Influencia de la moda rápida en el comportamiento de compra de los consumidores del sector textil de los centros comerciales de Arequipa 2019

La presente investigación tuvo como objetivo analizar el comportamiento de los consumidores, frente a lamoda rápida en los principales centros comerciales deArequipa 2019. La investigación es de tipo cuantitativo de campo con un nivel descriptivo, con un diseño no experimental de corte transversal. Como técnica para la recolección de información se utilizó la técnica encuesta mediante un cuestionario como instrumento para observar el comportamiento del consumidor y la revisión documental para analizar la moda rápida. La muestra fue constituida por 300 personas que asistieron a los mayores Centros comerciales de la ciudad de Arequipa. El análisis de los datos fue realizado mediante el uso de la estadística descriptiva con cuadros. Luego de analizados los resultados se puede observar una prevalencia de sexo femenino con un 69,67% y el masculino con 30,33% entre los visitantes a los centros comerciales. El 83,33% de los encuestados presentan edades comprendidas entre los 20 y los 49 años, de igual forma se determinó que un 88,33%de las personas entrevistadas visitan algún CC al menos 3 veces a la semana. Se debe resaltar que el 63,67% de los encuestados dijo tener preferencia por tiendas ubicadas en los centros comerciales almomento de adquirir las prendas de vestir. Igualmente, el 92,00% de las personas encuestadas adquieren prendas de vestir con la finalidad de estar en la moda, para expresar su estilo o como una necesidad. Un 52,00% manifestó que han adquirido prendas de vestir en ofertas así no sean necesarias. Otro 85,00% de las personas encuestadas adquieren entre 1 a 6 prendas de vestir mensualmente. El 91,33% de los encuestados tiene un presupuesto máximo mensual para invertir en la adquisición de prendas de vestir por 500 soles

Le site de la Gravière à Fareins (Ain) : une occupation rurale de la fin de l’Âge du Fer au Moyen Âge central dans le sud du Val de Saône

Une opération d’archéologie préventive réalisée sur le site de La Gravière à Fareins (Ain), commune localisée au sud du Val de Saône, a permis de suivre une occupation discontinue de rebord de plateau, depuis le second Âge du Fer jusqu’au Moyen Âge central. Si une partie des vestiges a souffert de destructions dans le cadre d’une exploitation d’une gravière dans les années 1980, le plan mis au jour correspond pour les périodes laténiennes et médiévales à celui d’un habitat rural à vocation agricole lié notamment au traitement des céréales. Pour la période antique, la nature de l’occupation demeure relativement floue compte tenu de la faiblesse de la documentation. La parcelle de fouille est probablement localisée en marge d’un établissement de qualité. Quoi qu’il en soit, ces découvertes constituent une pièce nouvelle à verser au dossier des formes de l’habitat gaulois et médiéval de la basse vallée de la Saône.Rescue archaeology on the site of La Gravière at Fareins (Ain), a municipality in the southern Saône valley, has enabled study of the discontinuous occupation of the rim of the plateau from the second Iron Age until the central Middle Ages. Although some of the remains were destroyed during exploitation of a gravel pit during the 1980s, current understanding for the La Tène and medieval periods suggests it was a rural agricultural settlement, linked in particular with the treatment of cereals. Understanding of the nature of the occupation during Antiquity remains hazy due to the poor quality of the data. The parcel of land excavated probably lies beside a high quality establishment. Whatever the actual situation, the finds offer new information on the forms of Gaulois and medieval habitats in the lower Saône valley.Eine Präventivgrabung in „La Gravière“ in Fareins (Departement Ain) im Süden des Val de Sâone bot Gelegenheit eine Siedlung am Rand eines Plateaus zu verfolgen, die mit Unterbrechungen von der jüngeren Eisenzeit bis zum Hochmittelalter angedauert hat. Zwar waren die Überreste durch die Ausbeutung einer Kiesgrube in den 1980er Jahren teilweise zerstört worden, doch der Grundriss der latenezeitlichen und mittelalterlichen Perioden zeugt von einer landwirtschaftlich geprägten, auf die Getreideverarbeitung ausgerichteten ländlichen Siedlung. Die Besiedlung der Antike ist aufgrund fehlender Dokumentation noch recht unklar. Wahrscheinlich liegt das ergrabene Areal am Rand einer Siedlung gehobenen Standards. Auf jeden Fall handelt es sich bei diesen Entdeckungen um ein neues Element, das die Typologie der gallischen und mittelalterlichen Siedlungsformen im unteren Saône-Tal ergänzt

La villa des « Vernes » à La Boisse (Ain) : contribution des fouilles récentes à la compréhensionde l’évolution d’un établissement rural antique et de son espace funéraire

