Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Interim guidance for health‐care professionals and administrators providing hospital care to adult patients with cognitive impairment, in the context of COVID‐19 pandemic

We developed interim guidance for the care of patients with cognitive impairment in hospital during the COVID-19 pandemic.A Guidance Committee and Readers Group were recruited. The content was identified by the Committee and content-specific subgroups, resulting in a draft document, which was sent to the Readers for review. People with dementia and care partners were involved in all aspects of the process.Infection control measures can lead to an escalation of distress. In an environment where visiting bans are applied to care partners/advocates, hospitals need to ensure care partners can continue to provide decision-making support. Health-care professionals can proactively engage care partners using videoconferencing technologies. Developing models of care that proactively support best practice can minimise the risk of delirium, mitigate escalating symptoms and guide the use of non-pharmacological, pharmacological (start low, go slow) or physical restraint in managing behavioural and psychological symptoms

Weight management and physical activity throughout the cancer care continuum

Mounting evidence suggests that weight management and physical activity (PA) improve overall health and well being, and reduce the risk of morbidity and mortality among cancer survivors. Although many opportunities exist to include weight management and PA in routine cancer care, several barriers remain. This review summarizes key topics addressed in a recent National Academies of Science, Engineering, and Medicine workshop entitled, "Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum." Discussions related to body weight and PA among cancer survivors included: 1) current knowledge and gaps related to health outcomes; 2) effective intervention approaches; 3) addressing the needs of diverse populations of cancer survivors; 4) opportunities and challenges of workforce, care coordination, and technologies for program implementation; 5) models of care; and 6) program coverage. While more discoveries are still needed for the provision of optimal weight-management and PA programs for cancer survivors, obesity and inactivity currently jeopardize their overall health and quality of life. Actionable future directions are presented for research; practice and policy changes required to assure the availability of effective, affordable, and feasible weight management; and PA services for all cancer survivors as a part of their routine cancer care

CEERS Key Paper. I. An Early Look into the First 500 Myr of Galaxy Formation with JWST

We present an investigation into the first 500 Myr of galaxy evolution from the Cosmic Evolution Early Release Science (CEERS) survey. CEERS, one of 13 JWST ERS programs, targets galaxy formation from z ∼ 0.5 to >10 using several imaging and spectroscopic modes. We make use of the first epoch of CEERS NIRCam imaging, spanning 35.5 arcmin2, to search for candidate galaxies at z > 9. Following a detailed data reduction process implementing several custom steps to produce high-quality reduced images, we perform multiband photometry across seven NIRCam broad- and medium-band (and six Hubble broadband) filters focusing on robust colors and accurate total fluxes. We measure photometric redshifts and devise a robust set of selection criteria to identify a sample of 26 galaxy candidates at z ∼ 9–16. These objects are compact with a median half-light radius of ∼0.5 kpc. We present an early estimate of the z ∼ 11 rest-frame ultraviolet (UV) luminosity function, finding that the number density of galaxies at M UV ∼ −20 appears to evolve very little from z ∼ 9 to 11. We also find that the abundance (surface density [arcmin−2]) of our candidates exceeds nearly all theoretical predictions. We explore potential implications, including that at z > 10, star formation may be dominated by top-heavy initial mass functions, which would result in an increased ratio of UV light per unit halo mass, though a complete lack of dust attenuation and/or changing star formation physics may also play a role. While spectroscopic confirmation of these sources is urgently required, our results suggest that the deeper views to come with JWST should yield prolific samples of ultrahigh-redshift galaxies with which to further explore these conclusions

CEERS Key Paper. I. An Early Look into the First 500 Myr of Galaxy Formation with JWST

We present an investigation into the first 500 Myr of galaxy evolution from the Cosmic Evolution Early Release Science (CEERS) survey. CEERS, one of 13 JWST ERS programs, targets galaxy formation from z ∼ 0.5 to >10 using several imaging and spectroscopic modes. We make use of the first epoch of CEERS NIRCam imaging, spanning 35.5 arcmin ^2 , to search for candidate galaxies at z > 9. Following a detailed data reduction process implementing several custom steps to produce high-quality reduced images, we perform multiband photometry across seven NIRCam broad- and medium-band (and six Hubble broadband) filters focusing on robust colors and accurate total fluxes. We measure photometric redshifts and devise a robust set of selection criteria to identify a sample of 26 galaxy candidates at z ∼ 9–16. These objects are compact with a median half-light radius of ∼0.5 kpc. We present an early estimate of the z ∼ 11 rest-frame ultraviolet (UV) luminosity function, finding that the number density of galaxies at M _UV ∼ −20 appears to evolve very little from z ∼ 9 to 11. We also find that the abundance (surface density [arcmin ^−2 ]) of our candidates exceeds nearly all theoretical predictions. We explore potential implications, including that at z > 10, star formation may be dominated by top-heavy initial mass functions, which would result in an increased ratio of UV light per unit halo mass, though a complete lack of dust attenuation and/or changing star formation physics may also play a role. While spectroscopic confirmation of these sources is urgently required, our results suggest that the deeper views to come with JWST should yield prolific samples of ultrahigh-redshift galaxies with which to further explore these conclusions