ВЛИЯНИЕ ИНСТРУКЦИЙ НА ЭФФЕКТИВНОСТЬ ТРЕНИНГА ПРОИЗВОЛЬНОГО ПОВЫШЕНИЯ МОЩНОСТИ В ИНДИВИДУАЛЬНОМ ВЫСОКОЧАСТОТНОМ АЛЬФА-ДИАПАЗОНЕ ЭЭГ

We studied how the efficiency of individual alpha power stimulating training depends on the use of instructions and the presence or absence of feedback. A new method of calculating the efficiency of a single training session was suggested.Изучена зависимость эффективности обучения произвольному увеличению мощности в индивидуальном высокочастотном альфа-диапазоне от инструкций и наличия или отсутствия обратной связи. Предложен метод расчета эффективности отдельной сессии тренинга

Complex regulation by Apetala2 domain-containing transcription factors revealed through analysis of the stress-responsive TdCor410b promoter from durum wheat

Expression of the wheat dehydrin gene Cor410b is induced several fold above its non-stressed levels upon exposure to stresses such as cold, drought and wounding. Deletion analysis of the TdCor410b promoter revealed a single functional C-repeat (CRT) element. Seven transcription factors (TFs) were shown to bind to this CRT element using yeast one-hybrid screens of wheat and barley cDNA libraries, of which only one belonged to the DREB class of TFs. The remaining six encoded ethylene response factors (ERFs) belong to three separate subfamilies. Analysis of binding selectivity of these TFs indicated that all seven could bind to the CRT element (GCCGAC), and that three of the six ERFs could bind both to the CRT element and the ethylene-responsive GCC-box (GCCGCC). The TaERF4 subfamily members specifically bound the CRT element, and did not bind either the GCC-box or DRE element (ACCGAC). Molecular modeling and site-directed mutagenesis identified a single residue Pro42 in the Apetala2 (AP2) domain of TaERF4-like proteins that is conserved in monocotyledonous plants and is responsible for the recognition selectivity of this subfamily. We suggest that both DREB and ERF proteins regulate expression of the Cor410b gene through a single, critical CRT element. Members of the TaERF4 subfamily are specific, positive regulators of Cor410b gene expression.Omid Eini, Nannan Yang, Tatiana Pyvovarenko, Katherine Pillman, Natalia Bazanova, Natalia Tikhomirov, Serik Eliby, Neil Shirley, Shoba Sivasankar, Scott Tingey, Peter Langridge, Maria Hrmova, Sergiy Lopat

Биоуправление в психомоторном обучении. Результаты двухмесячного курса

With the aim to compare the impact of usual training and training with the use of biofeedback, the psychometric and electrophysiological features of 36 musical students were investigated. Two month biofeedback training caused increase in self actualization, improving the musical performance score, decrease state and trait anxiety, increase of the individual adjusted alpha-2 indices, but theta-, alpha-1 and beta- activities did not change. Optimal psychomotor reaction for usual self practice (enhancement in alphaactivity and decrease in muscle tension) was achieved during biofeedback training. Training efficiency depended on the baseline electropsysiological features of optimal functioning: peak frequency, band width, power and coherence in individual alpha range, reaction activation. It was concluded that upper alpha stimulating and EMG decreasing biofeedback training leads to development of optimal psychomotor behavioral strategy.Для сравнения традиционного обучения и обучения с использованием биоуправления изучались психометрические и электрофизиологические характеристики исполнительского движения у 36 студентов-музыкантов. После двухмесячного курса биоуправления экспертные оценки за исполнение музыки и уровень самоактуализации повысились, показатели ситуативной и личностной тревожности снизились. Тренинг произвольной модификации электрофизиологических параметров музыкально-исполнительского движения не вызывает изменения уровня индивидуальных параметров альфаактивности в состоянии покоя, но формирует новый тип реакции альфа-электроэнцефалограммы (ЭЭГ) на исполнение музыки: увеличивается частота максимального пика и альфа-мощность, углубляется и стабилизируется реакция на открывание глаз и расширяется диапазон, в котором эта реакция проявляется, удлиняются альфа-веретена, при этом снижается интегральная мощность электромиографии (ЭМГ) мышц, не участвующих в движении. Эти изменения электрофизиологических параметров ассоциируют с улучшением оценок исполнения музыки. Индивидуальные показатели альфа-активности (частота максимального пика, ширина диапазона, глубина десинхронизации, амплитуда, длительность и вариабельность амплитуды альфа-веретена) служат прогностическими критериями способности к музыкально-исполнительской деятельности и успешности ее произвольной модификации. Таким образом, тренинг биоуправления способствует выработке поведенческого паттерна оптимального психомоторного функционирования

