The phase portrait of a matter bounce in Horava-Lifshitz cosmology

The occurrence of a bounce in FRW cosmology requires modifications of general relativity. An example of such a modification is the recently proposed Horava-Lifshitz theory of gravity, which includes a ``dark radiation'' term with a negative coefficient in the analog of the Friedmann equation. This paper describes a phase space analysis of models of this sort with the aim of determining to what extent bouncing solutions can occur. A simplification, valid in the relevant region, allows a reduction of the dimension of phase space so that visualization in three dimensions is possible. It is found that a bounce is possible, but not generic in models under consideration. Apart from previously known bouncing solutions some new ones are also described. Other interesting solutions found include ones which describe a novel sort of oscillating universes.Comment: 14 pages, 8 figure

Modified F(R) Horava-Lifshitz gravity: a way to accelerating FRW cosmology

We propose a general approach for the construction of modified gravity which is invariant under foliation-preserving diffeomorphisms. Special attention is paid to the formulation of modified $F(R)$ Ho\v{r}ava-Lifshitz gravity (FRHL), whose Hamiltonian structure is studied. It is demonstrated that the spatially-flat FRW equations of FRHL are consistent with the constraint equations. The analysis of de Sitter solutions for several versions of FRHL indicates that the unification of the early-time inflation with the late-time acceleration is possible. It is shown that a special choice of parameters for FRHL leads to the same spatially-flat FRW equations as in the case of traditional $F(R)$-gravity. Finally, an essentially most general modified Ho\v{r}ava-Lifshitz gravity is proposed, motivated by its fully diffeomorphism-invariant counterpart, with the restriction that the action does not contain derivatives higher than the second order with respect to the time coordinate.Comment: LaTeX 11 pages. v4: Some errors have been correcte

Thin accretion disk signatures of slowly rotating black holes in Ho\v{r}ava gravity

In the present work, we consider the possibility of observationally testing Ho\v{r}ava gravity by using the accretion disk properties around slowly rotating black holes of the Kehagias-Sfetsos solution in asymptotically flat spacetimes. The energy flux, temperature distribution, the emission spectrum as well as the energy conversion efficiency are obtained, and compared to the standard slowly rotating general relativistic Kerr solution. Comparing the mass accretion in a slowly rotating Kehagias-Sfetsos geometry in Ho\v{r}ava gravity with the one of a slowly rotating Kerr black hole, we verify that the intensity of the flux emerging from the disk surface is greater for the slowly rotating Kehagias-Sfetsos solution than for rotating black holes with the same geometrical mass and accretion rate. We also present the conversion efficiency of the accreting mass into radiation, and show that the rotating Kehagias-Sfetsos solution provides a much more efficient engine for the transformation of the accreting mass into radiation than the Kerr black holes. Thus, distinct signatures appear in the electromagnetic spectrum, leading to the possibility of directly testing Ho\v{r}ava gravity models by using astrophysical observations of the emission spectra from accretion disks.Comment: 12 pages, 15 figures. V2: 13 pages, clarifications and discussion added; version accepted for publication in Classical and Quantum Gravit

f(R) theories

Over the past decade, f(R) theories have been extensively studied as one of the simplest modifications to General Relativity. In this article we review various applications of f(R) theories to cosmology and gravity - such as inflation, dark energy, local gravity constraints, cosmological perturbations, and spherically symmetric solutions in weak and strong gravitational backgrounds. We present a number of ways to distinguish those theories from General Relativity observationally and experimentally. We also discuss the extension to other modified gravity theories such as Brans-Dicke theory and Gauss-Bonnet gravity, and address models that can satisfy both cosmological and local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in Relativity, Published version, Comments are welcom

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Matter couplings in Hoava-Lifshitz theories and their cosmological applications

In this paper, the issue of how to introduce matter in Hoava-Lifshitz theories of gravity is addressed. This is a key point in order to complete the proper definition of these theories and, more importantly, to study their possible phenomenological implications. As is well known, in Hoava-Lifshitz gravity, the breakdown of Lorentz invariance invalidates the usual notion of minimally coupled matter. Two different approaches to bypass this problem are described here. One is based on a Kaluza-Klein reinterpretation of the 3+1 decomposition of the gravity degrees of freedom, which naturally leads to a definition of a U(1) gauge symmetry and, hence, to a new type of minimal coupling. The other approach relies on a midi-superspace formalism and the subsequent parametrization of the matter stress-energy tensor in terms of deep infrared variables. Using the last option, the phase space of Hoava-Lifshitz cosmology in the presence of general matter couplings is studied. It is found, in particular, that the equation of state of the effective matter may be very different from the actual matter one, owing to the nonlinear interactions which exist between matter and gravity. \ua9 2011 IOP Publishing Ltd

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

International audienceIn 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field