136 research outputs found
Observing response processes with eye tracking in international large-scale assessments: evidence from the OECD PIAAC assessment
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/05/2018
- Field of study
This paper reports on a pilot study that used eye tracking techniques to make detailed observations of item response processes in the OECD Programme for the International Assessment of Adult Competencies (PIAAC). The lab-based study also recorded physiological responses using measures of pupil diameter and electrodermal activity. The study tested 14 adult respondents as they individually completed the PIAAC computer-based assessment. The eye tracking observations help to fill an ‘explanatory gap’ by providing data on variation in item response processes that are not captured by other sources of process data such as think aloud protocols or computer-generated log files. The data on fixations and saccades provided detailed information on test item response strategies, enabling profiling of respondent engagement and response processes associated with successful performance. Much of that activity does not include the use of the keyboard and mouse, and involves ‘off-screen’ use of pen and paper (and calculator) that are not captured by assessment log-files. In conclusion, this paper points toward an important application of eye tracking in large-scale assessments. This includes insights into response processes in new domains such as adaptive problem-solving that aim to identify individuals’ ability to select and combine resources from the digital and physical environment
IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation.
- Author
- Anderson
- Baker
- Barry Storer
- Beatty
- Bettens
- Blazar
- Blazar
- Bryan M. Grogan
- Cavet
- Chien
- Crawley
- Dickinson
- Effie Petersdorf
- Fan
- Ferrara
- Fiorentino
- Flomenberg
- Frodsham
- Gibson
- Groux
- Hempel
- Hoffmann
- Holler
- Jason W. Chien
- John A. Hansen
- Josephson
- Keen
- Keijsers
- Krenger
- Lee
- Li-Hui Tseng
- Lin
- Lin
- Lue P. Zhao
- Mari Malkki
- Ming-Tseh Lin
- Miura
- Morishima
- Mullally
- Paul J. Martin
- Pei-Jer Chen
- Perreault
- Pestka
- Petersdorf
- Petersdorf
- Petersdorf
- Przepiorka
- Shaw
- Smith
- Socie
- Sullivan
- Takatsuka
- Taylor
- Turner
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 15/03/2009
- Field of study
BACKGROUND: Results of a previous study with human leukocyte antigen (HLA)-identical siblings showed individual and synergistic associations of single nucleotide polymorphisms in the promoter region of the recipient's IL10 gene and the donor's IL10 receptor beta (IL-10RB) gene with development of grades III-IV acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation. METHODS: In this study of 936 patients who had unrelated donors, genotypes of single nucleotide polymorphisms in the IL10 gene and the IL-10RB gene were evaluated as correlates with outcomes after transplantation. RESULTS: We found no statistically significant associations of polymorphisms at positions -3575, -2763, -1082, and -592 of the IL10 gene or codon 238 of the IL10RB gene with severe acute GVHD, extensive chronic GVHD or nonrelapse mortality after hematopoietic cell transplantation. Among HLA-matched unrelated pairs, the patient's IL10/-592 genotype and donor's IL10RB/c238 genotype showed trends suggesting individual and combined associations with grades III-IV acute GVHD similar to those observed among patients with HLA-identical sibling donors. CONCLUSIONS: Although genetic variation in IL10 pathway affects risk of acute GVHD and non-relapse mortality in HLA-identical sibling transplants, the current results indicate that genetic variation in the IL10 pathway does not significant affect these outcomes in unrelated donor transplants suggesting that the strength of the alloimmune response in the latter exceeds the anti-inflammatory activity of IL10
