20 research outputs found
Splenic infarction during Plasmodium ovale acute malaria: first case reported
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, the course was spontaneously favourable, suggesting that this complication was relatively benign compared to splenic rupture, which is life-threatening and usually necessitating surgery
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
- Bloos Frank
- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
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- Bourne Michelle
- Bourne Richard
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- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
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- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
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- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
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- Brugman Curt
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- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
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- Budd Joanna
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- Butler Susan
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- Byrne Rahim
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- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
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- Campbell Bridget
- Campbell Debbie
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- Campion Alexandra
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- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
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- Carrier François
- Carrier Marc
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- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
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- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
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- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
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- Chan Peter
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- Chapman Susan
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- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
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- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
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- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
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- Cooper Nichola
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- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
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- Ellis Christine
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- Elmahi Einas
- Elsefi Tarek
- Eltayeb Ayaa
- Elvira Evangeline
- England Jenna
- Englert Sarah
- English Shane
- Epelmanž Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
- Evans Debra
- Evans Gabrielle
- Everitt Robert
- Evers Mirjam
- Evetts George
- Ewalds Esther
- Ezekowitz Justin
- Fagan Laura
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- Fartoukh Muriel
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- Fergusson Dean
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- Ferrier Janet
- Ferringer Cindy
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- Finnis Mackenzie
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- Fitzgerald Mark
- Fitzpatrick Meghan
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- Flint Neil
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- Ford Megan
- Forster Elliot
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- Fowler Robert
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- Fox Eleonore
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- Frakking Thuy
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- Frankfurter Claudia
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- Garrod Esther
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- Garvey James
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- Gemmell Lisa
- Gendall Emma
- Geng Wenli
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- Geri Guillaume
- Geurts Heidi
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- Ghamraoui Ali
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- Ghosh Alison
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- Gill Mandy
- Gilliam Matthew
- Gilmour Kate
- Girard Timothy
- Girijadevi Dinuraj
- Gladas Kirsty
- Glasby Kathleen
- Gledhill Lisa
- Glister Georgina
- Glynou Loukia
- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
- Goligher Ewan
- Gomez Keith
- Gommans Frank
- Goodwin Jayne
- Goossens Herman
- Gopal Shameer
- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
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- Greener Danni
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- Gresham Rebecca
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- Grieve Richard
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- Grimmer Lisa
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- Guerineau Elodie
- Guitton Christophe
- Gummadi Mahitha
- Gupta Abhinav
- Gurung Anita
- Guérin Emmanuelle
- GĂłmez Francisco
- Göpel Siri
- Habeichi Wadih
- Habraken Hannah
- Hadebe Bernard
- Haffiane Abdelmagid
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- Haghi Theerata
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- Haider Nafeesah
- Haider Syeda
- Hajdu Bence
- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
- Hall Kathryn
- Hall Rebecca
- Hamilton David
- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
- Hammonds Fiona
- Hand James
- Haniffa Rashan
- Hanisch Alexis
- Hanley Joanne
- Hansen Dan
- Hanson Helen
- Hanson Jane
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- Harding Daniel
- Hardy Chloe
- Harford Rachel
- Harland Cain
- Harper Heather
- Harrington Claire
- Harrington Kate
- Harris Celia
- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
- Harvey Alice
- Harvey Daniel
- Harvey James
- Harward Meg
- Hashmi Madhia
- Hashmi Madiha
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- Hawcutt Daniel
- Hawes Joanne
- Hawkins Nancy
- Hay Sophie
- Haydon Tim
- Hayes Amber
- Hayes Anne
- Hayes Kati
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- HC Ooi
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- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
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- Hey Samuel
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- Higgins Alisa M.
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- Hornsby James
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- Horvat Christopher M.
- Howcroft Clare
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- Huang David T.
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- Kilner Mari
- Kim Edy Y.
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- Kochert Erik
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- Koirala Kanchan
- Koirala Sabin
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- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
- Kunwar Puja
- Kunz Kevin
- Kurenda Catherine
- Kutsogiannis Demetrios
- Kuybida Yuriy
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- Kyle Laura
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- Labbe Vincent
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- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
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- Lembo Rosalba
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- Lewis Roger J.
- Lewis Sarah
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- Wright Kim
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- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaineâs rewarding effects but preserves natural reward processing
- Author
- Allichon Marie-Charlotte
- Andrianarivelo Andry
- Barik Jacques
- Bemelmans Alexis-Pierre
- Betuing Sandrine
- Caboche Jocelyne
- de Smedt-Peyrusse Veronique
- Fernandez Sebastian
- Heck Nicolas
- Javitch Jonathan
- Joséphine CharlÚne
- KappĂšs Vincent
- Mechawar Naguib
- Ortiz Vanesa
- Petitbon Anna
- Pousinha Paula
- Saint-Jour Estefani
- Trifilieff Pierre
- Turecki Gustavo
- Vanhoutte Peter
- Walle Roman
- Zhu Ying
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2021
- Field of study
International audienc
Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcome
- Author
- Balint Balazs
- Berns Els
- Classe Jean-Marc
- Colombo Pierre,
- Coutant Charles
- Craina Marius
- de Koning Leanne
- de La Rochefordiere Anne
- de Saint-Jorre Nicolas
- Dema Alis
- Dema Sorin
- Deutsch Eric
- Djuran Branislav
- Dubot Coraline
- Dureau Sylvain
- Fabbro Michel
- Feron Jean,
- Floquet Anne
- Fourchotte Virginie
- Fumoleau Pierre
- Garbay Delphine
