Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter

This study aims to statistically describe histologically stained white matter brain sections to subsequently inform and validate diffusion MRI techniques. For the first time, we characterise volume fraction distributions of three of the main structures in deep subcortical white matter (axons, astrocytes, and myelinated axons) in a representative cohort of an ageing population for which well-characterized neuropathology data is available. We analysed a set of samples from 90 subjects of the Cognitive Function and Ageing Study (CFAS), stratified into three groups of 30 subjects each, in relation to the presence of age-associated deep subcortical lesions. This provides volume fraction distributions in different scenarios relevant to brain diffusion MRI in dementia. We also assess statistically significant differences found between these groups. In agreement with previous literature, our results indicate that white matter lesions are related with a decrease in the myelinated axons fraction and an increase in astrocytic fraction, while no statistically significant changes occur in axonal mean fraction. In addition, we introduced a framework to quantify volume fraction distributions from 2D immunohistochemistry images, which is validated against in silico simulations. Since a trade-off between precision and resolution emerged, we also performed an assessment of the optimal scale for computing such distributions

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters

Measurement of the Lambda(b) cross section and the anti-Lambda(b) to Lambda(b) ratio with Lambda(b) to J/Psi Lambda decays in pp collisions at sqrt(s) = 7 TeV

The Lambda(b) differential production cross section and the cross section ratio anti-Lambda(b)/Lambda(b) are measured as functions of transverse momentum pt(Lambda(b)) and rapidity abs(y(Lambda(b))) in pp collisions at sqrt(s) = 7 TeV using data collected by the CMS experiment at the LHC. The measurements are based on Lambda(b) decays reconstructed in the exclusive final state J/Psi Lambda, with the subsequent decays J/Psi to an opposite-sign muon pair and Lambda to proton pion, using a data sample corresponding to an integrated luminosity of 1.9 inverse femtobarns. The product of the cross section times the branching ratio for Lambda(b) to J/Psi Lambda versus pt(Lambda(b)) falls faster than that of b mesons. The measured value of the cross section times the branching ratio for pt(Lambda(b)) > 10 GeV and abs(y(Lambda(b))) < 2.0 is 1.06 +/- 0.06 +/- 0.12 nb, and the integrated cross section ratio for anti-Lambda(b)/Lambda(b) is 1.02 +/- 0.07 +/- 0.09, where the uncertainties are statistical and systematic, respectively.Comment: Submitted to Physics Letters

Measurement of isolated photon production in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV

Isolated photon production is measured in proton-proton and lead-lead collisions at nucleon-nucleon centre-of-mass energies of 2.76 TeV in the pseudorapidity range |eta|<1.44 and transverse energies ET between 20 and 80 GeV with the CMS detector at the LHC. The measured ET spectra are found to be in good agreement with next-to-leading-order perturbative QCD predictions. The ratio of PbPb to pp isolated photon ET-differential yields, scaled by the number of incoherent nucleon-nucleon collisions, is consistent with unity for all PbPb reaction centralities.Comment: Submitted to Physics Letters

Search for new physics in events with opposite-sign leptons, jets, and missing transverse energy in pp collisions at sqrt(s) = 7 TeV

A search is presented for physics beyond the standard model (BSM) in final states with a pair of opposite-sign isolated leptons accompanied by jets and missing transverse energy. The search uses LHC data recorded at a center-of-mass energy sqrt(s) = 7 TeV with the CMS detector, corresponding to an integrated luminosity of approximately 5 inverse femtobarns. Two complementary search strategies are employed. The first probes models with a specific dilepton production mechanism that leads to a characteristic kinematic edge in the dilepton mass distribution. The second strategy probes models of dilepton production with heavy, colored objects that decay to final states including invisible particles, leading to very large hadronic activity and missing transverse energy. No evidence for an event yield in excess of the standard model expectations is found. Upper limits on the BSM contributions to the signal regions are deduced from the results, which are used to exclude a region of the parameter space of the constrained minimal supersymmetric extension of the standard model. Additional information related to detector efficiencies and response is provided to allow testing specific models of BSM physics not considered in this paper.Comment: Replaced with published version. Added journal reference and DO

Search for Multimessenger Sources of Gravitational Waves and High-energy Neutrinos with Advanced LIGO during Its First Observing Run, ANTARES, and IceCube

