CLINICAL STUDY OF BABOOL (ACACIA ARABICA WILLD.) AND KUKUNDAR (BLUMEA LACERA D.C.) ON ASRIGDARA

Rakta is known to be a vital substance of body. As the disease is characterized by excess flow of blood out of the body, Raktastambhana Chikitisa is beneficial. Treatment prescribed for Raktatisara, Raktapitta, Raktarsha, Guhyaroga and Garbhasrava is also useful. Considering this aspect, Raktastambhaka, Raktsodhana, Raktapittaghna effects are desired in treatment. Haemostatic drugs should be used by giving due consideration to the association of Doshas diagnosed on the basis of colour and smell of the blood. Aims and Objectives: To evaluate the efficacy of Babool and Kukundar and comparative clinical study of Babool and Kukundar on Asrigdara. Materials and Methods: For the present study, patients fulfilling the clinical criteria for diagnosis of Asrigdara will be selected irrespective of their age, sex, religion, etc, in random from O.P.D. section of M. M. M. Govt. Ayurveda College hospital, Udaipur (Raj.). Case history of all the patients was taken in the specially prepared proforma. Conclusion: Babool due to its astringent taste and Kunkundar due to its bitter taste, both drugs pacify excessive Pitta humour which is main cause of Asrigdara. Their chemical constituents possess haemostatic and anti-inflammatory properties thus considering these facts, these drugs have been selected for present study

Mechanical properties and quality of plasma sprayed, functionally graded tungsten/steel coatings after process upscaling

The First Wall of a fusion reactor needs to withstand high heat flux as well as particle bombardment. For this, a First Wall made of steel requires a protective coating with a material that may still transfer heat for conversion to energy, such as tungsten. Its thermal expansion mismatch towards steel is overcome by vacuum plasma spraying of a functionally graded material onto the steel wall, followed by a tungsten top coat. This process was recently transferred to industry for upscaling, to develop a coating technology that can cover the large dimensions of First Wall components without deteriorating the substrate steel\u27s properties by overheating. This work represents an instrumented indentation study of the achieved coating quality and properties, combined with microstructural analysis. Hardness profiles within coating and substrate indicate successful establishment of a linearly functionally graded material and only minor substrate overheating. The latter observation is supported by electron backscatter diffraction showing no change in the substrate\u27s microstructure. The substrate hardness was investigated on several positions of coated plates sizing up to 500 × 250 mm2. The results indicate faster cooldown in the plate corners. Cooling channel bores that were pre-fabricated in the plates had no effect on plate hardness after coating. The elastic modulus of the coating\u27s interlayers, determined by instrumented indentation, was found lower than predicted from bulk properties. This is attributed to the heterogeneous microstructure of the thermally sprayed coating

Computer Vision Algorithm for the detection of fracture cracks in Oil Hardening Non-Shrinking (OHNS) die steel after machining process

A variant of neural network for processing with images is a convolutional neural network (CNN). This type of neural network receives input from an image and extracts features from the image while also providing learnable parameters to effectively do the classification, detection, and many other tasks. In the present work, U-Net convolutional neural network is implemented on Jupyter platform by using Python programming for fracture surface image segmentation in Oil Hardening Non-Shrinking (OHNS) die steel after the machining process. The results showed that the fracture cracks can be validated by testing with higher accuracy

Coexistence of carcinoma cheek with tuberculosis: a rarity

Coexistence of tuberculosis and cheek malignancy is a rare phenomenon and it has never been reported to the best of our knowledge. Here, we present a case of carcinoma cheek with tuberculosis in a 50 year old male patient who was successfully managed by multimodality approach by combining anti-tubercular therapy with chemotherapy and radiotherapy

Fracture behaviour of Ti/TiN multilayer thin film modeling and experimental validation

Although titanium nitride is used as a hard protective coating, it is brittle. The multilayering of Ti/TiN film improves the nitride coating’s damage tolerance and expands its applications. The influence of layer spacing on multilayer fracture toughness (KIC) is not known and quantification is important for designing a multilayer with enhanced damage tolerance. The effect of multilayering on the crack tip driving force is investigated using finite element method (FEM) in this work. Elastic-plastic mismatch in Ti/TiN system is incorporated in simulation. Numerical simulations are performed for varying layer spacing for Ti/TiN systems. Please click Download on the upper right corner to see the full abstract

A cross-sectional epidemiological study of socio-demographic characteristics, and the functional assessment in geriatric population in field practice area of an urban health centre

