Smart and Sustainable Nanotechnological Solutions in a Battle against COVID-19 and Beyond: A Critical Review

The variety of available biocidal features make nanomaterials promising for fighting infections. To effectively battle COVID-19, categorized as a pandemic by the World Health Organization (WHO), materials scientists and biotechnologists need to combine their knowledge to develop efficient antiviral nanomaterials. By design, nanostructured materials (spherical, two-dimensional, hybrid) can express a diverse bioactivity and unique combination of specific, nonspecific, and mixed mechanisms of antiviral action. It can be related to the material's specific features and their multiple functionalization strategies. This is a complex guiding approach in which an interaction target is constantly moving and quickly changing. On the other hand, in such a rush, sustainability may be put aside. Therefore, to elucidate the most promising nanotechnological solutions, we critically review available data within the frame of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other types of viruses. We highlight solutions that are, or could be, more sustainable and less toxic. In this regard, reduction of the number of synthetic routes, organic solvents, byproducts, and residues is highly recommended. Such efficient, green solutions may be further used for the prevention of virion-host interactions, treatment of the already developed infection, reducing inflammation, and finally, protecting healthcare professionals with masks, fabrics, equipment, and in other associated areas. Further translation into the market needs putting on the fast track with respect to principles of green chemistry, feasibility, safety, and the environment. © 2021 American Chemical Society

КЛИНИКО-ЛАБОРАТОРНЫЕ ПАРАЛЛЕЛИ ПРИ НОВОЙ КОРОНАВИРУСНОЙ ИНФЕКЦИИ COVID-19 И ГЕМОРРАГИЧЕСКОЙ ЛИХОРАДКЕ С ПОЧЕЧНЫМ СИНДРОМОМ

Клинические проявления у пациентов с COVID-19 и геморрагической лихорадкой с почечным синдромом по хронологии развития имеют одинаковые сроки развития, а также ряд лабораторных показателей по срокам изменения характеризуются одинаковой динамикой, что позволило провести параллели в развитии заболеваний, выдвинуть гипотетическую концепцию патогенеза новой коронавирусной инфекции – COVID-19 (НКВИ) на основе изученного патогенеза ГЛПС, предложить классификацию новой коронавирусной инфекции с учетом этого. Необходимы дальнейшие исследования в данном направлении

The strategic role of msme challenges in the covid-19 situation

The poverty and unemployment rates in Indonesia are still very large. The number of poor people was recorded at around 29.13 million people while the absolute number of unemployed, namely those who do not have a job, is no less than 12 million people. A synergistic and comprehensive program is needed to overcome this. Thus, the small and medium enterprises sector can be expected to overcome one of the main problems in this country, namely the problem of poverty and unemployment. Therefore, reducing unemployment requires a paradigm shift that cannot be implemented on a large scale business (capital market), but provides more opportunities for people's economic business units, including micro, small and medium enterprises. MSMEs have been able to prove themselves as one of the solutions for the very high growth of the new workforce in Indonesia. The intrinsic properties of their business spring or even non formal make SMEs are able to provide business opportunities among household scale industries that were encountered in each area. Its significant role in labor absorption makes MSMEs very effective as tools to strengthen national stability

COVID-19: ETIOLOGY, CLINICAL PICTURE, TREATMENT [COVID-19: ЭТИОЛОГИЯ, КЛИНИКА, ЛЕЧЕНИЕ]