- Gestraud Pierre
- Girard Elodie
- Gleeson Noreen
- Guyon Frédéric
- Hillemanns Peter
- Hupe Philippe
- Jordanova Ekaterina
- Kamal Maud
- Kenter Gemma
- Kereszt Attila
- Kerr Christine
- Koprivsek Katarina
- Lecuru Fabrice
- Malenkovic Goran
- Mandic Aljosa
- Marchal Frédéric
- Margan Madalin
- Mesgouez-Nebout Nathalie
- Minsat Mathieu
- Morice Philippe
- Nagy Istvan
- Ngo Charlotte
- Popovic Marina
- Rivin del Campo Eleonor
- Rouzier Roman
- Samet Nina
- Samuels Sanne
- Savignoni Alexia
- Scholl Suzy
- Servant Nicolas
- von Der Leyen Heiko
- Wimberger Pauline
- Zijlmans Henry
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
International audienceBACKGROUND: There is a lack of information as to which molecular processes, present at diagnosis, favor tumour escape from standard-of-care treatments in cervical cancer (CC). RAIDs consortium (www.raids-fp7.eu), conducted a prospectively monitored trial, [BioRAIDs (NCT02428842)] with the objectives to generate high quality samples and molecular assessments to stratify patient populations and to identify molecular patterns associated with poor outcome.METHODS: Between 2013 and 2017, RAIDs collected a prospective CC sample and clinical dataset involving 419 participant patients from 18 centers in seven EU countries. Next Generation Sequencing has so far been carried out on a total of 182 samples from 377 evaluable (48%) patients, allowing to define dominant genetic alterations. Reverse phase protein expression arrays (RPPA) was applied to group patients into clusters. Activation of key genetic pathways and protein expression signatures were tested for associations with outcome.FINDINGS: At a median follow up (FU) of 22âŻmonths, progression-free survival rates of this FIGO stage IB1-IV population, treated predominantly (87%) by chemoradiation, were65âą4% [CI95%: 60âą2-71.1]. Dominant oncogenic alterations were seen in PIK3CA (40%), while dominant suppressor gene alterations were seen in KMT2D (15%) and KMT2C (16%). Cumulative frequency of loss-of-function (LOF) mutations in any epigenetic modulator gene alteration was 47% and it was associated with PIK3CA gene alterations in 32%. Patients with tumours harboring alterations in both pathways had a significantly poorer PFS. A new finding was the detection of a high frequency of gains of TLR4 gene amplifications (10%), as well as amplifications, mutations, and non-frame-shift deletions of Androgen receptor (AR) gene in 7% of patients. Finally, RPPA protein expression analysis defined three expression clusters.INTERPRETATION: Our data suggests that patient population may be stratified into four different treatment strategies based on molecular markers at the outset. FUND: European Union's Seventh Program grant agreement No 304810
Corrigendum to âclinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcomeâ (EBioMedicine (2019) 43 (253â260), (S2352396419302142), (10.1016/j.ebiom.2019.03.069))
- Author
- Balint Balazs
- Berns Els
- Classe Jean-Marc
- Colombo Pierre Emmanuel
- Coutant Charles
- Craina Marius
- de Koning Leanne
- de la Rochefordiere Anne
- de Saint-Jorre Nicolas
- del Campo Eleonor Rivin
- Dema Alis
- Dema Sorin
- Deutsch Eric
- Djuran Branislav
- Dubot Coraline
- Dureau Sylvain
- Fabbro Michel
- Feron Jean Guillaume
- Floquet Anne
- Fourchotte Virginie
- Fumoleau Pierre
- Garbay Delphine
- Gestraud Pierre
- Girard Elodie
- Gleeson Noreen
- Guyon Federic
- Hillemanns Peter
- Hupe Philippe
- Jordanova Ekaterina
- Kamal Maud
- Kenter Gemma
- Kereszt Attila
- Kerr Christine
- Koprivsek Katarina
- Lecuru Fabrice
- Malenkovic Goran
- Mandic Aljosa
- Marchal Frederic
- Margan Madalin
- Mesgouez-Nebout Nathalie
- Minsat Mathieu
- Morice Philippe
- Nagy Istvan
- Ngo Charlotte
- Popovic Marina
- Rouzier Roman
- Samet Nina
- Samuels Sanne
- Savignoni Alexia
- Scholl Suzy
- Servant Nicolas
- von der Leyen Heiko
- Wimberger Pauline
- Zijlmans Henry
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2020
- Field of study
The authors wish to clarify that the authors Aljosa Mandic, Katarina Koprivsek, and Goran Malenkovic are also affiliated with Faculty of Medicine Novi Sad, University of Novi Sad, Serbia, as well as Gynecologic Oncology Department Clinic for Operative Oncology, Institute of Oncology of Vojvodina, Serbia
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- Nuova Antologia
- O'Brien
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- Oeuvres de Jules Renard
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- Palma Ricardo
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- Parayicino Fray Hortensie Felix E.
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- Prorerbes
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- °o
- ·» I
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1940
- Field of study
C. Literaturwissenschaft.
- Author
- Abba Giuseppe Cesare A.
- Abril Xavier
- Acciaiuoli Edoardo P.
- Aceyedo Hernandez
- Actes
- Adam Paul
- Adamsspiel K.
- Adolfus von Wien E.
- Agoult Marie C.
- Aimon de Varennes H.
- Aita A.
- Alain-Fournier
- Alain-Fournier
- Alarcon Pedro Antonio
- Albergati Fabio E.
- Alcala Yanez
- Alciati Andrea J. L.
- Alcover J.
- Aldana Francisco
- Alexander
- Alexius
- Alfredo Panzini
- Algunes
- Alguns
- Alguns
- Alguns
- Alonso A.
- Alonso Cortes N.
- Alvarez J. C.
- Alvarez Quintero Serafin C
- Amades J.
- Amades J.
- Amades J.
- Amades J.
- Amado Jörge R. A.
- Ambrosiue L. T.
- Amiel Henri-Fre'doric B.
- Amiel J. H.
- Amoretti
- Amoretti
- Amoretti
- Amrein Martha
- Amyot
- Anagnine E.
- Andreas Capellanus A
- Angeli Diego G. R.
- Anglfes H.
- Annali R
- Annunzio
- Anrieta R. A.
- Antologia
- Antologia
- Antologia S
- Antologias
- Apicius J.
- Arabella Williame H.
- Arco R.
- Arderiu Clementina J.
- Aretino Pietro B.
- Arioslo Lodovico
- Aroztegui Abdon
- Arrighi P.
- Arteaga Stefano M.
- Aspects
- Ass
- Asti
- Atkinson W. C.
- Auerbach E.
- Augier Ismile B.
- Augustmus J.
- Autos
- Autour
- Azorin J. A.
- Babillot Fran
- Baccini D.
- Bacelar J.
- Badin J.
- Baer G.
- Bainville Jacques
- Baldensperger F.
- Ballensiefen H.
- Bandin L.
- Baour-Lormian M.
- Barbey
- Barbey
- Barcelona
- Barfucci E.
- Bari
- Barinaga Graciella
- Baroja Pio J. A.
- Barreda Ernesto Mario P.
- Barrelle G.
- Barres Maurice
- Barres Maurice
- Barres Maurice
- Barres Maurice
- Barres Maurice
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- Basurto Fernando
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- Battistini M.
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- Baudelaire
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- Baudelaire J.
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- Bayet A.
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- Beccadelli Antonio A.
- Becquer Gustavo Adolfo J. A.
- Beio J. M.
- Beitran de Heredia V.
- BeitrÀn O. R.
- Bell A. F. G.
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- Benavente Jacinto R. K.
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- Benedeit E.
- Benedetto L
- Benini R.
- Bennett R. E.
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- Berchet Giovanni F.
- Berga J.
- Bergson Henri G.
- Bergson Henri G.
- Berlin
- Berliner
- Bernardin de Saint-Pierre C. W.
- BernÀldez Andres R.
- Berry Ana M.
- Berthon S.
- Bertini G. M.
- Bertoni G.
- Bertoni G.
- Bertoni G.
- Betteloni Vittorio G.
- Biarguren C.
- Bibl
- Bibl
- Bibl
- Bibl S
- Bibl S
- Biblioteca de Cultura S
- Bieler L.
- Biiffon Georges-Louis
- Bilder
- Bilder
- Binni
- Binni
- Blasco Ibanez Vicente
- Bluteau R.
- Bobbio A.
- Boccaccio Giovanni II
- Boccalini Ph. H.
- Bockmann H.
- Bocquet L.
- Bodlin Jean J. L.
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- Sannazaro Jacopo A. T.
- Santana F.
- Sapegno N.
- Sarasola L.
- Sarfatti Margherita N.
- Sarmiento Domingo Faustino D. F
- Sarmiento Domingo Faustino D. F
- Sassone F.
- Sauer Lotte
- Scarfoglio Edoardo B.
- Scarlata G. P.
- Scarlata G. P.
- Scarron Paul M.
- Schalk
- Schalk
- Schipa M.
- Schlosser J. v.
- Schmid K.
- Schmidt Jul
- Schneider
- Schneider Ernst
- Schneider F.
- Schneider Reinhold
- Schneider Reinhold II
- SchnĂŒret G.
- Schoenstedt F.
- Schramm E.
- Schramm E.
- Schreckenberg W.
- Schreiber E.
- Schroeder W.
- Schumacher H.
- Schutz A. H.
- Schwabe M.
- Schwarz Rieh
- Schwengeler A. H.
- SchÀfer W.
- Scialhub G.
- Scudery Georges
- Scudery Madeleine
- Second Jean A.
- Semler R.
- Serao Matilde A
- Serpa Enrique M.
- Serpa Enrique M.
- Serra Renato
- Serveri de Girona A.
- Serveri de Girona A.
- Sesini U.
- Sesini U.
- Sestini Bartolomeo G.
- Settanni E.
- Seura Salvo C.
- Shaw J. E.
- Siebertz P.
- Silio Corte
- Silva Castro R.
- Silvestre Gregorio A
- Simeon G. D.
- Simone F.
- Simoni Renato B.
- Singleton Ch S.
- Sitzungsber
- Smith
- Soc
- Solas Garcia J.
- Soldevila F.
- Soldevila F.
- Sonder P.
- Sorel Georges
- Sorge Maria
- Spaak Paul J.
- Spell J. R.