ВЛИЯНИЕ АЛЬФА-, ЭМГ-БИОУПРАВЛЕНИЯ И ТЕХНИК ПРОИЗВОЛЬНОЙ САМОРЕГУЛЯЦИИ НА ПОКАЗАТЕЛИ ВАРИАБЕЛЬНОСТИ СЕРДЕЧНОГО РИТМА

With the purpose to study the impact of the upper frequency alpha EEG power increasing neurofeedback training (ANFT) on the cognitive performance, EEG alpha-activity and heart rate variability (HRV) 27 healthy men aged 18–34 years in pre, post and follow up one month 10 sessions ANFT time were investigated. The AFNT enhanced the fluency in cognitive performance, alpha frequency and power in upper frequency range and HRV only in participants with low baseline alpha frequency. While mock AFNT did change neither cognitive performance, nor alpha-activity, nor HRV indices. ANT reduces activation in cognitive load, and this effect persists for a month.C целью изучения влияния тренинга увеличения мощности в индивидуальном высокочастотном альфа-диапазоне электроэнцефалограммы (ЭЭГ) с помощью альфастимулирующего нейробиоуправления (АНТ) на психометрические показатели эффективности когнитивной деятельности, характеристики альфа-активности ЭЭГ и вариабельность сердечного ритма (ВСР) были обследованы 27 здоровых мужчин в возрасте 18–34 лет до, после и через месяц после 10 сессий АНТ. Результаты показали, что курс АНТ улучшает выполнение когнитивных задач, увеличивает показатели альфа-активности ЭЭГ и ВСР только у лиц с исходно низкой (менее 10 Гц) альфа-частотой. В то же время использование обычных техник саморегуляции (ложное биоуправление) не влияет на эти показатели. АНТ снижает реакцию активации при когнитивных нагрузках, и этот эффект сохраняется через месяц

ВЛИЯНИЕ АЛЬФА-, ЭМГ-БИОУПРАВЛЕНИЯ И ТЕХНИК ПРОИЗВОЛЬНОЙ САМОРЕГУЛЯЦИИ НА ПОКАЗАТЕЛИ КОГНИТИВНЫХ ФУНКЦИЙ И АЛЬФА-АКТИВНОСТЬ ЭЭГ

Comparison the influence of voluntary increasing alpha power and decreasing EMG by using biofeedback (BFB) and usual self-regulation techniques (SRT) on cognitive functions and alpha activity in 27 male subjects was provided. The results show that alpha-BFB improve cognitive task performance and enhance the alpha activity in participants with low alpha frequency. SRT without feedback has no such effect.Проведено сравнение влияния произвольного увеличения альфа-мощности и понижения мощности ЭМГ с помощью биоуправления (БУ) или техник саморегуляции (ТС) на показатели когнитивной деятельности. Исследованы 27 мужчин. Установлено, что курс тренинга БУ улучшает выполнение когнитивных задач и увеличивает альфа-активность у лиц с исходно низкой альфачастотой. ТС без сигнала обратной связи не дает такого эффекта

Wheat wounding-responsive HD-Zip IV transcription factor GL7 is predominantly expressed in grain and activates genes encoding defensins

