Michael Silk, Ingo Gildenhard, Rosemary Barrow, The Classical Tradition: Art, Literature, Thought

A review of Michael Silk, Ingo Gildenhard, Rosemary Barrow (eds), The Classical Tradition: Art, Literature, Thought. Oxford: Wiley-Blackwell, 2014. Print

Accurate Determination of Conformational Transitions in Oligomeric Membrane Proteins

The structural dynamics governing collective motions in oligomeric membrane proteins play key roles in vital biomolecular processes at cellular membranes. In this study, we present a structural refinement approach that combines solid-state NMR experiments and molecular simulations to accurately describe concerted conformational transitions identifying the overall structural, dynamical, and topological states of oligomeric membrane proteins. The accuracy of the structural ensembles generated with this method is shown to reach the statistical error limit, and is further demonstrated by correctly reproducing orthogonal NMR data. We demonstrate the accuracy of this approach by characterising the pentameric state of phospholamban, a key player in the regulation of calcium uptake in the sarcoplasmic reticulum, and by probing its dynamical activation upon phosphorylation. Our results underline the importance of using an ensemble approach to characterise the conformational transitions that are often responsible for the biological function of oligomeric membrane protein states

A community\u27s dominant religion: A counter definition

Religious orientations, practices, and attitudes held by people relate in many ways to their behavior in secular society. To evaluate these various relationships several questions were considered. To what degree do religious beliefs influence an individual\u27s daily attitudes and behaviors? Is there a segment of society that benefits from religious practices? Is a part of society harmed by these beliefs?;Seeking to eliminate the possible effects of diffusion and acculturation, a rural town with a dominant religious ideology was chosen. Of the hamlet\u27s four thousand people approximately seventy-five percent were Mormon; The data was compiled using a complete participant observer research strategy. A pair of researchers, one male and one female, spent a year in the field gathering the data. While observing the daily interactions within the community, the male acted as an historian allowing for interviews to be openly solicited. The ability to openly interview the local residents enhanced the quality of the information gathered. The female researcher provided the family look while at the same time observing the clarifying the daily observations. The presentation is in ethnographic configuration; The field notes were placed within the framework of functional analysis for interpretation. We observed how the people of the village lived their daily lives then analyzed how the doctrines functioned for the people and the community; The tentative conclusions we reached revealed that the doctrines of the Mormon Church appeared to be dysfunctional for this community. The dysfunctionality seems to stem from a structural change in some of the Church\u27s policies. (Abstract shortened with permission of author.)

Productivity Working From Home During The Pandemic

I will be focusing my research on productivity during working from home. Specifically I will be focusing on men versus women productivity levels working from home, as well as single women versus women with children. This research is also designed to investigate the extent of work employees do while working at home and their productivity levels. The Covid19 pandemic had a major impact on the working environment. People were stuck inside their houses and were not able to go to their offices for months to years and this is still an ongoing problem we are dealing with today. It can be harder to focus, be productive, and get work done at home for reasons like family, pets, laundry, etc. Working from home has become the new normal in today’s world and people do not plan on going back into the office full time. Since working from home seems to be our future, we want to know how productive it really is. This paper investigates the amount of work that gets done, what factors play a role in who is more productive at home, and overall how focused people are while working from their home. This topic is important because our future entails mostly hybrid or remote jobs, so the results will help us understand if that is good or bad for the economy

Corzuelas House

https://openscholarship.wustl.edu/bcs/1415/thumbnail.jp

Pratiques éducatives en education rurale: Enseigner les sciences naturelles

Se expone y analiza el proceso de diseño e implementación de secuencias de actividades propuestas desde los enfoques de indagación y modelización para generar aprendizajes en Ciencias Naturales, en la escolaridad primaria en plurigrado rural. Se trata de los resultados parciales de un trabajo de investigación interinstitucional desarrollado en Argentina (Provincia de Santa Fe), por dos Institutos de Educación Superior, que tomó como objeto de estudio las prácticas de enseñanza de las Ciencias Naturales en dos escuelas rurales de Educación Primaria con grados agrupados. Se muestran criterios de diseño y análisis de secuencias para este contexto y se concluye que el enfoque de indagación-modelización promueve el desarrollo de habilidades de indagación y la construcción de modelos explicativos por parte de los estudiantes, en un escenario que enriquece este tipo de propuestas, el plurigrado.The process of designing sequences of activities to generate learning in the context of rural plurigrado is exposed and analyzed. This is the partial results of an interinstitutional research project developed in Argentina (Province of Santa Fe), by two Institutes of Higher Education, which took as object of study the teaching practices of the Natural Sciences in two rural schools of Primary Education with grouped degrees. Design criterions and sequences analysis are shown for this context and it is concluded that the investigation/inquiry-modelling/representation approach promotes the development of inquiry/investigation abilities and the construction of explanatory models by students, in a scene that enriches/improves this kind of proposals, the multigrade.On expose et on analyse le processus de conception et d’application de séquences des activités proposées à partir des objectifs de la recherche et de la modélisation afin de produire des apprentissages en Sciences naturelles, à l’école primaire (en zone) rurale, regroupant plusieurs niveaux. Ce sont les résultats partiels d’un travail d’enquête inter-institutionnel, développé en Argentine (Province de Santa Fe), par deux Instituts d’Enseignement supérieur, qui a eu pour sujet d’étude les pratiques d’enseignement des Sciences naturelles dans deux écoles primaires rurales comprenant des niveaux regroupés. Les critères de conception et d’analyse des séquences pour ce cas sont mis en évidence. Ils conduisent à la conclusion que la mise en oeuvre d’un modèle opérationnel favorise le développement des compétences pour la recherche méthodique et initie l’élaboration de modèles explicatifs pour une partie des étudiants, dans une démarche enrichissant ce type d’initiative, le regroupement des scolaires de niveaux différents

Metal Enhanced fluorescence emission and Quenching protection effect with a host-guest Nanophotonic-supramolecular structure

The functionalization of the nanoparticle's (NP) surface is one method for tuning their overall properties to fit targeted applications. We developed a nanosensor based on the specific supramolecular interactions between β-cyclodextrin (βCD) nanocavities and organic molecules of biological interests using the metal-enhanced fluorescence effect (MEF) as the detection signal. We grafted βCD, a typical macrocyclic host molecule that interacts specifically with different organic molecules and changes their physical properties (such as their fluorescence emission intensity), on gold NPs. To evaluate this nanosensor and the effect of the metallic core, we worked with a typical organic molecule, Rhodamine B (RhB), that has a strong association constant with βCD (5700 M-1) and is well-known to be quenched in the presence of cyclodextrins (CDs). The results show that, by grafting βCD on gold NPs, it is possible to increase the sensitivity of RhB detection by 70%, 80%, and 294% when compared with solutions in (1) a phosphate buffer, (2) with βCD, and (3) with Au NPs, respectively. These results show that the use of a supramolecular system attached to a metallic NP can interact specifically with a dye to enhance its fluorescence emission through the MEF effect. Moreover, this type of nanosystem can overcome the quenching of the signal by the matrix, such in the case of RhB with CDs. Eventually, this concept could be extended to other dyes with different quenching effects. For this reason, this type of nanosensor system could be used in the future to protect and enhance the dye emission of fluorophores in different biological media.Fil: Veglia, Alicia Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Bracamonte, Angel Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina. Laval University; Canad