Dans le cadre de l’aménagement d’un diffuseur autoroutier sur la commune de La Boisse (Ain), à une vingtaine de kilomètres au nord-est de Lyon, une opération d’archéologie préventive, réalisée en 2005-2006, a permis d’enrichir la documentation d’une villa du Ier s. après J.-C. Si une partie de cet établissement avait déjà été explorée en 1980 lors de la construction de l’autoroute A42, la fouille a permis de compléter le plan de la pars urbana, et surtout de préciser la datation de l’occupation gallo-romaine. Cette villa de plan classique n’est en effet pas une création ex nihilo ; elle a succédé à deux ensembles architecturaux antérieurs, caractérisés par des constructions en terre et bois. La villa a été abandonnée à l’extrême fin du Ier s. ap. J.-C. ou au début du siècle suivant. Deux structures isolées à caractère funéraire qui, par leur richesse, constituent un unicum régional, sont aussi datées de cette période.As part of the construction of a motorway interchange in the municipality of La Boisse (Ain), about twenty kilometres north-east of Lyon, a preventive archaeology project carried out in 2005–2006 furnished additional information about a villa built in the 1st century AD. Whereas a section of the site had already been explored during the construction of the A42 motorway, the latter excavation not only enabled the plan of the pars urbana to be completed and, above all, it allowed the dating of the Gallo-Roman occupation to be made with precision. This classically laid out villa was not an ex nihiloconstruction: it had been built over two earlier sets of architectural buildings made from wood and mud. The villa was abandoned at the extreme end of the 1st century AD or at the start of the following century. Two isolated, apparently funerary structures – which, through the wealth of their contents, are unique for the region – have also been dated to the same period.Im Rahmen des Baus eines Autobahnverteilers auf dem Gebiet der Gemeinde La Boisse (Departement Ain) etwa 20 km nordöstlich von Lyon, konnte durch eine 2005-2006 durchgeführte Präventivgrabung die Dokumentation einer villa des 1. Jh. n. Chr. bereichert werden. Ein Teil dieses Areals war bereits 1980 anlässlich des Baus der Autobahn A42 erforscht worden, doch die neue Grabung bot Gelegenheit, den Grundriss der pars urbana zu ergänzen, und vor allem die Datierung der gallo-römischen Phase zu präzisieren. Diese villa mit klassischem Grundriss war in der Tat keine Gründung ex nihilo ; sondern sie folgte auf zwei Vorgängerbauten in Holz-Erde-Bauweise. Die villa wurde Ende des 1. Jh. n. Chr. oder Anfang des folgenden Jahrhunderts aufgegeben. Zwei isolierte Grabstrukturen, deren Reichtum in der Region einzig ist, werden ebenfalls in diese Zeit datiert

The Conserved Candida albicans CA3427 Gene Product Defines a New Family of Proteins Exhibiting the Generic Periplasmic Binding Protein Structural Fold

Nosocomial diseases due to Candida albicans infections are in constant rise in hospitals, where they cause serious complications to already fragile intensive care patients. Antifungal drug resistance is fast becoming a serious issue due to the emergence of strains resistant to currently available antifungal agents. Thus the urgency to identify new potential protein targets, the function and structure of which may guide the development of new antifungal drugs. In this context, we initiated a comparative genomics study in search of promising protein coding genes among the most conserved ones in reference fungal genomes. The CA3427 gene was selected on the basis of its presence among pathogenic fungi contrasting with its absence in the non pathogenic Saccharomyces cerevisiae. We report the crystal 3D-structure of the Candida albicans CA3427 protein at 2.1 Å resolution. The combined analysis of its sequence and structure reveals a structural fold originally associated with periplasmic binding proteins. The CA3427 structure highlights a binding site located between the two protein domains, corresponding to a sequence segment conserved among fungi. Two crystal forms of CA3427 were found, suggesting that the presence or absence of a ligand at the proposed binding site might trigger a “Venus flytrap” motion, coupled to the previously described activity of bacterial periplasmic binding proteins. The conserved binding site defines a new subfamily of periplasmic binding proteins also found in many bacteria of the bacteroidetes division, in a choanoflagellate (a free-living unicellular and colonial flagellate eukaryote) and in a placozoan (the closest multicellular relative of animals). A phylogenetic analysis suggests that this gene family originated in bacteria before its horizontal transfer to an ancestral eukaryote prior to the radiation of fungi. It was then lost by the Saccharomycetales which include Saccharomyces cerevisiae

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

La « Gravière » à Fareins (Ain). Site diachronique de la fin du second âge du Fer au Moyen Age central dans le sud du Val de Saône

International audienc

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

Abstract The contribution of inflammation to neurodegenerative diseases is increasingly recognized, but the role of inflammation in sporadic amyotrophic lateral sclerosis (sALS) is not well understood and no animal model is available. We used enzyme-linked immunosorbent assays (ELISAs) to measure the cytokine interleukin-17A (IL-17A) in the serum of ALS patients (n = 32; 28 sporadic ALS (sALS) and 4 familial ALS (fALS)) and control subjects (n = 14; 10 healthy subjects and 4 with autoimmune disorders). IL-17A serum concentrations were 5767 ± 2700 pg/ml (mean ± SEM) in sALS patients and 937 ± 927 pg/ml in fALS patients in comparison to 7 ± 2 pg/ml in control subjects without autoimmune disorders (p = 0.008 ALS patients vs. control subjects by Mann-Whitney test). Sixty-four percent of patients and no control subjects had IL-17A serum concentrations > 50 pg/ml (p = 0.003 ALS patients vs. healthy subjects by Fisher's exact test). The spinal cords of sALS (n = 8), but not control subjects (n = 4), were infiltrated by interleukin-1β- (IL-1β-), and tumor necrosis factor-α-positive macrophages (co-localizing with neurons), IL-17A-positive CD8 cells, and IL-17A-positive mast cells. Mononuclear cells treated with aggregated forms of wild type superoxide dismutase-1 (SOD-1) showed induction of the cytokines IL-1β, interleukin-6 (IL-6), and interleukin-23 (IL-23) that may be responsible for induction of IL-17A. In a microarray analysis of 28,869 genes, stimulation of peripheral blood mononuclear cells by mutant superoxide dismutase-1 induced four-fold higher transcripts of interleukin-1α (IL-1α), IL-6, CCL20, matrix metallopeptidase 1, and tissue factor pathway inhibitor 2 in mononuclear cells of patients as compared to controls, whereas the anti-inflammatory cytokine interleukin-10 (IL-10) was increased in mononuclear cells of control subjects. Aggregated wild type SOD-1 in sALS neurons could induce in mononuclear cells the cytokines inducing chronic inflammation in sALS spinal cord, in particular IL-6 and IL-17A, damaging neurons. Immune modulation of chronic inflammation may be a new approach to sALS