Whereas the XX century marked the history of acute respiratory disease investigation as a period for generating in-depth system of combating influenza viruses (Articulavirales: Orthomyxoviridae, Alpha-/Betainfluenzavirus) (based on environmental and virological monitoring of influenza A virus in its natural reservoir — aquatic and semi-aquatic birds — to supervising epidemic influenza), a similar system is necessary to build up in the XXI century with regard to especially dangerous betacoronaviruses (Nidovirales: Coronaviridae, Betacoronavirus): Severe acute respiratory syndrome-related coronavirus (SARS-CoV) (subgenus Sarbecovirus), Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) (Sarbecovirus), Middle East respiratory syndrome-related coronavirus (MERS-CoV) (Merbecovirus). This became particularly evident after pandemic potential has been revealed in 2020 by the SARS-CoV-2. This review provides an insight into the historic timeline of discovering this virus, its current taxonomy, ecology, virion morphology, life cycle, molecular biology, pathogenesis and clinical picture of the etiologically related COVID-19 (Coronavirus disease 2019) as well as data available in the scientific literature on the anti-SARS-CoV-2-effectiveness of passive immunotherapy and most debated drugs used to treat COVID-19: Chloroquine, Hydroxychloroquine, Nitazoxanide, Ivermectin, Lopinavir and Ritonavir, Camostat mesilate, Remdesivir, Ribavirin, Tocilizumab, Anakinra, corticosteroids, and type I interferons. The pathogenesis of SARS-CoV-2 infection implicates decreased efficacy of artificial respiration, which, in this case might be replaced by more efficient extracorporeal membrane blood oxygenation supplemented with nitrogen oxide and/or Heliox inhalations. © 2020 Saint Petersburg Pasteur Institute. All rights reserved

Study of cell culture strains sensitivity to sacbrood virus

A huge number of cell culture strains obtained from one organ (tissue) of an animal, sensitive to causative agents of various infections, are known. However, a comparative characterization of various cell culture strains sensitivity to such bee viruses as SBV has not yet been carried out. This work was carried out in the Department of Cell Biotechnology and the Laboratory of Bee Diseases of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”. For the study, we took cell cultures of the African green monkey kidneys (Vero (3 strains) - Vero (strain from the FSC VIEV Collection)), Vero K (strain from the FSC VIEV Collection), Vero (strain from Germany). We have shown that all 3 of the Vero cell cultures above strains are sensitive to SBV, however, the cell model in which the most pronounced signs of CPD were revealed is the Vero K cell line. The first signs of CPD manifestation virus in the culture of Vero K cells were observed at first passage. After 6 days. screeds were found in the monolayer after infection. At the second passage of the virus after 5 days. culturing CPD manifested itself as the appearance of voids, cell strands, and rounding of the cells part

Analisis Sentimen Physical Distancing pada Twitter Menggunakan Text Mining dengan Algoritma Naive Bayes Classifier

Abstrak Physical distancing kini sedang ramai menjadi perbincangan publik sebagai salah satu cara pemerintah dalam menekan penyebaran virus covid-19 yang sedang melanda beberapa negara di belahan dunia. Tidak tersaringnya cuitan terkait physical distancing bisa memunculkan berbagai macam opini, tidak hanya opini yang positif tapi juga yang negatif. Maka dari itu, Twitter di anggap lebih diminati oleh masyarakat indonesia dikarenakan twitter dirasa lebih mudah untuk mengungkapkan opininya. Metode yang digunakan yaitu Naive Bayes Classifier (NBC). Data terkumpul dilakukan filter dari cuitan tersebut dengan menghapus data yang double maka setelah di filter data yang terambil yaitu sebanyak 547 tweets . Pada perhitungan analisis sentimen terhadap physical distancing di tengah pandemi covid-19 menggunakan metode NBC memperoleh hasil akurasi sebesar 50,26%. Tujuan dari penelitian ini, agar dapat mengkategorikan opini negatif atau positif, dari pembahasan physical distancing . Nantinya informasi terkait kebijakan Physical Distancing bisa sampai tepat informasinnya kepada masayarakat. Kata Kunci : naïve bayes, physyical distancing, twitter   Abstract Physical distancing is now busy becoming a public conversation as a way for the government to spread the Covid-19 virus which is currently hitting several countries around the world. There are public tweets related to physical distance that is free from various kinds of opinions, not only positive but also negative ones. Therefore, Indonesian people consider Twitter to be more desirable because it is easier for Indonesians to express their opinion. The method used is the Naive Bayes Classifier (NBC). The data collected was filtered from the tweets with double data, then after filtering the data were taken as many as 547 tweets. In calculating the sentiment analysis of physical distance in the middle of the Covid-19 pandemic using the NBC method, it gets an accurate result of 50.26%. The purpose of this study, to find and categorize negative or positive opinions, from the discussion of physical distancing. So that the implementation of the Physical Distance policy can get accurate information to the public. Keywords : naïve bayes, physical distancing, twitte