Background: India like many other developing countries in the world is witnessing the rapid aging of its population. Urbanization, modernization, and globalization have led to change in the economic structure, the erosion of societal values, weakening of social values, and social institutions such as the joint family. Active aging aims to extend healthy life expectancy and quality of life (QOL) in older persons, and the QOL are largely determined by its ability to maintain autonomy and independence. Aims and Objectives: The present study was conducted at a teriary apex institute to study the socio-demographic characteristics, and the functional assessment in the elderly subjects in urban community. Materials and Methods: It was a cross-sectional observational study conducted at the area situated near western suburb of metro city and population of around one lakh sixty thousand. It consisted of housing buildings, multiple slum area. The current study was conducted over 1 year 6 months (18 months).The sampling unit being 102 Geriatric individuals of selected area of urban health center. Results: Out of 102 study, subjects 22 (21.56%) were complete independent to perform daily instrumental activities. Maximum study 48 (47.05%) subjects were required moderate assistance for performing the instrumental activities. Numbers of female study subjects were more among moderates assistance 24 (44.44%) and modified assistance 20 (19.60%). Out of 102 study subjects 55 (53.92%) were complete independent followed by 30 (29.41%) modified independence. Numbers of female subjects were more among moderate assistance 10 (58.82%). Conclusion: No study subject was dependent or maximal assistance for their self-care activities. Male and female in the present study can perform their self-care activities of daily living with equal efficiency

Treatment with clobetasol propionate 0.025% topical therapy in various dermatoses

Owing to their anti-inflammatory and vasoconstrictive properties. Topical corticosteroids (TCs) provide benefits in various dermatological conditions, including atopic eczema, psoriasis, chronic hand eczema, and localized vitiligo. Clobetasol propionate (CP) is the most common topical agent possessing anti-inflammatory, antimitotic, antipruritic, and immunosuppressive properties that are employed in the management of plaque psoriasis. CP 0.025% cream was approved by the United States food and drug administration for the treatment of moderate-to-severe psoriasis in adult patients. The formulation is free from known contact allergens, such as propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers, and has demonstrated hypoallergenic effects. High penetration of active ingredients and a lower degree of systemic absorption make CP 0.025% an effective and safe agent. This case series discusses the clinical experience of using CP 0.025% cream in various dermatologic conditions, focusing on its efficacy and safety

Computer Vision Algorithm for the detection of fracture cracks in Oil Hardening Non-Shrinking (OHNS) die steel after machining process

A variant of neural network for processing with images is a convolutional neural network (CNN). This type of neural network receives input from an image and extracts features from the image while also providing learnable parameters to effectively do the classification, detection, and many other tasks. In the present work, U-Net convolutional neural network is implemented on Jupyter platform by using Python programming for fracture surface image segmentation in Oil Hardening Non-Shrinking (OHNS) die steel after the machining process. The results showed that the fracture cracks can be validated by testing with higher accuracy. The plot of accuracy vs. number of epochs showed the obtained accuracy score 0f 1.0 which means that 100 % of points were correctly labeled by our implemented algorithm

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

RELATIONSHIP OF PELVIC ALIGNMENT WITH BALANCE AND GAIT IN PATIENTS WITH STROKE: A SYSTEMATIC REVIEW: Pelvic alignment and balance

Background- Pelvis is the key structure that connects the spine and the lower limbs. Altered Pelvic Alignment and asymmetrical weight bearing on affected lower limbs is a common problem leading to pelvic instability which may have an effect on balance and gait in patients with stroke. Hence, it was aimed to investigate the interdependence of these three components in patients with stroke. Methods- Four databases (PubMed, Google Scholar, Cochrane, Science Direct) were searched to identify eligible studies using the keywords Pelvic Alignment, Gait, Balance, Stroke. Only observational studies published in last 10 years (2010-2020) were included in this review. Results- Thirteen studies were included in the review conducted on sub-acute and chronic stage. All studies investigated the affection of pelvic mal-alignment, balance and gait in combination of two variables except 3 studies which investigated the combined effect of pelvic inclination on both balance and gait. The abnormal pelvic tilt results in lateral displacement of the pelvis on affected side, altered Base of Support, reduced balance control, asymmetry in weight bearing leading to altered gait. Conclusion- Pelvic tilt, anterior and lateral has a significant impact on static balance, gait variables, weight bearing symmetry