Emergence of Anthrax Edema Toxin as a Master Manipulator of Macrophage and B Cell Functions
- Author
- Ahuja
- Alileche
- Ashok K. Chopra
- Bailly
- Banks
- Beatty
- Bermudez
- Brachman
- Bradley
- Bryan T. Gnade
- Cataldi
- Chakrabarty
- Cleret
- Comer
- Comer
- Cote
- Cote
- Cote
- Crawford
- Cross
- de Rooij
- Fang
- Firoved
- Friedlander
- Glomski
- Hart
- Heninger
- Hong
- Hoover
- Johnny W. Peterson
- Kawasaki
- Kim
- Kirby
- Krzysiek
- Kumar
- Lebowich
- Leppla
- Leppla
- Linsey A. Yeager
- Lomo
- Maldonado-Arocho
- Molin
- Okada
- Orlikowsky
- O’Brien
- Paccani
- Park
- Pezard
- Pezard
- Popov
- Puhar
- Reif
- Rossi Paccani
- Scobie
- Scott T. Moen
- Shen
- Szarowicz
- Tang
- Tournier
- Turk
- Vitale
- Voth
- Welkos
- Wortis
- Xu
- Yeager
- Zhang
- Publication venue
- MDPI
- Publication date
- 01/07/2010
- Field of study
Anthrax edema toxin (ET), a powerful adenylyl cyclase, is an important virulence factor of Bacillus anthracis. Until recently, only a modest amount of research was performed to understand the role this toxin plays in the organism’s immune evasion strategy. A new wave of studies have begun to elucidate the effects this toxin has on a variety of host cells. While efforts have been made to illuminate the effect ET has on cells of the adaptive immune system, such as T cells, the greatest focus has been on cells of the innate immune system, particularly the macrophage. Here we discuss the immunoevasive activities that ET exerts on macrophages, as well as new research on the effects of this toxin on B cells
Interpretation and analysis of planetary structures
- Author
- Ackermann
- Anderson
- Andrews-Hanna
- Andrews-Hanna
- Arvidson
- Atkinson
- Aydin
- Aydin
- Balme
- Banerdt
- Barnett
- Beatty
- Bieniawski
- Billings
- Binder
- Bryan
- Byerlee
- Cailleau
- Carr
- Cartwright
- Chin
- Chris H. Okubo
- Christensen
- Clark
- Collins
- Collins
- Collins
- Cowie
- Cowie
- Crider
- Cunningham
- Davis
- Davison
- DeGraff
- Delamere
- Delaney
- Dzurisin
- Earth Impact Database
- Erdogan
- Ernst Hauber
- Figueredo
- Figueredo
- Fossen
- Fossen
- Fueten
- Fueten
- Fueten
- Geissler
- Giese
- Giese
- Golombek
- Greenberg
- Greenberg
- Greenberg
- Groenleer
- Grott
- Grotzinger
- Gwinner
- Gwinner
- Hansen
- Harrison
- Hauber
- Hauber
- Hauck
- Helfenstein
- Hoek
- Hoppa
- Hoppa
- Huntoon
- Hurford
- Hurford
- Jaeger
- Jaumann
- Kargel
- Kattenhorn
- Kattenhorn
- Kattenhorn
- Kattenhorn
- Kenkmann
- Kirk
- Knapmeyer
- Kriens
- Kronberg
- Lawn
- Leith
- Lucchitta
- Lucchitta
- Lucchitta
- Malin
- Malin
- Manga
- Manighetti
- Mansfield
- Margot
- Marshall
- Matsuyama
- Maxwell
- McEwen
- McEwen
- McGill
- McGill
- Melosh
- Melosh
- Moore
- Morley
- Mège
- Nahm
- Nemčok
- Neuffer
- Nimmo
- Nimmo
- Nimmo
- Nimmo
- Ojakangas
- Ojakangas
- Okubo
- Okubo
- Okubo
- Okubo
- Okubo
- Okubo
- Okubo
- Olson
- Pappalardo
- Pati
- Peacock
- Peacock
- Peulvast
- Peulvast
- Phillips
- Phillips
- Plescia
- Polit
- Pollard
- Porco
- Price
- Prockter
- Prockter
- Prockter
- Ramsay
- Richard A. Schultz
- Roatsch
- Roering
- Rudolph
- Schenk
- Schenk
- Schlische
- Scholten
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Schultz
- Simon A. Kattenhorn
- Smith
- Smith-Konter
- Soliva
- Soliva
- Solomon
- Solomon
- Solomon
- Solomon
- Squyres
- Strom
- Strom
- Tanaka
- Tanaka
- Tembe
- Thomas R. Watters
- Trudgill