- Spiess Annemarie
- Spoerri Th
- Stabili Francesco H.
- Stadelmann R.
- Steier Andreia A.
- Steinborn W.
- Steiner
- Stendhal
- Storia
- Studies
- Sur
- SuÀrez de Mendoza J. A.
- Swain J. O.
- Szerb A.
- SĂŒdl
- SĂŒsskind
- Tableau
- Taf
- Taf
- Taf S
- Tal
- Tamayo
- Tamayo
- Tanro A.
- Tansillo Luigi D.
- Tarcaniota Michele Marullo B.
- Tartufari Clarice B.
- Tasis R.
- Tasso Torquato
- Taube O.
- Taube O. v.
- Teatro
- Teltecher L
- Terminio Antonio B.
- Terrazzi R.
- Tessin G.
- Testa
- The
- TheOphile Bordeu
- Thibaudet A.
- Thibaudet A.
- Thibaudet Albert J.
- Thomas
- Thomas J.
- Thomas-Bourgeois C. A.
- Thomson S. H.
- Thomson S. H.
- Thovez Enrico C.
- Throop P. A
- Tieghem P
- Tiraferri E.
- Tirso de Molina G. G.
- Toffanin G.
- Toll K.
- Torelli Pomponio B.
- Tori de Diegues Lola
- Torner E. M.
- Torres A.
- Trahard P.
- Trapani G
- Traversari Ambrogio G.
- Trojandt Gerda
- Turnbull Jane M.
- Udaondo E.
- Un
- Une
- Une
- Une
- Urwin K.
- Uslar Pietri A.
- v. Jan
- v. Richthof
- Vaeconcelos A.
- Valbuena Prat A.
- Valdes
- Valdes
- Valera Juan S.
- Valle J. G.
- Valle-Inclan Ramon
- Vargas F.
- Varona Enrique Joso
- Vaughan
- Vaz Ferreira C.
- Vedel N. A.
- Vega M. .
- Vega Morales M. A.
- Veiras Denis E
- Velez de Guevara Luis
- Verdeyen R.
- Verga Giovanni
- Verga Giovanni
- Verga Giovanni
- Verhaeren Emile
- Verhaeren Emile
- Verlaine
- Verlaine Paul H.
- Verlaine Paul H.
- Verlinden C.
- Verlinden Ch
- Verona Guido Th.
- Verri Pietro C. A.
- Vgl G.
- Viau Thoophile
- Vicens J.
- Vidal J.
- Vidal Jove J.
- Vidier P.
- Vie de Saint Antoine J.
- Viele-Griff A.
- Viele-Griff A.
- Viezma Sancho J. G.
- Vignaux P.
- Vigny Alfred
- Vila P.
- Villehardouin
- Vincke J.
- Vincke J.
- Violant R.
- Viotti M.
- Viscardi A.
- Viscardi A.
- Viscardi A.
- ViTes Jose
- Vivanti Annie B.
- Vofsler K.
- Vofsler K.
- Voiture Vincent G.
- Voltaire
- Vossler K.
- Vossler K.
- VĂ€rady E.
- Wackernagel M.
- Wade
- Wade
- Wade
- Wade Ira O.
- Wahnrau G.
- Wallbott R.
- Walter F.
- Walzel O.
- Wandruszka von Wanstetten M. W.
- Wangenheim S. v.
- Wappier E.
- Was
- Weber O.
- Weck R.
- Weis E.
- Weise O.
- Wels L. E.
- Werneck SodrÂŁ N.
- Werner
- Wiegand J.
- Wietzorek Marg
- Wilhelm Jul
- Wilhelmslied Ph. A.
- Willige
- Wilmart A.
- Wilmotte M.
- Wilson W. E.
- Winkler E.
- Winkler E.
- Winkler E.
- Wissenschaftliche Quellen
- Witte Martha
- Wittlin A.
- Wolff Max J.
- Xavier A. J.
- Yallis M.
- Yepez Miranda
- Zanella Giacomo
- Zanella Giacomo A.
- Zara Ph
- Zieeemer W.
- Zimmermann C.
- Zoppi G.
- Zr
- Zr 0
- ZrPoo
- Zu
- Zu
- zu Pfandl
- Zurita Jeronimo G.
- °o
- ·« G.
- Ălt A.
- ÎÎż
- âŹautier ΀ηÎÎżÏÎÎÎČ R.
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1943
- Field of study
D. Die einzelnen romanischen Sprachen und Literaturen.
- Author
- A
- A
- A
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A. B
- A. B
- A. C
- A. C
- A. C
- A. D
- A. D.
- A. D.
- A. H
- A. J. V
- A. K
- A. M
- A. S.
- A. S.
- A. V
- A. W. E
- Abba
- Abel Bonnard
- Abel Hermant
- Abh S. M.
- Achille Luchaire
- Achille Z
- Ad Venturi
- Ada C
- Adalbert
- Adam Villiere
- Adame Edward
- Adolf Bernhardt
- Adolf Jacob XiOvera
- Adolf Schulten
- Adolfo B
- Adolfo Gandiglio Bonardi Carlo
- Adolfo Posada
- Aiglantine Hueline
- Aigremont Buef
- Aigremont Buef
- Aimee
- Ais Cadet
- AL
- Alb Corbellini
- Alb Matschnig
- Alb Wagner
- Albert Cim
- Albert Dauzat
- Albert Dauzat
- Albert Gaben
- Albert Heumann
- Albert Lanzendörfer
- Albert Samain
- Albert Schinz
- Albert Thibaudet
- Albert Thibaudet
- Albert Thibaudet
- Alberto Chiapelli
- AlbHin
- Albola M.
- Alcan F.
- Alceste Roflexions
- Alcover A.
- Aldo M
- Alejandro Sux
- Aless Ancona
- Aless Dumas
- Alessandro Luzio
- Alex Dumas
- Alex Samouillan
- Alexander Boecker
- Alexander Carteilieri
- Alexandre Dumas
- Alexandre Kubin
- Alfons H
- Alfr Herrmann
- Alfred Poizat
- Alfrede Vazquez Varela
- Alice F
- Allein
- Allem
- Allg S. M.
- Allg S. M.
- Almeida Nogueira Almeida Nogueira
- Aloysio V. A.
- Aloysio V. A.
- Alsace Legendes
- Alvarez Quintero S.
- Alvarez Quintero S.
- Alvarez Quintero S.
- Alvarez Quintero S.
- Alvarez Quintero S.
- Alvarez Quintero S.
- Amerindo Camilli
- Amerindo Camilli
- Amile Amis
- Amile Amis
- Amman H.
- An.
- An.
- An.
- Anatole Franoe
- Ancona A.
- Andre Beaunier
- Andre Beaunier
- Andre Chenier
- Andre Leval
- Andres Gimenez Soler
- Andres Gonzalez Blanco
- Andro Beaunier
- Andro Birabeau
- Andro Chevrillon
- AndrÂŁ Beaunier
- AndrÂŁ Suares
- Anduze Clara
- Ang Gubernatis
- Ang Ottolini
- Ang Poliziano
- Ang Poliziano
- Ange Chute
- Angebert
- Angelo Monteverdi
- Angelo O
- Anghelesco
- Angicourt Perrin
- Angleterre Montaigne
- Anmerkgn S.
- Annales Romantiques
- Annette Brown H
- Annibale Pastore
- Annita S. M.
- Ant Campari
- Ant MĂ€rend
- Ant Reetori
- Ant Salvini
- Ant Santi
- Ant Scura
- Antoine Albalat
- Antoine Albalat
- Antoine Jeanroy
- Antoine Thomas
- Antoine Thomas
- Antolin Lopez Felaez
- Antologia Nuova
- Anton Stitz
- Antonietta B
- Antonio Ballesteros
- Antonio Belloni
- Antonio Pilot
- Appel
- Aquino Rinaldo
- Arabi Turchi
- Aranzadi Telesforo
- Araujo
- Arbeiten S. M.
- Arbeiten S. M.