Corrected by: Correction to: Wheat wounding-responsive HD-Zip IV transcription factor GL7 is predominantly expressed in grain and activates genes encoding defensins, in Plant Molecular Biology volume 101, pages 63–64 (2019). Due to an unfortunate turn of events, the panels O to S are missing in Fig. 8 of the original publication. The correct Fig. 8 and its caption is published here and should be treated as definitive.HD-Zip class IV transcription factors constitute a family of multidomain proteins. A full-length cDNA of HD-Zip IV, designated TaGL7 was isolated from the developing grain of bread wheat, using a specific DNA sequence as bait in the Y1H screen. 3D models of TaGL7 HD complexed with DNA cis-elements rationalised differences that underlined accommodations of binding and non-binding DNA, while the START-like domain model predicted binding of lipidic molecules inside a concave hydrophobic cavity. The 3′-untranslated region of TaGL7 was used as a probe to isolate the genomic clone of TdGL7 from a BAC library prepared from durum wheat. The spatial and temporal activity of the TdGL7 promoter was tested in transgenic wheat, barley and rice. TdGL7 was expressed mostly in ovary at fertilisation and its promoter was active in a liquid endosperm during cellularisation and later in the endosperm transfer cells, aleurone, and starchy endosperm. The pattern of TdGL7 expression resembled that of genes that encode grain-specific lipid transfer proteins, particularly defensins. In addition, GL7 expression was upregulated by mechanical wounding, similarly to defensin genes. Co-bombardment of cultured wheat cells with TdGL7 driven by constitutive promoter and seven grain or root specific defensin promoters fused to GUS gene, revealed activation of four promoters. The data confirmed the previously proposed role of HD-Zip IV transcription factors in the regulation of genes that encode lipid transfer proteins involved in lipid transport and defence. The TdGL7 promoter could be used to engineer cereal grains with enhanced resistance to insects and fungal infections.Nataliya Kovalchuk, Wei Wu, Natalia Bazanova, Nicolas Reid, Rohan Singh, Neil Shirley, Omid Eini, Alexander A. T. Johnson, Peter Langridge, Maria Hrmova, Sergiy Lopat

Зависимость электроэнцефалографических признаков невербальной креативности от пола и возраста

It is important to define the creativity psychophysiologic traits and their modification possibility for biofeedback creativity training. It was shown earlier that creativity is connected with alpha-rhythm indices (individual alpha-peak frequency, individual alpha band width, spindle span time and variability). This study aim was to explore psychophysiologic creativity indicators modification possibility. For this purpose age and gender factors influence on creativity indicators and electroencephalographic alpha activity indices were studied. The creativity was measured with Torrance Test then encephalogram was recorded. It was shown that individual alpha activity indices and nonverbal creativity level increase simultaneously with age. Total Torrance coefficient depends on individual alpha band width in males and alpha amplitude variability in females. Fluency correlates positively with individual alpha peak frequency in males and negatively with individual alpha activity suppression in females. Flexibility and Originality depend on individual alpha band width in both gender groups and may be possibly modified with biofeedback training.Исследованы возможности модификации признаков креативности в зависимости от пола и возраста. Результаты показали, что наиболее информативными электроэнцефалографическими признаками интегрального показателя креативности являются ширина альфа-диапазона у мужчин и вариабельность амплитуды альфа-веретена у женщин. Альфа-предиктором беглости выполнения креативных заданий является индивидуальная частота максимального альфа-пика в мужской группе и глубина активации в женской группе, пластичности и оригинальности — ширина альфа-диапазона в обеих гендерных группах. На основании того, что уровень альфа-активности по показателям частоты, активации, ширины диапазона, вариабельности амплитуды и длительности альфа-веретена увеличивается с возрастом и ассоциируется с характеристиками беглости и пластичности, делается вывод о возможности произвольной модификации невербальной креативност

КРАТКИЕ РЕКОМЕНДАЦИИ ДЛЯ АВТОРОВ ПО ПОДГОТОВКЕ И ОФОРМЛЕНИЮ НАУЧНЫХ СТАТЕЙ В ЖУРНАЛАХ, ИНДЕКСИРУЕМЫХ В МЕЖДУНАРОДНЫХ НАУКОМЕТРИЧЕСКИХ БАЗАХ ДАННЫХ

The Ministry  of Education  and Science  has developed brief recommendations for authors  on the preparation  and design of scientific articles in journals indexed in international scientific databases. The recommendations explain in detail the publication process, the procedures for reviewing and publishing, as well as the generally accepted requirements for the structure of a scientific article.Министерство образования  и науки разработало  краткие рекомендации для авторов по подготовке и оформлению научных статей в журналах, индексируемых в международных наукометрических базах данных. Рекомендации  детально объясняют  публикационный процесс,  процедуры рецензирования  и опубликования, а также общепринятые требования к структуре научной статьи

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe