Constructing TI-Friendly Substitution Boxes Using Shift-Invariant Permutations

The threat posed by side channels requires ciphers that can be efficiently protected in both software and hardware against such attacks. In this paper, we proposed a novel Sbox construction based on iterations of shift-invariant quadratic permutations and linear diffusions. Owing to the selected quadratic permutations, all of our Sboxes enable uniform 3-share threshold implementations, which provide first order SCA protections without any fresh randomness. More importantly, because of the shift-invariant property, there are ample implementation trade-offs available, in software as well as hardware. We provide implementation results (software and hardware) for a four-bit and an eight-bit Sbox, which confirm that our constructions are competitive and can be easily adapted to various platforms as claimed. We have successfully verified their resistance to first order attacks based on real acquisitions. Because there are very few studies focusing on software-based threshold implementations, our software implementations might be of independent interest in this regard

A multi-targeted approach to suppress tumor-promoting inflammation

Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes

Amplification of a Zygosaccharomyces bailii DNA Segment in Wine Yeast Genomes by Extrachromosomal Circular DNA Formation

We recently described the presence of large chromosomal segments resulting from independent horizontal gene transfer (HGT) events in the genome of Saccharomyces cerevisiae strains, mostly of wine origin. We report here evidence for the amplification of one of these segments, a 17 kb DNA segment from Zygosaccharomyces bailii, in the genome of S. cerevisiae strains. The copy number, organization and location of this region differ considerably between strains, indicating that the insertions are independent and that they are post-HGT events. We identified eight different forms in 28 S. cerevisiae strains, mostly of wine origin, with up to four different copies in a single strain. The organization of these forms and the identification of an autonomously replicating sequence functional in S. cerevisiae, strongly suggest that an extrachromosomal circular DNA (eccDNA) molecule serves as an intermediate in the amplification of the Z. bailii region in yeast genomes. We found little or no sequence similarity at the breakpoint regions, suggesting that the insertions may be mediated by nonhomologous recombination. The diversity between these regions in S. cerevisiae represents roughly one third the divergence among the genomes of wine strains, which confirms the recent origin of this event, posterior to the start of wine strain expansion. This is the first report of a circle-based mechanism for the expansion of a DNA segment, mediated by nonhomologous recombination, in natural yeast populations

Plastic helical coil heat exchanger as an alternative for a domestic water storage tank

A reduction in weight and cost of a domestic hot water storage vessels is an interesting case for the industry, that can be reached by an alternative material of the helical coil heat exchanger inside them. The goal of the present study was to design a fully polymer solar boiler demonstrator and to explore its thermal performance in the low pressure and low temperature conditions. The metal coil of the conventional solar boiler for domestic usage was replaced by a plastic tube and the heat transfer behavior of helically coiled smooth plastic tube heat exchanger was investigated experimentally. The heat exchanger is placed in the middle of the tank in two parallel coils that fill almost whole height of the vessel in order to achieve maximal surface area. The water inside the tank was heated by circulating in closed loop with heater to achieve constant initial temperature across the whole volume of the vessel. When reached, the heating was stopped and a cold water of the tap temperature started to flow inside the polymeric tube. All the required parameters like inlet and outlet temperatures of tube-side and stratified temperatures in fifteen different points, flow rate of fluids and pressure drop were measured using appropriate instruments. The test runs were performed for different initial temperatures inside the tank ranging from 30-60°C from which the overall heat transfer coefficient and thermal resistances were calculated. The validity of obtained results was compared with the numerical simulation and the experimental results on the initial metallic tube.Papers presented at the 13th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Portoroz, Slovenia on 17-19 July 2017 .International centre for heat and mass transfer.American society of thermal and fluids engineers

Национальное государство и процесс глобализации

Секция I. Международные отношения, внешняя политика и дипломатия Республики Беларус