- Arch
- Arch In Nuovo
- Arch In Nuovo
- Ardeechah Jean
- Arille Carlier
- Armana
- Armand Dayot
- Armand Garnier
- Armande Palacio Valdes
- Arnold Alge
- Arnoul Greban
- Arnoul Greban
- Arrigo
- Arrigo B
- Arrigo Balladore
- Arthonice Salon
- Arthur
- Arthur
- Arthur Bauer
- Arthur BS
- Arthur L
- Arthur Livingston
- Arthur Meyer
- Artur
- Artur F
- Artur Gorovei
- Arturo
- Arturo Campion
- Arturo Graf
- Atktnson Jenkins
- Attilio Butti
- Attilio Certo
- Attilio Levi
- Attilio Levy
- Attilio M
- Attilio Rillosi
- Aube Bertrand
- Aubray F. G.
- Auch
- Auch
- Auch
- Aug Mayer
- Aug Ot. Ph.
- Aug Wiedenhofen
- Aug Zahn
- Augsten
- August K
- August Schmedtper
- Auguste Longnon
- Augusto M
- Augusto M
- Aus M.
- Auvergne Huon
- Auzias MĂ€r
- Axular
- Azevedo P.
- B
- B
- B
- B
- B
- B.
- B.
- B. C
- Bacinaohi
- Baeddeker
- Baldensperger
- Balvioni
- Balzac Honore
- Balzao ÎοηοÎčÎ
- Barbey
- Barcelona
- Barini Giorgio
- Barlosa
- Barras
- Barras
- Barras
- Barriere F.
- Bartholomaeis
- Bartolucci
- Barzizza
- Baskisch Ublenbeok C. C.
- Basoan
- Bateve
- Batlle
- Battisti
- Bauer Constantin
- Bayo
- Bayonne J. B.
- Bd El
- Bd Filippo Er
- Bd S. M.
- Bd.
- Beatis A.
- Beaudry
- Beauduin Nicolas
- Beaumarchais
- Beaunier
- Bechtel
- Bedier
- Bedin
- Beinaoh
- Beinhold
- Beitr S. M.
- Beitr S. M.
- Belcari
- Belgique La Langue
- Bell A. F.
- Bell A. F. G.
- Bello D.
- Belloni A.
- Benedetto Croce
- Beoqper Gustavo
- Beranger P.
- Bergue
- Berlin
- Berlin
- Berlitz M.
- Berluc-Perussis
- Bernard
- Bernard
- Bernard Mystere
- Bernh Sohmitz
- Bernhard
- Bernheiin
- Bersaucourt A.
- Bertoni
- Bertrand Auerbach
- Bezard
- Biagi
- Bibl III
- Bibl M.
- Bibliografica Enciclopedia
- Bire
- Blanche Oberle
- Blanco Garcia
- Blondheim D. S.
- Bodel Jean
- Bogel A.
- Bogel A.
- Bogel A.
- Boger Noelle
- Bois Joseph
- Bon Le
- Bordeaux
- Borgershoff J.
- Borgese G. A.
- Borland
- Borou
- Borsi Giosue
- Bossert
- Botrel
- Boucher Le
- Bouchor
- Bouery-Veysseyre
- Bouohendhomme
- Bourg
- Bourguin
- Bovet
- Boylesve
- Boylesve
- Boylesve
- Br
- Bratli
- Brebeuf
- Bricaud Joanny
- Brissot
- Brizeux
- Brod Robert
- Bruggers Nebst Antwort
- Brunacci
- Brunel
- Bruno Fetermann
- Bruno Herlet
- Bruyere La
- Bruyere La
- Bruyere La
- Bruyere La
- BrĂŒnettere
- BrĂŒnettere
- BSD
- BSD
- Budapest
- Budapest
- Budapest
- Budapest
- Budapest
- Buffum Douglas
- Bull In
- Bullettin
- Buls J.
- Burnam John
- Butte
- Byer Du
- Böig Elie-Joseph
- Böig Elie-Joseph
- BĂŒohtemann
- C
- C.
- C.
- C.
- C. F
- C. G. A
- C. G. M
- C. Jure
- C. L
- C. R
- Cabrera
- Caillet
- Calmette
- Calonghi F.
- Cam Manfroni
- Cameron M.
- Camille Bellaigue
- Camille Jullian
- Camille Martin
- Camille P
- Camille-Georges
- Campoaxnor
- Campos Julio Nombela
- Canada Les
- Candido Decembrio Pier
- Canzionere
- Canzoniore
- Capus
- Capus
- Capus
- Car Dati
- Car Donati
- Car Huit
- Car Porta
- Car Porta
- Cara
- Carl B
- Carl Becker
- Carl Becker
- Carl Steinweg
- Carl Voretzsch
- Carlo
- Carlo Pascal
- Carlo S
- Carlo Salvioni
- Carlos Laealde
- Carmine C
- Carmine C
- Carmontelle
- Carolina Invernizio
- Carolina Invernizio
- Carolina Invernizio
- Carolina Invernizio
- Carolina Invernizio
- Carolina Invernizio
- Carolina Invernizio
- Carolina Invernizio
- Carraroli
- Carreras
- Catone Dantesco Nuove
- Cayotte
- Cecohi
- Ceeare
- Ceferi Rocafort
- Cejador
- Celso Costantini
- Cervantes
- Cervantes
- Ces Giulio
- Cesare Levi
- Cesareo G.
- Cessi Roberto
- Ch A.
- Ch Chapelet
- Ch Oulmont
- Ch.
- Ch.
- Ch. T
- Chalotaie La
- Chambers Samuel
- Champfleury
- Champion
- Champion H.
- Chanson
- Chants
- Charks
- Charles
- Charles
- Charles
- Charles
- Charles
- Charles
- Charles B
- Charles B. L
- Charles Bastide
- Charles Iiemenestrel
- Charles Oulmont
- Charles Querin
- Charles-LeOn Bernardin
- Charlotte Lady
- Chartularium
- Chateaubriand
- Chateaubriand Sur
- Chavatte Manteau M.
- Chenal
- Chinard
- Chine
- Chorange
- Chr Pfister
- Chr Thorn
- Chr Thorn A.
- Christina M. M
- Christof Bardola
- Christof Bardola
- Christof Bardola
- Christoph Book
- Chronique
- Chronological
- Cian
- Cipolla
- Cipriani Charlotte
- Cl Basto
- Cl Delle Corte
- Cl. D
- Claretie
- Claretie
- Clark J.
- Cledat
- Clemente Cortejon
- Cloment
- Codebo Mlle P. O.
- Coester
- Cohen
- Cohen
- Cola di Rienzo La Vita
- Colson Pedro Tfovo
- Coltection S.
- Concepcion Arenal
- Condillac
- Condurachi J. D.
- ConoeiQao
- Constantinopoli Viaggio
- Contes
- Coraly
- Cornel Gurlitt
- Cornu P.
- Cornu P.
- Corsi Furio
- Counson
- Cours
- Coutant Amroann A.
- Couturien
- Cozzi
- Crebillon J.
- Crescini Vincenzo
- Critica
- Cubano Parnaso
- Curzon
- D
- D.
