Paula
- Ruhrmann Stephan
- Rujescu Dan
- Rybakowski Filip
- Saemundsen Evald
- Samuels Jack F
- Sanders Alan R
- Sanders Stephan J
- Sandin Sven
- Sandor Paul
- Santangelo Susan L
- Satterstrom F Kyle
- Schachar Russell
- Schaefer Catherine
- Schall Ulrich
- Schalling Martin
- Scharf Jeremiah M
- Scherag André
- Schlögelhofer Monika
- Schmidt Ulrike
- Schofield Peter R
- Schulte Eva C
- Schulze Thomas G
- Schwab Sibylle G
- Scott Laura J
- Scott Rodney J
- Seitz Jochen
- Serretti Alessandro
- Sham Pak C
- Shi Jianxin
- Shin Eun-Young
- Sigurdsson Engilbert
- Silverman Jeremy M
- Sim Kang
- Singer Harvey
- Slachtova Lenka
- Slof-Op't Landt Margarita C T
- Slopien Agnieszka
- Smeland Olav B
- Smith Daniel J
- Smoller Jordan W
- Song Dong-Ho
- Song Jungeun
- Sorbi Sandro
- Southam Lorraine
- Spalletta Gianfranco
- St Pourcain Beate
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Kari
- Stein Dan J
- Stein Murray B
- Steinberg Stacy
- Steixner Agnes A
- Stewart S Evelyn
- Storch Eric A
- Stordal Eystein
- Stranger Barbara
- Streit Fabian
- Strober Michael
- Strohmaier Jana
- Stuhrmann Manfred
- Sullivan Patrick F
- Sutcliffe James S
- SĂĄnchez-Mora Cristina
- Talkowski Michael E
- Tarnok Zsanett
- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Thornton Laura M
- Tiemeier Henning
- Tischfield Jay A
- Tooney Paul A
- Tortorella Alfonso
- Tozzi Federica
- Treasure Janet
- Treutlein Jens
- Tucker-Drob Elliot M
- Turecki Gustavo
- Turley Patrick
- Tziouvas Konstantinos
- TĂŒbing Jennifer
- Uher Rudolf
- Vaaler Arne E
- van der Auwera Sandra
- van Elburg Annemarie A
- van Os Jim
- Vawter Marquis P
- Vieta Eduard
- Vincent John B
- Visscher Frank
- Vulink Nienke
- Wade Tracey D
- Wagner Gudrun
- Wagner Michael
- Walitza Susanne
- Walsh Dermot
- Walters G Bragi
- Walters James T R
- Walters Raymond K
- Walton Esther
- Wanderer Sina
- Wang Meg M-J
- Wang Yunpeng
- Watson Hunna J
- Weiser Mark
- Weiss Lauren A
- Weissman Myrna M
- Werge Thomas
- Wichmann H-Erich
- Wildenauer Dieter B
- Williams Nigel M
- Willsey A Jeremy
- Witt Stephanie H
- Won Hyejung
- Woods Martin
- Woodside D Blake
- Worbe Yulia
- Wormley Brandon K
- Wray Naomi R
- Yu Dongmei
- Zai Clement C
- Zai Gwyneth
- Zandi Peter
- Zayats Tetyana
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Fuquan
- Zheutlin Amanda
- Zhu Zhaozhong
- Zinner Samuel H
- Zipfel Stephan
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
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- Nakato Eriko
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- Naranjo Cleo M.
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
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- Pennacchio Len A.
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- Quiles Miyo M.
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- Rise Cecil
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- Un Chun
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- Wang Ying
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- Wangdi Tsering
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- Watanabe Saki
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- Wickremasinghe Manosha I.
