Semen parameters can be predicted from environmental factors and lifestyle using artificial intelligence methods

Fertility rates have dramatically decreased in the last two decades, especially in men. It has been described that environmental factors as well as life habits may affect semen quality. In this paper we use artificial intelligence techniques in order to predict semen characteristics resulting from environmental factors, life habits, and health status, with these techniques constituting a possible decision support system that can help in the study of male fertility potential. A total of 123 young, healthy volunteers provided a semen sample that was analyzed according to the World Health Organization 2010 criteria. They also were asked to complete a validated questionnaire about life habits and health status. Sperm concentration and percentage of motile sperm were related to sociodemographic data, environmental factors, health status, and life habits in order to determine the predictive accuracy of a multilayer perceptron network, a type of artificial neural network. In conclusion, we have developed an artificial neural network that can predict the results of the semen analysis based on the data collected by the questionnaire. The semen parameter that is best predicted using this methodology is the sperm concentration. Although the accuracy for motility is slightly lower than that for concentration, it is possible to predict it with a significant degree of accuracy. This methodology can be a useful tool in early diagnosis of patients with seminal disorders or in the selection of candidates to become semen donors.This study was partially funded by Vicerrectorado de Investigación, University of Alicante, Alicante, Spain (Vigrob-137)

A Machine Learning and Integration Based Architecture for Cognitive Disorder Detection Used for Early Autism Screening

About 15% of the world’s population suffers from some form of disability. In developed countries, about 1.5% of children are diagnosed with autism. Autism is a developmental disorder distinguished mainly by impairments in social interaction and communication and by restricted and repetitive behavior. Since the cause of autism is still unknown, there have been many studies focused on screening for autism based on behavioral features. Thus, the main purpose of this paper is to present an architecture focused on data integration and analytics, allowing the distributed processing of input data. Furthermore, the proposed architecture allows the identification of relevant features as well as of hidden correlations among parameters. To this end, we propose a methodology able to integrate diverse data sources, even data that are collected separately. This methodology increases the data variety which can lead to the identification of more correlations between diverse parameters. We conclude the paper with a case study that used autism data in order to validate our proposed architecture, which showed very promising results.This work was partially funded by Grant RTI2018-094283-B-C32, ECLIPSE-UA (Spanish Ministry of Education and Science)

A systematic review of the applications of Expert Systems (ES) and machine learning (ML) in clinical urology.

BackgroundTesting a hypothesis for 'factors-outcome effect' is a common quest, but standard statistical regression analysis tools are rendered ineffective by data contaminated with too many noisy variables. Expert Systems (ES) can provide an alternative methodology in analysing data to identify variables with the highest correlation to the outcome. By applying their effective machine learning (ML) abilities, significant research time and costs can be saved. The study aims to systematically review the applications of ES in urological research and their methodological models for effective multi-variate analysis. Their domains, development and validity will be identified.MethodsThe PRISMA methodology was applied to formulate an effective method for data gathering and analysis. This study search included seven most relevant information sources: WEB OF SCIENCE, EMBASE, BIOSIS CITATION INDEX, SCOPUS, PUBMED, Google Scholar and MEDLINE. Eligible articles were included if they applied one of the known ML models for a clear urological research question involving multivariate analysis. Only articles with pertinent research methods in ES models were included. The analysed data included the system model, applications, input/output variables, target user, validation, and outcomes. Both ML models and the variable analysis were comparatively reported for each system.ResultsThe search identified n = 1087 articles from all databases and n = 712 were eligible for examination against inclusion criteria. A total of 168 systems were finally included and systematically analysed demonstrating a recent increase in uptake of ES in academic urology in particular artificial neural networks with 31 systems. Most of the systems were applied in urological oncology (prostate cancer = 15, bladder cancer = 13) where diagnostic, prognostic and survival predictor markers were investigated. Due to the heterogeneity of models and their statistical tests, a meta-analysis was not feasible.ConclusionES utility offers an effective ML potential and their applications in research have demonstrated a valid model for multi-variate analysis. The complexity of their development can challenge their uptake in urological clinics whilst the limitation of the statistical tools in this domain has created a gap for further research studies. Integration of computer scientists in academic units has promoted the use of ES in clinical urological research

A non-invasive diagnostic system for early assessment of acute renal transplant rejection.

Early diagnosis of acute renal transplant rejection (ARTR) is of immense importance for appropriate therapeutic treatment administration. Although the current diagnostic technique is based on renal biopsy, it is not preferred due to its invasiveness, recovery time (1-2 weeks), and potential for complications, e.g., bleeding and/or infection. In this thesis, a computer-aided diagnostic (CAD) system for early detection of ARTR from 4D (3D + b-value) diffusion-weighted (DW) MRI data is developed. The CAD process starts from a 3D B-spline-based data alignment (to handle local deviations due to breathing and heart beat) and kidney tissue segmentation with an evolving geometric (level-set-based) deformable model. The latter is guided by a voxel-wise stochastic speed function, which follows from a joint kidney-background Markov-Gibbs random field model accounting for an adaptive kidney shape prior and for on-going visual kidney-background appearances. A cumulative empirical distribution of apparent diffusion coefficient (ADC) at different b-values of the segmented DW-MRI is considered a discriminatory transplant status feature. Finally, a classifier based on deep learning of a non-negative constrained stacked auto-encoder is employed to distinguish between rejected and non-rejected renal transplants. In the “leave-one-subject-out” experiments on 53 subjects, 98% of the subjects were correctly classified (namely, 36 out of 37 rejected transplants and 16 out of 16 nonrejected ones). Additionally, a four-fold cross-validation experiment was performed, and an average accuracy of 96% was obtained. These experimental results hold promise of the proposed CAD system as a reliable non-invasive diagnostic tool