- Turcotte
- Wahr
- Watters
- Watters
- Watters
- Watters
- Watters
- Watters
- Watters
- Watters
- Watters
- Watts
- Wilkins
- Wise
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The Science Performance of JWST as Characterized in Commissioning
- Author
- Abell Jim
- Abney Faith
- Abul-Huda Yasin
- Acton D. Scott
- Adams Evan
- Adler David
- Aguilar Jonathan
- Ahmed Nasif
- Alarcon Rafael Ramos
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Marsha
- Altenburg Martin
- Alvarez Jose Lorenzo
- Andersen Greg
- Anderson Harry
- Anderson Sara
- Argyriou Ioannis
- Armstrong Amber
- Arribas Santiago
- Artigau Etienne
- Arvai Amanda
- Atkinson Charles
- Bacon Gregory
- Bair Thomas
- Banks Kimberly
- Barrientes Jaclyn
- Barringer Bruce
- Bartosik Peter
- Bast William
- Baudoz Pierre
- Beatty Thomas
- Bechtold Katie
- Beck Tracy
- Bergeron Eddie
- Bergkoetter Matthew
- Bhatawdekar Rachana
- Birkmann Stephan
- Blazek Ronald
- Blome Claire
- Boccaletti Anthony
- Boeker Torsten
- Boia John
- Bonaventura Nina
- Bond Nicholas
- Bosley Kari
- Boucarut Ray
- Bourque Matthew
- Bouwman Jeroen
- Bower Gary
- Bowers Charles
- Boyer Martha
- Bradley Larry
- Brady Greg
- Braun Hannah
- Breda David
- Bresnahan Pamela
- Bright Stacey
- Britt Christopher
- Bromenschenkel Asa
- Brooks Brian
- Brooks Keira
- Brown Bob
- Brown Matthew
- Brown Patricia
- Bunker Andy
- Burger Matthew
- Bushouse Howard
- Cale Steven
- Cameron Alex
- Cameron Peter
- Canipe Alicia
- Caplinger James
- Caputo Francis
- Cara Mihai
- Carey Larkin
- Carniani Stefano
- Carrasquilla Maria
- Carruthers Margaret
- Case Michael
- Catherine Riggs
- Chance Don
- Chapman George
- Charlot Stéphane
- Charlow Brian
- Chayer Pierre
- Chen Bin
- Cherinka Brian
- Chichester Sarah
- Chilton Zack
- Chonis Taylor
- Clampin Mark
- Clark Charles
- Clark Kerry
- Coe Dan
- Coleman Benee
- Colon Knicole
- Comber Brian
- Comeau Tom
- Connolly Dennis
- Cooper James
- Cooper Rachel
- Coppock Eric
- Correnti Matteo
- Cossou Christophe
- Coulais Alain
- Coyle Laura
- Cracraft Misty
- Curti Mirko
- Cuturic Steven
- Davis Katherine
- Davis Michael
- de Oliveira Catarina Alves
- Dean Bruce
- Del Pino Bruno Rodriguez
- DeLisa Amy
- deMeester Wim
- Dencheva Nadezhda
- Dencheva Nadia
- DePasquale Joseph
- Deschenes Jeremy
- Detre Örs Hunor
- Diaz Rosa
- Dicken Dan
- DiFelice Audrey
- Dillman Matthew
- Dixon William
- Doggett Jesse
- Donaldson Tom
- Douglas Rob
- Doyon René
- DuPrie Kimberly
- Dupuis Jean
- Durning John
- Easmin Nilufar
- Eck Weston
- Edeani Chinwe
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan
- Eisenhower Michael
- Elie Michelle
- Elliott James
- Elliott Kyle
- Ellis Tracy
- Engesser Michael
- Espinoza Nestor
- Etienne Odessa
- Etxaluze Mireya
- Falini Patrick
- Feeney Matthew
- Feinberg Lee
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph
- Fincham Brian
- Fix Mees
- Flagey Nicolas
- Florian Michael
- Flynn Jim
- Fontanella Erin
- Ford Terrance
- Forshay Peter
- Fox Ori
- Franz David
- Friedman Scott
- Fu Henry
- Fullerton Alexander
- Galkin Sergey
- Galyer Anthony
- Gardner Jonathan
- Gardner Lisa
- Garland Dennis
- Garrett Bruce
- Gasman Danny
- Gaspar Andras
- Gaudreau Daniel
- Gauthier Peter
- Geers Vincent
- Geithner Paul
- Gennaro Mario
- Giardino Giovanna
- Girard Julien
- Giuliano Mark
- Glasse Alistair
- Glassmire Kirk
- Glauser Adrian
- Glazer Stuart
- Godfrey John
- Golimowski David
- Gollnitz David
- Gong Fan
- Gonzaga Shireen
- Gordon Karl
- Gordon Michael
- Goudfrooij Paul
- Greene Thomas
- Greenhouse Matthew
- Grimaldi Stefano
- Groebner Andrew
- Grundy Timothy
- Guillard Pierre
- Gutman Irvin
- Ha Kong Q.