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- Williamson Helen
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- Wray Paul
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- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
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- Wu Qingfa
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- Wu Xiaojing
- Wu Zaining
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- Xi Yingying
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- Xu Jing
- Xu Ruqin
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- Xu Yuning
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- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
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- Yamamoto Yuko
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- Yamazaki Satoru
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- Yang Huanming
- Yang Huanming
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- Yang Shudong
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- Yao Zhijian
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- Zembeck Lisa
- Zeng Yixin
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- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- AasarĂžd Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso InĂȘs
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- BlĂŒher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
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- Coresh Josef
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- Corre Tanguy
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- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
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- Deelen Joris
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- Devuyst Olivier
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- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
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- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
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- Dupuis Josee
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- Durda Peter
- Döring Angela
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- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
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- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
- Esko TÔnu
- Esko Tönu
- Estrada Karol
- Eury Elodie
- Evangelou Evangelos
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- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
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- Fall Tove
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- Fava Cristiano
- Feenstra Bjarke
- Fehrmann Rudolf
- Feitosa Mary
- Feranil Alan B
- Ferrannini Ele
- Ferrario Marco M
- Ferreira Teresa
- Ferreli Liana
- FerriĂšres Jean
- Ferrucci Luigi
- Fischer Krista
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- Folkersen Lasse
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- Fontanillas Pierre
- Ford Ian
- Fornage Myriam
- Foroud Tatiana
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- Forrester Terrence
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- Fowke Jay
- Fowkes F Gerald R
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- Franceschini Nora
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- Franke Andre
- Franke Lude
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- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
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- Frost Morten
- Fuchsberger Christian
- Galan Pilar
- Ganesh Santhi K
- Ganna Andrea
- Gansevoort Ron T
- Gao Xiaoyi
- Garcia Melissa
- Garcia-Giralt NatĂ lia
- Garnaas Maija
- Gasparini Paolo
- Gauguier Dominique
- Gaunt Tom R
- Gautvik Kaare M
- Geller Frank
- Gharavi Ali G
- Giedraitis Vilmantas
- Gieger Christian
- Gierman Hinco J
- Gigante Bruna
- Gill Geoffrey V
- Giroux Sylvie
- Giulianini Franco
- Glass Daniel
- Glazer Nicole
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- Glenn Kim
- Glorioso Nicola
- Go Alan S
- Go Min Jin
- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
- Goldstein Benjamin A
- Goltzman David
- Gong Jian
- GonzĂĄlez-MacĂas JesĂșs
- Goodall Alison H
- Goodarzi Mark O
- Goodloe Robert
- Gordin Daniel
- Gordon Scott D
- Gorski Mathias
- Grabe Hans-Jörgen
- Graff Misa
- Grallert Harald
- Grammer Tanja B
- Gravito Martha L
- Greenwood Celia M T
- Grewal Jagvir
- Grimsby Jonna
- Grobbee Diederick E
- Groop Leif
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- Gu Tianwei
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- Gudnason Villi
- Gudnason Vilmundur
- Guiducci Candace
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- Guo Xiuqing
- Gurdasani Deepti
- Gustafsson Stefan
- Gyllensten Ulf
- Gyllensten Ulf B
- Hadjadj Samy
- Hadley David
- Haessler Jeff