Astrophysical sources of gravitational waves, such as binary neutron star and black hole mergers or core-collapse supernovae, can drive relativistic outflows, giving rise to non-thermal high-energy emission. High-energy neutrinos are signatures of such outflows. The detection of gravitational waves and high-energy neutrinos from common sources could help establish the connection between the dynamics of the progenitor and the properties of the outflow. We searched for associated emission of gravitational waves and high-energy neutrinos from astrophysical transients with minimal assumptions using data from Advanced LIGO from its first observing run O1, and data from the Antares and IceCube neutrino observatories from the same time period. We focused on candidate events whose astrophysical origins could not be determined from a single messenger. We found no significant coincident candidate, which we used to constrain the rate density of astrophysical sources dependent on their gravitational-wave and neutrino emission processes

The search for high-energy neutrinos coincident with fast radio bursts with the ANTARES neutrino telescope

[EN] In the past decade, a new class of bright transient radio sources with millisecond duration has been discovered. The origin of these so-called fast radio bursts (FRBs) is still a mystery, despite the growing observational efforts made by various multiwavelength and multimessenger facilities. To date, many models have been proposed to explain FRBs, but neither the progenitors nor the radiative and the particle acceleration processes at work have been clearly identified. In this paper, we assess whether hadronic processes may occur in the vicinity of the FRB source. If they do, FRBs may contribute to the high-energy cosmic-ray and neutrino fluxes. A search for these hadronic signatures was carried out using the ANTARES neutrino telescope. The analysis consists in looking for high-energy neutrinos, in the TeV-PeV regime, that are spatially and temporally coincident with the detected FRBs. Most of the FRBs discovered in the period 2013-2017 were in the field of view of the ANTARES detector, which is sensitive mostly to events originating from the Southern hemisphere. From this period, 12 FRBs were selected and no coincident neutrino candidate was observed. Upper limits on the per-burst neutrino fluence were derived using a power-law spectrum, dN/DE nu proportional to E-nu(-gamma), for the incoming neutrino flux, assuming spectral indexes gamma = 1.0, 2.0, 2.5. Finally, the neutrino energy was constrained by computing the total energy radiated in neutrinos, assuming different distances for the FRBs. Constraints on the neutrino fluence and on the energy released were derived from the associated null results.The authors acknowledge financial support from the following funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge technical support from Ifremer, AIM and Foselev Marine for the sea operation and CC-IN2P3 for the computing facilities.Albert, A.; Andre, M.; Anghinolfi, M.; Anton, G.; Ardid Ramírez, M.; Aubert, J.; Aublin, J.... (2019). The search for high-energy neutrinos coincident with fast radio bursts with the ANTARES neutrino telescope. Monthly Notices of the Royal Astronomical Society. 482(1):184-193. https://doi.org/10.1093/mnras/sty2621S1841934821Aartsen, M. G., Abbasi, R., Abdou, Y., Ackermann, M., Adams, J., Aguilar, J. A., … Bai, X. (2013). First Observation of PeV-Energy Neutrinos with IceCube. Physical Review Letters, 111(2). doi:10.1103/physrevlett.111.021103Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Arlen, T. C. (2015). Atmospheric and astrophysical neutrinos above 1 TeV interacting in IceCube. Physical Review D, 91(2). doi:10.1103/physrevd.91.022001Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., … Archinger, M. (2015). A COMBINED MAXIMUM-LIKELIHOOD ANALYSIS OF THE HIGH-ENERGY ASTROPHYSICAL NEUTRINO FLUX MEASURED WITH ICECUBE. The Astrophysical Journal, 809(1), 98. doi:10.1088/0004-637x/809/1/98Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Arlen, T. C. (2015). SEARCH FOR PROMPT NEUTRINO EMISSION FROM GAMMA-RAY BURSTS WITH ICECUBE. The Astrophysical Journal, 805(1), L5. doi:10.1088/2041-8205/805/1/l5Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., … Anderson, T. (2016). OBSERVATION AND