- D. B
- D. D
- D. S
- D. S
- da Cortona Ricciardo
- da Ferrara Ferrarino
- Dandicolle
- Daniel Mornet
- Daniel Petit
- Danielou
- Danon
- Danrit
- Dante
- Dantesca Questioni
- Dantis Lectura
- Dantis Lectura
- Dantis Lectura
- Daranata
- Dauzat
- de Apologos Castellanos Antologia
- de Apologos Castellanos Antologia
- de Arellano Raiael Ramirez
- de Balzac Les
- de Beihencourt D. Francisco Fernandez
- de Biie Jehan
- de Blaivies Jourdain
- de Bourges Lion
- de Chalussay Le Boulanger
- de Chateaubriand La
- de Chateaubriand Les
- de Chateaubriand Les
- de Chronologie Rousseauiste Questions
- de Coincy Gautier
- de Corbian Peire
- de Deguileville Quillaume
- de Euskal Tirage
- de Flaubert Le
- de Florencia La Espanola
- de France Marie
- de Girone Serberi
- de Guillaume Chanson
- de Guillaume Chanson
- de Hantone Boeve
- de Helayne Yetoire
- de Hodez Guida
- de La Bruydre Jean
- de la Gaya Doctrina Libro
- de La Jean
- de La Jean
- de la Vega Garcilaeo
- de Lamartine Mauuscrits
- de Lesser Creuze
- de Lisle Leconte
- de Louis Veuillot Un
- de Madariaga Juan Mufloz
- de Maohaut Guillaume
- de Maohaut Guillaume
- de Maohaut Guillaume
- de Margival Nicole
- de Mery Huon
- de Metz Guerre
- de Miranda Sa
- de Monglane Garin
- de Monglane Garin
- de Monglane Garin
- de Mont-Saore Olenyx
- de Montaigne Une
- de Montaigne Une
- de Monvel« Beutet
- de Muret Bataille
- de Narbonne Aymeri
- de Narbonne Aymeri
- de Nostre Dame Miracles
- de Ooulanges Fustel
- de Organo Canto
- de Paris Geflroi
- de Pascal Autour
- de Pisan Christine
- de Preuve Livre
- de Provence Contes
- de Queiroa Teixeira
- de Raison Livre
- de Regla Libro
- de Rome Gilles
- de Saint Adrien Mystere
- de Savoie Louise
- de Stendhal Le
- de Stendhal Le
- de Tournant Gui
- de Valenoe Aote
- de Vaucouleurs Thierry
- de Vega Lope
- de Victor Hugo Autour
- de VogĂŒo Eugene-Melchior
- Dech
- Dechepare
- Decurtins
- Decusara E.
- Dederioh
- Degano
- Degli
- Dejob
- Dejob Charles
- del Castillo Antonio Canovas
- del Cavallero Cifar Hietoria
- del Meli Le
- Del Pequewiese
- del Toro Le
- Del Vecohio
- Delaunay
- Delia Benincasa
- Deliflle
- Deliflle
- Deliflle
- den GĂ€rten Aus
- Denes Gagghy
- der Grofse Friedrich
- der Qrofse Friedrich
- der Venediger Aigremont
- des Groisen Ode Friedrichs
- des Reaux Tallemant
- des Verbums Die Entwicklung
- Descartes
- Descartes
- Desiderio Pasolini Pier
- Desonnaux
- Di
- di Agnolo Firenzuola I
- di Carini Baronessa
- di Giuseppe L'anima
- Dictionnaire
- Dictionnaire
- Die Feichtinger W. M.
- Die Nieuwbarn P. M. C.
- Dihigo J. M.
- Dima Soloeta
- Din S.
- Dino Mantovani
- Diss
- Diss S.
- DL
- DL
- Documenti S.
- Documents
- Documents
- Dodici
- Dolores Panza
- Dom Batacchi
- Dom Ferretti
- Domenico Ciampoli
- Donald C
- Donato Hugues
- Dontenville
- Doumic
- Dr
- Dr
- Dr
- Dr
- du Conseil Lai
- du Faill Noel
- du Hardi Cheval Dit
- du Pin La Tour
- du Prieure Cartulaire
- du Vilain Mire Fablei
- Duhem
- Dumas
- Dumas
- Dumas
- Dunand Ph.
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- Dupuy
- Duranti
- Duret
- E
- E.
- E.
- E.
- E.
- E.
- E.
- E.
- E.
- E.
- E. C
- E. C
- E. C
- E. Du R
- E. Fi
- E. G
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- E. G.
- E. R
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- Eberh Sauer
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- Edgar Quinet Euvres
- Edgardo G
- Edgardo Gamerra
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- Edm Goncourt
- Edmond Eateve
- Edmond Faral
- Edmond Faral
- Edmond Faral
- Edmondo C
- Edoardo B
- Eduard Kosohwitz
- Eduard Muoth
- Edward S
- Egberto B
- Egidio Bellorini
- Ein Pranzetti
- EinfĂŒhrung S. M.I.SO.
- Einl Nationalbibliothek
- Elenco
- Elsö
- Em Bodrero
- Em. P
- Emil Jaoobsen
- Emil Otto
- Emil P
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- Emile Faguet
- Emile Faguet
- Emile Faguet
- Emile Faguet
- Emile Faguet
- Emile Faguet
- Emile Faguet
- Emile Faguet
- Emile Legouis
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- Emilio Bobadilla
- Emilio Bodero
- Emilio L
- Emilio Re
- Emilio Teza
- Emmert B.
- Encore
- Encore
- Enea Cianetti
- Enenkel
- Enenkel
- English Rudmoee-Brown T. B.
- Enrico F
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- Euskalerriaren
- Euvres
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- Ezio Levi
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- Ezzio Levi
- F
- F
- F.
- F.
- F.
- F.
- F.
- F.
- F.
- F. B
- F. M.
- F. M.
- F. O.
- Fabliau
- FaecĂ
- Faguet
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- Farnes
- Fastre
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- I
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- Ital III.
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- L
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- Macaulay G.
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- Quirielle Pierre
- R
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- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S.
- S. ASR
- S. BSD
- S. Gsli
- S. Gsli
- S. Gsli
- S. Gsli
- S. Gsli
- S. i.
- S. LE
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.
- S. M.I.SO.
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rbli
- S. Rblt
- S. Rcr N. S.
- S. Ro
- S. RR
- S. s.
- S. SFM
- S.-A.
- S.-A.
- Sabbadino
- Sacken E.
- Sacristain Moine
- Sage Le
- Sage Le
- Saillard
- Saint Babut E. Ch.
- Salvatore Farina
- Salvatore Farina
- Salverda
- Salvioni C. A.
- Sambon
- Sammig S. M.
- San Bonilla
- San Giuliano
- Sanctis
- Sanctis
- Sand
- Sandron R.
- Sandron R.
- Saniere Debenedetti
- Sanson
- Sansoni G. C.
- Sansoni G. C.
- Santorre D
- Santorre Debenedetti
- Sarazin
- Sardinien
- Scalvanti
- Scarpatelli
- Schlager Jahrg
- Schlatter Edward
- Schofler
- Schreinecke
- Schuohardt
- Scritti
- Seb Palmeri
- Sebarthee
- Seche
- Seche
- Seconda
- Seconda
- Seilliere
- Seoane Marques
- Sept Juli
- Serafino P
- Sero
- Sesto Fassini
- Sevigne Mme
- Sidney G
- Sidney G
- Siecle
- Siegfr Brase
- Siehe
- Siena
- Sigmar Mehring
- Silvain Pouvreau
- Simioneeou
- Simon Caratsch
- Simon Caratsch
- Siso Joaquin Botet
- Smith M.
- Snow William
- Sociote In La
- Sode Les
- Sode Les
- Soldati-Manis Nozze
- Soler A.
- Solone M
- Sommer
- Sommer
- Sophie Apponyi Lettres
- Sovira
- Spanish Lang H. R.
- Spencer Dodgeon Eduardo
- Spencer Dodgson Eduardo
- Spitzer
- Stael Mme
- Stanislas Reizler
- Stanley Leman G
- Steiner Eszti
- Steinilber
- Stendhal
- Storia
- Storia
- Storia
- Stoweil William
- Straohey G. L.
- Stuart D.
- Stuart M
- Studi
- Studi
- Sturel
- Stuttgart
- Stuttgart
- Sues
- Suit Iturralde
- Sul
- Sur
- Sur
- Suzanne Caille
- Sylvain Trebucq
- Szczepanski Mac
- Szombathely Marino
- Sötte Chanson
- T
- T.
- T. G
- T. G
- Taine
- Taine
- Taine
- Tallgren O.
- Tappolet
- Tappolet
- Tappolet
- Tardent Henry
- Tareot M. L.
- Tavola
- Taylor Una
- Teildruck M.