- Hager Jörg
- Haiman Christopher
- Haines Jonathan
- Hall Alistair S
- Hall Per
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- Haller Toomas
- Hallmans Goran
- Hallmans Göran
- Hamsten Anders
- Han Bok-Ghee
- Hankinson Susan E
- Hanson Robert L
- Hardy Rebecca
- Haritunians Talin
- Harjutsalo Valma
- Harris Tamara
- Hartikainen Anna-Liisa
- Hartman Catharina A
- Hass Merli
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- Hassinen Maija
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- Hastie Nick
- Hattersley Andrew T
- Haun Margot
- Havulinna Aki S
- Hayward Caroline
- Hazen Stanley L
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- Heath Andrew C
- Heath Simon
- Heckbert Susan R
- Hedblad Bo
- Hedman Ă sa K
- Heid Iris M
- HeikkilÀ Kauko
- HeikkilÀ Outi
- Heiss Gerardo
- Heliövaara Markku
- Helmer Catherine
- Helmer Quinta
- Henders Anjali K
- Henderson Brian
- Hengstenberg Christian
- Henneman Peter
- Hercberg Serge
- Herder Christian
- Hernandez Dena
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- Herrera Lizbeth
- Herzig Karl-Heinz
- Hicks Andrew A
- Hietala Kustaa
- Higashio Julia
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- Hilton Gina
- Hindorff Lucia
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- Hirschhorn Joel N
- Hivert Marie-France
- Ho Weang K
- Hocking Lynne J
- Hoffmann Wolfgang
- Hofman Albert
- Holliday Elizabeth G
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- Horikoshi Momoko
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- Howard Philip
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- Hu Frank B
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- Illig Thomas
- Imboden Medea
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- Ingle Catherine
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- Ioannidis John P A
- Iribarren Carlos
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- Islam Muhammad
- Ittermann Till
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- Juliusdottir Thorhildur
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- Jöckel Karl-Heinz
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- Kahali Bratati
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- Van Zuydam Natalie
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- Vedantam Sailaja
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- Verlaan Dominique
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- Völzke Henry
- Wadén Johan
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- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
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- Waite Lindsay L
- Walker Mark
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- Wang Jie Jin
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- Wang Xiaoling
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- Waterworth Dawn
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- Weder Alan B
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- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- WĂŒrtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo LoĂŻc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia MarĂa T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ărnlöv Johan
- Ăsterholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (PÂ <Â 5Â ĂÂ 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Analysis of shared heritability in common disorders of the brain
- Author
- Adams Hieab H.H.
- Air Tracy
- Al-Chalabi Ammar
- Alda Martin
- Alegret Montserrat
- Alfredsson Lars
- Amouyel Philippe
- Andlauer Till F.M.
- Andreassen Ole A.
- Anjorin Adebayo
- Anney Richard
- Anttila Verneri
- Arias Vasquez Alejandro
- Arking Dan
- Arnold Paul
- Arranz Maria JesĂșs
- Artto Ville
- Aschauer Harald
- Attia John
- Avbersek Andreja
- Bacchelli Elena
- Bailey Anthony
- Baker Jessica H.
- Bal Vanessa
- Banaschewski Tobias
- Barnes Lisa L.
- Barr Cathy L.
- Battaglia Agatino
- Battey Thomas
- Bau Claiton H.D.
- Bauer Michael
- Baum Larry
- Baune Bernhard T.
- Bayer Anthony
- Beach Thomas G.
- Becker Felicitas
- Bedoya-Berrio Gabriel
- Beekman Aartjan TF
- Beiser Alexa
- Belin Andrea C.
- Bergen Andrew W.
- Bergen Sarah E
- Berkovic Samuel
- Berr Claudine
- Betancur Catalina
- Bevan Steve
- Bienvenu O. Joseph
- Bis Joshua C
- Blackwood Douglas
- Boada MercĂš
- Boland Anne
- Bolton Patrick
- Boncoraglio Giorgio
- Boomsma Dorret
- Boraska Perica Vesna
- Borck Guntram
- Bradfield Jonathan
- Bramon Elvira
- Bras Jose
- Breen Gerome
- Brentani Helena
- Buccola Nancy
- Buitelaar Jan K.
- Bulik Cynthia M.
- Bulik-Sullivan Brendan
- Buono Russell
- Buring Julie E.
- Burton Christie
- BĂžrglum Anders D.
- Cahn Wiepke
- Cairns Murray
- Camarena Beatriz
- Cantor Rita
- Cappi Carolina
- Casas Miguel
- Catarino Claudia B.
- Cath Danielle
- Cavallini Maria
- Celestino-Soper PatrĂcia
- Chasman Daniel I.
- Chen Wei-Min
- Cheng Wei
- Chong Siow A.
