The geology and geophysics of Kuiper Belt object (486958) Arrokoth

The Cold Classical Kuiper Belt, a class of small bodies in undisturbed orbits beyond Neptune, are primitive objects preserving information about Solar System formation. The New Horizons spacecraft flew past one of these objects, the 36 km long contact binary (486958) Arrokoth (2014 MU69), in January 2019. Images from the flyby show that Arrokoth has no detectable rings, and no satellites (larger than 180 meters diameter) within a radius of 8000 km, and has a lightly-cratered smooth surface with complex geological features, unlike those on previously visited Solar System bodies. The density of impact craters indicates the surface dates from the formation of the Solar System. The two lobes of the contact binary have closely aligned poles and equators, constraining their accretion mechanism

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

The morphology and surface processes of Comet 19/P Borrelly

The flyby of the nucleus of the Comet 19P/Borrelly by the Deep Space 1 spacecraft produced the best views to date of the surface of these interesting objects. It transformed Borrelly from an astronomical object shrouded in coma of gas and dust into a geological object with complex surface processes and a rich history of erosion and landform evolution. Based on analysis of the highest resolution images, stereo images, photometry, and albedo we have mapped four major morphological units and four terrain features. The morphological units are named dark spots, mottled terrain, mesas, and smooth terrain. The features are named ridges, troughs, pits, and hills. In strong contrast to asteroids, unambiguous impact craters were not observed on Borrelly's surface. Because of the relatively short period of this comet, surface erosion by volatile sublimation is, in geologic terms, a very active process. The formation and the morphologies of units and features appear to be driven by differential rates of sublimation erosion. Erosional rates across the comet are probably controlled by solar energy input and the location of the subsolar point during perihelion. Differences in energy input may produce different varieties of sublimation erosional landforms. The terrains on Borrelly suggest that solar energy input could map directly into erosional processes and landforms

Imaging Borrelly

The nucleus, coma, and dust jets of short-period Comet 19P/Borrelly were imaged from the Deep Space 1 spacecraft during its close flyby in September 2001. A prominent jet dominated the near-nucleus coma and emanated roughly normal to the long axis of nucleus from a broad central cavity. We show it to have remained fixed in position for more than 34 hr, much longer than the 26-hr rotation period. This confirms earlier suggestions that it is co-aligned with the rotation axis. From a combination of fitting the nucleus light curve from approach images and the nucleus' orientation from stereo images at encounter, we conclude that the sense of rotation is right-handed around the main jet vector. The inferred rotation pole is approximately perpendicular to the long axis of the nucleus, consistent with a simple rotational state. Lacking an existing IAU comet-specific convention but applying a convention provisionally adopted for asteroids, we label this the north pole. This places the sub-solar latitude at ~60° N at the time of the perihelion with the north pole in constant sunlight and thus receiving maximum average insolation

Observations of comet 19P/Borrelly from the Miniature Integrated Camera and Spectrometer (MICAS) aboard Deep Space 1

Images from the DS1 MICAS CCD camera reveal in three dimensions, the complex characteristics of Borrelly's nucleus, coma, and jets. The images acquired during the last 2 hours of the approach, as the nucleus became resolved and grew to roughly 150 pixels in length, provide stereo coverage of both the nucleus and inner coma over a wide range of phase angle and exposure time. The principal structure in the coma is a sunward-pointed collimated jet that is also visible in ground-based images. This jet is canted about 30 degrees off the sun line and appears to be roughly aligned with the local vertical at the surface from where it originates. Long-exposure images reveal details of the structure of the inner coma. They show the jet, visible at long range, to be composed of at least three discrete components whose locations evidently correspond to specific surface features. The elongated nucleus exhibits topographically distinct terrains and strong albedo variegations (of at least a factor of 2). The jets emanate from within the brighter smoother rolling plains. A consistent model is that the main jets are co-aligned with the rotation axis of the nucleus and issue from regions on the plains that are currently in constant sunlight. The other major terrain is a rough unit that is darker than the average, includes even darker isolated spots, and appears as a jumbled topography. Other surface features include parallel ridges, crater-like depressions, numerous narrow dark fracture-like features, and areas of mottled albedo. However no small fresh impact craters are evident attesting to a geologically young, actively evolving surface

Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians

OnlinePubl.Purpose: Physical health-related quality of life (HRQoL) is associated with adverse health outcomes, including hospitalizations and all-cause mortality. However, little is known about how physical HRQoL changes over time in older people and the predictors of this trajectory. This study (a) identified trajectories of physical HRQoL among older people and (b) explored whether economic factors, social health or stressful life events impact physical HRQoL trajectories. Method: A cohort of 12,506 relatively ‘healthy’ community-dwelling Australians aged ≥ 70 years (54.4% females), enrolled in the ASPREE Longitudinal Study of Older Persons (ALSOP) study and was followed for six years. Economic factors, social health and life events in the last 12 months were assessed through a questionnaire at baseline. Physical HRQoL was measured by using the 12-item short form at baseline and annual follow-ups. Growth mixture and structural equation modelling were used to identify physical HRQoL trajectories and their predictors. Results: Four physical HRQoL trajectories were identified—stable low (7.1%), declining (9.0%), stable intermediate (17.9%) and stable high (66.0%). Living in more disadvantaged areas, having a lower household income, no paid work, no voluntary work, loneliness and stressful life events (i.e. spousal illness, friend/family illness, financial problem) were associated with a 10%–152% higher likelihood of being in the stable low or declining physical HRQoL trajectory than the stable high group. Conclusion: Specific stressful life events had a greater impact on adverse physical HRQoL trajectories in older people than other factors. Volunteering may prevent physical HRQoL decline and requires further investigation.Aung Zaw Zaw Phyo, David A. Gonzalez-Chica, Nigel P. Stocks, Robyn L. Woods, Jane Fisher, Thach Tran, Alice J. Owen, Stephanie A. Ward, Carlene J. Britt, Joanne Ryan, Rosanne Freak-Poli, on behalf of the ASPREE Study Grou

9969 Braille: Deep Space 1 infrared spectroscopy, geometric albedo, and classification

Spectra of Asteroid 9969 Braille in the 1.25–2.6 µm region returned by the Deep Space 1 (DS1) Mission show a ~10% absorption band centered at 2 µm, and a reflectance peak at 1.6 µm. Analysis of these features suggest that the composition of Braille is roughly equal parts pyroxene and olivine. Its spectrum between 0.4 and 2.5 µm suggests that it is most closely related to the Q taxonomic type of asteroid. The spectrum also closely matches that of the ordinary chondrites, the most common type of terrestrial meteorite. The geometric albedo of Braille is unusually high (pv=0.34), which is also consistent with its placement within the rarer classes of stony asteroids, and which suggests it has a relatively fresh, unweathered surface, perhaps due to a recent collision