- Haderlein Peter
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hami Maryam
- Hamilton Forrest
- Hammel Heidi
- Hansen Carl
- Harkins Tom
- Harr Michael
- Hart Jessica
- Hart Quyen
- Hartig George
- Hashimoto Ryan
- Haskins Sujee
- Hathaway William
- Havey Keith
- Hayden Brian
- Hecht Karen
- Heller-Boyer Chris
- Henriques Caroline
- Henry Alaina
- Hermann Karl
- Hernandez Scarlin
- Hesman Brigette
- Hicks Brian
- Hilbert Bryan
- Hines Dean
- Hoffman Melissa
- Holfeltz Sherie
- Holler Bryan J.
- Hoppa Jennifer
- Hott Kyle
- Howard Joseph
- Howard Rick
- Hunter Alexander
- Hunter David
- Hurst Brendan
- Husemann Bernd
- Hustak Leah
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra
- Jackson Wallace
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James LeAndrea
- Januszewski William
- Jenkins Ann
- Jirdeh Hussein
- Johnson Phillip
- Johnson Timothy
- Jones Danny
- Jones Olivia
- Jones Ron
- Jones Vicki
- Jordan Ian
- Jordan Margaret
- Jurczyk Sarah
- Jurling Alden
- Kaleida Catherine
- Kalmanson Phillip
- Kammerer Jens
- Kang Huijo
- Kao Shaw-Hong
- Karakla Diane
- Kavanagh Patrick
- Kelly Doug
- Kendrew Sarah
- Kennedy Herbert
- Kenny Deborah
- Keski-kuha Ritva
- Keyes Charles
- Kidwell Richard
- Kimble Randy
- Kinzel Wayne
- Kirk Jeff
- Kirkpatrick Mark
- Kirshenblat Danielle
- Klaassen Pamela
- Knapp Bryan
- Knight J. Scott
- Knollenberg Perry
- Koehler Robert
- Koekemoer Anton
- Kovacs Aiden
- Kulp Trey
- Kumari Nimisha
- Kyprianou Mark
- La Massa Stephanie
- Labador Aurora
- Lagage Pierre-Olivier
- Lajoie Charles-Phillipe
- Lallo Matt
- Lallo Matthew
- Lam May
- Lamb Tracy
- Lambros Scott
- Lampenfield Richard
- Langston James
- Larson Kirsten
- Law David
- Lawrence Jon
- Lee David
- Leisenring Jarron
- Lepo Kelly
- Leveille Michael
- Levenson Nancy
- Levine Marie
- Levy Zena
- Lewis Dan
- Lewis Hannah
- Libralato Mattia
- Lightsey Paul
- Link Miranda
- Liu Lily
- Lo Amy
- Lockwood Alexandra
- Logue Ryan
- Long Chris
- Long Douglas
- Loomis Charles
- Lopez-Caniego Marcos
- Love-Pruitt Jennifer
- Lucy Adrian
- Luetzgendorf Nora
- Maghami Peiman
- Maiolino Roberto
- Major Melissa
- Malla Sunita
- Malumuth Eliot
- Manjavacas Elena
- Mannfolk Crystal
- Marin Macarena Garcia
- Marquez Javier Alvarez
- Marrione Amanda
- Marston Anthony
- Martel André
- Maschmann Marc
- Masci Gregory
- Masciarelli Michaela
- Maszkiewicz Michael
- Mather John
- McElwain Michael
- McKenzie Kenny
- McLean Brian
- McMaster Matthew
- Melbourne Katie
- Meléndez Marcio
- Menzel Michael
- Merz Kaiya
- Meyett Michele
- Meza Luis
- Milam Stefanie
- Miskey Cherie
- Misselt Karl
- Moller Christopher
- Morrison Jane
- Morse Ernie
- Moseley Harvey
- Mosier Gary
- Mountain Matt
- Mueckay Julio
- Mueller Michael
- Mullally Susan
- Murphy Jess
- Murray Claire
- Murray Katherine
- Mustelier David
- Muzerolle James
- Mycroft Matthew