- Chouraki Vincent
- Churchhouse Claire
- Cichon Sven
- Clementi Maurizio
- Cloninger Robert
- Cohen David
- Cohen-Woods Sarah
- Cook Edwin
- Cormand Bru
- Corvin Aiden
- Cossette Patrick
- Cotsapas Chris
- Craddock Nick
- Crespo-Facorro Benedicto
- Crosbie Jennifer
- Crowley James
- Cruceanu Cristiana
- Cruchaga Carlos
- Cuenca-Leon Ester
- Curtis David
- Cusi Daniele
- Czerski Piotr M.
- Dalsgaard Soeren
- Daly Mark
- Danner Unna N.
- Darrow Sabrina
- Davidson Michael
- Davis Oliver S. P.
- Dawson Geraldine
- de Geus Eco
- De Jager Philip L.
- De Jonghe Peter
- De Rubeis Silvia
- De-Luca Daniel Moreno-
- Degenhardt Franziska
- Deleuze Jean-François
- DeLisi Lynn
- Delorme Richard
- Demirci F. Yesim
- Dempfle Astrid
- Denys Damiaan
- Depienne Christel
- Depondt Chantal
- Derks Eske M.
- Dichgans Martin
- Dick Danielle M.
- Dietrich Andrea
- Dinan Timothy
- Dlugos Dennis
- Docampo Elisa
- Donohoe Gary
- Doyle Alysa E.
- Drapeau Elodie
- Duan Jubao
- Duncan Laramie
- Dunn Erin
- Duque Frederico
- Duron Emmanuelle
- Edenberg Howard J.
- Ehrlich Stefan
- Elia Josephine
- Eriksson Nicholas
- Escott-Price Valentina
- Espeseth Thomas
- Falcone Guido J.
- Faraone Stephen V.
- Farh Kai-How
- Farrer Lindsay A.
- Fernandez Thomas
- Ferrari Michel D.
- Ferraro Thomas N.
- Ferrier I. Nicol
- Figee Martijn
- Finucane Hilary K.
- Fischer Sascha B.
- Forstner Andreas J.
- Forzan Monica
- Fox Nick C.
- Franke Barbara
- Freilinger Tobias
- Freimer Nelson
- Freitag Christine
- French Jacqueline
- Fullerton Janice M.
- Furlotte Nicholas
- Gasser Thomas
- Gejman Pablo V.
- Gerber Gloria
- Gershon Elliot S.
- Geschwind Daniel H.
- Gibbs Raphael
- Goate Alison M.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott D.
- Gormley Padhraig
- Grabe Hans-Jorgen
- Grados Marco
- Gratacos Monica
- Green Andrew
- Greenberg Erica
- Grenier-Boley Benjamin
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Guerreiro Rita
- Guzman-Parra José
- Göbel Hartmut
- Haan Lieuwe
- Haavik Jan
- Hakonarson Hakon
- Halmi Katherine A.
- Hampel Harald
- Hanna Gregory L.
- Hannequin Didier
- Hansen Thomas
- Harold Denise
- Hartmann Andreas
- Hauser Joanna
- Head Elizabeth
- Heinzen Erin L.
- Helder Sietske G.
- Henskens Frans
- Herms Stefan
- Herpertz-Dahlmann Beate
- Hervas Amaia
- Heutink Peter
- Hickie Ian
- Hirschtritt Matthew E.
- Hjalgrim Helle
- Hoekstra Pieter J.
- Hoffmann Per
- Holliday Elizabeth
- Holmans Peter
- Homuth Georg
- Hottenga Jouke-Jan
- Hougaard David
- Hrafnsdottir Maria
- Huang Alden
- Huang Hailiang
- Huang Jie
- Huckins Laura M.
- Hudson James I.
- Huentelman Matthew J.
- Hulette Christine M.
- Huyser Chaim
- Hyman Bradley T.
- HÀmÀlÀinen Eija
- Illmann Cornelia
- Jamain Stéphane
- Jamnadas-Khoda Jennifer
- Jansen Rick
- Jenike Michael
- Jicha Gregory A.