CHARACTERIZATION OF A COSMIC MUON NEUTRINO FLUX FROM THE NORTHERN HEMISPHERE USING SIX YEARS OF ICECUBE DATA. The Astrophysical Journal, 833(1), 3. doi:10.3847/0004-637x/833/1/3Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Anderson, T. (2018). A Search for Neutrino Emission from Fast Radio Bursts with Six Years of IceCube Data. The Astrophysical Journal, 857(2), 117. doi:10.3847/1538-4357/aab4f8Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., … Adya, V. B. (2017). GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral. Physical Review Letters, 119(16). doi:10.1103/physrevlett.119.161101Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., … Adya, V. B. (2017). Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A. The Astrophysical Journal, 848(2), L13. doi:10.3847/2041-8213/aa920cAdrián-Martínez, S., Al Samarai, I., Albert, A., André, M., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2012). SEARCH FOR COSMIC NEUTRINO POINT SOURCES WITH FOUR YEARS OF DATA FROM THE ANTARES TELESCOPE. The Astrophysical Journal, 760(1), 53. doi:10.1088/0004-637x/760/1/53Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., … Anghinolfi, M. (2016). Letter of intent for KM3NeT 2.0. Journal of Physics G: Nuclear and Particle Physics, 43(8), 084001. doi:10.1088/0954-3899/43/8/084001Ageron, M., Aguilar, J. A., Al Samarai, I., Albert, A., Ameli, F., André, M., … Ardid, M. (2011). ANTARES: The first undersea neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 656(1), 11-38. doi:10.1016/j.nima.2011.06.103Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). All-sky search for high-energy neutrinos from gravitational wave event GW170104 with the Antares neutrino telescope. The European Physical Journal C, 77(12). doi:10.1140/epjc/s10052-017-5451-zAlbert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). First all-flavor neutrino pointlike source search with the ANTARES neutrino telescope. Physical Review D, 96(8). doi:10.1103/physrevd.96.082001Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). Search for high-energy neutrinos from bright GRBs with ANTARES. Monthly Notices of the Royal Astronomical Society, 469(1), 906-915. doi:10.1093/mnras/stx902Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Barrios-Martí, J. (2018). All-flavor Search for a Diffuse Flux of Cosmic Neutrinos with Nine Years of ANTARES Data. The Astrophysical Journal, 853(1), L7. doi:10.3847/2041-8213/aaa4f6Bailes, M., Jameson, A., Flynn, C., Bateman, T., Barr, E. D., Bhandari, S., … Temby, D. (2017). The UTMOST: A Hybrid Digital Signal Processor Transforms the Molonglo Observatory Synthesis Telescope. Publications of the Astronomical Society of Australia, 34. doi:10.1017/pasa.2017.39Bannister, K. W., Shannon, R. M., Macquart, J.-P., Flynn, C., Edwards, P. G., O’Neill, M., … Clarke, N. (2017). The Detection of an Extremely Bright Fast Radio Burst in a Phased Array Feed Survey. The Astrophysical Journal, 841(1), L12. doi:10.3847/2041-8213/aa71ffBhandari, S., Keane, E. F., Barr, E. D., Jameson, A., Petroff, E., Johnston, S., … Burke-Spolaor, S. (2017). The SUrvey for Pulsars and Extragalactic Radio Bursts – II. New FRB discoveries and their follow-up. Monthly Notices of the Royal Astronomical Society, 475(2), 1427-1446. doi:10.1093/mnras/stx3074Biehl, D., Heinze, J., & Winter, W. (2018). Expected neutrino fluence from short Gamma-Ray Burst 170817A and off-axis angle constraints. Monthly Notices of the Royal Astronomical Society, 476(1), 1191-1197. doi:10.1093/mnras/sty285Caleb, M., Flynn, C., Bailes, M., Barr, E. D., Bateman, T., Bhandari, S., … Krishnan, V. V. (2016). Fast Radio Transient searches with UTMOST at 843 MHz. Monthly Notices of the Royal Astronomical Society, 458(1), 718-725. doi:10.1093/mnras/stw109Caleb, M., Flynn, C., Bailes, M., Barr, E. D., Bateman, T., Bhandari, S., … Venkatraman Krishnan, V. (2017). The first interferometric detections of fast radio bursts. Monthly Notices of the Royal Astronomical Society, 468(3), 3746-3756. doi:10.1093/mnras/stx638Cao, X.-F., & Yu, Y.