- Myers Richard
- Myrick Kaila
- Nanavati Shashvat
- Nance Elizabeth
- Nayak Omnarayani
- Naylor Bret
- Neff Susan
- Neira Irma Quispe
- Nelan Edmund
- Nickson Bryony
- Nielson Alethea
- Nieto-Santisteban Maria
- Nikolov Nikolay
- Noriega-Crespo Alberto
- O'Shaughnessy Brian
- O'Sullivan Brian
- Ochs William
- Ogle Patrick
- Oleszczuk Brenda
- Olmsted Joseph
- Ortega Alvaro Labiano
- Osborne Shannon
- Ottens Richard
- Owens Beverly
- Pacifici Camilla
- Pagan Alyssa
- Page James
- Park Sang
- Parrish Keith
- Patapis Polychronis
- Paul Lee
- Pauly Tyler
- Pavlovsky Cheryl
- Pedder Andrew
- Peek Matthew
- Pena-Guerrero Maria
- Pennanen Konstantin
- Perez Yesenia
- Perna Michele
- Perriello Beth
- Perrin Marshall
- Phillips Kevin
- Pietraszkiewicz Martin
- Pinaud Jean-Paul
- Pirzkal Norbert
- Pitman Joseph
- Piwowar Aidan
- Platais Vera
- Plate Maurice Te
- Player Danielle
- Plesha Rachel
- Pollizi Joe
- Polster Ethan
- Pontoppidan Klaus
- Porterfield Blair
- Proffitt Charles
- Pueyo Laurent
- Pulliam Christine
- Quirt Brian
- Ramsay Leah
- Rapp Greg
- Rapp Robert
- Rauscher Bernard
- Ravindranath Swara
- Rawle Timothy
- Regan Michael
- Reichard Timothy A.
- Reis Carl
- Ressler Michael E.
- Rest Armin
- Reynolds Paul
- Rhue Timothy
- Richon Karen
- Rickman Emily
- Ridgaway Michael
- Rieke George
- Rieke Marcia
- Rigby Jane
- Ritchie Christine
- Rix Hans-Walter
- Robberto Massimo
- Robinson Gregory
- Robinson Michael
- Robinson Orion
- Rock Frank
- Rodriguez David
- Roellig Thomas
- Rohrbach Scott
- Roman Anthony
- Romelfanger Fred
- Rose Perry
- Roteliuk Anthony
- Roth Marc
- Rothwell Braden
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Royle Patricia
- Rui Chunlei
- Rumler Peter
- Runnels Joel
- Russ Melissa
- Rustamkulov Zafar
- Ryden Grant
- Ryer Holly
- Sabata Modhumita
- Sabatke Derek
- Sabbi Elena
- Samuelson Bridget
- Sapp Benjamin
- Sappington Bradley
- Sargent B.
- Sauer Arne
- Scheithauer Silvia
- Schlawin Everett
- Schlitz Joseph
- Schmitz Tyler
- Schneider Analyn
- Schreiber Jürgen
- Schulze Vonessa
- Schwab Ryan
- Scott John
- Sembach Kenneth
- Shanahan Clare
- Shaughnessy Bryan
- Shaw Richard
- Shawger Nanci
- Shay Christopher
- Sheehan Evan
- Shen Sharon
- Sherman Allan
- Shiao Bernard
- Shih Hsin-Yi
- Shivaei Irene
- Sienkiewicz Matthew
- Sing David
- Sirianni Marco
- Sivaramakrishnan Anand
- Skipper Joy
- Sloan Gregory
- Slocum Christine
- Slowinski Steven
- Smith Corbett
- Smith Denise
- Smith Eric
- Smith Erin
- Snyder Gregory
- Soh Warren
- Sohn Tony
- Soto Christian
- Spencer Richard
- Stallcup Scott
- Stansberry John
- Stark Christopher
- Starr Carl
- Starr Elysia
- Stewart Alphonso
- Stiavelli Massimo
- Straughn Amber
- Strickland David
- Stys Jeff
- Summers Francis
- Sun Fengwu
- Sunnquist Ben
- Swade Daryl
- Swam Michael
- Swaters Robert
- Swoish Robby
- Taylor Joanna M.