The Effect of Green Software: A Study of Impact Factors on the Correctness of Software

Unfortunately, sustainability is an issue very poorly used when developing software and hardware systems. Lately, and in order to contribute to the earth sustainability, a new concept emerged named Green software which is computer software that can be developed and used efficiently and effectively with minimal or no impact to the environment. Currently, new teaching methods based on students’ learning process are being developed in the European Higher Education Area. Most of them are oriented to promote students’ interest in the course’s contents and offer personalized feedback. Online judging is a promising method for encouraging students’ participation in the e-learning process, although it still has to be researched and developed to be widely used and in a more efficient way. The great amount of data available in an online judging tool provides the possibility of exploring some of the most indicative attributes (e.g., running time, memory) for learning programming concepts, techniques and languages. So far, the most applied methods for automatically gathering information from the judging systems are based on statistical methods and, although providing reasonable correlations, these methods have not been proven to provide enough information for predicting grades when dealing with a huge amount of data. Therefore, the great novelty of this paper is to develop a data mining approach to predict program correctness as well as the grades of the students’ practices. For this purpose, powerful data mining technologies taken from the artificial intelligence domain have been used. In particular, in this study, we have used logistic regression, decision trees, artificial neural network and support vector machines; which have been properly identified as the most suitable ones for predicting activities in the e-learning domains. The results have achieved an accuracy of around 74%, both in the prediction of the program correctness as well as in the practice grades’ prediction. Another relevant issue provided in this paper is a comparison among these four techniques to obtain the best accuracy in predicting grades based on the availability of data as well as their taxonomy. The Decision Trees classifier has obtained the best confusion matrix, and time and memory efficiency were identified as the most important predictor variables. In view of these results, we can conclude that the development of green software leads programmers to implement correct software.This work has been funded by the Spanish Ministry of Economy and Competitiveness (MINECO/FEDER) under the granted project SEQUOIA-UA (TIN2015-63502-C3-3-R), project GINSENG-UMU (TIN2015-70259-C2-2-R) supported by the Spanish Ministry of Economy, Industry and Competitiveness and European FEDER funds. This work has also been partially funded by University of Alicante, under project GRE14-10 and by the Generalitat Valenciana, Spain, under project GV/2016/087

Diffusion-weighted magnetic resonance imaging in diagnosing graft dysfunction : a non-invasive alternative to renal biopsy.

The thesis is divided into three parts. The first part focuses on background information including how the kidney functions, diseases, and available kidney disease treatment strategies. In addition, the thesis provides information on imaging instruments and how they can be used to diagnose renal graft dysfunction. The second part focuses on elucidating the parameters linked with highly accurate diagnosis of rejection. Four parameters categories were tested: clinical biomarkers alone, individual mean apparent diffusion coefficient (ADC) at 11-different b- values, mean ADCs of certain groups of b-value, and fusion of clinical biomarkers and all b-values. The most accurate model was found to be when the b-value of b=100 s/mm2 and b=700 s/mm2 were fused. The third part of this thesis focuses on a study that uses Diffusion-Weighted MRI to diagnose and differentiate two types of renal rejection. The system was found to correctly differentiate the two types of rejection with a 98% accuracy. The last part of this thesis concludes the work that has been done and states the possible trends and future avenues

Advances in Electronic-Nose Technologies Developed for Biomedical Applications

The research and development of new electronic-nose applications in the biomedical field has accelerated at a phenomenal rate over the past 25 years. Many innovative e-nose technologies have provided solutions and applications to a wide variety of complex biomedical and healthcare problems. The purposes of this review are to present a comprehensive analysis of past and recent biomedical research findings and developments of electronic-nose sensor technologies, and to identify current and future potential e-nose applications that will continue to advance the effectiveness and efficiency of biomedical treatments and healthcare services for many years. An abundance of electronic-nose applications has been developed for a variety of healthcare sectors including diagnostics, immunology, pathology, patient recovery, pharmacology, physical therapy, physiology, preventative medicine, remote healthcare, and wound and graft healing. Specific biomedical e-nose applications range from uses in biochemical testing, blood-compatibility evaluations, disease diagnoses, and drug delivery to monitoring of metabolic levels, organ dysfunctions, and patient conditions through telemedicine. This paper summarizes the major electronic-nose technologies developed for healthcare and biomedical applications since the late 1980s when electronic aroma detection technologies were first recognized to be potentially useful in providing effective solutions to problems in the healthcare industry

Epilepsy

With the vision of including authors from different parts of the world, different educational backgrounds, and offering open-access to their published work, InTech proudly presents the latest edited book in epilepsy research, Epilepsy: Histological, electroencephalographic, and psychological aspects. Here are twelve interesting and inspiring chapters dealing with basic molecular and cellular mechanisms underlying epileptic seizures, electroencephalographic findings, and neuropsychological, psychological, and psychiatric aspects of epileptic seizures, but non-epileptic as well