Oil price shocks and the return and volatility spillover between industrial and precious metals

This study explores the dynamic return and volatility connectedness for some dominant industrial (Aluminium, Copper, Lead, Nickel, Tin, and Zinc) and precious metals (Gold, Palladium, Platinum, Silver) to crude oil shocks (risk, demand, and supply) during the sample period between January 2, 2009 and July 17, 2020. Our findings indicate that, demand shocks and risk shocks are the dominant receiver (transmitter) of shocks from (to) for metal returns. Second, we document the time-varying nature of both total return and volatility connectedness. Third, both net directional return and volatility connectedness show that some metals such as Tin, Gold and, even, Nickel, Lead and Aluminium appear as net transmitters, at least in some intervals of the sample period analysed. On the other hand, other industrial and precious metal markets show a net receiver profile, such as Copper, Zinc and Platinum, among others. Lastly, we find more differences between the net dynamic connectedness of the metal markets analysed in terms of return than volatility. The net directional volatility connectedness increases sizably during the global crisis due to the spread of the SARS-CoV-2 coronavirus

Development of the e-Government in the Context of the 2020 Pandemics

The epidemic caused by the coronavirus COVID-19 influenced the world and had a major economic impact. A sudden and dramatic increase in online activity and necessity to stay at home increased a demand for relevant and reliable information accounting and its fast diffusing. Some of these changes will continue beyond this pandemic. In this article, the author examines the creation, development and implementation in the work of state and municipal institutions of the Government Platform in Russian health care system, including creation of the information platform (COVID-19). Using pandemics as a research context, we have evaluated the role of information and communication technologies (ICTs) in emergency situations which includes technologies to inform, prevention technologies, technologies to engage. This paper focuses on a case study. We made a conclusion about results of implementation the Government Platform in health care system during crises caused by pandemic 2020 through the lenses of technologies implementation. Our results show that largely the information platform (COVID-19) used technologies to inform and prevention technologies, however engaging mechanisms are quite poor

Травматизация страхом: психологические последствия пандемии Covid-19

Пандемия COVID-19 в сочетании с высоким уровнем передачи инфекции и смертности создала беспрецедентное чрезвычайное положение во всем мире. Риск заражения и угрозы жизни, переживание социальной изоляции и потери контроля над ситуацией, масштабы устрашающего информационного воздействия стали причиной «пандемии страха», распространившейся по регионам и странам. Цель представленного в данной статье обзора публикаций – обобщение и сравнительный анализ результатов многочисленных исследований психологических последствий пандемии COVID-19, как для населения разных стран и мира в целом, так и для отдельных категорий населения, а также соответствующих факторов риска. Относительно высокие показатели симптомов страха, тревоги, депрессии, посттравматического стрессового расстройства, психологического дистресса и стресса наблюдались и продолжают наблюдаться среди жителей Китая, Испании, Италии, Ирана, США, Турции, Непала, Дании и др. Наиболее выраженные симптомы психологической травматизации демонстрируют медицинские работники, женщины, молодежь, те, кто потерял работу во время кризиса, люди с хроническими заболеваниями и др. Продолжение исследований, направленных на выявление и смягчение опасных последствий COVID-19 для психического здоровья и психологического благополучия людей, является приоритетной международной и междисциплинарной задачей научного сообщества

Study of the impact of speech-like interference on the psychological and emotional state of a human

The protection of speech information should not only be as effective as possible, but also convenient for people who are in the protected room. Currently, the active protection devices, which are noise generators, are more often used for this purpose. The most effective is speech-like interference. But at the same time, it is noted that this type of interference creates more discomfort compared to others. This study is aimed at identifying the noise annoyance of speech-like interference, created on the basis of syllabic and word articulation tables, as well as reverberation speech-like interference. The experiments have shown that the most annoying is speech-like interference based on syllabic articulate on tables. The main negative consequences were headache, annoyance, and fatigue. Modification of the speech-like interference in the form of peak trimming improved the auditory perception of the interference by people, while the efficiency did not decrease