- Johansson Stefan
- Jones Ian R.
- JuliĂ Antonio
- Kamatani Yoichiro
- Kamboh M. Ilyas
- Kaprio Jaakko
- Karachanak-Yankova Sena
- Karwautz Andreas
- Kaunisto Mari
- Kauwe John S.K.
- Kaye Jeffrey A.
- Kaye Walter
- Kendler Kenneth S.
- Keski-Rahkonen Anna
- Khrunin Andrey
- Klauck Sabine M.
- Klovins Janis
- Knowles James A.
- Koeleman Bobby
- Konkashbaev Anuar
- Kornhuber Johannes
- Kourkoulis Christina
- Kubisch Christian
- Kukull Walter A.
- Kuntsi Jonna
- Kunz Wolfram S.
- Kuperman Samuel
- Kurki Mitja I.
- Kurth Tobias
- KuÄinskas Vaidutis
- KÀlviÀinen Reetta
- Langley Kate
- Lanzagorta Nuria
- Larson Eric B.
- Lawlor Brian
- Leber Markus
- Leboyer Marion
- Lee Chee Keong Jimmy
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- Rabionet Raquel
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- Russo Giancarlo
- Rybakowski Filip
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- Schosser Alexandra
- Schott Jonathan M.
- Schreiber Stefan
- Schulze Thomas G.
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- Scott Rodney
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- Sharma Manu
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- Sim Kang
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- Smith Philip
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- So Hon-Cheong
- Sonnen Joshua A.
- Sperling Michael
- St George-Hyslop Peter
- Stahl Eli
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- Stein Dan J.
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- Streit Fabian
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- Strober Michael
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- Sudlow Cathie
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- Szatkiewicz Jin Peng
- SĂĄnchez-Mora Cristina
- Terwindt Gisela M.
- The Brainstorm Consortium
- Thijs Vincent
- Thomas G. Neil
- Thompson Robert C.
- Thornton Laura M.
- Toncheva Draga
- Tortorella Alfonso
- Trace Sara E.
- Tsetsos Fotis
- Tsolaki Magda
- Turecki Gustavo
- Turley Patrick
- Tziouvas Konstantinos
- Valencia-Duarte Ana
- Van Deerlin Vivianna M.
- van den Maagdenberg Arn M.J.M.
- van der Lee Sven J.
- van Elburg Annemarie A.
- Van Eldik Linda J.
- Van Nieuwerburgh Filip
- van Os Jim
- Vardarajan Badri N.
- VepsÀlÀinen Salli
- Vicente Astrid
- Viktorin Alexander
- Visscher Frank
- Vorstman Jacob
- Waddington John
- Wagner Gudrun
- Waldman Irwin
- Walters James
- Walters Raymond K.
- Wassink Thomas
- Weatherall Sarah
- Webb Bradley
- Webber Caleb
- Wedenoja Juho
- Wei Zhi
- Weiser Mark
- Weiss Lauren A.
- Wendland Jens R.
- Werge Thomas
- Whelan Christopher D.
- Wijsman Ellen
- William Rayner N.
- Williams Julie
- Williams Nigel
- Wilmot Beth
- Winsvold Bendik
- Witt Stephanie H.
- Wolanczyk Tomasz
- Wood Nicholas W.
- Worbe Yulia
- Wray Naomi R.
- Yilmaz Zeynep
- Yu Dongmei
- Zai Gwyneth
- Zandi Peter P.
- Zara Federico
- Zayats Tetyana
- Zimprich Fritz
- Zwart John-Anker
- Publication venue
- American Association for the Advancement of Science
- Publication date
- 01/01/2018
- Field of study
ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
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- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
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- T. Williams
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- Tammy Gilchrist
- Thorsten Brenner
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- Tiziana Bachetti
- Tomas Luther
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- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
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- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
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- V. Sarathy
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- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
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