- Taylor Rolanda
- Tea Mason
- Teague Kelly
- Telfer Randal
- Temim Tea
- Thatte Deepashri
- Thompson Christopher
- Thompson Linda
- Thomson Shaun
- Tikkanen Tuomo
- Tippet William
- Todd Connor
- Toolan Sharon
- Tran Hien
- Trejo Edwin
- Truong Justin
- Tsukamoto Chris
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael
- Valenti Jeff
- Van Campen Julie
- Vandal Thomas
- Vandenbussche Bart
- Vila Begoña
- Volk Kevin
- Wahlgren Glenn
- Waldman Mark
- Walker Chanda
- Wander Michel
- Warfield Christine
- Warner Gerald
- Wasiak Matthew
- Watkins Mitchell
- Weaver Andrew
- Weilert Mark
- Weiser Nick
- Weiss Ben
- Weissman Sarah
- Welty Alan
- West Garrett
- Wheate Lauren
- Wheatley Elizabeth
- Wheeler Thomas
- White Rick
- Whiteaker Kevin
- Whitehouse Paul
- Whiteleather Jennifer
- Whitman William
- Williams Christina
- Willmer Christopher
- Willott Chris
- Willoughby Scott
- Wilson Andrew
- Wirth Gregory
- Wislowski Emily
- Wolf Erin
- Wolfe David
- Wolff Schuyler
- Workman Bill
- Wright Gillian
- Wright Ray
- Wu Carl
- Wu Rai
- Wymer Kristen
- Yates Kayla
- Yeager Christopher
- Yeates Jared
- Yerger Ethan
- Yoon Jinmi
- Young Alice
- Yu Susan
- Zak Dean
- Zeidler Peter
- Zhou Julia
- Zielinski Thomas
- Zincke Cristian
- Zonak Stephanie
- Publication venue
- 'IOP Publishing'
- Publication date
- 10/04/2023
- Field of study
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
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- Wislowski Emily Christine
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- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
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- Vlahova Aleksandrina
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- Wallinder Hans
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- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
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- Wilson J R
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- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
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- Woodhams Simon
- Woodhouse C
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- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Multi-messenger observations of a binary neutron star merger
- Author
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- Aartsen MG
- Abbott BP
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- Abbott TD
- Abbott TMC
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- Abramo LR
- Abramowski A
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- Albuquerque IFM
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- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
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- Array LWA Long Wavelength
- Array MWA Murchison Widefield
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- Artola R
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- Li X
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- Li XB
- Li XF
- Li YG
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- Observat Toros Transient Robotic
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- Pan Y-C
- Pan-STARRS
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- Pandya H
- Paneque D
- Pang B
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- Pant BC
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- Passuello D
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- Pearlstone BL
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- Peixoto CJ Todero
- Pekeur NW
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- Piccinni OJ
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- Picozza P
- Piel Q
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- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
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- Pillant G
- Pimenta M
- Pinard L
- Pinat E
- Pinto IM
- Piotrowski LW
- Piran T
- Piran T
- Piranomonte S
- Pirello M
- Piro AL
- Piro L
- Piron F
- Pirronello V
- Pisanu T
- Pita S
- Pitkin M
- Pittori C
- Placco VM
- Platino M
- Plazas AA
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- Podesta F
- Podesta RC
- Podsiadlowski P
- Poe M
- Poggiani R
- Poh J
- Poireau V
- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Porter EK
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- Possenti A
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- Powell J
- Pozanenko AS