- Temps In Le
- Temps In Le
- Temps In Le
- Temps In Le
- Temps In Le
- Temps In Le
- Temps In Le
- Temps In Le
- Teodoro Flournoy
- Teofilo Qay
- Terenzio Tocoi
- Teresa Ruga Maria
- Terraoina
- Textes
- Th A.
- Th Bornecque H. B.
- The
- The Kastner L. E.
- The Northup G. T.
- The Spanish Rennert H. A.
- Theo Spira
- Theodor Gerold
- Theodor Kalepky
- Theodor Kalepky
- Theodor Kalepky
- Theodor Kalepky
- Theuriet
- Theuriet
- Thomas
- Thomasset
- Thoophile Gautier
- Thoophile Gautier
- Thoophile Gautier
- Thoophile Gautier
- Thoophile Gautier
- Thoriaque La
- Timoneda Juan
- Tischner
- Tod
- Toledo Bd. I
- Tonelli F.
- Toni Fischer
- Torino
- Torquato Tasso
- Torquato Tasso
- Torquato Tasso
- Torre La
- TOU.
- Touflet
- Toujours
- Tournyol
- Trabajos de Diego Galan Cautiverio
- Trattato
- Tristan
- Tristan F. M. War r en Enoas
- Tristan Tomo XV.
- Tuttle Edwin
- Tuttle Edwin
- U. F
- U. F
- U. F
- U. Franz C
- UB.
- Ubaldo M
- Ubaldo Mazzim
- Ueenberg
- Ugo
- Ugo Cristofani
- Ugo Foscolo
- Ugo Pellie
- Umberto Cosmo
- Umberto M
- Una
- Una
- Univ S.
- Uribe Benito Mariano Andrade
- Urquijo Julio
- V.
- V.
- V.
- V. B
- V. E.
- V. E.
- V. F
- V. F
- V. G
- v. Navarra Margareta
- v. Orleans Elisabeth Charlotte
- V. R
- v. Troyes Nioolas
- v. Valois Margareta
- v. Valois Margareta
- Vacandard
- Vaganay
- Vaillat
- Valdruche
- Valentin
- Valfrido Garda
- Vallier
- VarietÀ
- Vay
- Velasoo Lino Munarriz
- Velleman
- Venetian Livingeton A. A.
- Verdi
- Veronica Franco
- Verrier
- Vestigi
- Veuillot
- Veuillot
- VI
- Vianey
- Vianey
- Vicente Gay
- Vict Du Bled
- Victor
- Victor
- Victor
- Victor
- Victor C
- Victor Du Bled
- Victor Du Bled
- Victor Giraud
- Victor Hugo
- Victor Sallentien
- Vicuna Cifuentes
- Vidal
- VII
- Villari
- Villeneuve
- Villon
- Vinc Bartholomaeis
- Vinc Toscano
- Vincenzina Messina
- Vincenzo P
- Vindry F.
- Vineon
- Vineon
- Virgilio P
- Viterbo
- Vladimiro
- VogĂŒe Marquis
- Voltaire
- Voltaire
- von Ballaigues Sinner
- von Beaujeu Renaut
- von Bouillon Godefroi
- Von G. L. P
- Von Georg R
- von Marseille Folquet
- von Metz Herviz
- von Romans Folquet
- Vorone Chateaubriand
- Vorst B.
- Vreiz-Izel Evit Alnumak
- VĂ€lsan GiĂglea G. u. G.
- W.
- W.
- W. F
- W. K
- W. Seh
- W. v.
- Waddington William
- Wagner J. K. G.
- Walberg
- Walter Bonary
- Walter Pater
- Walther Franke Max
- Walther KĂŒchler
- Walther S
- Warszawska Biblioteka
- Weigand
- Weill
- Werder
- Werke S. M.
- Werr Gassner H.
- Wiehert
- Wilhelm T
- Wilhelm Weinmann
- Willcox C.
- Willibald
- Willibald
- Wilmotte
- Winifred Smith
- Witte
- WoHf Max
- Wolf Max
- Wolff
- Wolfg Wurzbach
- X S.
- X S.
- XV
- XVI
- XVII
- XXVIII
- XXVIII
- Yderroman
- York New
- Zaharrak U
- Zamacois
- Zamet
- Zanders
- Zeitschr S. M.
- Zeitschr S. M.
- Zola
- zu St Bibliothek
- Zur
- £·
- °·
- Ăeatrice Cenci Guerrazzi F.D.
- Ăeatrice Cenci Guerrazzi F.D.
- Àficas R. C.
- Àge
- Àhrig S.
- Àtre de Maeterlinck Le
- öallo Juan Guzmann
- ös Sammlung
- ös Sammlung
- ös Sammlung
- ös Sammlung
- ösischen Zur
- ĂŒn
- ÎÎÎÎČÏίηÎČ Jean
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1914
- Field of study
D. Die einzelnen romanischen Sprachen und Literaturen.
- Author
- A
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A.
- A. Albert P
- A. B
- A. Della
- A. H
- A. P
- A.A.
- Abel Hugo
- Abel Leger
- Abeneour
- Ada Negri
- Adolf Tobler
- AL
- Albert G
- Albert Leon
- Albert Mathiez
- Albert Rennert Hugo
- Aldo
- Aless Chiappelli
- Alessandro
- Alessandro Marasca
- Alexander
- Alexander
- Alexis B
- Alexis Pitou
- Alfred
- Alfred de Musset Un
- Alfred M
- Alfrede G
- Alfredo Segre
- Alfredo Segre
- Alos Ramon
- Alphonse
- Alphonse Daudet
- Alzola
- Amedeo Arullani Vittorio
- Amelia B
- Amerindo Camilli
- Ancora
- Andre Chenier
- Andre Gide
- Andres Martinez Salazar
- AndĂŒly Robert Eugene Griselle Arnauld
- Angel Marvaud
- Angers
- Annuario
- Anthology S.
- Antoine Barbier
- Antoine Benoifit
- Antoine Chanoux
- Antoine Deresse
- Antoine Heroet
- Antoine Thomas
- Antoine Thomas
- Antoine Thomas
- Antoine Thomas
- Antoine Thomas
- Antoine Thomas
- Antonio B
- Aragon Jacques
- Aranzadi
- Aranzadi
- Aranzadi Telesforo
- Archivio
- Arezzo Ugo
- Aristide Marre
- Armas Joso
- Arnaldo A
- Arnaldo Della
- Aroaldo B
- Aron Terraoini Benvenuto
- Arras B
- Arthur Harter
- Arthur Rossat
- Arthur Tilley
- Artur
- Arturo
- Arturo Campion
- Arturo Farinelli
- Aten In
- Atkinson Jenkine T.
- Attinger
- Auguste Angellier
- Auguste Angellier
- Auguste Longnon
- Auguste Vidal
- Augusto L
- Ayala Pero
- Azevedo P.
- Azevedo P.
- B. C
- B. C
- Baccini
- Bada Viana A. R.
- Bagnard
- Bagnard
- Baker A. T.
- Balzac Honore
- Barcelona
- Baron Desazare
- Bartholomaeia V.
- Basto
- Bataille
- BattiĂta Alberti Leon
- Batz Baron
- Baumann
- Bauval
- Bd.
- Belleza
- Belli
- Ben Croce
- Benedetto Dei
- Benrubi
- Benvenuti
- Berardi
- Bernardo Capello
- Berte
- Berthon H. E.
- Bertinelli S. D. C
- Bi
- Biblioteca
- Biblioteca
- Bibliotheque
- Bildnis S.
- Bildnis S.
- Bindo C
- Binet
- Blanchefleur Flore
- Blanchefleur Flore
- Blanchet
- Boberto Cesei
- Boieeonnade
- Boillot
- Bollettino
- Bonaparte L. L.