-W. (2018). Superconducting cosmic string loops as sources for fast radio bursts. Physical Review D, 97(2). doi:10.1103/physrevd.97.023022Champion, D. J., Petroff, E., Kramer, M., Keith, M. J., Bailes, M., Barr, E. D., … Lyne, A. G. (2016). Five new fast radio bursts from the HTRU high-latitude survey at Parkes: first evidence for two-component bursts. Monthly Notices of the Royal Astronomical Society: Letters, 460(1), L30-L34. doi:10.1093/mnrasl/slw069Chatterjee, S., Law, C. J., Wharton, R. S., Burke-Spolaor, S., Hessels, J. W. T., Bower, G. C., … van Langevelde, H. J. (2017). A direct localization of a fast radio burst and its host. Nature, 541(7635), 58-61. doi:10.1038/nature20797Cordes, J. M., & Wasserman, I. (2016). Supergiant pulses from extragalactic neutron stars. Monthly Notices of the Royal Astronomical Society, 457(1), 232-257. doi:10.1093/mnras/stv2948DeLaunay, J. J., Fox, D. B., Murase, K., Mészáros, P., Keivani, A., Messick, C., … Turley, C. F. (2016). DISCOVERY OF A TRANSIENT GAMMA-RAY COUNTERPART TO FRB 131104. The Astrophysical Journal, 832(1), L1. doi:10.3847/2041-8205/832/1/l1Dey, R. K., Ray, S., & Dam, S. (2016). Searching for PeV neutrinos from photomeson interactions in magnetars. EPL (Europhysics Letters), 115(6), 69002. doi:10.1209/0295-5075/115/69002Fahey, S., Kheirandish, A., Vandenbroucke, J., & Xu, D. (2017). A Search for Neutrinos from Fast Radio Bursts with IceCube. The Astrophysical Journal, 845(1), 14. doi:10.3847/1538-4357/aa7e28Falcke, H., & Rezzolla, L. (2014). Fast radio bursts: the last sign of supramassive neutron stars. Astronomy & Astrophysics, 562, A137. doi:10.1051/0004-6361/201321996Goldstein, A., Preece, R. D., Mallozzi, R. S., Briggs, M. S., Fishman, G. J., Kouveliotou, C., … Burgess, J. M. (2013). THE BATSE 5B GAMMA-RAY BURST SPECTRAL CATALOG. The Astrophysical Journal Supplement Series, 208(2), 21. doi:10.1088/0067-0049/208/2/21Guetta, D., Hooper, D., Alvarez-Muñiz, J., Halzen, F., & Reuveni, E. (2004). Neutrinos from individual gamma-ray bursts in the BATSE catalog. Astroparticle Physics, 20(4), 429-455. doi:10.1016/s0927-6505(03)00211-1Hümmer, S., Rüger, M., Spanier, F., & Winter, W. (2010). SIMPLIFIED MODELS FOR PHOTOHADRONIC INTERACTIONS IN COSMIC ACCELERATORS. The Astrophysical Journal, 721(1), 630-652. doi:10.1088/0004-637x/721/1/630Hümmer, S., Baerwald, P., & Winter, W. (2012). Neutrino Emission from Gamma-Ray Burst Fireballs, Revised. Physical Review Letters, 108(23). doi:10.1103/physrevlett.108.231101Johnston, S., Taylor, R., Bailes, M., Bartel, N., Baugh, C., Bietenholz, M., … Wolleben, M. (2008). Science with ASKAP. Experimental Astronomy, 22(3), 151-273. doi:10.1007/s10686-008-9124-7Katz, J. I. (2014). Coherent emission in fast radio bursts. Physical Review D, 89(10). doi:10.1103/physrevd.89.103009Keane, E. F., Johnston, S., Bhandari, S., Barr, E., Bhat, N. D. R., Burgay, M., … Bassa, C. (2016). The host galaxy of a fast radio burst. Nature, 530(7591), 453-456. doi:10.1038/nature17140Li, X., Zhou, B., He, H.-N., Fan, Y.-Z., & Wei, D.-M. (2014). MODEL-DEPENDENT ESTIMATE ON THE CONNECTION BETWEEN FAST RADIO BURSTS AND ULTRA HIGH ENERGY COSMIC RAYS. The Astrophysical Journal, 797(1), 33. doi:10.1088/0004-637x/797/1/33Lorimer, D. 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A burst in a wind bubble and the impact on baryonic ejecta: high-energy gamma-ray flashes and afterglows from fast radio bursts and pulsar-driven supernova remnants. Monthly Notices of the Royal Astronomical Society, 461(2), 1498-1511. doi:10.1093/mnras/stw1328Murase, K., Mészáros, P., & Fox, D. B. (2017). Fast Radio Bursts with Extended Gamma-Ray Emission? The Astrophysical Journal, 836(1), L6. doi:10.3847/2041-8213/836/1/l6Palaniswamy, D., Wayth, R. B., Trott, C. M., McCallum, J. N., Tingay, S. J., & Reynolds, C. (2014). A SEARCH FOR FAST RADIO BURSTS ASSOCIATED WITH GAMMA-RAY BURSTS. The Astrophysical Journal, 790(1), 63. doi:10.1088/0004-637x/790/1/63Palmer, D. M., Barthelmy, S., Gehrels, N., Kippen, R. M., Cayton, T., Kouveliotou, C., … Tueller, J. (2005). A giant γ-ray flare from the magnetar SGR 1806–20. Nature, 434(7037), 1107-1109. doi:10.1038/nature03525Pen, U.-L., & Connor, L. (2015). LOCAL CIRCUMNUCLEAR MAGNETAR SOLUTION TO EXTRAGALACTIC FAST RADIO BURSTS. 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The SUrvey for Pulsars and Extragalactic Radio Bursts – II. New FRB discoveries and their follow-up

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Measurement of the mass difference between top quark and antiquark in pp collisions at root s=8 TeV

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