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- Prado RR
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- Pratt JWW
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- Price LR
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- Principe G
- Principe M
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- Privitera P
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- Prochaska JX
- Prodi GA
- Prokhorov D
- Prokhorov LG
- Prokoph H
- Prouza M
- Prrer M
- Przybylski GT
- Pulone L
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- Punch M
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- Punturo M
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- Quataert E
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- Querchfeld S
- Querel R
- Quetschke V
- Quimby RM
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- Quirrenbach A
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- Ramirez KE
- Ramirez-Ruiz E
- Ramos-Buades A
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- Reichart DE
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- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
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- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
- Reyes R De Los
- Reyes SD
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- Rho CD
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- Riccobene G
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- Rios-Lopez E
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- Riviere C
- Rizi V
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- Robertson NA
- Robertson S
- Robie R
- Robinet F
- Rocchi A
- Rochester LS
- Rodi J
- Rodriguez H
- Rojas D Avila
- Rojas-Bravo C
- Rojo J Rodriguez
- Rol E
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- Rollins JG
- Roma VJ
- Romano R
- Romel CL
- Romer AK
- Romero M Dominguez
- Romie JH
- Romoli C
- Roncoroni MJ
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- Roodman A
- Roques J-P
- Rosa-Gonzlez D
- Rosell A Carnero
- Rosenberg M
- Rosetti S
- Rosinska D
- Ross MP
- Rossi A
- Rosswog S
- Rosswog S
- Roth M
- Rott C
- Roulet E
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- Rowan S
- Rowell G
- Rowlinson A
- Rowlinson A
- Roy R
- Ruan JJ
- Rudak B
- Ruehl P
- Ruggi P
- Ruhe T
- Ruiter AJ
- Ruiz R Gracia
- Ruiz-Velasco E
- Rulten CB
- Rumyantsev VV
- Rusu F
- Rutins G
- Ryan K
- Rybicki KA
- Ryckbosch D
- Rykoff ES
- Rysewyk D
- Saba A
- Sachdev S
- Sadecki T
- Sadeghian L
- Sadler EM
- Sadler EM
- Saffe C
- Saffi SJ
- Saftoiu A
- Sahakian V
- Sai N
- Saito S
- Saito T
- Saito Y
- Sakamaki A
- Sakamoto T
- Sakellariadou M
- Sako M
- Sako S
- Salafia OS
- Salamida F
- Salazar H
- Salazar H
- Salconi L
- Saldaa M
- Saleem M
- Saleh A
- Salemi F
- Salina G
- Salmon L
- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
- Sanchez DA
- Sanchez E
- Sanchez EJ
- Sanchez F
- Sanchez LE
- Sanchez-Losa A
- Sanchez-Lucas P
- Sanchez-Ramirez R
- Sanchis-Gual N
- Sand DJ
- Sandberg V
- Sanders JR
- Sandoval A
- Sandrock A
- Sandroos J
- Sanguineti M
- Sansom EK
- Santander M
- Santangelo A
- Santos E
- Santos EM
- Sapienza P
- Sarazin F
- Sarkar S
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- Sarmiento-Cano C
- Sasaki M
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- Satalecka K
- Sathyaprakash BS
- Sato R
- Saulson PR
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- Sauter O
- Savage RL
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- Sawadsky A
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- Schlegel DJ
- Schlickeiser R
- Schlunder P
- Schmalz SE
- Schmidt BP
- Schmidt D
- Schmidt J
- Schmidt P
- Schmidt T
- Schnabel R
- Schneider A
- Schneider M
- Schneiter M
- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
- Schubnell M
- Schuette D
- Schulte BW
- Schultz ASB
- Schulz A
- Schulz A
- Schulze S
- Schumacher J
- Schumacher L
- Schutz BF
- Schwalbe SG
- Schwanke U
- Schwemmer S
- Schweyer T
- Sciutto SJ
- Scolnic D
- Scott J
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- Secco LF
- Seckel D
- Seglar-Arroyo M
- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
- Selsing J
- Sengupta AS
- Sentenac D
- Sequino V
- Sergeev A
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- Serino M
- Serra G
- Serra-Ricart M
- Serrau M
- Settimo M
- Seunarine S
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
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