Realidad Virtual: la recuperación de instalaciones artísticas a través VR, ER y AR.

pre-print180 K

Impact on the first year of life of newborns with gestational infection by SARS-COV-2. Analysis of auditory effects.

Introduction One of the causes of congenital hearing loss are infections suffered by the mother during pregnancy. The objective of this study was to investigate the effects on hearing in newborns to SARS-CoV-2 seropositive mothers during pregnancy. We also studied the hearing impact in the first year of life of the newborns to investigate whether neonatal infection produced a risk of infantile sensorineural hearing loss. Material and methods All children born in our center whose mother had been infected with SARS-CoV-2 positive COVID were included and were audiologically studied at two and a half months and at one year of life. All infants were evaluated by brainstem evoked response audiometry (BERA) and auditory steady-state responses (ASSR). Results The range of the latencies for BERA founded were inside the desired ranges of normality both at two and a half months and at one year of life No significant differences by sex and ears were found in the BERA performed (p > 0,05). The mean ASSR values were found to be significantly below 30 dB in all frequencies studied both at two and a half months, and at one year of life (p < 0,05). Conclusion There is no association between COVID-19 infection during pregnancy and neonatal hearing loss. Further studies are needed to clarify this field since it is still unclear whether pregnant women infected with SARS-CoV-2 can produce hearing alterations in their newborns according to the current evidence in the literature.post-print1748 K

Variables predictoras de la adherencia terapéutica (farmacológica y no farmacológica) en Esclerosis Múltiple: bases para la intervención.

Doctorado en Biotecnología, Medicina y Ciencias Biosanitaria

Estudio comparativo del riesgo de complicaciones en un programa de cooperación en cirugía pediátrica.

Doctorado en Biotecnología, Medicina y Ciencias Biosanitaria

Relectura de la obra arquitectónica de León Battista Alberti desde una visión integradora del renacimiento.

Doctorado en Humanidades y Ciencias Sociale

Functional mobility and physical fitness are improved through a multicomponent training program in institutionalized older adults.

Physical exercise has demonstrated its efectiveness in the management of the deleterious process of aging. However, it is less studied in institutionalized elderly people. This investigation aims to clarify the benefts of a multicomponent training program in institutionalized older adults. A randomized controlled trial was conducted with institutionalized older adults (≥70 years old). Intervention group (IG; N=18) were submitted to a multicomponent training program based on muscle power training and interval endurance exercise, 2 times/week for 12 weeks. Control group (CG; N=16) continued their usual mobility exercises. Independence was estimated with the Barthel index, and physical ftness and functionalpost-print375 K

Maternal COVID-19 Serological Changes—Comparison between Seroconversion Rate in First and Third Trimesters of Pregnancy and Subsequent Obstetric Complications: A Cohort Study.

Pregnant women are especially vulnerable to respiratory diseases. We aimed to study seroconversion rates during pregnancy in a cohort of consecutive pregnancies tested in the first and third trimesters and to compare the maternal and obstetric complications in the women who seroconverted in the first trimester and those who did so in the third. This was an observational cohort study carried out at the Hospital Universitario de Torrejón, in Madrid, Spain, during the first peak of the COVID-19 pandemic. All consecutive singleton pregnancies with a viable fetus attending their 11–13-week scan between 1 January and 15 May 2020 were included and seropositive women for SARS-CoV2 were monthly follow up until delivery. Antibodies against SARS-CoV-2 (IgA and IgG) were analyzed on stored serum samples obtained from first- and third-trimester routine antenatal bloods in 470 pregnant women. Antibodies against SARS-CoV-2 were detected in 31 (6.6%) women in the first trimester and in 66 (14.0%) in the third trimester, including 48 (10.2%) that were negative in the first trimester (seroconversion during pregnancy). Although the rate of infection was significantly higher in the third versus the first trimester (p = 0.003), no significant differences in maternal or obstetric complications were observed in women testing positive in the first versus the third trimester.post-print1063 K

