Estudio de viabilidad de una instalación solar fotovoltaica en una granja de pollos en el término municipal de Robres (Huesca)

A lo largo de este proyecto se estudia la rentabilidad de tres tipos de instalaciones solares fotovoltaicas, dos aisladas y una conectada a la red de distribución. Estas instalaciones servirán para abastecer una granja de pollos, formada por dos naves de 20.000 pollos cada una, en la localidad de Robres, Huesca. Esto se lleva a cabo para analizar las consecuencias de la eliminación de subvenciones en este sector, así como para buscar una posible alternativa a las elevadas facturas eléctricas de la explotación. Para los cálculos se han empleado los soportes informáticos PVsyst y PVGIS. El proyecto consta de dos partes, memoria y anexos, donde se amplia la información de la misma

[Cuestiones de abonos]

Obra facticia que contiene: Del aprovechamiento para abono agrícola de los grandes depósitos de hueso enterrado descubiertos en Castilla La Mancha : apuntes acerca de la facultad fertilizante del fosfato de cal, y acerca de los abonos químicos con él fabricados / por Diego López de Quintana. -- Madrid : Imp. de J.M. Lapuente, 1876. -- 44, VIII p. -- Abonos agrícolas : memoria presentada á la Real Sociedad Económica Aragonesa de Amigos del País... / de su autor José Alloza y Temprado. -- Zaragoza : Imp. del Hospicio Provincial, 1888. -- 67, VIII p. -- Elaboración de abonos económicos con destino á los principales cultivos : memoria exponiendo medios seguros para que los agricultores... / por Enrique Sagols y Ferrer. -- Zaragoza : Imp. del Hospicio Provincial, 1988. -- 73 p. -- Indice -- Experiencias comparativas en el cultivo de la Avena empleando el Nitrato de sosa, el sulfato de amoniaco y la sangre desecada : resumen de los resultados obtenidos en veintiún departamentos de Francia... / por D.L. Grandeau. -- Londres : Permanent Nitrate Comité, 1897. -- 15, VIII p. -- Abonos para agricultura : apuntes para un libro / por Juan Juste y Cararach. -- Zaragoza : Imp. del Hospicio Provincial, 1888. -- 128 p., [2] h. de lám

BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque

Carotid atherosclerotic plaque rupture can lead to cerebrovascular accident (CVA). By comparing RNA-Seq data from vascular smooth muscle cells (VSMC) extracted from carotid atheroma surgically excised from a group of asymptomatic and symptomatic subjects, we identified more than 700 genomic variants associated with symptomatology (p < 0.05). From these, twelve single nucleotide polymorphisms (SNPs) were selected for further validation. Comparing genotypes of a hospital-based cohort of asymptomatic with symptomatic patients, an exonic SNP in the BIRC6 (BRUCE/Apollon) gene, rs35286811, emerged as significantly associated with CVA symptomatology (p = 0.002; OR = 2.24). Moreover, BIRC6 mRNA levels were significantly higher in symptomatic than asymptomatic subjects upon measurement by qPCR in excised carotid atherosclerotic tissue (p < 0.0001), and significantly higher in carriers of the rs35286811 risk allele (p < 0.0001). rs35286811 is a proxy of a GWAS SNP reported to be associated with red cell distribution width (RDW); RDW was increased in symptomatic patients (p < 0.03), but was not influenced by the rs35286811 genotype in our cohort. BIRC6 is a negative regulator of both apoptosis and autophagy. This work introduces BIRC6 as a novel genetic risk factor for stroke, and identifies autophagy as a genetically regulated mechanism of carotid plaque vulnerability.This work was financially supported by grants from the Departments of Education (Ref. PIBA2018-67) and Health (Ref. RIS3-2019222038) of the Basque Government, Vitoria-Gasteiz, Spain; by the Spanish Neurovascular Network (INVICTUSplus) (Ref. RD16/0019/0007) funded by the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain; and by the research project grant (IKERIKTUS) funded by the RefbioII Trans-Pyrenean Cooperation Network for Biomedical Research financed by Horizon 2020. I.A. is supported by the Maratón EiTB 2017 for Funding of Research into Stroke, Bilbao, Spain (Ref. BIO18/IC/005); R.T.N. is the recipient of a fellowship from the Secretaría Nacional de Ciencia y Tecnología e Innovación (SENACYT; Convocatoria Doctorado de Investigación Ronda III, 2018; Ref. BIDP-III-2018-12) of the Gobierno Nacional, República de Panamá

Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia

Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia

[Cuestiones de abonos]

Contiene: Del aprovechamiento para abono agrícola de los grandes depósitos de hueso enterrado descubiertos en Castilla La Mancha : apuntes acerca de la facultad fertilizante del fosfato de cal, y acerca de los abonos químicos con él fabricados / por Diego López de Quintana. -- Madrid : Imp. de J.M. Lapuente, 1876. -- 44, VIII p. -- Abonos agrícolas : memoria presentada á la Real Sociedad Económica Aragonesa de Amigos del País... / de su autor José Alloza y Temprado. -- Zaragoza : Imp. del Hospicio Provincial, 1888. -- 67, VIII p. -- Elaboración de abonos económicos con destino á los principales cultivos : memoria exponiendo medios seguros para que los agricultores... / por Enrique Sagols y Ferrer. -- Zaragoza : Imp. del Hospicio Provincial, 1988. -- 73 p. -- Indice -- Experiencias comparativas en el cultivo de la Avena empleando el Nitrato de sosa, el sulfato de amoniaco y la sangre desecada : resumen de los resultados obtenidos en veintiún departamentos de Francia... / por D.L. Grandeau. -- Londres : Permanent Nitrate Comite, 1897. -- 15, VIII p. -- Abonos para agricultura: apuntes para un libro / por Juan Juste y Cararach. -- Zaragoza : Imp. del Hospicio Provincial, 1888. -- 128 p., [2] h. de lám.Enc. cartonéEnc. varias obras formando un vol. facticioNota ms sueltaSello en guarda : Encuadernador Cayetano Fernández, ZaragozaTít. tomado del lom

Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions

Challenge B: Human sciences in transition scenarios

Coordinators: Josep Martí Pérez (IMF, CSIC), Idoia Murga Castro (IH, CSIC).This challenge is formulated in terms of “humanities in transition,” that is, their approach and articulation in the face of the changes they must undergo to achieve the social weight that, due to their intrinsic relevance, should correspond to them. Faced with these situations that would demand a reinforcement in research and dissemination in diverse aspects of the humanities, from multiple perspectives, paradoxically an adverse panorama is drawn for the development and dissemination of humanistic knowledge, which concerns different factors. Some are related to the consideration of the area of knowledge itself, its organization within the scientific system, the questioning of its own limits, and the interaction with another knowledge. Considering current transition scenarios does not mean having to abandon old objectives, but it adds to the work conducted new objects of study closely related to current reality, such as: the informational revolution; the relations with the ecosystem and the environmental crisis; globalization; the intensification of human mobility and migration flows; the growing economic and social inequality; the frictions derived from the articulation of collective identities; the decolonization of discourses; demographic dynamics; integration of technological advances; and viability and support for alternative models of society.Peer reviewe

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field