- Bonarelli
- Bonfigli
- Bonifaoio Calvo
- Bonne Mire Florian« La
- Bonner Henri
- Boooh-Arkossy
- Borgherini Scarabellin
- Bottini G. II
- Bouchaud Pierre
- Br Freiburg
- Braaoamp Freire
- Braconnier
- Braga Barreiroe
- Brandes
- Bransby
- Brauns
- Brazil
- Bredif
- Bruno
- Bruno Busse
- Bruno E
- Bruxelles
- Bry M.
- BSD
- BSD
- BSD N.
- Bucbanan Milton
- Bueey-Babutin
- C
- C.
- C.
- C.
- C. B
- C. B. B
- Ca
- Canaille P
- Caprin Giulio
- Cardinal Peire
- Carlo Zilli
- Caroline Spalding Mary
- Castaldo A.
- Catalina
- Cbampeval
- Cecchi Eugenio
- Cesare Masoara Filippo
- Ch Dangibeaud
- Ch Lecomte
- Ch.
- Ch.
- Ch.
- Ch. B
- Charasson
- Charles
- Charles Baudelaire
- Charles Beauquier
- Charles Colle
- Charles S
- Charles Seignobos
- Charlotte Lady
- Chateaubriand
- ChervoĂŒlot
- Cheze J.-B. L. B
- Chiarini G.
- Chiarini GK A. P
- Chr Pflster
- Christian
- Churchman Philip
- Ciarette
- Cifuentes Vicuna
- Claretie
- Claude Garnier
- Clemente Barbieri
- Clemente Barbieri
- Codecasa
- Colin A.
- Colton M.
- Commedia La Divina
- Comptes
- Comptes
- Comte
- Concetto Marchesi
- Conversazioni
- Coppee
- Corrado Corradino
- Corriere
- Costanzo Binaudo
- Counson
- Courteault
- Cousin
- Crisoetomo Ferrucci
- Crouzet P.
- Crowe
- Cygne Chevalier
- D
- D
- D. A
- D. B
- D. B
- D. B
- Dame Salut Notre
- Danoif
- Dante
- Dante
- Dante
- Dante· Enrico
- Daranatz J. B.
- Das M.
- de Blasi Jolanda
- de Boranger Chansons
- de Charlemagne Enfances
- de Fauvel Roman
- de Hesdin Jehan Acart
- de la Servitude Volontaire Diecours
- de Mendoza Diego Hurtado
- de Montauban Chanson
- de Noblesse Trosor
- de Paris Qeufroi
- de Sainte-Maure Benoit
- de Savoie Heuree
- de Thaon Philippe
- de Thaon Philippe
- de Thoophile Gautier De Pinfluence
- de Troyee Chretien
- de Vega Lope
- de VĂŒloison AnsĂ€e
- Decreto
- del Olmet Fernando Anton
- del Tassoni Le
- della Domemca Fanfulla
- della Domemca Fanfulla
- Della Giovanna J. II
- della Gioventa In Amicö
- der Sprachen Bd M.
- des Houesayeg Cotton
- Deschamps
- di Ludovico Ariosto L'Erbolato
- di Pesoina Maral
- Dialogue
- Dias
- Die Schriften
- Dienne
- Direttore Agostino
- DL
- DL
- Documents
- Documents
- Dodgson E.
- Domenico Carutti
- Dominguez Arevalo Toraas
- Doutrepont
- Drame
- Du Bellay L'Olive
- du Boudin Dit
- du Lic II.
- Dubarat
- Dudley Frank Colman
- Dumas
- Duoore
- Duprat
- Duschinsky
- Dutil
- Duvoi
- E.
- E.
- E.
- E.
- E.
- E.
- E.
- E.
- E. C
- E. D
- E. G.
- E. G.
- E. L
- E. M
- E. M
- Eaton Gerothwohl
- Echecs
- Ecole des Hautes-Etudes S.
- Ed Hrkal
- Edmund G.
- Edouard C
- Edward Henry F
- Edward Montier
- El
- El
- El Bolognese
- el Trentino Lingua
- Eleizalde Luis
- Elia F.
- Emil P
- Emile F
- Emile Faguet
- Emile Magne
- Emile Verhaerens Die Gesichter
- Emmanuel Philipot
- Eneae
- Enr Thovez
- Eohaux Bertrand
- Eohegaray
- Ernest Lunel
- Ernest Seiliiere
- Ernesto Monaoi
- Erneut
- Erneut
- Ernst Tappolet
- Ertr S.
- Espagne Mispoulet J.-B.
- Espinohal Comte
- Estr S.
- Etienne Deville
- Ett Malde
- Ettmayer
- Ettore
- Ettore
- Etudes
- Etymologias V. J.
- Etymologies
- Eugene Griselle
- Evera II.
- Extrait du Bull S.
- Ezio Levi
- F.
- F.
- F.
- F.
- F.
- F.
- F.
- F.
- F. R
- Fabrizio A.
- Faddegon
- Fagniez
- Faul L
- Favitta
- Fazzi Bertino
- Fedeiico Olivero
- Felice Tocco
- Ferd O
- Ferdinand Brunot
- Ferdinande R
- Ferdinando Russo
- Fernand Baldeneperger
- Fernand Cortez
- Fiammetta
- Fiammetta
- Figueroa Francisco
- Filippo O
- Filippon Severino
- Finamore
- Flammarion Paris
- Florian Melcher
- Fontaines Des
- Fortunat Stroswki
- Foulche-Delbosc
- Fournier
- Fr
- Fr Hanssen
- Fr. B
- Francesco Luigi M
- Franz Funck-Brentano
- Frdr Weber
- Fribourg
- Fritz KrĂŒger
- Fritz Strohmeyer
- G
- G.
- G.
- G.
- G. B. P
- G. Dupont
- G. L.
- G. M
- G. S. G
- Gabriel Faure
- Gar Goldoni
- Gargano G.
- Gaston Desohamps
- Gaston Maugras
- Gaulois Le
- Gauvain Enfances
- Gavel
- Gazier
- Geiger Mathias«
- Gentile
- Geopraphie
- Georg Caro
- George
- Georges
- Georges
- Gerig Aneatu John L.
- Gh Bally
- Gh Grandmougin
- Giaoomo S.
- Ginguene
- Giordano Bruno
- Giosuö Carducci
- Giov Boqoacoio
- Giov Segantini
- Giovanni Camerana
- Giovanni Crocioni
- Giovanni Jaffei
- Giovanni Papini
- Giovanni Ptaonik
- Giovanni Rabizzani
- Giovanni Rizzi
- Giraldo
- Giuliani
- Giulio
- Giulio Bertoni
- Giulio Bertoni
- Giulio Bertoni
- Giunio Qaravani
- Gius Tomassetti
- Giuseppe Agnelli
- Giuseppe C
- Giuseppe Peoohio
- Giuseppe Pitrfc
- Giuseppe Tambara
- Giuseppe Tofianin
- Giuseppe V
- Giuseppina Fumagalli
- Gnesio Basapopi
- Gomes Pereira
- Gomez Pereira
- Gottfried Baist
- Goutmann K.
- Graf
- Grassi G.
- Gregorio
- GrĂŒtzner P.
- Gsli
- Gsli
- Gsli
- Gsli
- Gsli
- Gsli
- Gualterio C
- Gualterio C
- Guarnerio P. E.
- Guarnerio P.E.
- Guerra D. J.
- Guerra Juan
- Guevara Luie Velez
- Guido Muoni
- Gustave
- Gustave
- Gustave Roiin
- Guy C
- Guynemer
- GĂ€htgens
- H.
- H.
- H.
- H. C
- H. C
- H. C
- H. Mono
- Habillo
- Haghee Vaganay
- Hanesen
- Harpe La
- Hartmann
- Hayward K
- He Gerghel
- Hegesippe Moreau
- Hegesippe Moreau
- Heidelberg
- Heinrich
- Henri
- Henri B
- Henri B
- Henri Bourgeois
- Henri Cordier Harrisee Henryf
- Henri Fouqueray
- Henri Hauvette
- Henri Liebrecht
- Henri Qheon
- Henri Qheon
- Henri Welschinger
- Henry
- Henry
- Henry Bordeaux
- Henry Coonin
- Henry Guy
- Henry Murger
- Herelle
- Herold A.
