147 research outputs found

    Synthesis of Novel Glycosylidene-Based Quinolines

    Get PDF

    Synthesis of Novel Glycosylidene-Based Quinolines

    Get PDF

    Helping me, helping you: behavioral and neural development of social competence from childhood to adolescence

    Get PDF
    Why do some children easily find their way in social situations and are satisfied with their social lives, while others experience more difficulties? One key component that may explain this is social competence: the ability to fulfill both own and other’s social goals. This thesis focused on individual differences in social competence from childhood to adolescence by examining contextual, developmental and neurobiological influences on aggressive and prosocial responses to social evaluation. Findings showed robust neural processes related to social feedback and subsequent aggression already in middle childhood. Additionally, this thesis revealed that the period between childhood and adolescence is important for the behavioral and neural development of inhibition of aggression following negative, neutral and positive social feedback. Aggression following social feedback decreased towards adolescence, but aggression following positive feedback decreased earlier in childhood than following negative feedback. Moreover, the involvement of the dorsolateral prefrontal cortex, known for its role in executive functioning, decreased over time. Finally, results indicated that the co-occurrence of aggression following rejection and prosocial behavior following observed rejection may possibly protect against externalizing behaviors and promote wellbeing. This thesis highlights the importance of examining the interplay of developmental processes across social contexts to understand mental health outcomes. Netherlands Organziation for Scientific Research (NWO)Pathways through Adolescenc

    Family History:Relatives, Roots, and Databases

    Get PDF
    How are the concepts of ‘me’, ‘my relatives’ and ‘family’ shaped in the specific historical practice of contemporary family histories, written by family historians about their own relatives? Object of this study is a corpus of more than 120 contemporary histories, selected at the CBG (Centraal Bureau voor Genealogie), a national desk that facilitates genealogical research in The Netherlands. The analysis of this corpus covers templates of timelines, digital influences, concepts of family, and repertoires of family historians as writers. The intertwining of classical concepts and software-terms, and the intimate relations between individuals and their technological, digital artifacts is studied here in the tradition of Bruno Latour’s Actor-Network Theory (ANT). This study discloses the conceptual juggling with concepts needed in our descriptions of the past of our relatives

    Episodic memory enhancement versus impairment is determined by contextual similarity across events

    Get PDF
    For over a century, stability of spatial context across related episodes has been considered a source of memory interference, impairing memory retrieval. However, contemporary memory integration theory generates a diametrically opposite prediction. Here, we aimed to resolve this discrepancy by manipulating local context similarity across temporally disparate but related episodes and testing the direction and underlying mechanisms of memory change. A series of experiments show that contextual stability produces memory integration and marked reciprocal strengthening. Variable context, conversely, seemed to result in competition such that new memories become enhanced at the expense of original memories. Interestingly, these patterns were virtually inverted in an additional experiment where context was reinstated during recall. These observations 1) identify contextual similarity across original and new memories as an important determinant in the volatility of memory, 2) present a challenge to classic and modern theories on episodic memory change, and 3) indicate that the sensitivity of context-induced memory changes to retrieval conditions may reconcile paradoxical predictions of interference and integration theory

    Kopervoorziening blijft punt van aandacht

    Get PDF
    Zowel een tekort als een overmaat is schadelijk. Naast het kopergehalte in het rantsoen is de benutting een belangrijke factor

    Kopervoorziening bij melkvee in West-Nederland

    Get PDF
    In dit rapport is de huidige kennis van de kopervoorziening van melkvee, met speciale aandacht voor het westelijk veenweidegebied, gebundeld. Praktische adviezen zijn opgesteld en kennishiaten zijn aangegeven

    Perceived stress as mediator for longitudinal effects of the COVID-19 lockdown on wellbeing of parents and children

    Get PDF
    Dealing with a COVID-19 lockdown may have negative effects on children, but at the same time might facilitate parent-child bonding. Perceived stress may influence the direction of these effects. Using a longitudinal twin design, we investigated how perceived stress influenced lockdown induced changes in wellbeing of parents and children. A total of 106 parents and 151 children (10-13-year-olds) filled in questionnaires during lockdown and data were combined with data of previous years. We report a significant increase in parental negative feelings (anxiety, depression, hostility and interpersonal sensitivity). Longitudinal child measures showed a gradual decrease in internalizing and externalizing behavior, which seemed decelerated by the COVID-19 lockdown. Changes in parental negative feelings and children's externalizing behavior were mediated by perceived stress: higher scores prior to the lockdown were related to more stress during the lockdown, which in turn was associated with an increase in parental negative feelings and children's' externalizing behavior. Perceived stress in parents and children was associated with negative coping strategies. Additionally, children's stress levels were influenced by prior and current parental overreactivity. These results suggest that children in families with negative coping strategies and (a history of) parental overreactivity might be at risk for negative consequences of the lockdown.Pathways through Adolescenc

    Development of social feedback processing and responses in childhood:an fMRI test-replication design in two age cohorts

    Get PDF
    This study investigated behavioral and neural correlates underlying social feedback processing and subsequent aggressive behaviors in childhood in two age cohorts (test sample: n = 509/n = 385 and replication sample: n = 354/n = 195, 7-9 years old). Using a previously validated Social Network Aggression Task, we showed that negative social feedback resulted in most behavioral aggression, followed by less aggression after neutral and least aggression after positive feedback. Receiving positive and negative social feedback was associated with increased activity in the insula, medial prefrontal cortex and ventrolateral prefrontal cortex. Responding to feedback was associated with additional activation in the dorsolateral prefrontal cortex (DLPFC) following positive feedback. This DLPFC activation correlated negatively with aggression. Furthermore, age analyses showed that older children showed larger reductions in aggression following positive feedback and more neural activation in the DLPFC when responding to positive feedback compared to younger children. To assess the robustness of our results, we examined these processes in two independent behavioral/functional magnetic resonance imaging samples using equivalence testing, thereby contributing to replicable reports. Together, these findings demonstrate an important role of social saliency and regulatory processes where regulation of aggression rapidly develops between the ages of 7 and 9 years.</p
    • …
    corecore