Factores de entrenamiento en esports: una revisión sistemática

El fenómeno de los esports ha venido creciendo de manera exponencial durante los últimos años. Numerosos equipos han creado centros de alto rendimiento para generar deportistas cada vez más competitivos. Diferentes estudios han indicado la importancia del entrenamiento en los jugadores de esports. El objetivo de este trabajo fue realizar una revisión sistemática sobre los artículos científicos publicados en los últimos 10 años (2012-2022) sobre el entrenamiento en jugadores de esports. Se realizó una búsqueda en PubMed con las palabras clave “esports” y “training”. En la revisión se incluyeron trabajos en inglés, que reportaran información cuantitativa sobre los entrenamientos y variables entrenables que tenga por objeto mejorar el rendimiento deportivo. En un primer paso se obtuvieron 62 artículos, pero únicamente 8 cumplieron los criterios de inclusión. A pesar de la importancia de la industria del videojuego en general y de los esports en concreto, han sido muy pocos los estudios encontrados sobre el entrenamiento para el rendimiento de las diferentes variables. Asimismo, los estudios encontrados no son concluyentes debido a que no se pueden contrastar, tienen un pobre diseño, o mezclan criterios de elegibilidad de la muestra. Esta investigación pone de manifiesto la necesidad de desarrollar estudios longitudinales con intervención que expongan relaciones causales entre las propuestas y la mejora del rendimiento obtenida.post-print129 K

Tafamidis Efficacy Among Octogenarian Patients in the Phase 3 ATTR-ACT and Ongoing Long-Term Extension Study.

Background Tafamidis was approved to treat patients with transthyretin amyloid cardiomyopathy (ATTR-CM) on the basis of findings from the phase 3 Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT). Objectives This study was a post hoc analysis exploring tafamidis efficacy in octogenarian patients. Methods Analysis of patients aged <80 and ≥80 years in ATTR-ACT and its ongoing open-label long-term extension (LTE) study, where all patients receive tafamidis. Results After 30 months in ATTR-ACT, least squares (LS) mean change from baseline in 6-minute walk test (6MWT) distance, N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration, and Kansas City Cardiomyopathy Questionnaire Overall Summary (KCCQ-OS) score were smaller (all P < 0.05) in patients aged ≥80 years treated with tafamidis (n = 51) vs placebo (n = 37). At the LTE study interim analysis, patients aged ≥80 years treated continuously with tafamidis had a smaller decline in KCCQ-OS score (P < 0.05) and trended toward longer median survival (45 vs 27 months; all-cause mortality HR: 0.6828 [95% CI: 0.4048-1.1517]; P = 0.1526) than those initially treated with placebo in ATTR-ACT. Similar efficacy was observed in patients aged <80 years in ATTR-ACT, including smaller LS mean change from baseline in 6MWT distance, NT-proBNP concentration, and KCCQ-OS score, and lower rate of cardiovascular-related hospitalizations with tafamidis (n = 125) vs placebo (n = 140). In the LTE study, patients aged <80 years treated continuously with tafamidis had a longer median survival (80 vs 41 months; HR = 0.4513 [95% CI: 0.3176-0.6413]; P < 0.0001) and a smaller decline in KCCQ-OS score than those initially treated with placebo. Conclusions The findings demonstrate tafamidis efficacy for patients with ATTR-CM both in those aged <80 and those aged ≥80 years. (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial [ATTR-ACT]; NCT01994889/Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy; NCT02791230)post-print492 K

Perception and use of flywheel resistance training amongst therapists in sport.

Flywheel (isoinertial) resistance training is a valid strength training method that has been incorporated in sport for decades, yet little is known about how therapists working in sport apply flywheel resistance training. We aimed to describe and understand current application and perception of flywheel resistance training amongst therapists working in sport. Seventy- three therapists (13 ± 10 years of experience) started part of this survey with 52 completing the entire electronic questionnaire. Nine multiple choice questions on application and perceptions of flywheel training (prerequisites, use of technology, barriers, and upper- and lower-body exercises) preceded two 6-point Likert scale statements on strength and reduction of injury likelihood. Most therapists (47/73) either used or intended to use flywheel training with their athletes and stated familiarisation would be a priority prior to initiating training. Although more than half suggested they were confident flywheel training could enhance strength (27/52) and muscular prehabilitation outcomes (40/52), many remained unsure. Nonetheless, it appears that therapists would mostly include flywheel training within prehabilitation (40/52) or during the later stages of rehabilitation (37/52). To monitor progress, therapists slightly prefer power (30/52) over velocity outputs, while few would not use them at all. Although therapists would prescribe most exercises - the squat, rotational exercise, and unilateral leg curl would be the most selected. Meanwhile, therapists reported remain most unsure or would avoid prescribing the lateral squat and unilateral hip extension. The biggest perceived barriers to flywheel training are equipment cost/space, evidence, and scheduling. The investigation provides valuable insight into the application and perception of flywheel training amongst therapists working in sport.post-print1632 K