- Herzog
- Hevesy Andro
- Hibezzo
- Histoire Nicollet F. N.
- Historische Bibliothek S. M.
- Historische S.
- Holme James
- Hortis Attilio
- Houssaye Henry
- Houssaye Henry
- Huet
- Hugo Schuchardt
- Hugues Vaganay
- Ictterarie In Cronache
- II
- II.
- II.
- Iiorenzo Schiavi
- In Critica
- In Dante
- In Dante
- In Dante
- In Dante
- In Fortnightly
- In GD
- In La
- In Le
- In Les
- In MLR
- In Quellen
- In Rpl
- In Vtrs
- Inez Fauna
- Investigattur
- Ireneo Sanesi
- Italia Scrittori
- Italia Scrittori
- Italienische Forschungen M.
- Iturralde Juan
- J.
- J.
- J.
- J.
- J.
- J.
- J.
- J. B
- J. B. D
- J. B. D
- J. C
- J. D
- J. G. P
- Jaberg
- Jac Burokhardt
- Jacques Boulenger
- Jacques Delille
- Jacques Normand
- Jacques R
- Jacquet L.
- James Caterley
- Jan H
- Jchard
- Jean
- Jean
- Jean
- Jean A
- Jean Bonnard
- Jean Carrere
- Jean Deriee
- Jean Dornis
- Jeanroy
- Jesus Teresa
- Joachim Murat Weil M. H.
- Joeo Heredia
- John
- John C. R
- John Fitz Gerald
- John V
- Joseph
- Joseph A
- Joseph Autran
- Joseph Bedier
- Joseph Joubert
- Joseph Turquan
- JRP
- Juan Tixnoneda
- Jud
- Jud
- Jujio Cejador
- Jul Bierbaum
- Jules Feller
- Jules Marsan
- Julien Vineon
- Julien Vinson
- Julien Vinson
- Julien Vinson
- Julien Vinson
- Kader Salza
- Karl
- Karl B
- Karl Gruber
- Karl W
- Karte
- Kenneth Maokenzie
- Kirschner
- Kont
- Koracsonyi
- Kurt
- L'umorismo
- L.
- L.
- L.
- L.
- L. E. K
- L. G. P
- L. T
- La
- La
- La
- La Guarnerio P. E.
- La Jaoobsen J. P.
- la Lyoorn· Dame
- La S.
- Lacombe G.
- Lambert
- Las Cuebas
- Laurens H.
- Laurent T
- LC
- Le
- Leite
- Lelong Eugene
- Leo Spitzer
- Leon
- Leon
- Leon
- Leonardo da Vinci La
- Leroux
- Les
- Letteratura
- Lily Higgin
- Lippi Lorenzo
- Literatur S.
- Livingeton A.
- Livingston A. A.
- Loga Valerian
- Lombardo Archivio Storico
- Longnon Auguste
- Loopold Medan
- Lor Campana
- Lorme
- Lote
- Louis Daville
- Louis Delpit
- Louis Karl
- Louis M
- Louis MĂ€del
- Loutchisky
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- Vittoria Aganoor
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- von Pisan Christine
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- Walberg
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- Warren F. M.
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- Werner Söderhjelm
- Weslowski
- William EvOrett
- Willy Etzrodt
- Wilmotte
- With
- Wohlfahrt
- Wolfgang
- Wolfram
- XI
- Xtodocanachi
- York New
- Zaccagnini
- Zevaco
- Zu Roland
- ÂŁe Flaubert Le
- Ăalnt-Simon
- Ăes
- österheld Erich
- ÎĄÎÎżÎ±ÎœÏηÏοΠVivo
- Publication venue
- 'Walter de Gruyter GmbH'
- Publication date
- 01/01/1912
- Field of study
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
- Author
- Aceituno A
- Acosta I
- Adams A
- Adatia S
- Aerden Leo A.m.
- Aeron-thomas John
- Aggour Mohamed
- Aghaebrahim A
- Agid R
- Aguettaz Pierre
- Ahle Guido
- Aja L
- Akhtar N
- Al Najjar-carpentier Amen-adam
- Al'boutros S
- Al-ajlan F
- Albers Gregory W
- Albers Gregory W.
- Alexandrou M
- Alhazzaa M
- Ali L
- Allen E
- Almekhlafi M
- Alseraya A
- Aly J
- Amar Arun
- Amaro S
- Amato-marzialli B
- Amerson L
- Amiri H
- Andersen G
- Andersen L
- Anderson A
- Andersson Tommy
- Ang Timothy
- Anton C
- Anxionnat René
- Apoil-brissard Marion
- Aram H
- Arenillas Lara Jf
- Arenillas J
- Ariño H
- Arkin S
- Armbruster K
- Armitage K
- Arquizan C
- Arquizan Caroline
- Arteaga Charles
- Ashforth Ra
- Ashok Vasdev
- Attia John
- Ayrignac X
- Azizi A
- Añon J
- Bach E
- Badve Monica
- Baillot Pierre-alexandre
- Bain M
- Bakchine Serge
- Baker C
- Balasa M
- Balgude A
- Bamford John
- Banaras Azra
- Bang Oh Young
- Bang Oy
- Barber P. Alan
- Barber Pa
- Barbier Charlotte
- Barbieux Marianne
- Barnwell S
- Baronnet-chauvet Flore
- Barral Francis-guy
- Barreau Xavier
- Barros Renan Sales
- Bartolini Mario Bruno
- Barton K
- Barton K
- Bartt R
- Basir G
- Bataille Mathieu
- Bauer A
- Baxendell L
- Baxendell L
- Baxter B
- Baxter Bw
- Beadell N
- Beauchamp B
- Beaujeux RĂ©my
- Beck C
- Beck P
- Becker M
- Beenen Ludo F.m.
- Bejot Yannick
- Belagaje Sr
- Belden J
- Bellew M
- Bellon R
- Bendszus M
- Bennett Patricia
- Berge JĂ©rĂŽme
- Berhoune Nadia-nawel
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- Berkhemer Olvert A
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- Bharatha A
- Bhatt A
- Biberacher V
- Biethahn S
- Billigan J
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- Birchenall Julia
- Bitner A
- Blacquiere D
- Bladin Christopher F
- Blanc Raphael
- Blasco J
- Blayney S
- Blue-schaller A
- Bodenant Marie
- Bodiguel Eric
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- Boers Merel
- Boiten Jelis
- Bonafé Alain
- Bonafé Alain
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- Bonneville Jean-françois
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- Bounolleau Pierre
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- Bourdain Frédéric
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- Dellinger C
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- Dixit Anand
- Dobbe Roeland
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- Domigo Valérie
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- Doppelheuer S
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- Dubas Frédéric
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- Ducrocq Xavier
- Ducrocq Xavier
- Ducruet A
- Ducruet A
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- Dugay Marie-hélÚne
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- Dussaule Claire
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- Ecker Rd
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- Jannes Jim
- Jansen Ivo
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- Vuillier Fabrice
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- Wardlaw Joanna
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- Whelan R
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- Wiese C
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- Wisco D
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- Wodarg F
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- Wong Andrew
- Wong Jh
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- Wong Kitty
- Wortmann G
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- Wunderlich S
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- Yanase L
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- Yassi Nawaf
- Yavagal D
- Yavagal Dileep R
- Yavagal Dileep R.
- Yeo Ta
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- Yoo J
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- Yu Y
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- Zaidi S
- Zavanone Chiara
- Zech M
- Zegarac V
- Zerlauth Jean-baptiste
- Zimmel L
- Zuniga Paolo
- Zurasky J
- Publication venue
- 'Elsevier BV'
- Publication date
- 16/12/2017
- Field of study
Background:
General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods:
For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered.
Findings:
Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09â2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75â3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14â2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low.
Interpretation:
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons